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Review, Journal: A systematic review of the impact of 7-keto-DHEA on body weight. (Pubmed Central) - Dec 26, 2022 Various possible mechanisms in favor of weight loss are discussed; however, with the evidence currently available, no clear answer can be given regarding 7-keto-DHEA and weight loss. Further studies need to be conducted to clarify the efficacy and safety of this drug before it can be recommended for therapeutic use.
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Journal: An LC-MS/MS method for the simultaneous quantification of 32 steroids in human plasma. (Pubmed Central) - Jun 9, 2022 Validation demonstrated that the method was applicable for the quantitative analysis of two C- steroids (estrone, estradiol), nineteen C- steroids (testosterone, epitestosterone, dihydrotestosterone, 11-ketodihydrotestosterone, 11β-hydroxyandrostenedione, 11β-hydroxytestosterone, 11-ketotestosterone, dehydroepiandrosterone, 7α-hydroxydehydroepiandrosterone, 7β-hydroxydehydroepiandrosterone, 7-ketodehydroepiandrosterone, androsterone, epiandrosterone, androstenedione, androstenediol, 5α-androstane-3α,17β-diol, 5α-androstane-3β,17β-diol, 5β-androstane-3α,17β-diol, 5β-androstane-3β,17β-diol), and eleven C- steroids (cortisol, 21-deoxycortisol, 11-deoxycortisol, cortisone, corticosterone, 11-deoxycorticosterone, pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, 5α-dihydroprogesterone)...The accuracy, intra- and inter-day precision values as well as stability tests were in accordance with FDA Guidelines. The method will be a useful tool in investigating the mechanisms of steroid-related diseases and will serve as a steppingstone for the development of other methods for steroid analyses in various biological matrices such as prostate tissue, cerebrospinal fluid, urine, seminal fluid, and saliva.
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Journal: Metabolomics workflow as a driven tool for rapid detection of metabolites in doping analysis. Development and validation. (Pubmed Central) - Nov 7, 2021 The application of metabolomics tools as an investigation strategy could reduce the time and resources required to identify and characterize intake markers maximizing the information that can be extracted from the data and extending the research field by avoiding a priori bias. Therefore, metabolic fingerprinting of prohibited substance intakes could be an appropriate analytical approach to reduce the risk of false-positive/negative results, aiding in the interpretation of "abnormal" profiles and discrimination of pseudo-endogenous steroid intake in the anti-doping field.
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Phase classification: 7-Keto DHEA for the Treatment of PTSD (clinicaltrials.gov) - Oct 30, 2015 P2, N=71, Completed, These C12α-hydroxy steroids will be used as tools to identify new biochemical properties of the enzymatic products of P450 8B1, the oxysterol 12α-hydroxylase. Phase classification: P1/2 --> P2
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Trial completion, Enrollment change: 7-Keto DHEA for the Treatment of PTSD (clinicaltrials.gov) - Mar 17, 2015 P1/2, N=71, Completed, Phase classification: P1/2 --> P2 Recruiting --> Completed | N=120 --> 71
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