- |||||||||| Tavegil (clemastine) / GSK
Journal: MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial. (Pubmed Central) - May 12, 2023
An increase in myelin water fraction was documented in the normal-appearing white matter of the corpus callosum, in correspondence with the administration of the remyelinating treatment clemastine...Moreover, our work strongly suggests that significant myelin repair occurs outside of lesions. We therefore propose myelin water fraction within the normal-appearing white matter of the corpus callosum as a biomarker for clinical trials looking at remyelination.
- |||||||||| Tavegil (clemastine) / GSK
Journal: Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis. (Pubmed Central) - May 10, 2023
We therefore propose myelin water fraction within the normal-appearing white matter of the corpus callosum as a biomarker for clinical trials looking at remyelination. Based on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.
- |||||||||| Tavegil (clemastine) / GSK
Pro-Myelinating Drugs Promote Functional Recovery in an ASD Mouse Model of Pitt-Hopkins Syndrome (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_427;
Results In vitro, clemastine treatment reduced excess oligodendrocyte precursor cells (OPCs) and normalized OL density...Conclusions In this study, we show that two different pro-myelinating compounds with independent modes of action, are effective at restoring myelination defects in a PTHS mouse model. Together, these results provide preclinical evidence that pro-myelinating therapies may be beneficial in PTHS and potentially other neurodevelopmental disorders characterized by hypomyelination.
- |||||||||| Tavegil (clemastine) / GSK
Preclinical, Journal: Deficient deposition of new myelin impairs adult optic nerve function in a murine model of diabetes. (Pubmed Central) - Mar 21, 2023
In addition, clemastine, an antimuscarinic compound that enhances myelination, significantly restored oligodendroglia, and promoted the functional recovery of the optic nerve in diabetic mice. Together, our results point to the role of new myelin deposition in optic neuropathy under diabetic insult and provide a promising therapeutic target for restoring visual function.
- |||||||||| Tavegil (clemastine) / GSK
Journal: Insufficient oligodendrocyte turnover in optic nerve contributes to age-related axon loss and visual deficits. (Pubmed Central) - Mar 20, 2023
To test whether enhancing oligodendrogenesis can prevent age-related visual deficits, 12-month-old mice were treated with clemastine, a pro-myelination drug, or induced deletion of the muscarinic receptor 1 in oligodendrocyte precursor cells...Conversely, pro-myelination approaches significantly increased new myelin generation in aging ONs, and consequently preserved retinal integrity and visual function. Our findings indicate that promoting OL generation might be a promising strategy to preserve visual function from age-related decline.
- |||||||||| Tavegil (clemastine) / GSK
Preclinical, Journal: Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice. (Pubmed Central) - Mar 14, 2023
Moreover, clemastine-treated mice showed increased mature oligodendrocyte density, reduced axonal injury, an increased number of myelinated axons and thicker myelin in the IC lesions compared with control (PBS-treated) mice. These results suggest that the lysophosphatidylcholine-induced IC demyelination model is useful for evaluating changes in motor functions following pharmacological treatments that promote remyelination.
- |||||||||| sevoflurane / Generic mfg.
Preclinical, Journal: Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice. (Pubmed Central) - Dec 12, 2022
Collectively, we first demonstrated the bi-directional influence of early sevoflurane exposures on oligodendrocyte maturation and proliferation, which contributes to the cognitive impairment induced by general anesthesia. These findings illustrated the dynamic changes in oligodendrocytes in the developing brain following anesthetic exposures, as well as possible therapeutic strategies for multiple general anesthesia associated cognitive impairment.
- |||||||||| Tavegil (clemastine) / GSK
Review, Journal: Drug repurposing: Clemastine fumarate and neurodegeneration. (Pubmed Central) - Nov 15, 2022
Hence, whether clemastine fumarate would make a protective impact on neurodegenerative diseases and what contribution fumarate probably makes are intriguing to us. In this review, we summarize the potential mechanism surrounding clemastine fumarate in current literature, and try to distinguish independent or synergistic effect between clemastine and fumarate, aiming to find worthwhile research direction for neurodegeneration diseases.
- |||||||||| dexamethasone / Generic mfg., clemastine / Generic mfg.
Enrollment change: Efficacy and Safety of the Association Drugs in Patients With Allergic Dermatitis (clinicaltrials.gov) - Nov 3, 2022
P3, N=0, Withdrawn,
In this review, we summarize the potential mechanism surrounding clemastine fumarate in current literature, and try to distinguish independent or synergistic effect between clemastine and fumarate, aiming to find worthwhile research direction for neurodegeneration diseases. N=104 --> 0
- |||||||||| Tavegil (clemastine) / GSK
Enhancing Myelination as a Therapeutic Intervention for Autism Spectrum Disorder (Grand Sonoran E) - Oct 31, 2022 - Abstract #ACNP2022ACNP_721;
Methods Clemastine (CF) is an antihistamine that is effective at promoting myelination through its block of muscarinic receptors...Conclusions Treatment with CF, an FDA approved compound, is effective at rescuing the OL population, electrophysiology and behavior in a PTHS mouse model. These findings provide novel preclinical data that suggests CF or other remyelinating agents may be beneficial to PTHS patients and potentially other related ASDs.
- |||||||||| Tavegil (clemastine) / GSK
CN045 is a novel small molecule lead for remyelinating therapies in multiple sclerosis (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_1799;
We have generated novel and patentable analogs of CN045 that retain OPC differentiation with greater potency than CN045, T3, Clemastine and Beztropine. A remyelination therapy, in combination with the current anti-inflammatory therapies, will promote myelin repair and halt neurological decline in MS patients.
- |||||||||| Tavegil (clemastine) / GSK
Repurposing clemastine to suppress glioblastoma stem cells (West/Central Hall) - Sep 28, 2022 - Abstract #SNO2022SNO_1090;
Finally, we demonstrated that a mouse neural stem cell-derived glioma model was similarly susceptible to clemastine treatment. Taken together, our study identifies pathways essential for the perpetuation of stemness in GBM, and implicates a non-oncology drug with a well-established safety profile that can be repurposed to mitigate the stem-like properties of GBM.
- |||||||||| clemastine / Generic mfg.
Enrollment open, Trial initiation date: RESTORE: Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis (clinicaltrials.gov) - Sep 23, 2022
P3, N=80, Recruiting,
Taken together, our study identifies pathways essential for the perpetuation of stemness in GBM, and implicates a non-oncology drug with a well-established safety profile that can be repurposed to mitigate the stem-like properties of GBM. Not yet recruiting --> Recruiting | Initiation date: Apr 2022 --> Aug 2022
- |||||||||| Tavegil (clemastine) / GSK
Journal: The Neurotrophic Receptor Tyrosine Kinase in MEC-mPFC Neurons Contributes to Remote Memory Consolidation. (Pubmed Central) - Jul 24, 2022
Notably, TrkB deletion seriously inhibited experience-dependent maturation of oligodendroglia in the PFC, resulting in defects in remote recall that were rescued by clemastine administration...We evaluated the contextual fear memory and labeled cells, which revealed deletion of TrkB interrupts newborn oligodendrocyte and reactivation of cells in mPFC at remote recall. Our data provide the implication that remote memory is relevant to neurotrophic receptor signaling as well as its influence on non-neuronal cells.
- |||||||||| paclitaxel / Generic mfg., ranitidine hydrochloride / Generic mfg.
Retrospective data, Journal: Ranitidine and the incidence of hypersensitivity reactions to paclitaxel: A retrospective cohort study. (Pubmed Central) - Jul 13, 2022
Sixty-three patients did not receive premedication in the form of ranitidine, of whom 10 (15.8%) had a HSR, p-value of .80. In conclusion, we found no difference in the incidence of HSRs during paclitaxel infusions between patients who received ranitidine as premedication versus those who did not.
- |||||||||| Review, Journal: Novel Drugs in a Pipeline for Progressive Multiple Sclerosis. (Pubmed Central) - Jun 25, 2022
In search of innovative solutions, several research studies have been conducted to evaluate the effectiveness of drugs with neuroprotective or remyelinating effects in PMS, including biotin, ibudilast, simvastatin, alpha-lipoic acid, clemastine, amiloride, fluoxetine, riluzole, masitinib, opicinumab, and lamotrigine. The current review includes those compounds, which have entered the clinical phase of assessment, and the authors discuss future prospects for successful PMS treatment.
- |||||||||| Tavegil (clemastine) / GSK
Metal allergy – molybdenum – on a total hip arthroplasty: an anaesthetic challenge (Poster eBoard 1) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1450;
It was administered 125mg of methylprednisolone and 2mg of clemastine prior to induction...RA would be preferred because it has less cardiovascular and pulmonary complications, reduced risk of thromboembolic events and would permit a faster recovery. On the other hand, GA was the safest alternative according to the lack of information on the components of RA’ needles.
- |||||||||| Tavegil (clemastine) / GSK
Postoperative ACE inhibitor-induced angioedema (Poster eBoard 2) - Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1084;
Ibuprofen and lisinopril were discontinued...It may be triggered by anesthesia/surgery, typically occurring within 1-8 hours. It is the most likely diagnosis.In anaesthesia/surgery, there are several possible triggers for ACEI induced angioedema, such as trauma, airway irritation and surgical stress.
- |||||||||| Tavegil (clemastine) / GSK
Preclinical, Journal: Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy. (Pubmed Central) - Jun 10, 2022
Furthermore, clemastine does not improve VEP latency following demyelinating injury when administered to a transgenic animal incapable of forming new myelin. Therefore, using the capacity for therapeutic enhancement and biological loss of function we demonstrate conclusively that VEP measures myelin status and is thereby a validated tool for preclinical verification of remyelination.
- |||||||||| imatinib / Generic mfg.
Imatinib Promotes Reverse Cholesterol Transport And Elevates Sr-bi (Grand Ballroom ABC) - Jun 1, 2022 - Abstract #ATVBPVDGPM2022ATVB_PVD_GPM_457;
Furthermore, in wildtype C57Bl/6 mice on a high fat, high cholesterol diet, imatinib treatment (50mg/kg) was sufficient to decrease plasma total cholesterol, HDL-C and triglyceride levels and elevate hepatic SR-BI expression. In summary, our data supports the exploration of imatinib-mediated SR-BI regulation, HDL metabolism, and RCT pathway to identify new therapeutic targets for dyslipidemia.
- |||||||||| Tavegil (clemastine) / GSK
Journal: Metabolic Effects of Sodium Fluorocitrate and Potential Treatments on Saccharomyces Cerevisiae: Changes in Oxygen Consumption. (Pubmed Central) - May 14, 2022
As a result, the compounds nifuroxazide, pyrvinium pamoate, vinpocitine, clemastine fumarate, bisacodyl, and L-ascorbic acid are moving forward for further testing in cardiomyocytes and hepatic spheroids, with potential in vivo assessment, to characterize their effectiveness against 1080 poisoning. Future studies will continue to use yeast as a valuable screening method to identify other potential treatments for sodium fluoroacetate.
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