| clemastine / Generic mfg. |
2021-003677-66: Clemastine fumarate as a treament for eye movement disorders in patients with multiple sclerosis Clemastine fumaraat als behandeling voor een stoornis in de oogbewegingen bij patiënten met multiple sclerose |
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| Not yet recruiting | 3 | 80 | Europe | Clemastine fumarate, Fampridine, Tablet, Clemastine Milstein 1 mg, tabletten, Fampyra 10 mg prolonged-release tablets | Amsterdam University Medical Center, Stichting VUmc Fonds | Multiple sclerosis (MS)Internuclear ophthalmoparesis (INO) Multiple sclerose (MS)Internucleaire oftalmoplegie (INO), Multiple sclerosis (MS)Eye movement disorder Multiple scleroseOogbewegingsstoornis, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT06315699: Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome |
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| Recruiting | 3 | 50 | RoW | Clemastine Fumarate Tablets, fructose | Qilu Hospital of Shandong University | Williams Syndrome, Child, Neurodevelopmental Delay | 03/25 | 12/25 | | |
RESTORE, NCT05338450: Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis |
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| Recruiting | 3 | 80 | Europe | Clemastine Fumarate, clemastine, Tavegyl, Placebo | Amsterdam UMC, location VUmc | Multiple Sclerosis, Internuclear Ophthalmoplegia | 12/27 | 12/27 | | |
NCT06087757: Clemastine Treatment in Individuals With Williams Syndrome |
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| Recruiting | 3 | 30 | RoW | Open Label Clemastine with a blinded randomize withdrawal | Sheba Medical Center, Tel Aviv University | Williams Syndrome | 12/24 | 12/25 | | |
2018-001756-35: A Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis |
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| Not yet recruiting | 2 | 70 | Europe | TAVEGIL TABLETS, Tablet, TAVEGIL TABLETS | University of California, San Francisco | acute optic neuritis, Optic neuritis is an inflammatory, demyelinating disease of the optic nerve. It is most often characterized by visual loss or blurred vision along with dyschromotopsia accompanied by pain., Body processes [G] - Cell Physiological Phenomena [G04] | | | | |
2022-000054-28: Combining Clemastine and Aerobic Exercise to Treat Cognitive Dysfunction in Schizophrenia by Targeting Myelin Plasticity (OligoTreat) Die Behandlung der kognitiven Dysfunktion durch Verbesserung der Myelinplastizität mittels Kombination von Clemastin und aerobem Ausdauertraining bei Patienten mit einer Schizophrenie (OligoTreat) |
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| Not yet recruiting | 2 | 90 | Europe | Clemastinfumarat, Tablet | Klinikum der Universität München, Stanley Foundation | Schizophrenia Schizophrenie, Schizophrenia Schizophrenie, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT05131828: CCMR Two: A Phase IIa, Randomised, Double-blind, Placebo-controlled Trial of the Ability of the Combination of Metformin and Clemastine to Promote Remyelination in People With Relapsing-remitting Multiple Sclerosis Already on Disease-modifying Therapy |
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| Recruiting | 2 | 70 | Europe | Metformin and clemastine in combination, Placebo | Cambridge University Hospitals NHS Foundation Trust, University of Cambridge | Multiple Sclerosis | 05/25 | 05/25 | | |
OligoTreat, NCT06315972: Combining Clemastine and Aerobic Exercise to Treat Cognitive Dysfunction in Schizophrenia by Targeting Myelin Plasticity |
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| Not yet recruiting | 2 | 90 | NA | clemastine (8 mg/day), Placebo | LMU Klinikum | Schizophrenia | 11/26 | 04/28 | | |
| Recruiting | 2 | 90 | US | Clemastine, Tavist, Clemastine fumarate, Walhist, Placebo | University of California, San Francisco, Moorfields Eye Hospital NHS Foundation Trust | Optic Neuritis | 08/26 | 08/26 | | |
CLIMB, NCT06591091: Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression |
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| Not yet recruiting | 2 | 80 | NA | Clemastine Fumarate, Placebo | University of Illinois at Chicago, Cures Within Reach | Depression | 01/25 | 03/25 | | |
NCT03109288: Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS) |
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| Recruiting | 1/2 | 250 | US | Pioglitazone, clemastine fumarate, Dantrolene, Pirfenidone | National Institute of Allergy and Infectious Diseases (NIAID) | Multiple Sclerosis | 01/26 | 01/29 | | |
ReVIVE, NCT05359653: Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy |
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| Recruiting | 1/2 | 74 | US | Clemastine Fumarate, Clemastine, Dayhist, Dayhist Allergy, Placebo, Sugar pill | University of California, San Francisco, United States Department of Defense | Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis Relapse, Multiple Sclerosis Brain Lesion, Multiple Sclerosis Benign | 06/25 | 06/25 | | |
ReINFORCE, NCT06065670: Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy |
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| Not yet recruiting | 1/2 | 44 | US | Clemastine Fumarate, Clemastine, Dayhist, Dayhist Allergy, Placebo, Sugar pill | University of California, San Francisco | Demyelinating Diseases, Demyelination; Corpus Callosum, Multiple Sclerosis Brain Lesion, Multiple Sclerosis Acute and Progressive, Clinically Isolated Syndrome, CNS Demyelinating | 10/26 | 10/26 | | |
CROSS II, NL447: Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer |
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| Completed | N/A | 368 | Netherlands | paclitaxel - Generic mfg., dexamethasone - Generic mfg., clemastine - Generic mfg., ranitidine hydrochloride - Generic mfg. | Daniel den Hoed Cancer Center | Esophageal or Junctional Cancer | | | | |
H1-Switch, NCT06039137: The Effect of Switching the H1-antagonist Clemastine to Cetirizine in Premedication Regimens During Paclitaxel Treatment |
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| Completed | N/A | 395 | Europe | Cetirizine, Clemastine IV | Erasmus Medical Center | Solid Tumor | 04/23 | 10/23 | | |
