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- | lithium carbonate ER / Generic mfg.
Journal: Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder. (Pubmed Central) - Nov 20, 2022
The lithium responders exhibited elevated choline (GPC) in the left DLPFC compared to non-responders.
- | lithium carbonate ER / Generic mfg.
Journal: Robust 2D MoS Artificial Synapse Device Based on a Lithium Silicate Solid Electrolyte for High-Precision Analogue Neuromorphic Computing. (Pubmed Central) - Nov 18, 2022
Thus, a high classification accuracy of 96.77% (close to the software baseline of 98%) is demonstrated in the Modified National Institute of Standards and Technology (MNIST) simulations. These results provide a future perspective for robust synaptic device architecture of lithium solid-state electrolytes stacked with 2D van der Waals layered channels for high-precision analogue neuromorphic computing systems.
- | lithium carbonate ER / Generic mfg.
Journal: Lithium rescues dendritic abnormalities in Ank3 deficiency models through the synergic effects of GSK3β and cyclic AMP signaling pathways. (Pubmed Central) - Nov 17, 2022
Altogether, our results suggest that dendritic abnormalities observed in loss of function ANK3 variants and BD patients may be rescued by lithium treatment. Additionally, drugs selectively targeting GSK3β and cAMP pathways could be beneficial in BD.
- | lithium carbonate ER / Generic mfg.
Journal: Mood Stabilizers and Risk of All-Cause, Natural, and Suicide Mortality in Bipolar Disorder: A Nationwide Cohort Study. (Pubmed Central) - Nov 15, 2022
Additionally, drugs selectively targeting GSK3β and cAMP pathways could be beneficial in BD. In addition to having protective effects against suicide and all-cause mortality, mood stabilizers also exert a substantial protective effect against natural mortality, with lithium associated with the lowest risk of mortality.
- | lithium carbonate ER / Generic mfg., risperidone / Generic mfg.
Journal: Later onset of Childhood Disintegrative Disorder (CDD): a case report. (Pubmed Central) - Nov 15, 2022
Following treatment with lithium carbonate combined with risperidone, the patient experienced a reduction in irritability and aggression. CDD is a rare condition; therefore, the data presented may be useful to investigate its characteristics of the onset, to improve the understanding of the aspects of differentiation from the Autism Spectrum Disorder and finally to propose the possibility of treatment.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Pomegranate (Punica granatum) peel alleviates lithium-induced alterations in the thyroid gland of rats by modulating apoptosis and oxidative stress. (Pubmed Central) - Nov 15, 2022
Lithium carbonate (LC) is known to alter thyroid gland function...These changes were mitigated upon PG treatment. In conclusion, PG alleviated the morphological and functional changes in the thyroid glands induced by LC by modulating apoptosis and oxidative stress.
- | lithium carbonate ER / Generic mfg.
Journal: A carbothermic hybrid synthesized using waste halogenated plastic in sub/supercritical CO and its application for lithium recovery. (Pubmed Central) - Nov 15, 2022
Mechanism study indicated that cathode powder was transformed into low-valence states of transition metals/metal oxides and released lithium as lithium carbonate due to collapse of oxygen framework via carbothermic reduction. This work provides an applicable and green process for synthesis of alternative carbon carrier from waste halogenated plastic and its application as carbothermic reductant in lithium recovery.
- | lithium carbonate ER / Generic mfg.
Journal: 20-year medication use trends in first-episode bipolar disorder. (Pubmed Central) - Nov 15, 2022
This work provides an applicable and green process for synthesis of alternative carbon carrier from waste halogenated plastic and its application as carbothermic reductant in lithium recovery. (i) The use of antidepressants is too prevalent, (ii) the use of lithium is declining and needs to be increased, and (iii) LAIs are markedly underutilized as compared to their oral counterparts.
- | lithium carbonate ER / Generic mfg.
Retrospective data, Journal, Heterogeneity: Heterogeneous early illness courses of Korean patients with bipolar disorders: replication of the staging model. (Pubmed Central) - Nov 13, 2022
The stage progression pattern differed from the early phase in BD-I and BD-II patients. Psychotic comorbidity, age at onset, age at starting psychiatric treatment showed associations with the illness progression.
- | lithium carbonate ER / Generic mfg.
Observational data, Journal: Self-Reported Low Lithium Adherence Among Chinese Patients with Bipolar Disorder in Shenzhen: A Cross-Sectional Study. (Pubmed Central) - Nov 10, 2022
Health services should actively provide lithium-associated information. A greater need for medication information based on WeChat was observed, implying its potential role in adherence-related psychoeducation.
- | lithium carbonate ER / Generic mfg.
Trial primary completion date: Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia (clinicaltrials.gov) - Nov 8, 2022
P2, N=60, Recruiting, Sponsor: Columbia University
A greater need for medication information based on WeChat was observed, implying its potential role in adherence-related psychoeducation. Trial primary completion date: Sep 2022 --> Mar 2023
- | lithium carbonate ER / Generic mfg.
Journal: Pharmacotherapy for bipolar disorder in adults with high-functioning autism. (Pubmed Central) - Nov 5, 2022
Among antipsychotics, dopamine receptor antagonists with combined serotonergic activity are preferable. Further research is needed to improve the diagnostic process and to delineate the effectiveness of different drugs for BD in HFA subjects.
- | lithium carbonate ER / Generic mfg.
Journal: Effectiveness and safety of monoamine oxidase inhibitor treatment for bipolar depression versus unipolar depression: an exploratory case cohort study. (Pubmed Central) - Nov 5, 2022
MAOIs may be more effective - and as safe - for patients with bipolar depression versus unipolar depression. Future studies should explore this possible advantage using a larger sample size.
- lithium carbonate ER / Generic mfg.
Lithium Attenuates Graft-Versus-Host Disease Via Effects on the Intestinal Stem Cell Niche (Hall D (Ernest N. Morial Convention Center)) - Nov 4, 2022 - Abstract #ASH2022ASH_4637;
In a clinical pilot study conducted at Fred Hutchinson Cancer Research Center (FHCRC) and the University of Washington, twenty patients with steroid-refractory gut GVHD and mucosal denudation at endoscopy were treated with oral lithium carbonate in addition to second line therapy...PloS one. 2017; 12(8):e0183284.
- | lithium carbonate ER / Generic mfg.
Journal: Metal ions in cerebrospinal fluid: Associations with anxiety, depression, and insomnia among cigarette smokers. (Pubmed Central) - Nov 4, 2022
Active smokers had significantly higher CSF levels of magnesium, zinc, iron, lead, lithium, and aluminum. Furthermore, CSF aluminum played a mediating role in the relationship between smoking and depression, which further confirmed its neurotoxicity.
- | lithium carbonate ER / Generic mfg.
Journal: Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder. (Pubmed Central) - Nov 4, 2022
Our results highlight that Li exerts modulatory effects on immune-related functions and that epigenetic mechanisms, especially miRNAs, can influence the modulation of different genes and pathways involved in Li response. Moreover, our data suggest the potentiality to integrate data coming from different high-throughput approaches as a tool to prioritize genes and pathways.
- | lithium carbonate ER / Generic mfg.
Journal: Electroconvulsive therapy combined with lithium developed reversible pure anomic aphasia: a case report. (Pubmed Central) - Nov 4, 2022
The anomic aphasia appeared after ECT was reversible. Li-ECT should be administered with caution to middle- and older-aged patients with comorbidities, and serum Li levels should be closely monitored during the treatment period.
- | lithium carbonate ER / Generic mfg.
Journal: Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs. (Pubmed Central) - Nov 2, 2022
We further show that PEX11 and RIM20 regulate the expression of PGM2 mRNA at the translation level. The observed alteration of translation seems to target the structured 5'-untranslated region (5'-UTR) of the PGM2 mRNA.
- | lithium carbonate ER / Generic mfg., imipramine / Generic mfg.
Preclinical, Journal: Imipramine Can Be Effective on Depressive-Like Behaviors, but Not on Neurotrophic Factor Levels in an Animal Model for Bipolar Disorder Induced by Ouabain. (Pubmed Central) - Nov 2, 2022
The observed alteration of translation seems to target the structured 5'-untranslated region (5'-UTR) of the PGM2 mRNA. It can be suggested that acute administration of imipramine alone can be effective on depressive-like symptoms but not on neurotrophic factor alterations present in BD.
- Caplyta (lumateperone) - Intra / Cellular Therapies
Lumateperone in the Treatment of Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: Evaluation of Extrapyramidal and Motor Symptoms in Late-Phase Clinical Trials (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_1204;
P3
Benztropine and propranolol use was rare, with less than 1% of patients in any group receiving these treatments... In patients with bipolar I or bipolar II disorder experiencing an MDE, lumateperone 42-mg monotherapy or adjunctive therapy had a favorable EPS profile in both acute and long-term treatment.
- Caplyta (lumateperone) - Intra / Cellular Therapies
Glucocorticoid Receptors in the Orbitofrontal Cortex Mediate Cocaine-Induced Response Biases (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_1154;
P3
In patients with bipolar I or bipolar II disorder experiencing an MDE, lumateperone 42-mg monotherapy or adjunctive therapy had a favorable EPS profile in both acute and long-term treatment. In patients with bipolar II disorder experiencing an MDE, short-term treatment with lumateperone 42 mg as monotherapy or as adjunctive therapy significantly improved symptoms of depression, disease severity, and quality of life.
- Caplyta (lumateperone) - Intra / Cellular Therapies
Efficacy of Lumateperone in Pooled Short-Term Late-Phase Clinical Trials for the Treatment of Major Depressive Episodes Associated With Bipolar II Disorder (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_704;
P3
In patients with bipolar II disorder experiencing an MDE, short-term treatment with lumateperone 42 mg as monotherapy or as adjunctive therapy significantly improved symptoms of depression, disease severity, and quality of life. In patients with bipolar II disorder experiencing an MDE, short-term treatment with lumateperone 42 mg as monotherapy or as adjunctive therapy significantly improved symptoms of depression, disease severity, and quality of life.
- Caplyta (lumateperone) - Intra / Cellular Therapies
Metabolic Profile of Lumateperone in Late-Phase Clinical Trials for the Treatment of Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_332;
P3
In patients with bipolar II disorder experiencing an MDE, short-term treatment with lumateperone 42 mg as monotherapy or as adjunctive therapy significantly improved symptoms of depression, disease severity, and quality of life. In patients with bipolar I or bipolar II disorder experiencing an MDE, lumateperone 42-mg monotherapy or adjunctive therapy had a favorable metabolic profile for both acute and long-term treatment.
- Caplyta (lumateperone) - Intra / Cellular Therapies
Evaluation of Mania and Hypomania in Late-Phase Clinical Trials of Lumateperone in the Treatment of Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder () - Oct 31, 2022 - Abstract #ACNP2022ACNP_205;
P3
In patients with bipolar I or bipolar II disorder experiencing an MDE, lumateperone 42-mg monotherapy or adjunctive therapy had a favorable metabolic profile for both acute and long-term treatment. In patients with bipolar I or bipolar II disorder experiencing an MDE, lumateperone 42-mg monotherapy or adjunctive therapy was associated with low rates of treatment-emergent mania and hypomania that were similar to those of placebo-treated patients for both acute and long-term treatment.
- lithium carbonate ER / Generic mfg.
Comparative Effectiveness of Medications in Bipolar Disorder in Real-World Settings Based on 60,045 Patients (Grand Saguaro) - Oct 31, 2022 - Abstract #ACNP2022ACNP_159;
Lithium and certain long-acting injectable antipsychotics were associated with best outcomes and should be favoured. Quetiapine and ziprasidone were associated with significantly increased risk for both psychiatric and non-psychiatric hospitalizations.
- | lithium carbonate ER / Generic mfg.
Journal: Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation. (Pubmed Central) - Oct 30, 2022
Our experiments reveal that common genetic variation modulates lithium-induced neural progenitor proliferation and that GNL3 expression is necessary for the full proliferation-stimulating effects of lithium. These results suggest that performing genome-wide associations in genetically diverse human cell lines is a useful approach to discover context-specific pharmacogenomic effects.
- | lithium carbonate ER / Generic mfg.
Journal: Triple Diagnosis of Attention-Deficit/Hyperactivity Disorder with Coexisting Bipolar and Alcohol Use Disorders: Clinical Aspects and Pharmacological Treatments. (Pubmed Central) - Oct 29, 2022
Clinical experience and scientific evidence rather show that tailoring treatments for these three conditions considering their co-occurrence as a sole complex disorder yields more fulfilling and durable clinical outcomes. In light of the above considerations, the purpose of the present review is to critically discuss the pharmacological strategies in the personalized treatment of complex conditions defined by ADHD-bipolarityalcoholism coexistence.
- || lithium carbonate ER / Generic mfg., quetiapine / Generic mfg.
Clinical, Journal: Is Quetiapine Effective for Obsessive and Compulsive Symptoms in Patients with Bipolar Disorder? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. (Pubmed Central) - Oct 27, 2022
In light of the above considerations, the purpose of the present review is to critically discuss the pharmacological strategies in the personalized treatment of complex conditions defined by ADHD-bipolarityalcoholism coexistence. Our double-blind placebo-controlled clinical trial showed that quetiapine may be an effective adjuvant agent for reducing OC symptoms in BD patients.
- | lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
Journal: Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway. (Pubmed Central) - Oct 26, 2022
However, pharmacological inhibition of mammalian target of rapamycin (mTOR) signaling with rapamycin (10 mg/kg), a specific mTOR inhibitor, had no effect on ketamine-induced mania-like behavior. These results suggest that chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway, which may be a novel target for the development of BD treatment.
- | lithium carbonate ER / Generic mfg.
Journal: A one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts. (Pubmed Central) - Oct 26, 2022
The risk of reattempts was higher for CYP2D6 ultrarapid (AS > 2) metabolizers (β = 0.561, p = 0.005) and violent suicide survivors (β = -0.219, p = 0.042) if the attempt occurred during the first 6-month period, individuals with an increased number of MINI DSM-IV Axis I mental disorders (β = 0.092, p = 0.032) during the second 6-month period and individuals with a combined high CYP2D6-CYP2C19 metabolic capacity (AS > 4) (β = 0.345, p = 0.024) and an increased use of drugs other than antidepressants, anxiolytics-depressants and antipsychotics-lithium (β = 0.088, p = 0.005) in multiple repeaters during both periods. CYP2D6 and CYP2C19 rapid metabolism and polypharmacy treatment for somatic comorbidities must be considered to prevent the severe side effects of short-term multiple suicide reattempts after a previous attempt.
- | lithium carbonate ER / Generic mfg.
Journal: Identifying mental health training needs of general practice pharmacy workforce to advance practice: a training needs analysis survey. (Pubmed Central) - Oct 26, 2022
Respondents identified a range of training needs which varied between technicians and pharmacist, and staff banding. Addressing these learning needs may help pharmacy staff to better support practices and patients.
- | lithium carbonate ER / Generic mfg.
Journal: Ruthenium(II)-Catalyzed Hydrogenation and Tandem (De)Hydrogenation via Metal-Ligand Cooperation: Base- and Solvent-Assisted Switchable Selectivity. (Pubmed Central) - Oct 26, 2022
Mechanistic aspects, evaluated from spectroscopic studies, in situ monitoring of the reaction progress, control studies, and labeling studies, further indicate the involvement of a tandem dehydrogenation-condensation-hydrogenation sequence in the reaction, in which the interconvertible coordination mode (imino N → Ru and amido N-Ru) of coordinated imidazole with Ru(II)-para-cymene is crucial, without which the efficiency and selectivity of the catalyst are completely lost. The catalyst demonstrates good efficiency, selectivity, and functional group tolerance and displays a broad scope (69 examples) for monomethylation and hydrogenation of unsaturated chalcones, double methylation of ketones, and N-methylation of amines.
- | lithium carbonate ER / Generic mfg.
Journal: Anti-suicide effect of lithium at infratherapeutic dose, a case report. (Pubmed Central) - Oct 25, 2022
The catalyst demonstrates good efficiency, selectivity, and functional group tolerance and displays a broad scope (69 examples) for monomethylation and hydrogenation of unsaturated chalcones, double methylation of ketones, and N-methylation of amines. An anti-suicide effect has been well documented in prolonged lithium treatments, with high-quality evidence in bipolar disorder and unipolar depression, shown to be significantly superior to other mood stabilizers, with a 50-80% of reduction in suicide risk.
- | lithium carbonate ER / Generic mfg.
Journal: Association of mental disorders and psychotropic medications with bone texture as measured with trabecular bone score. (Pubmed Central) - Oct 25, 2022
Our results suggest that alcohol use disorder, antidepressants, and lithium are associated with poorer bone texture in women. These findings add to the current literature on the link of bone pathology with mental disorders and psychotropic medications.
- | lithium carbonate ER / Generic mfg.
Preclinical, Journal: Analysis on in vitro effect of lithium on telomere length in lymphoblastoid cell lines from bipolar disorder patients with different clinical response to long-term lithium treatment. (Pubmed Central) - Oct 25, 2022
These findings add to the current literature on the link of bone pathology with mental disorders and psychotropic medications. Our findings suggest that a 7-day lithium treatment protocol and the use of LCLs might not represent a suitable approach to deepen our understanding on the role of altered telomere dynamics in BD as previously suggested by studies in vivo.
- || lithium carbonate ER / Generic mfg.
Review, Journal: Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine. (Pubmed Central) - Oct 25, 2022
The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.
- | lithium carbonate ER / Generic mfg.
New P4 trial, Surgery: Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass (clinicaltrials.gov) - Oct 25, 2022
P4, N=62, Not yet recruiting, Sponsor: China Medical University, China
- | lithium carbonate ER / Generic mfg.
Journal: Association of Lithium Treatment With Reduced Left Ventricular Concentricity in Patients With Bipolar Disorder. (Pubmed Central) - Oct 23, 2022
Such Li-doped biomaterials have significant clinical potential in the foreseeable future. No abstract available
- || lithium carbonate ER / Generic mfg.
Retrospective data, Review, Journal, Monotherapy: Efficacy and safety of adjunctive therapy to lamotrigine, lithium, or valproate monotherapy in bipolar depression: a systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Oct 22, 2022
Our results suggest that adjunctive second-generation antipsychotics, lamotrigine, lithium, or valproate increase both the benefits and risks in patients with bipolar depression, although there is no significant difference in severe adverse events. Adjunctive therapy should be provided through shared decision-making while considering the patients' condition in clinical settings.
- | lithium carbonate ER / Generic mfg.
Trial completion: Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients (clinicaltrials.gov) - Oct 21, 2022
P3, N=50, Completed, Sponsor: Al-Azhar University
Adjunctive therapy should be provided through shared decision-making while considering the patients' condition in clinical settings. Recruiting --> Completed
- ||||| lithium carbonate ER / Generic mfg.
Clinical: Throughout my career I have found lithium to be a life saving treatment for many people living with bipolar disorder. I congratulate Drs. Fagiolini and Cuomo in this new pocket guide. (Twitter) - Oct 20, 2022
- | lithium carbonate ER / Generic mfg.
Journal: French Expert advice on the management of valproate in childbearing and pregnant women with bipolar disorder (Pubmed Central) - Oct 20, 2022
Recruiting --> Completed Although the adaptation to French practice of the recommendations from the European expert opinion highlighted some differences in the criteria taken into consideration to guide the therapeutic decision, this expert advice will guide the clinician for switching and discontinuation of valproate in BD women able to have children or pregnant.
- | clozapine / Generic mfg.
Journal: Combination of strategies to initiate clozapine for refractory schizophrenia in a patient with low neutrophil levels. (Pubmed Central) - Oct 20, 2022
These strategies consisted of discontinuation of antipsychotics, treatment with lithium carbonate and adenine, and light exercise before blood testing. Combining these procedures may be an effective option in the treatment of patients with refractory schizophrenia whose neutrophil levels are not sufficient to initiate clozapine.
- || lithium carbonate ER / Generic mfg.
PK/PD data, Journal: Lithium Pharmacokinetics in the Perinatal Patient with Bipolar Disorder. (Pubmed Central) - Oct 19, 2022
Lithium elimination clearance returned to baseline at 4 to 9 weeks postpartum. To maintain lithium effectiveness during pregnancy and prevent toxicity postpartum, lithium therapeutic drug monitoring and dose adjustments are warranted.
- | lithium carbonate ER / Generic mfg.
Journal: Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder. (Pubmed Central) - Oct 19, 2022
We found several potentially relevant differences in the clinical profile of OABD treated with lithium compared with those treated with other mood stabilisers. However, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonisation.
- lithium carbonate ER / Generic mfg.
Pharmacologic and Psychotherapeutic Treatments for Pediatric Bipolar Depression () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1344;
Quetiapine immediate release (IR) and extended release (ER) did not show a statistically significant improvement in the symptoms of bipolar depression compared to placebo...Lurasidone and the olanzapine-fluoxetine combination are evidence-based treatments for pediatric bipolar depression. There are several evidence-based therapies for pediatric bipolar depression, and there is a need for more research on the pharmacologic treatment of pediatric bipolar depression.
- lithium carbonate ER / Generic mfg.
Micronutrients as Treatment and Prevention: New Findings From 2 RCTs (MADDY and NutriMum) for ADHD, Emotional Dysregulation, and Antenatal Depression () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1228;
Glyphosate burden may interfere with response to BSM or be a marker of BSM nonresponse. BSM appears to benefit both gestational depression and subsequent infants’ function.
- lithium carbonate ER / Generic mfg.
Does Lithium With Antipsychotics Make Children and Adolescents With Bipolar Disorder Gain Weight? () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1044;
Conclusions No significant weight gain was observed in the children and adolescents with bipolar disorder who had antipsychotics for 7 weeks. In addition, valproate caused more weight gain than lithium.
- lithium carbonate ER / Generic mfg.
Anomalous Endothelial Function in Depressed and Mixed Mood States in Youth with Bipolar Disorder () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1003;
Conclusions We found that symptomatic youth with BD have anomalous RHI, which varies in direction according to mood states. Future studies in larger samples with prospective repeated measures are warranted to examine the temporal association between RHI and mood.
- lithium carbonate ER / Generic mfg.
Factors Associated With Sleep Disturbance Among Youth With Bipolar Disorder () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1002;
Future research is warranted to better understand the temporal association between sleep disturbance and its correlates in youth with BD. Relatedly, interventions that integrate mood disturbance and sleep disturbances can help improve overall functioning.