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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal, Adverse events:  Long-Term Lithium Therapy: Side Effects and Interactions. (Pubmed Central) -  Jan 22, 2023   
    Their own observations on ultra-long lithium treatment of patients with bipolar disorder are also presented. The review can help psychiatrists to perform a successful lithium prophylaxis in bipolar patients.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Does circadian dysrhythmia drive the switch into high or low activation states in bipolar I disorder? (Pubmed Central) -  Jan 21, 2023   
    Our findings support earlier research showing that many individuals with ASD receive pharmacotherapy without being diagnosed with a co-occurring psychiatric disorder, indicating that the main reasons for prescription and the type of compound frequently have little to no link with specific psychopathology. Based on the reviewed evidence, our view is that circadian dysrhythmia is a plausible driver of transitions into high and low activation states and deserves prioritisation in research in bipolar disorders.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  "Addressing the core trait of bipolar disorder": a concept analysis of mood stabilizing drugs. (Pubmed Central) -  Jan 19, 2023   
    Prophylaxis is pivotal to the concept, whose utility lies in implying a drug able to truly treat bipolar disorder, as opposed to merely targeting symptoms. Consistent use of the term could encourage investigation of drugs that modify long-term outcomes and illness trajectory, instead of simply approaching symptom clusters.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Biomarker, Journal:  Quality of laboratory biomarker monitoring during treatment with lithium in patients with bipolar disorder. (Pubmed Central) -  Jan 19, 2023   
    Consistent use of the term could encourage investigation of drugs that modify long-term outcomes and illness trajectory, instead of simply approaching symptom clusters. In a Swedish community sample, lithium and creatinine monitoring was inconsistent with guideline recommendations that call for measurement of annual biomarker levels.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    THE GREAT ESCAPE: LITHIUM-INDUCED ESCAPE CAPTURE BIGEMINY (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_730;    
    Lithium-associated ECB has rarely been reported. While our patient's bradycardia was reversible, lithium can have permanent effects on the cardiac cycle and can even cause cardiac arrest.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal, Real-world evidence, Real-world:  Real-World Clinical Practice Among Patients With Bipolar Disorder and Chronic Kidney Disease on Long-term Lithium Therapy. (Pubmed Central) -  Dec 31, 2022   
    Our data suggest that LA, as an effective treatment option in geriatric patients, should be closely monitored to avoid AKIs. Bipolar disorder patients on LTLT who discontinued Li had a higher risk for relapse and a shorter time to the first mood episode, suggesting a need for more thorough discussion before Li discontinuation after the CKD diagnosis.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Dietary lithium intake, graft failure and mortality in kidney transplant recipients. (Pubmed Central) -  Dec 24, 2022   
    Several strategies can be easily implemented in order to minimize lithium side effects and improve its tolerability profile. Dietary lithium intake may be a potentially modifiable-yet rather overlooked-risk factor for adverse long-term kidney graft outcomes and patient survival.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Lithium induced hypercalcemia: an expert opinion and management algorithm. (Pubmed Central) -  Dec 23, 2022   
    Dietary lithium intake may be a potentially modifiable-yet rather overlooked-risk factor for adverse long-term kidney graft outcomes and patient survival. Standardized consensus driven management may diminish the potential risk of clinicians avoiding the use of lithium because of uncertainties about managing side-effects and consequently hindering some patients from receiving an optimal treatment.
  • ||||||||||  Caplyta (lumateperone) - Intra / Cellular Therapies
    Journal:  Lumateperone normalizes pathological levels of acute inflammation through important pathways known to be involved in mood regulation. (Pubmed Central) -  Dec 23, 2022   
    Additionally, lumateperone altered genes and pathways that maintain blood-brain barrier integrity, restored an index of blood-brain barrier function, reduced anxiety-like behavior in rodents, and enhanced mTORC1 pathway signaling in the prefrontal cortex. These results highlight the anti-inflammatory actions of lumateperone and describe how lumateperone may reduce immune pathophysiology, which is associated with depressive symptoms.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia (clinicaltrials.gov) -  Dec 19, 2022   
    P2,  N=17, Completed, 
    These results highlight the anti-inflammatory actions of lumateperone and describe how lumateperone may reduce immune pathophysiology, which is associated with depressive symptoms. Recruiting --> Completed | N=60 --> 17 | Trial completion date: Mar 2023 --> Nov 2022 | Trial primary completion date: Mar 2023 --> Nov 2022
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Lithium-Induced Dysgeusia and Hyposmia: A Case Report and a Literature Review. (Pubmed Central) -  Dec 16, 2022   
    Therefore, physicians who prescribe lithium should be aware of them. Further structured studies are needed to better understand these lithium rare adverse effects and the appropriate way to assess and monitoring them.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Stainless Steel-Like Passivation Inspires Persistent Silicon Anodes for Lithium-Ion Batteries. (Pubmed Central) -  Dec 14, 2022   
    The results demonstrate that the passivation can enhance the lithiation of Li2Si and de-lithiation of Li3.75Si, induce the formation of F-rich robust solid electrolyte interphase, stabilize the Si/LiF/Li2CO3 composite, and mitigate the volume change of Si anodes upon cycling. The 3D passivated Si anode can fully retain a high capacity of 3701 mAh g-1 after 1500 cycles and tolerate high rates up to 50 C. This work provides insight into how to construct durable Si anodes through effective passivation.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity. (Pubmed Central) -  Dec 13, 2022   
    Better understanding of how inhibition of GSK3 contributes to the therapeutic effects of lithium should allow for identification of more specific targets for future drug development. It may also provide a framework for the understanding of how lithium effects overlap with those of other drugs such as ketamine and antipsychotics, which also inhibit brain GSK3.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Bipolar Disorder and Bone Mineral Density Z-Scores in Relation to Clinical Characteristics and Lithium Medication. (Pubmed Central) -  Dec 12, 2022   
    Low mineral density was not associated with any of the addressed aspects of disease and treatment history. In conclusion our results support that patients on lithium treatment have higher bone mineral density; further studies are needed to address if lithium medication causes an increase in bone mineral density, and lowers the risk of bone fractures in bipolar disorder.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  BMP/Smad Pathway Is Involved in Lithium Carbonate-Induced Neural-Tube Defects in Mice and Neural Stem Cells. (Pubmed Central) -  Dec 12, 2022   
    Cell proliferation was significantly promoted by LiCO exposure or the absence of inositol in mNSCs, which was reversed by LDN-193189. These results suggest that the activation of the BMP/Smad signaling pathway might play an important role in the development of NTDs induced by maternal LiCO exposure via inositol deficiency.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Dementia risk in patients with bipolar disorder. (Pubmed Central) -  Dec 11, 2022   
    These results suggest that the activation of the BMP/Smad signaling pathway might play an important role in the development of NTDs induced by maternal LiCO exposure via inositol deficiency. No abstract available
  • ||||||||||  lithium carbonate ER / Generic mfg., ketamine / Generic mfg.
    Review, Journal:  Ketamine and Other Glutamate Receptor Modulating Agents for Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials. (Pubmed Central) -  Dec 8, 2022   
    Lithium, lanicemine, D-cycloserine, and decoglurant showed mixed results for efficacy, and, riluzole, and 7-chlorokynurenic acid were mostly comparable to placebo...Nevertheless, ketamine could be used as an efficacious drug in TRD; still, additional studies are needed to delineate the optimum dosage, duration of efficacy, and intervals. Further studies are also recommended on the effectiveness of glutamatergic system modulators other than ketamine on treatment-resistant depression.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Psychopharmacological Treatment Algorithms of Manic/Mixed and Depressed Episodes in Pediatric Bipolar Disorder. (Pubmed Central) -  Dec 7, 2022   
    We offer an update to the 2005 AACAP algorithms for the treatment of pediatric bipolar mixed/manic episodes and added an evidence-based algorithm for the treatment of depression in PBD. In addition to treatment algorithms, we review current evidence for efficacy of agents proposed in the AACAP algorithm and provide tables summarizing medication side effects and efficacy.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Prevalence and association of comorbid substance dependence on the course and outcome of bipolar disorder: Findings from the bipolar disorder course and outcome study from India (BiD-CoIN study). (Pubmed Central) -  Dec 3, 2022   
    Compared to those without comorbid substance dependence, those with a dual diagnosis (i.e., using at least one substance in a dependent pattern) were less educated, more often males, more often currently single, more often employed, had a lower number of depressive episodes per year of illness, had a higher number of manic and mixed episodes per year of illness in the first 5 years of illness, had a higher level of disability, and more often had a history of hospitalization and a history of receiving electroconvulsive therapy (ECT); also, a higher proportion of them had manic predominant polarity, more often had recurrent mania course, and were more often receiving a combination of lithium and valproate. About one-fourth of BD patients have comorbid SUDs, and presence of SUD has a negative impact on the course and outcome of BD.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  A systematic analysis of neurobiological roles of lithium (Pubmed Central) -  Nov 29, 2022   
    Clinical applications of lithium treatment include various neurodegenerative diseases, primarily Alzheimer disease, with increasing importance given to the use of lithium microdoses. Chemoreactome screening is used to find more safe and effective lithium compounds.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Preclinical, Journal:  Lithium Provides Broad Therapeutic Benefits in an Alzheimer's Disease Mouse Model. (Pubmed Central) -  Nov 29, 2022   
    The study found that lithium exerts therapeutic effects across several AD-associated early neuronal signaling abnormalities including aberrant Ca2+ signaling, nNOS, and p-tau formation and enhances short-term synaptic plasticity. Lithium could serve as an effective treatment or co-therapeutic for AD.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Identifying the neuropsychiatric health effects of low-dose lithium interventions: a systematic review. (Pubmed Central) -  Nov 28, 2022   
    Despite the paucity and heterogeneity of studies, LDL's apparent pro-cognitive effects and positive safety profile open promising avenues in the fields of neurodegeneration, and augmentation in affective disorders. We urge future examinations of LDL's potential to prevent cognitive/affective syndromes.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Chemical-Physical Properties and Bioactivity of New Premixed Calcium Silicate-Bioceramic Root Canal Sealers. (Pubmed Central) -  Nov 27, 2022   
    The aim of the study was to analyze the chemical-physical properties and bioactivity (apatite-forming ability) of three recently introduced premixed bioceramic root canal sealers containing varied amounts of different calcium silicates (CaSi): a dicalcium and tricalcium silicate (1-10% and 20-30%)-containing sealer with zirconium dioxide and tricalcium aluminate (CERASEAL); a tricalcium silicate (5-15%)-containing sealer with zirconium dioxide, dimethyl sulfoxide and lithium carbonate (AH PLUS BIOCERAMIC) and a dicalcium and tricalcium silicate (10% and 25%)-containing sealer with calcium aluminate, tricalcium aluminate and tantalite (NEOSEALER FLO)...In conclusion, CaSi-containing sealers met the required chemical and physical standards and released biologically relevant ions. Slight/limited apatite nucleation was observed in relation to the high carbonation processes.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Factors Associated With Sleep Disturbance Amongst Youth With Bipolar Disorder. (Pubmed Central) -  Nov 26, 2022   
    Future research is warranted to better understand the temporal association between sleep disturbance and its correlates in youth with BD. Relatedly, interventions that address both mood and sleep disturbances may help improve overall functioning.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Assessment of lethality and its clinical correlates in suicide attempters with mood disorders. (Pubmed Central) -  Nov 25, 2022   
    Lethality of suicide attempts was found to be associated with a multitude of clinical factors, notably male gender, bipolarity, multiple attempts, planned attempts and number of total and depressive episodes. Assessment of lethality and its correlates can help to plan strategies towards risk prevention in mood disorders.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Comparison of bipolar disorder type II and major depressive disorder. (Pubmed Central) -  Nov 22, 2022   
    BD2 and MDD subjects differed greatly in many descriptive, psychopathological and treatment measures, notably including more familial risk, earlier onset, more frequent recurrences and greater suicidal risk with BD2. Such differences can contribute to improving differentiation of the disorders and planning for their treatment.