- |||||||||| lithium carbonate ER / Generic mfg.
Factors Associated With Sleep Disturbance Among Youth With Bipolar Disorder () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1002;
Future research is warranted to better understand the temporal association between sleep disturbance and its correlates in youth with BD. Relatedly, interventions that integrate mood disturbance and sleep disturbances can help improve overall functioning.
- |||||||||| lithium carbonate ER / Generic mfg.
Review of Papers About Risk to Develop and Treatment of Bipolar Disorder, Recognizing Psychosis, Irritability and Depression, Disparities Treating Suicidality, and Consequences of COVID (Virtual) - Oct 19, 2022 - Abstract #AACAP2022AACAP_611;
Objectives This presentation will review 6 articles chosen by the Lifelong Learning Committee to discuss the following areas: 1) the association between different types of irritability and depression; 2) the course and outcome of offspring of parents with bipolar disorder who were recruited when they were aged 2 to 5 years old; 3) the efficacy of quetiapine and lithium for the acute treatment of youth hospitalized because of a manic/mix episode; 4) the importance of studying suicidality in minority populations; 5) the factors associated with a lack of early recognition of the first episode of psychosis; and 6) a review of cross-sectional studies describing the effects of COVID-19...This information will be key to developing appropriate preventative and acute and maintenance treatments. There is a need to include minorities (eg, race, ethnicity, sexual orientation) in all studies.
- |||||||||| lithium carbonate ER / Generic mfg.
Partial Nephrogenic Diabetes Insipidus Secondary to Lithium Use () - Oct 15, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_4344;
Treatment was started initially with chlorthalidone with inappropriate response, then dose increased to 100mg daily with further addition of amiloride 10mg twice daily with subsequent response and decrease of sodium level from 167 to 147 mEq/L...Treatment options include high doses of desmopressin, low sodium diet, thiazide diuretics, amiloride, and NSAIDs. Urine osmolalities during the desmopressin stimulation test
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium Induced Partial Nephrogenic Diabetes Insipidus: An Unusual Presentation () - Oct 15, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_4336;
Caretaker reported use of lithium carbonate 300 mg twice a day for the past 12 years...The uniqueness of our case lies on the rarity of this type of NDI reported on literature. Our patient successfully responded to low dose thiazide diuretic correcting dysnatremia and archiving satisfactory uresis.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Empagliflozin Associated Severe Hypernatremia in the Setting of Subclinical Diabetes Insipidus: A Case Report () - Oct 15, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_4256;
Lithium was discontinued and sodium valproate was initiated...Hydrochlorothiazide and a low salt diet were initiated...Discussion In this clinical vignette, we described a patient who developed severe hypernatremia in the setting of diabetes mellitus and concurrent diabetes insipidus. To our knowledge, our case report is the first to describe severe hypernatremia with empagliflozin in a patient with diabetes insipidus and uncontrolled diabetes mellitus.
- |||||||||| lithium carbonate ER / Generic mfg.
Concurrent antiepileptic and antipsychotic use moderates lithium’s effects on regional brain volumes: a mega-analysis from the ENIGMA-Bipolar Disorder Working Group (Corner 1 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1652;
In these preliminary findings, the normalizing effects of lithium on regional subcortical brain volumes in BD appears to be modified by concurrent usage of antiepileptic mood stabilisers or atypical antipsychotics. Ongoing multivariate analysis of a wider range of medications and deeper clinical phenotype data - including measures of clinical severity and alternative treatment modeling strategies, e.g., Neuroscience Based nomenclature (NBN) - may help to disentangle associations between psychotropic medication use, neuroanatomical variation and treatment response in BD.
- |||||||||| lithium carbonate ER / Generic mfg.
A multicentric multimodal in vivo microscopy MRI study of bipolar disorder reveals axonal loss and demyelination (Corner 1 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1533;
This underlines the plurality of the mechanisms that are involved in white matter microstructure changes in bipolar patients and may partly explain the heterogeneity of DTI studies in this condition. If replicated, these Result s may contribute to shed light on the microstructural mechanisms involved in bipolar disorder that cannot be deciphered with classical DTI acquisitions.
- |||||||||| lithium carbonate ER / Generic mfg.
Immune-inflammation and structural neuroimaging differentiate bipolar and unipolar depression: a machine learning study (Corner 2 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1503;
Age, sex, body mass index, lithium therapy, equivalent doses of chlorpromazine and imipramine, number of previous episodes, total intracranial volume and MRI scanner were entered as nuisance covariates...Immune-inflammatory signature during a depressive episode and specific structural neuroimaging alterations are important hallmarks for distinguishing BD from MDD, and their integration could be beneficial to achieve more accurate diagnosis prediction. These findings strengthen the importance of biomarker research for the translation of cutting-edge scientific knowledge into clinical practice.
- |||||||||| lithium carbonate ER / Generic mfg.
Bipolar disorder and polysubstance use disorder – sociodemographic and clinical correlates (Corner 2 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1471;
Given the significant impact of this comorbidity on the course and outcome, and the need to reduce polypharmacy to guarantee an adequate mood stabilization, further research on this topic is needed. Focusing the attention on this specific subtype of patients with BD may help integrating specific pharmacological and psychosocial therapies integrating the different professional roles.
- |||||||||| Valproic acid-induced hyperamonemic encephalopathy: a clinical case (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1342;
The authors describe a clinical case of a 48-year-old female patient, with no significant medical-surgical history, hospitalized due to behavioral changes framed in a manic episode, who was prescribed valproic acid, in association with lorazepam and olanzapine...The main pathophysiological mechanism involves the inhibition of an enzyme in the urea cycle with subsequent development of hyperammonemia. while ensuing central nervous system toxicity due to the hyperammonemia is thought to be mediated by excessive activation of glutamate receptors. It is essential that there is a high level of suspicion in clinicians for this secondary effect of valproic acid, in order to adequately treat the patient who presents with acute confusional conditions, not explained by other complications.
- |||||||||| lithium carbonate ER / Generic mfg.
Predictors of lithium response in unipolar depression (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1336;
In the next step, parameters easy to obtain in a daily clinical praxis should be identified. For example, in case of positive Result s using polysomnography and circadian rhythm of body temperature, wearables devices could be tested instead of rather costly and complex examinations.
- |||||||||| Valproate encephalopathy in a bipolar affective disorder: a case report (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1297;
A classic literature review was performed using PubMed, UpToDate and The Cochrane Library databases, as well as the literature with clinical relevance in the speciality...Therefore, valproate treatment was gradually suspended, and a progressive remission of the cognitive impairment and parkinsonian symptoms was observed during the next ten days of drug wash-out. Taking into account the clinical case, specifically the risk of kidney toxicity from lithium and neurological toxicity from valproate aripiprazole was considered for maintenance treatment, and so far the patient is stable.Discussion and Conclusion : This case highlights the existence of valproate-induced encephalopathy, with a non-toxic valproate serum, [7,8,9,10] and it warns of the need for clinicians to be familiar with this condition to act as early as possible.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Bipolar spectrum disorder: we do not treat it if we miss it (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1274;
These medications are typically medications like lithium, valproic acid, lamotrigine, carbamazepine, and atypical antipsychotics...The study of pharmacogenomics in mental health is quickly evolving, and it has allowed the identification of some genetic assets associated with bipolar spectrum disorders, which may provide the groundwork for the identification of genetic risk factors and personalized pharmacological profiles. Pharmacogenomics may offer a safer use of drugs, optimizing dosages and pharmacological combinations.
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium-induced neurotoxicity with non-toxic serum levels in a patient with bipolar disorder (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1261;
He had long been stabilised under risperidone 1mg/day and lithium 800mg/day to which he had been non-compliant prior to admission.In the ward, olanzapine 15mg/day and lithium 800mg/day were introduced...Rapid titration may lead to preferential accumulation in the white matter, the pons and the brainstem, leading to toxicity despite therapeutic serum levels. Additional mechanisms have been proposed, such as variations in cerebral hydration caused by effects of lithium on the antidiuretic hormone and altered distribution and removal of lithium from localised pathological tissue. Conclusion s This case highlights the importance of systematically consider lithium-induced neurotoxicity in patients presenting with neurological symptoms.
- |||||||||| lithium carbonate ER / Generic mfg.
Treatment resistant depression: epidemiology and consequences – a population wide study (Corner 2 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1223;
TRD was associated with a higher mortality, and although we did not have access to cause of death, the high rates of intentional self-harm indicate that suicide may be a contributing factor. The median time to reach TRD is longer than what could be expected from clinical management guided by current guidelines, and most patients were not prescribed treatments that have shown to be effective in TRD, indicating that care of these patients can be improved.
- |||||||||| lithium carbonate ER / Generic mfg.
Increased grey matter volumes in the temporal lobe of euthymic patients with bipolar disorder (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1109;
However, our Result s of increased grey matter volumes are in harmony with the largest longitudinal study in BD to date, suggesting that the fusiform and parahippocampal gyri suffer less cortical thinning than frontal and subcortical regions (1). Moreover, previous studies have observed that lithium may possess neuroprotective properties (2) that could be slowing the neuroprogession of BD in certain brain regions, including the fusiform gyrus (3).
- |||||||||| Gender-related connectivity patterns under burnout formation (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1011;
TRD was associated with a higher mortality, and although we did not have access to cause of death, the high rates of intentional self-harm indicate that suicide may be a contributing factor. The median time to reach TRD is longer than what could be expected from clinical management guided by current guidelines, and most patients were not prescribed treatments that have shown to be effective in TRD, indicating that care of these patients can be improved.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Eslicarbazepine acetate – an unexplored therapeutic option in the treatment of bipolar disorders (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_989;
It should be considered an option, as it may be more effective than oxcarbazepine, while having fewer adverse effects. However, clinical trials using this substance need to be conducted, particularly studies that compare eslicarbazepine with oxcarbazepine.
- |||||||||| lithium carbonate ER / Generic mfg.
Indoleamine 2,3-dioxygenase activity in bipolar disorder (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_979;
The catabolism may be influenced by being overweight, which is a frequent comorbidity in bipolar disorder. The findings of the role of lithium response might further elucidate the anti-inflammatory properties of lithium and are of clinical relevance towards the effort of a personalized selection of the mood-stabilizing treatment.
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Long-term lumateperone treatment in bipolar disorder – six-month open-label extension study (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_972;
P3
Function and quality of life also improved as measured by the mean change from baseline to Day 175 in Q-LES-Q-SF percent score (9.0). Conclusion : In patients with bipolar depression, long-term lumateperone treatment was generally well tolerated with low risk of extrapyramidal symptoms, weight gain, and cardiometabolic effects. These data further support the safety, tolerability, and effectiveness of lumateperone in patients with bipolar depression.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
The effect of lurasidone on anhedonia in adult patients with bipolar depression (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_960;
P3
A significant percent (48.4%; Wald 95% CI, 22.8, 74.0) of the lurasidone effect on improvement on the SDS total score was also mediated by improvement in the item-8 anhedonia score (P<0.0005). Conclusion : The Result s of this post-hoc analysis suggest that lurasidone treatment may be associated with improvement in anhedonia in patients with a diagnosis of bipolar I disorder who present with moderate-to-severe major depressive episodes. Improvement in both quality of life and functioning appeared to be largely mediated by improvement in anhedonia, indicating that the amelioration of patients’ pervasive inability to feel pleasure or take interest in their environment is an important therapeutic target.
- |||||||||| lithium carbonate ER / Generic mfg., haloperidol / Generic mfg.
Cycloid psychosis – in between humor and psychosis (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_914;
However, first-generation antipsychotics such as haloperidol can also be used...Several investigators have supported the nosological validity of cycloid psychosis. Some patients considered to represent cycloid psychosis do have relatively prominent affective features, however, as well as a family history of mood disorders. This condition has a generally good outcome with interepisode recovery and response to medications, particularly antipsychotics and patients are frequently able to function well in their lives. It should be noted that psychopharmacologic treatment of cycloid psychosis patients differs from those with bipolar disorder or schizophrenia, and may not require long-term maintenance medication. In neither ICD-10 nor DSM-IV is cycloid psychosis a distinct diagnostic option, which limits its clinical recognition today.
- |||||||||| lithium carbonate ER / Generic mfg.
Bipolar disorders and suicide: stumbling twice with the same stone? (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_910;
The main limitations of our study include its small sample size and its inability to establish causality. In Conclusion , there is more to be done in the fight against suicide.
- |||||||||| lithium carbonate ER / Generic mfg.
A multicentric multimodal in vivo microscopy MRI study of bipolar disorder reveals axonal loss and demyelination (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_751;
This underlines the plurality of the mechanisms that are involved in white matter microstructure changes in bipolar patients and may partly explain the heterogeneity of DTI studies in this condition. If replicated, these Result s may contribute to shed light on the microstructural mechanisms involved in bipolar disorder that cannot be deciphered with classical DTI acquisitions.
- |||||||||| lithium carbonate ER / Generic mfg.
Treatment resistant depression: epidemiology and consequences – a population wide study (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_641;
TRD was associated with a higher mortality, and although we did not have access to cause of death, the high rates of intentional self-harm indicate that suicide may be a contributing factor. The median time to reach TRD is longer than what could be expected from clinical management guided by current guidelines, and most patients were not prescribed treatments that have shown to be effective in TRD, indicating that care of these patients can be improved.
- |||||||||| lithium carbonate ER / Generic mfg.
Immune-inflammation and structural neuroimaging differentiate bipolar and unipolar depression: a machine learning study (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_532;
Age, sex, body mass index, lithium therapy, equivalent doses of chlorpromazine and imipramine, number of previous episodes, total intracranial volume and MRI scanner were entered as nuisance covariates...Immune-inflammatory signature during a depressive episode and specific structural neuroimaging alterations are important hallmarks for distinguishing BD from MDD, and their integration could be beneficial to achieve more accurate diagnosis prediction. These findings strengthen the importance of biomarker research for the translation of cutting-edge scientific knowledge into clinical practice.
- |||||||||| lithium carbonate ER / Generic mfg.
Bipolar disorder and polysubstance use disorder – sociodemographic and clinical correlates (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_461;
Given the significant impact of this comorbidity on the course and outcome, and the need to reduce polypharmacy to guarantee an adequate mood stabilization, further research on this topic is needed. Focusing the attention on this specific subtype of patients with BD may help integrating specific pharmacological and psychosocial therapies integrating the different professional roles.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, Adverse events: Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. (Pubmed Central) - Oct 13, 2022
Among 24 ADEs (PT) that were reported in more than 50 patients, lamotrigine was associated with increased risks of 13 ADEs (PT), followed by carbamazepine with increased risks of 8 ADEs (PT)...Lithium carbonate was associated with increased risks of rash (PT), drug interaction (PT), and tubulointerstitial diseases (SMQ)...The risk of hyperglycemia/new onset diabetes mellitus (SMQ) was increased by olanzapine, quetiapine fumarate, and risperidone. We are presenting the profiles of ADEs in patients with bipolar disorders using the JADER database, and propose risk factors for 19 ADEs (PT) and 4 ADEs (SMQ).
- |||||||||| Clinical, Journal: Lamotrigine-induced mania: warning report for the identification of vulnerable populations and expert clinical recommendations for prescription. (Pubmed Central) - Oct 12, 2022
A 38-year-old man, stabilized with asenapine due to a brief psychotic episode, presented depressive symptoms and LTG was titrated up to 200 mg/day in 6 weeks...LTG was withdrawn and he was treated with lithium and lurasidone...LTG was suspended and aripiprazole increased...LTG-induced mania may be more likely to happen in patients with BD-I, manic predominant polarity, an index manic episode, or those with a history of the antidepressant manic switch. Therefore, in BD patients with the aforementioned risk factors, LTG use should be carefully managed: starting with low doses, extending tapering lengths, using adjunctive treatments and close monitoring manic symptoms.
- |||||||||| lithium carbonate ER / Generic mfg.
The psychiatric disorder drug lithium affects human hippocampal neurogenesis (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_12090;
This study provides empirical support that adult hippocampal neurogenesis and gliogenesis are mechanisms that could contribute to the effects of lithium on human hippocampal volume. Future research should continue to bridge the gap between in vitro and in vivo observations, and to explore whether neurogenesis is also a critical mechanism explaining lithium’s therapeutic effects.
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium differentially affects synaptic plasticity in a dose-dependent manner (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_6776;
This differential effect could explain the contrasting findings on the effects lithium has on cognition as small changes in lithium concentration drastically change the synaptic response. This study has the potential to influence clinical lithium application and may lessen the negative impact lithium treatment has on cognition.
- |||||||||| lithium carbonate ER / Generic mfg.
Lithium orotate is more effective and less toxic than lithium carbonate in a mouse model of mania (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_4736;
LiOr demonstrates superior efficacy, potency, and tolerability to LiCO in both male and female mice. When coupled with the contrasting dissociative properties and differential response to pharmacological agents, these differences in effect seem to disprove the long-held belief pertaining to lithium compounds that a “salt is a salt.”
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