Suspended

4

60

 

Conventional treatent and hydroxychloroquine ;Conventional treatment

The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Chongqing Municipal Health Committee

Novel Coronavirus Pneumonia (COVID-19)

 

 

Not yet recruiting

4

286

Europe

L04AB01, Powder and solution for solution for injection, Solution for injection, Concentrate for solution for infusion, Solution for infusion, Concentrate for solution for injection, Tablet, Powder and solvent for solution for injection, ENBREL, HUMIRA, REMICADE, ORENCIA, SIMPONI, CIMZIA, ROACTEMRA, MABTHERA, SALAZOPYRINE, IMETH, METOJECT, PLAQUENIL

Hôpitaux Universitaires de Strasbourg, Ministry of Health

RHEUMATOID ARTHRITIS, PATIENTS WITH RHEUMATOID ARTHRITIS AND INSUFFICIENT RESPONSE TO METHOTREXATE, Diseases [C] - Immune System Diseases [C20]

 

 

Ongoing

4

190

Europe

Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine,

King\'s College London

Rheumatoid Arthritis

 

 

Ongoing

4

96

Europe

Prednisolone, Hydroxychloroquine sulphate, Methotrexate, Mycophenolate mofetil, Clobetasol propionate 0.05%, N/A, Prednisolone, Hydroxychloroquine sulphate, Clobetasol propionate 0.5%, Clobetasol proprionate 0.05%, Prednisolone, Hydroxychloroquine sulphate, Clobetasol propionate 0.5%, Clobetasol proprionate 0.05%

University of Nottingham, National Institute for Health Research

Vulval erosive lichen planus

 

 

Ongoing

4

130

Europe

Sulfasalazine, Hydroxychloroquine, Tablet, Methotrexate, sulfasalazine, Hydroxychloroquine

Leiden University Medical Centre, ZonMw

Juvenile idiopathic arthritis, Juvenile idiopathic arthritis jeugdreuma, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Completed

4

80

 

Prednisone+methotrexate+Hydrochloroquine ;placebo+methotrexate+Hydrochloroquine

Central Hospital of Jinhua; Central Hospital of Jinhua, Jinhua Municipal Science and Technology Bureau

rheumatoid arthritis

 

 

Not yet recruiting

4

98

Europe

Powder and solution for solution for injection, Coated tablet, ORENCIA, Dolquine

Fundació Clínic per a la Recerca Biomèdica, Bristol_ Myers Squibb . (BMS_Laboratorio)

PALINDROMIC RHEUMATISM REUMATISMO PALINDROMICO, Palindromic rheumatism is characterized by multiple recurrent episodes of arthritis and periarthritis (mono or oligoarticular) that may last hours or days, disappearing without sequels El reumatismo palindrómico se caracteriza por múltiples episodios recurrentes de artritis y periartritis (mono u oligoarticular) que pueden durar horas o días, desapareciendo sin secuelas., Diseases [C] - Immune System Diseases [C20]

 

 

Completed

4

90

 

Anbainuo plus methotrexate ;Methotrexate, salazopyridine, leflumide, hydroxychloroquine

The Affiliated ZhuZhou Hospital Of XiangYa School Of Medicine CSU.; The Affiliated ZhuZhou Hospital Of XiangYa School Of Medicine CSU., self-paying

Rheumatoid arthritis

 

 

Not yet recruiting

4

76

Europe

Film-coated tablet, Plaquenil - Hydroxychloroquine 200mg Film coated tablets

Guy's and St. Thomas' NHS Foundation Trust, Medical Research Council

The term ANCA-associated vasculitis (AAV) describes a subset of primary small vessel vasculitides characterized by the presence of anti-neutrophil cytoplasmic antibodies (ANCA): Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and Eosinophilic Granulomatosis with Polyangiitis (EGPA). AAV are serious multisystem autoimmune disorders that can affect any organ in the body and commonly involve the ear-nose-throat, lungs, kidneys, eyes and joints, ANCA vasculitis is the name of a group of autoimmune conditions characterized by the inflammation of the blood vessels caused by the immune system mistakenly attacking them., Body processes [G] - Immune system processes [G12]

 

 

Recruiting

4

78

 

oral intake hydroxycholoroquine 0.2 twice a day ;conventional therapy

The First Hospital of Peking University; The First hospital of Peking Universityirst hospital of Peking University, Government

Novel Coronavirus Pneumonia (COVID-19)

 

 

Ongoing

4

1530

Europe

Hidroxicloroquina sulfato, Coated tablet, Hidroxicloroquina Aristo

Sociedad Española de Farmacia Hospitalaria, Sociedad Española de Farmacia Hospitalaria, Instituto de Salud Carlos III

SARS-CoV-2 infection infección por SARS-CoV-2, SARS-CoV-2 COVID-19 infection Infección por coronavirus SARS-CoV-2 COVID-19, Health Care [N] - Environment and Public Health [N06]

 

 

Recruiting

4

100

 

Day1: first dose: 6 tablets（0.1g/table）, second dose: 6 tablets （0.1g/table）after 6h ；Day2~5: 2 tablets （0.1g/table), BID ;Day 1-3：500mg BID； Day 4-5：250mg BID

Peking University Third Hospital; Peking University Third Hospital, Peking University Third Hospital self-funds

Novel Coronavirus Pneumonia (COVID-19)

 

 

Ongoing

4

267

Europe

Plaquenil, Film-coated tablet, Plaquenil, Azromax

University College Dublin, University College Dublin

SARS-CoV-2 PCR-positive population, COVID-19 positive, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

4

280

Europe

Capsule, soft, Coated tablet, Sandimmun Neoral 25 mg cápsulas blandas Sandimmun Neoral 50 mg cápsulas blandas Sandimun Neoral 100 mg cápsulas blandas, Dolquine 200 mg comprimidos recubiertos

Tatiana Cobo Ibáñez, Gemma María Mora Ortega, Gonzalo Serralta San Martín, Hospital Universitario Infanta Sofía

COVID-19 PNEUMONIA NEUMONIA COVID-19, COVID-19 PNEUMONIA NEUMONIA COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

4

450

Europe

Tablet, Hidroxicloroquina

IDIVAL Instituto de Investigación Sanitaria Valdecilla, IDIVAL

SARS-CoV-2 infection (COVID-19) Infección por SARS-CoV-2 (COVID-19), SARS-CoV-2 infection (COVID-19) Infección por SARS-CoV-2 (COVID-19), Diseases [C] - Virus Diseases [C02]

 

 

Active, not recruiting

4

53

Europe

Hydroxychloroquine Sulfate, Plaquenil

University Hospital, Akershus

Corona Virus Infection

05/20

03/25

Completed

4

360

 

oral hydroxychloroquine sulfate tablets ;Conventional treatment meet the Guideline

Ruijin Hospital, Shanghai Jiaotong University School of Medicine; Ruijin Hospital, Shanghai Jiaotong University School of Medicine, SPH SHANGHAI ZHONGXI PHARMACEUTICAL CO., LTD

Novel Coronavirus Pneumonia (COVID-19)

 

 

Recruiting

4

220

 

Supportive treatment+Perindopril 8 mg/day ;Supportive treatment+Perindopril 8 mg/day+hydroxychloroquine sulfate (200mg 2/d) ;Low dose glucocorticoid (0.5mg/kg.d)+cyclosporine A (valley concentration controlled at 50-100ng/ml) ;Low dose glucocorticoid (0.5mg/kg.d)+cyclosporine A (valley concentration controlled at 50-100ng/ml)+hydroxychloroquine sulfate (200mg 2/d)

Nephrology Division, First Hospital Affiliated to Army Medical University; First Hospital Affiliated to Army Medical University, Training Program for Clinical Research Talents of Army Medical University

Idiopathic Membranous Nephropathy

 

 

Not yet recruiting

4

10

Europe

Hydroxychloroquine sulphate, Tablet, Plaquenil

UZ Leuven, UZ Leuven

The study is meant to have a better understanding in obesity and how we can prevent/cure it. Therefore, the product will first be tested in healthy, lean volunteers., The study is meant to have a better understanding in obesity and how we can prevent/cure it. Therefore, the product will first be tested in healthy, lean volunteers., Body processes [G] - Metabolic Phenomena [G03]

 

 

Recruiting

4

150

RoW

Remdesivir, Hydroxychloroquine, Tocilizumab, Actemra, Lopinavir/ Ritonavir, kaletra, Ivermectin, Iverazine

October 6 University, Beni-Suef University

Covid19, Pneumonia

03/21

04/21

Not yet recruiting

4

120

 

Iguratimod 25mg bid po ;hydroxychloroquine 0.2-0.4g/d+prednison0.2-0.5mg/kg.d

Shanghai Tongji Hospital; Shanghai Tongji Hospital, scientific research funds

Sjogren syndrome

 

 

Completed

4

130

 

Hydroxychloroquine (5mg/kg/day) plus prednisone (0.5mg/kg/day) ;Hydroxychloroquine (5mg/kg/day) plus prednisone (0.5mg/kg/day) plus Mycophenolate Mofetil 500mg bid

Ruijin Hospital; Ruijin Hospital, 81801592, 82101876, 2021YFC2501304, SHDC2020CR4011, SPROG202006, Ruijin-Zhongmeihuadong Lupus Funding

systemic lupus erythematosus

 

 

Recruiting

4

80

 

iguratimod ;hydroxychloroquine

the Third Xiangya Hospital of Central South University; the Third Xiangya Hospital of Central South University, Guangzhou pukang charitable foundation

systemic lupus erythematosus

 

 

Not yet recruiting

4

120

 

hydroxychloroquine+life style management ;life style management

Huadong Hospital Affiliated to Fudan University; Huadong Hospital Affiliated to Fudan University, Major clinical research projects of Shanghai Shenkang hospital development center to promote clinical skills and clinical innovation of municipal hospitals (2020-2022)

Hyperuricemia

 

 

Recruiting

4

78

RoW

Iguratimod Tablets, Hydroxychloroquine Sulfate Tablets

Second Affiliated Hospital, School of Medicine, Zhejiang University

Primary Sjögren's Syndrome

12/24

07/25

Recruiting

4

108

RoW

Hydroxychloroquine, Plaquenil

National Taiwan University Hospital

Graves Ophthalmopathy

09/25

12/26

Recruiting

4

102

 

hydroxychloroquine + Dexamethasone ;Dexamethasone

Jinshan Hospital, Fudan University; Jinshan Hospital, Fudan University, National Natural Science Foundation of China 81870098; Program of Shanghai Academic/Technology Researcher leader(20XD1401000)

primary immune thrombocytopenia

 

 

Completed

4

646

RoW

Dihydroartemisinin-Piperaquine, DP, D-Artepp, DuoCotecxin, Artekin, Eurartesim, Ridmal, Chloroquine, Aralen, Hydroxychloroquine, Lariago, Sulfadoxine pyrimethamine, SP

University of Maryland, Baltimore, Kamuzu University of Health Sciences, Doris Duke Charitable Foundation

Malaria,Falciparum, Anemia in Children

07/23

07/23

Recruiting

4

84

 

Hydroxychloroquine sulfate ;Conventional therapy

Daping Hospital, Army Medical University; Daping Hospital, Army Medical University, General Project of Chongqing Natural Science Foundation (cstc20jcyj-msxmx0013)

Henoch Schonlein purpura nephritis

 

 

Recruiting

4

30

RoW

Telitacicept, RC18, Hydroxychloroquine, HCQ, Prednisone, PRED, Methylprednisolone, MP, Cyclophosphamide, CTX, Mycophenolate Mofetil, MMF, Tacrolimus, TAC

Fen Li

Systemic Lupus Erythematosus

06/24

06/24

Not yet recruiting

4

1000

 

None ;Adalimumab tapering combined with methotrexate therapy. The recommended dosage of adalimumab is as follows: Adalimumab, 40 mg/2 weeks, subcutaneous injection, reduce the dose after full dose treatment after reaching low disease activity. The dose reduction is carried out as follows: to extend the duration of administration and limiting the maximum duration of administration interval to 6 weeks (it is recommended to extend the duration of administration interval to 3, 4 or 6 weeks). The recommended dose of methotrexate is as follows: Methotrexate, taken orally, 10-30 mg once a week. ;triple therapy is applied. According to the patient's condition and willingness of patients, three traditional synthetic anti-rheumatic drug combination treatment could be applied, including but not limited to: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, etc. Recommended usage and dosage are as follows: Methotrexate, oral, 10-30 mg each time, once a week; Leflunomide, 10-20 mg once daily; Sulfasalazine, orally, 500 mg-1,000 mg each time, 3-4 times a day; Hydroxychloroquine, orally, 0.2 g to 0.4 g, once a day.

The First Affiliated Hospital of Chengdu Medical College; The First Affiliated Hospital of Chengdu Medical College, Self-funded

rheumatoid arthritis

 

 

Not yet recruiting

4

585

RoW

Oral prednisolone and SoC, Wysolone® by Pfizer Ltd., Gut-directed budesonide and SoC, IgANEF® by MediART Life Sciences Pvt. Ltd., Mycophenolate mofetil (MMF) and SoC, Mycept® by Panacea Biotec Ltd., Hydroxychloroquine and SoC, Ipca HCQ® by IPCA Laboratories Ltd., Non-steroidal mineralocorticoid receptor antagonist and SoC, SoC defined as maximal labelled or tolerated dose of angiotensin-converting enzyme inhibitor/ angiotensin receptor blocker (ACEi/ARB) & steady dose of sodium-glucose cotransporter-2 inhibitor (SGLT2i), Dapmed® by Medgenix Pharma India Pvt. Ltd.

Christian Medical College, Vellore, India, Medical Research Council, India Alliance

IgA Nephropathy, Renal Insufficiency, Chronic, IgA Vasculitis, IGA Glomerulonephritis

08/29

08/29

Recruiting

4

286

Europe

Methotrexate + targeted therapy administration, methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration

University Hospital, Strasbourg, France

Rheumatoid Arthritis, Insufficient Response to Methotrexate or Leflunomide

Recruiting

4

1000

RoW

Dihydroartemisinin-Piperaquine, DP, D-Artepp, DuoCotecxin, Artekin, Eurartesim, Ridmal, Chloroquine, Aralen, Hydroxychloroquine, Lariago, Sulfadoxine-pyrimethamine-amodiaquine, SPAQ, SPAQ-Co

Liverpool School of Tropical Medicine, Kamuzu University of Health Sciences

Malaria,Falciparum, Anemia in Children

07/25

12/25

Not yet recruiting

4

126

 

Hydroxychloroquine and prednisone ;prednisone

The Second Affiliated Hospital of Kunming Medical University; The Second Affiliated Hospital of Kunming Medical University, Self-funded

primary immune thrombocytopenia

 

 

Not yet recruiting

4

146

 

Hydroxychloroquine (HCQ)+tacrolimus (FK506)+hormone (P) ;Placebo+tacrolimus (FK506)+hormone (P)

The Seventh Affiliated Hospital of Sun Yat sen University; The Seventh Affiliated Hospital of Sun Yat sen University, 735 Project of the Seventh Affiliated Hospital of Sun Yat sen University

idiopathic membranous nephropathy

 

 

Ongoing

3/4

100000

Europe

Remdesivir, Lyophilisate for solution for infusion, Tablet, , Chloroquine, HYDROXYCHLOROQUINE SULFATE, Lopinavir/Ritonavir, Interferón b 1A

FIB-HCSC, WHO (World Health Organization), Vilnius University Hospital Santaros Klinikos, World Health Organisation, Department of Health, AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA VERONA, AICIB, Ministerstvo Zdravotníctva Slovenskej republiky, World Health Organization, Ministry of Health, Ministry of Health of the Republic of Latvia, FIB-HCSC, Vilnius University Hospital Santaros Klinikos, World Health Organisation, Department of Health, WHO, AICIB, Ministerstvo zdravotníctva Slovenskej republiky, World Health Organization, Ministry of Health, Ministry of Health of Latvia, Ministry of Health of the Republic of Latvia

COVID-19 COVID-19, COVID-19 COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

252

Europe

Hydroxychloroquine, n/a, Tablet, Plaquenil

University of Leeds, Arthritis Research UK

Hand osteoarthritis, Pain in joints of the hand, Diseases [C] - Musculoskeletal Diseases [C05]

 

 

Ongoing

3

120

Europe

Plaquenil, Plaquenil, Plaquenil

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)

Syndrome de Sjögren primitif

 

 

Ongoing

3

200

Europe

hydroxychloroquine, Plaquenil, Plaquenil

Maasstad Hospital

Osteoarthritis of the hand

 

 

Ongoing

3

328

Europe

Hydroxychloroquine, Film-coated tablet, Quinoric

Guy's and St Thomas' NHS Foundation Trust, NIHR Research for Patient Benefit

Pregnant women with antiphospholipid antibodies, Pregnant women with antiphospholipid antibodies, Body processes [G] - Immune system processes [G12]

 

 

Ongoing

3

25

Europe

Coated tablet, Plaquenil 200 mg, comprimé pelliculé

Fondation Méditerranée Infection (FMI) - IHU Méditerranée Infection, Fondation Méditerranée Infection (FMI) - IHU Méditerranée Infection

Patients with documented respiratory infection with coronavirus SARS COV 2, Patients with coronavirus disease COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

3000

Europe

Plaquenil-Hydroxychloroquine, Azithromycin, Film-coated tablet, Plaquenil-Hydroxychloroquine, Azithromycin

University of Oxford / Clinical Trials and Research Governance, Department of Health

Suspected COVID-19, Suspected COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

4000

Europe

Truvada, Hydroxychloroquine, Tablet, Truvada, Hydroxychloroquine

Plan Nacional Sobre SIDA, Instituto de Salud Carlos III

COVID-19 COVID-19, COVID-19 Infection (Prophylaxis) Infección COVID-19 (Profilaxis), Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

132

Europe

Tablet, , Ibuprofen, Hidroxicloroquina, Azitromicina, Paracetamol

Instituto Investigación Sanitario Biocruces Bizkaia, Asociación Instituto Investigación Biocruces Bizkaia

COVID-19 infection Infección por COVID-19, COVID-19 infection Infección por COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

216

Europe

PLAQUENIL, [P01BA02], Capsule, hard, Plaquenil

ASUR (Azienda Sanitaria Unica Regionale) Marche

Emerging disease (COVID-19) due to a novel coronavirus (named SARS-CoV-2 latter) started in Wuhan, China and rapidly spread in China and outside and has been declared pandemic by WHO on March 12th 2020. It has been shown that an excessive immune response to the SARS-CoV-2 virus would results in hyper-inflammation, with excessive increase of cytokines IL6 and IL10. This may progress to a cytokine storm, followed by multiorgan failure and potentially death. L’esperienza in corso indica che COVID19 si caratterizza come una forma di infezione caratterizzata da un esordio con sintomi influenzali per poi evolvere verso una sintomatologia alle vie respiratorie più importante caratterizzata da un quadro di polmonite e via via, in una percentuale sempre più ristretta di persone verso un quadro da insufficienza respiratoria che può evolvere fino alla ARD grave., COVID-19 due to a novel coronavirus (named SARS-CoV-2 latter) may progress to a cytokine storm, followed by multiorgan failure and potentially death. COVID19 è una forma di infezione caratterizzata da un esordio con sintomi influenzali per poi evolvere verso un quadro da insufficienza respiratoria che può evolvere fino alla ARD grave., Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

216

Europe

Kevzara, Azitromicina, Hidroxicloroquina, 1171196003, Solution for injection, Tablet, Kevzara, Azitromicina, hidroxicloroquina

Consorci Parc de Salut Mar (PSMAR), ISCIII

Patients with confirmed COVID-19 infection and criteria for mild-moderate pneumonia (CURB-65 ≤1 i SatO2 ≥90%, MEWS score less than 3) and IL6 values of 20 pg / ml, will be randomly assigned to a sarilumab treatment group or another group receiving treatment according to the current therapeutic protocol of the PSMAR. Los pacientes con infección confirmada COVID-19 y con criterios de neumonía leve-moderada (CURB-65 ≤1 i SatO2 ≥90%, MEWS score menor de 3) y valores de IL6 de 20 pg/ml, se les asignará aleatoriamente a un grupo de tratamiento con sarilumab o a otro grupo que reciba tratamiento según el protocolo terapéutico vigente del PSMAR., Patients with mild or moderate neumonia with COVID19 infection Pacientes con neumonia leve o moderada e infección COVID19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

568

Europe

Tablet, Plaquenil

Rigshospitalet, Rigshospitalet

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Corona virus 2019, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

200

Europe

Tablet, HYDROXYCHLOROQUINE

NAVARRABIOMED - FUNDACIÓN MIGUEL SERVET, ISCIII

PRE-EXPOSURE PROPHYLAXIS WITH HYDROXYCHLOROQUINE IN SANITARIES HIGHLY EXPOSED TO COVID-19 PROFILAXIS PRE-EXPOSICIÓN CON HIDROXICLOROQUINA EN SANITARIOS ALTAMENTE EXPUESTOS A COVID-19, PRE-EXPOSURE PROPHYLAXIS WITH HYDROXYCHLOROQUINE IN SANITARIES HIGHLY EXPOSED TO COVID-19 PROFILAXIS PRE-EXPOSICIÓN CON HIDROXICLOROQUINA EN SANITARIOS ALTAMENTE EXPUESTOS A COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

435

Europe

Kaletra, PLAQUENIL, REZOLSTA, Avigan, [-], Tablet, Kaletra, PLAQUENIL - 200 MG COMPRESSE RIVESTITE 30 COMPRESSE, Rezolsta, Avigan

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE "LAZZARO SPALLANZANI"

Coronavirus Covid 19 infection Infezione da coronavirus Covid 19, Coronavirus Covid 19 infection Infezione da coronavirus Covid 19, Diseases [C] - Virus Diseases [C02]