- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Suicidal Ideation Induced by Treatment-Resistant Chronic Insomnia: A Case Study (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_779;
He failed trials on SSRIs/SNRIs, bupropion, trazodone, lithium, vortioxetine, quetiapine, zolpidem, and ketamine...Pharmacologic options include benzodiazepines, non-benzodiazepine hypnotics, tricyclic antidepressants, trazodone, and antihistamines. Clinicians should consider ECT, as the most effective treatment for depression, in the early stage of insomnia-induced suicidal ideation.
- |||||||||| lithium carbonate ER / Generic mfg.
Risk of Lithium Toxicity in Patients Taking Other Antipsychotic Therapies (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_776;
Simultaneous usage of Lithium and high potency antipsychotics like Haloperidol, resulted in sudden onset muscle stiffness with cogwheel rigidity and generalized myoclonus...One yields evidence of pure lithium induced neurotoxicity without any relation to antipsychotic usage, and the other hypothesis suggests that both lithium and other antipsychotic drugs block dopamine receptors. Based on our review, we suggest that close observation of neurological signs for at least 3 weeks is necessary when lithium therapy is combined with other antipsychotic therapies.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Unraveling a Case of Altered Mental Status Using a Collaborative Approach: A Case Report of Delirium and Benzodiazepine Withdrawal (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_720;
The etiology of her mental status change was uncertain but the working differential included: infection, electrolyte derangement (with concern for hyponatremia secondary to carbamazepine-induced SIADH), polypharmacy, or a primary psychiatric disorder...Eventually the addition of further collaboration from her outpatient prescriber led to a timely diagnosis of benzodiazepine withdrawal and a dramatic resolution of her encephalopathic presentation after the initiation of appropriate treatment. This case highlights the importance of (a) close collaboration with the primary medical team and the other medical services both within and outside of the hospital in preventing patient morbidity and mortality, (b) the crucial need for an accurate history and physical, and (c) a review of the mechanics and treatment of benzodiazepine withdrawal.
- |||||||||| lithium carbonate ER / Generic mfg.
The Heightened Propensity of Developing Depression in Children/Adolescents With Eczema: A Case Report (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_630;
The patient was stabilized and discharged on Aripiprazole 10 mg po at bedtime, Lithium 600 mg IR po at bedtime, Lithium 300 mg IR po daily, and prazosin 1 milligram po at bedtime...This patient was initially started on Lithium due to its proven benefit in treating BD and its role in suppressing inflammation through its effects on T suppressor lymphocytes [4]. Several studies in the past years have found a dose-response relationship between eczema severity and depression, yet the causal mechanism of this association remains unclear [5].
- |||||||||| lithium carbonate ER / Generic mfg., amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
Should We Be Silent About Silent Syndrome? (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_625;
Eventually, her symptoms were in remission on Lithium, Depakote, Adderall, and Trazadone regimen...SILENT is a disabling but preventable neurologic sequela. Close monitoring of lithium, early identification of any risk factors, and imparting education to patients and their families should be paramount.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Difficulties in Evaluating and Managing Sedative, Hypnotic, and Anxiolytic Use Disorder and Withdrawal in a Patient With Tardive Dyskinesia (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_594;
The patient was managed with a zolpidem taper with a goal of 50% dose reduction over one to two weeks and continued TD treatment with botox injections once the zolpidem taper was completed [4]...In this poster, we discuss the challenges of evaluating and managing zolpidem use and withdrawal in a patient with dependence for both psychological and physical symptoms. We also highlight the addictive potential of zolpidem when used in high doses, particularly in treatment-resistant TD.
- |||||||||| lithium carbonate ER / Generic mfg.
Covid-19 Creating a (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_590;
Additionally, this patient was treated with antipsychotic medication that is not known to have a significant anti-inflammatory effect (risperidone). This may represent further support for reported success with psychiatric medications that also have anti-inflammatory properties through the sigma receptor such as Fluvoxamine and Haloperidol.
- |||||||||| Challenges of Psychiatric Treatment in Patients With Systemic Lupus Erythematosus (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_585;
Review of the last hospitalization disclosed a previous presentation of agitated, disorganized behavior, treated with Depakote DR 1750 Daily, Lithium 1200 daily, Olanzapine 30 mg PO daily...The rheumatology team was consulted and recommended starting Plaquenil 200mg daily for diagnosis of Systemic Lupus Erythematosus (SLE)...We discuss our pharmacological approach to treatment in this patient population, taking into consideration many psychotropic medications can exacerbate some of the symptoms of SLE. Interdisciplinary collaboration is needed for the management of these patients, as lack of treatment of inflammatory conditions can lead to persistence of mood disturbances, and psychiatric misdiagnosis.
- |||||||||| Caplyta (lumateperone) - Intra / Cellular Therapies
Use of Electroconvulsive Therapy (ECT) to Treat Delirious Mania in a 57-Year-Old Man (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_560;
Interdisciplinary collaboration is needed for the management of these patients, as lack of treatment of inflammatory conditions can lead to persistence of mood disturbances, and psychiatric misdiagnosis. Prior psychiatric medications included lithium, divalproex, ziprasidone, risperidone, lumateperone, lorazepam, diazepam, clonazepam, and benztropine...By the time of discharge the patient
- |||||||||| A Case of Secondary Amenorrhea: Is It Only PCOS to Blame? (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_581;
Prolactin level ranging from 25-100 ng/mL is seen in medication-induced hyperprolactinemia, while particular medication like risperidone and phenothiazines can raise the level to more than 200 ng/mL. Newer agent paliperidone has been reported to induce hyperprolactinemia similarly to risperidone which explains significant prolactin elevation in this patient.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Racial differences in the major clinical symptom domains of bipolar disorder. (Pubmed Central) - May 11, 2023
Newer agent paliperidone has been reported to induce hyperprolactinemia similarly to risperidone which explains significant prolactin elevation in this patient. In two large studies spanning over a decade, we found highly consistent and enduring differences in symptoms across the major clinical symptom
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: A feasible process for recycling valuable metals from LiNiCoMnO cathode materials of spent Li-ion batteries. (Pubmed Central) - May 9, 2023
Mn, Co were extracted with Di-(2-ethylhexyl) phosphoric acid and 2-Ethylhexyl phosphonic acid mono-2-ethylhexyl ester respectively to obtain Ni, Co, Mn solutions, which eventually were crystallized for manganese sulphate, cobalt sulphate, lithium carbonate and nickel sulphate products, with high purity of 99.40%, 98.95%, 99.10%, and 99.95%. The results of this study improved the leaching efficiency of Li and were closely linked to the actual industrial preparation of Ni, Co and Mn sulphates, providing a feasible and promising basis for spent NCM cathode materials industrial recovery.
- |||||||||| lithium carbonate ER / Generic mfg.
Clinical Correlates of Lithium Use in Patients with Bipolar Disorder (Salon 4) - May 9, 2023 - Abstract #ASCP2023ASCP_401;
A lower proportion of patients with a history of lithium monotherapy among those with an evening chronotype is puzzling. Learning Objectives The proportion of patients with a history of lithium monotherapy is lower in those with an evening chronotype.
- |||||||||| lithium carbonate ER / Generic mfg.
Observational data, Review, Journal: Pharmacological Treatment of Bipolar Depression: A Review of Observational Studies. (Pubmed Central) - May 5, 2023
Lamotrigine, quetiapine, aripiprazole, and ketamine were the most investigated compounds...Finally, ketamine showed divergent response rates with a low certainty of evidence and, so far, unclear long-term effects. Heterogeneity in diagnosis, sample sizes, study designs, reporting of bias, and side effects limited the possibility of a head-to-head comparison.
- |||||||||| citalopram / Generic mfg., lithium carbonate ER / Generic mfg.
Journal: Editorial: Assessing the consequences of antidepressant treatments. (Pubmed Central) - May 5, 2023
Heterogeneity in diagnosis, sample sizes, study designs, reporting of bias, and side effects limited the possibility of a head-to-head comparison. No abstract available
- |||||||||| lithium carbonate ER / Generic mfg.
Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression (Aqua EF) - Apr 29, 2023 - Abstract #SOBP2023SOBP_1043;
Antidepressant effects of ketamine (10mg/kg) were determined using the open field and forced swim tests, and the association between behavioral response, insulin signaling, glucose uptake, cellular metabolism and inflammation in brain and peripheral blood mononuclear cells (PBMCs) was determined in vivo and ex vivo using Western blot, ELISA, HPLC, and metabolic assay...Augmentation of insulin signaling with lithium or metformin, or inflammatory stimulation with lipopolysaccharide (LPS), increased response rates to >90% in TRD animals (p<0.01; n=10-16). Conclusions Collectively, these data demonstrate that insulin-sensitive immunometabolic mechanisms moderate antidepressant response in TRD, offering novel therapeutic and biomarker targets.
- |||||||||| lithium carbonate ER / Generic mfg.
The Boost in Bipolar Disorder Genetics Reveals Molecular Pathways and Brain Imaging Features (Sapphire 410) - Apr 29, 2023 - Abstract #SOBP2023SOBP_1021;
Further information on genetic function are obtained by linking GWAS of cortical brain measures by applying advanced statistical approaches to inform genetic architecture with mixed effect with BD, and translating to specific mechanisms associated with lithium response in stem cell experiments. These presentations highlight advances in BD genetic research, based on improved ancestral diversity, understanding relevant biological mechanisms, interpreting its association with potential neuroimaging biomarkers, and studying cellular processes with stem cells.
- |||||||||| lithium carbonate ER / Generic mfg.
Is Age Really Just a Number? Accelerated Aging in Bipolar Disorder (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_764;
All other tested models without lithium incorporation ranged from Adj R2=0.2-0.5). Conclusions BD1 is associated with accelerated brain aging that may be mediated by age of diagnosis and medication exposure.
- |||||||||| lithium carbonate ER / Generic mfg.
A SPECT Study of Regional Cerebral Blood Flow in Bipolar Disorder (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_438;
Conclusions Our findings implicate generalized hypermetabolism, especially within frontostriatal circuits, as trait effects in BPD. These disturbances worsen with advancing age.
- |||||||||| lithium carbonate ER / Generic mfg.
Epigenetic Markers of Lithium Use in Bipolar Disorder (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_112;
Wnt signaling has consistently been associated with lithium, but our work shows that epigenetics is involved in this process. Further work is required to understand the epigenetic role of lithium in the treatment of BD.
- |||||||||| lithium carbonate ER / Generic mfg.
Circadian Rhythms in Striatal-Like Neurons Generated From Bipolar Disorder Patients (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_107;
Conclusions This work suggests there are circadian rhythm differences in BD patient derived GABAergic neurons and these differences may help distinguish lithium responders from lithium non-responders. Generating these neurons provides a novel model to study BD and complements previous work in iPSC-derived glutamatergic neurons.
- |||||||||| lithium carbonate ER / Generic mfg.
Biomarker, Journal: Methylomic biomarkers of lithium response in bipolar disorder: a clinical utility study. (Pubmed Central) - Apr 29, 2023
In BD subjects, both antidepressant and antipsychotic medications seems to play a role in the occurrence of mood switches, although the effects of different pharmacological compounds have yet to be fully investigated. Combining clinical predictors and DNA methylation markers of Li response may have greater utility in clinical practice than relying on clinical characteristics alone.
- |||||||||| ketamine / Generic mfg.
Preclinical, Review, Journal: Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review. (Pubmed Central) - Apr 28, 2023
Drugs shown to reduce the risk of suicide (antidepressants, lithium, or clozapine) necessitate a long delay of onset...Finally, numerous questions arose regarding the mechanisms by which ketamine may prevent an impulsive-aggressive phenotype in rodents and suicidal ideations in humans. Animal models of anxiety/depression are important tools to better understand the pathophysiology of depressed patients, and in helping develop novel and fast antidepressant drugs with anti-suicidal properties and clinical utility.
- |||||||||| lithium carbonate ER / Generic mfg.
Review, Journal: Lithium engages autophagy for neuroprotection and neuroplasticity: translational evidence for therapy. (Pubmed Central) - Apr 18, 2023
More recently, Li was shown to modulate autophagy through its action on mGluR5, thus pointing to an additional way of autophagy engagement by Li and to a substantial role of mGluR5 in neuroprotection related to neural e neuropsychiatry diseases. We propose Li engagement of autophagy through the canonical mechanisms of autophagy machinery and through the intermediary of mGluR5.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: An update on potential pharmacotherapies for cognitive impairment in bipolar disorder. (Pubmed Central) - Apr 17, 2023
Traditional treatments, such as lithium, anticonvulsants (lamotrigine), antipsychotics (aripiprazole, asenapine, cariprazine, lurasidone, and olanzapine), antidepressants (vortioxetine, fluoxetine, and tianeptine) and psychostimulants (modafinil), and emerging interventions, such as acetylcholinesterase inhibitors (galantamine and donepezil), dopamine agonists (pramipexole), erythropoietin, glucocorticoid receptor antagonists (mifepristone), immune modulators (infliximab, minocycline and doxycycline), ketamine, metabolic agents (insulin, metformin, and liraglutide), probiotic supplements, and Withania somnifera are discussed...In the past, methodological pitfalls in BD cognition trials have also been a critical limiting factor. Expanding on the existing literature and identifying novel pharmacological and non-pharmacological treatments for cognitive impairment in BD should be a priority.
- |||||||||| lithium carbonate ER / Generic mfg.
Long-Term Lithium-Therapy and Thyroid Disorders in Bipolar Disorder: A Historical Cohort Study (Salon 4) - Apr 15, 2023 - Abstract #ASCP2023ASCP_236;
In our primary analysis (N=136) mean age of participants was 40.5, predominantly females (57.4%) and with BD type I (69.9%). Compared to the non-Thyroid disorders group, patients with thyroid disorders had a higher median MCIRS scores (18 vs 21; p=0.01) and borderline increased history of trauma (32% vs 50%, p=0.05).
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Rapid Detection of Lithium Concentrations in Oral Fluid. (Pubmed Central) - Apr 4, 2023
These results demonstrate that lithium levels in oral fluid can be rapidly and reliably quantified using colorimetric approaches. These findings may facilitate the development of point-of-care lithium monitoring systems for use in oral fluid.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: Effects of lithium on aggression in Drosophila. (Pubmed Central) - Apr 4, 2023
Our genetic data showed that acute knockdown of GSK-3 in neurons can mimic the inhibitory effect of acute lithium on aggression, while specific overexpression of GSK-3 in a subset of P1 neurons profoundly promotes aggression which can be partially rescued by acute lithium application. Thus, these findings revealed the inhibitory effect of lithium on aggression in Drosophila and laid a groundwork for using Drosophila as a powerful model to investigate the mechanisms by which lithium reduces aggression.
- |||||||||| lithium carbonate ER / Generic mfg.
Climate Change Impact on Mental Health (Centennial II-IV; Virtual) - Apr 2, 2023 - Abstract #AAPP2023AAPP_88;
Describe the link between climate change and infectious diseases. Explain the role of the pharmacist in contributing to facilitating climate resilience and pro-environmental behaviors, particularly for heat-related illnesses and vaccine-preventable infectious diseases.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: The effects of lithium on human red blood cells studied using optical spectroscopy and laser trap. (Pubmed Central) - Mar 28, 2023
The lithium exposure may also have an effect on RBC membrane, which was investigated via optical stretching in a laser trap and the results suggest lower membrane fluidity for the lithium-exposed RBCs. The membrane fluidity of RBCs was further studied using the Prodan generalized polarization method and the results verify the reduction of membrane fluidity upon lithium exposure.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Sleep Attacks: Undiagnosed Kleine-Levin Syndrome (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8705;
2 Lithium and valproate have been shown to prevent recurrence of symptoms. The diagnosis of KLS is often delayed and should be part of the differential in patients with hypersomnia associated with unusual overeating, cognitive, and behavioral disorders.
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