- |||||||||| Feraccru (ferric maltol) / Shield Therap
Review, Journal: The Importance and Essentiality of Natural and Synthetic Chelators in Medicine: Increased Prospects for the Effective Treatment of Iron Overload and Iron Deficiency. (Pubmed Central) - May 11, 2024
Similarly, many other drugs or their metabolites with iron-chelation capacity such as hydroxyurea, tetracyclines, anthracyclines and aspirin, as well as dietary molecules such as gallic acid, caffeic acid, quercetin, ellagic acid, maltol and many other phytochelators, are known to interact with iron and affect iron metabolism and related diseases...The proposed use of iron chelators for modulating ferroptosis signifies a new era in the design of new therapeutic chelation strategies in many other diseases. The introduction of artificial intelligence guidance for optimal chelation therapeutic outcomes in personalised medicine is expected to increase further the impact of chelation in medicine, as well as the survival and quality of life of millions of patients with iron metabolic disorders and also other diseases.
- |||||||||| deferoxamine / Generic mfg.
Review, Journal: Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis. (Pubmed Central) - May 11, 2024
Herein, we describe the mechanism by which deferoxamine promotes angiogenesis and summarize its application in chronic wounds, bone repair, and diseases of the respiratory system. Furthermore, we discuss the drug delivery system of deferoxamine for treating various diseases, providing constructive ideas and inspiration for the development of new treatment strategies.
- |||||||||| deferoxamine / Generic mfg.
Journal: Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury. (Pubmed Central) - May 7, 2024
Finally, we elucidated the specific molecular mechanism underlying the protective effect of the iron chelator deferoxamine (DFO) on CIRI...Administering the iron chelator DFO effectively attenuated NCOA4-induced ferritinophagy, thereby alleviating CIRI. Nevertheless, the role of the cGAS-STING pathway in CIRI regulation likely involves intricate mechanisms, necessitating further validation in subsequent investigations.
- |||||||||| deferoxamine / Generic mfg.
Deferoxamine Has a Protective Role to Modulate Ischemia Reperfusion Injury in Marginal Donor Livers (Poster Hall, Exhibit Hall A, Level 2) - May 6, 2024 - Abstract #ATC2024ATC_2086;
This study further unvailed that reduction of iron content suppresses expression of ferroptosis-associated genes and lipid peroxidation, and that DFO treatment can suppress IRI even in MDLs with severe macrosteatosis. This study using human MDLs revealed the relationship between iron content and ferroptosis, providing a solid foundation for future development of IRI therapeutics.
- |||||||||| deferoxamine / Generic mfg.
Journal: Nanosponge for Iron Chelation and Efflux: A Ferroptosis-Inhibiting Approach for Myocardial Infarction Therapy. (Pubmed Central) - Apr 27, 2024
A chitosan-desferrioxamine nanosponge (CDNS) is designed by co-crosslinking chitosan and deferoxamine through noncovalent gelation to address these challenges...This intervention improves cardiac function and alleviates adverse cardiac remodeling post-MI, leading to decreased oxidative stress and the promotion of angiogenesis due to ferroptosis inhibition by CDNS in the infarcted heart. This study reveals a nanosponge-based nanomedicine targeting myocardial ferroptosis with efficient iron chelation and efflux, offering a promising MI treatment.
- |||||||||| RSL3 / Stanford University
Journal: Increased Vulnerability to Ferroptosis in FUS-ALS. (Pubmed Central) - Apr 26, 2024
Iron chelation with deferoxamine, as well as inhibition of the mitochondrial calcium uniporter (MCU), significantly alleviated ferroptotic cell death and lipid peroxidation. These findings suggest a link between ferroptosis and FUS-ALS, offering potential new therapeutic targets.
- |||||||||| Halaven (eribulin mesylate) / Eisai, ML210 / University of Sydney
Journal: Involvement of ferroptosis in eribulin-induced cytotoxicity in ovarian clear cell carcinoma. (Pubmed Central) - Apr 22, 2024
Taken together, our findings show firstly that eribulin triggers ferroptosis in OCCC and this effect occurs via the suppression of the Nrf2-HO-1 signaling pathway, SOD activity and the promotion of lipid peroxidation. These findings suggest that eribulin-induced ferroptosis is associated with its anti-tumor effect and also could be a potential therapeutic target in OCCC.
- |||||||||| deferoxamine / Generic mfg.
Journal: Bile Acid-Targeted Hyaluronic Acid Nanoparticles for Enhanced Oral Absorption of Deferoxamine. (Pubmed Central) - Apr 17, 2024
In addition, ferritin reduction studies indicated that the conjugation of DFO to TCA9-HA did not compromise its chelation efficiency at equivalent free DFO concentrations. This research provides supportive data for the idea that TCA conjugated to HA may enhance the oral absorption of DFO, improve its cytocompatibility, and maintain its iron chelation efficiency.
- |||||||||| deferoxamine / Generic mfg.
Journal: Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders. (Pubmed Central) - Apr 1, 2024
Using pharmacological or genetic approaches, we reduce iron overload in AgRP neurons by central deferoxamine administration or transferrin receptor 1 (Tfrc) deletion, ameliorating diet-induced obesity and related metabolic dysfunction...Mechanistically, the reduction of iron overload in AgRP neurons inhibits AgRP neuron activity; improves insulin and leptin sensitivity; and inhibits iron-induced oxidative stress, endoplasmic reticulum stress, nuclear factor ?B signaling, and suppression of cytokine signaling 3 expression. These results highlight the critical role of hypothalamic iron in obesity development and suggest targets for treating obesity and related metabolic disorders.
- |||||||||| Journal: Weak base drug-induced endolysosome iron dyshomeostasis controls the generation of reactive oxygen species, mitochondrial depolarization, and cytotoxicity. (Pubmed Central) - Mar 27, 2024
Atropine (anticholinergic), azithromycin (antibiotic), fluoxetine (antidepressant), metoprolol (beta-adrenergic), and tamoxifen (anti-estrogen) at pharmacologically and therapeutically relevant concentrations (1) de-acidified endolysosomes, (2) decreased Fe2+ levels in endolysosomes, (3) increased Fe2+ and ROS levels in cytosol and mitochondria, (4) induced mitochondrial membrane potential depolarization, and (5) increased cell death; effects prevented by the endocytosed iron-chelator deferoxamine. Weak-base pharmaceuticals induce lysosome-stress responses that may affect their safety profiles; a better understanding of weak-base drugs on Fe2+ interorganellar signaling may improve pharmacotherapeutics.
- |||||||||| deferoxamine / Generic mfg.
Journal: Excess iron accumulation mediated senescence in diabetic kidney injury. (Pubmed Central) - Mar 18, 2024
Compared to the non-DN individual, increased ferritin and senescence markers were verified in DN mice and patients, and the co-localization of ferritin and senescence markers was observed by immunofluorescence. These results suggested that accumulated iron was correlated with aggravated DNA damage and accelerated senescence, and revealed the role of iron in the cellular senescence of diseases.
- |||||||||| deferoxamine / Generic mfg.
Review, Journal: H Vessel Formation as a Marker for Enhanced Bone Healing in Irradiated Distraction Osteogenesis. (Pubmed Central) - Mar 18, 2024
We hypothesize that using localized application of deferoxamine (DFO) will enhance the H vessel-mediated vasculogenic response to radiation damage and ultimately enable osteogenic healing during DO...DFO treatment remediated new bone formation and bony union in irradiated fields associated with increased H vessel angiogenic-osteogenic coupling. While further studies are required to optimize this approach, the results of this study are incredibly promising for the long-awaited translation of localized DFO into the clinical arena.
- |||||||||| deferoxamine / Generic mfg.
MSC-EV PROTECTS AGAINST IMMUNOLOGICAL LIVER INJURY BY SUPPRESSING FERROPTOSIS VIA ACTIVATION OF THE NRF2/GPX4 SIGNAL AXIS (140AB - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_8268;
We found that inflammation associated hepatocytes ferroptosis occurred in ILI mice, whereas deferoxamine attenuated liver injury...Moreover, we found that there was a significant correlation between levels of circulating 4-HNE and transaminases and treatment response, while overactivation of ferroptosis was revealed in hepatocytes in AIH patients. In conclusion, MSC-EVs could ameliorate inflammatory injury in ILI by suppressing hepatocytes ferroptosis via the Nrf2/GPX4 signaling pathway.
- |||||||||| deferoxamine / Generic mfg.
IS LIVER FAT CONTENT MORE IMPORTANT THAN LIVER IRON IN TRYING TO REVERSE LIVER FIBROSIS IN PATIENTS WITH TRANSFUSION-DEPENDENT BETA THALASSAEMIA? - A FOLLOW-UP STUDY (Hall A) - Mar 14, 2024 - Abstract #DDW2024DDW_1820;
Using human MDLs, the relationship between iron content and ferroptosis, provides a solid foundation for future development of IRI therapeutics. Age, gender, BMI, serum ferritin, AST, ALT, LF, liver steatosis (CAP score), liver iron concentration (LIC in mg Fe/g dw), and endocrine complications were recorded at recruitment and after 2
- |||||||||| deferoxamine / Generic mfg.
Comparison of 89zr- radiopharmaceuticals for PET imaging of SSTR+ neuroendocrine tumors (In-person; Room 338 (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_946;
This work aims to test the in vivo stability of two zirconium-89 ( 89 Zr) chelators, deferoxamine (DFO) and tetraxetan (DOTA), conjugated with the long-lived somatostatin analogue, octreotide (TOC)...If successful, this work will demonstrate the ability to utilize the excellent nuclear and chemical properties of 89 Zr for sensitive detection and diagnoses of SSTR+ NETs, while giving insight into the preferential coordination complex formed by 89 Zr during radiolabeling. This work has the potential to greatly impact patient care through the possibility of earlier detection and improved NET diagnoses.
- |||||||||| deferoxamine / Generic mfg., atovaquone / Generic mfg.
Identification and Targeting of Metabolic Profiles in CTL-Resistant, HIV-Infected CD4+ T-Cells (Poster hall) - Mar 5, 2024 - Abstract #CROI2024CROI_265;
Our results suggest that lower levels of ROS and hypoxic responses in HIV-infected cells with particular metabolic features renders these cells less susceptible to killing by CTL. Treatment with FDA-approved and well-tolerated ROS inducer ATQ and hypoxia-inducing iron-chelator DFO increased CTL mediated elimination of infected cells in vitro.
- |||||||||| deferoxamine / Generic mfg.
Journal: 89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors. (Pubmed Central) - Feb 28, 2024
To create an imaging agent, the anti-EMP2 mAb was conjugated to p-SCN-Bn-deferoxamine (DFO) and radiolabeled with 89Zr...The results show that anti-EMP2 mAbs exhibit EMP2-dependent tumor uptake with low off-target accumulation in preclinical cancer models. The development of improved anti-EMP2 antibody fragments may be useful to track EMP2 positive tumors for subsequent therapeutic interventions.
- |||||||||| Auryxia (ferric citrate) / Japan Tobacco, Akebia Therap, erastin - Whitehead Institute for Biomedical Research, Dana / Farber Cancer Institute, Columbia University, Prolexys
Journal: A Smooth Muscle Cell-Based Ferroptosis Model to Evaluate Iron-Chelating Molecules for Cardiovascular Disease Treatment. (Pubmed Central) - Feb 23, 2024
Erastin with ferric citrate was able to decrease intracellular GSH and induce lipid peroxidation after overnight incubation. Only deferiprone was able to rescue the cells from ferroptosis by decreasing lipid peroxidation via iron ion chelation in a 3:1 molar ratio.
- |||||||||| deferoxamine / Generic mfg., acetylcysteine solution / Generic mfg.
Journal: Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer. (Pubmed Central) - Feb 22, 2024
Additionally, AA-induced inhibition of cell growth and ferroptosis was suppressed by STAT3 and GPX4 overexpression, respectively. In summary, AA inhibited oropharyngeal cancer cell growth in vitro by regulating STAT3/GPX4-mediated ferroptosis, which may provide a novel theoretical basis for the clinical treatment of oropharyngeal cancer with AA.
- |||||||||| deferoxamine / Generic mfg.
Preclinical, Journal: Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice. (Pubmed Central) - Feb 22, 2024
These findings collectively suggest that altered iron levels influence the circadian rhythm by regulating PER1 expression and thereby modulating the molecular circadian clock. In conclusion, our study identifies the regulation of brain iron levels as a potential new target for treating age-related disruptions in the circadian rhythm.
- |||||||||| deferoxamine / Generic mfg.
Peroxiredoxin 6 Protects Pulmonary Epithelial Cells From Cigarette-related Ferroptosis Via Inhibition of Oxidative Stress (Marriott Marquis San Diego Marina, Grand Ballroom 2-4 (Lobby Level, North Tower)) - Feb 20, 2024 - Abstract #ATS2024ATS_660;
After the stimulation of CSE and deferoxamine, cell viability, the related gene and protein expression were assessed.Our clinical and experimental data showed labile iron accumulation, oxidation-redox imbalance and enhanced lipid peroxidation in COPD patients, the experimental COPD mice, and CSE-stimulated Beas-2B cells...The present study demonstrated that ferroptosis was involved in the pathogenies of COPD. Moreover, PRDX6 played key roles in regulating CSE-induced epithelia death and ferroptosis via enhanced oxidative stress and upregulation of HO-1 expression, which suggested PRDX6 might be a new target to prevent the epithelial cytotoxicity caused by cigarette smoke exposure.
- |||||||||| deferoxamine / Generic mfg.
Journal: Intranasal administration enhances size-dependent pulmonary phagocytic uptake of poly(lactic-co-glycolic acid) nanoparticles. (Pubmed Central) - Feb 15, 2024
Moreover, PRDX6 played key roles in regulating CSE-induced epithelia death and ferroptosis via enhanced oxidative stress and upregulation of HO-1 expression, which suggested PRDX6 might be a new target to prevent the epithelial cytotoxicity caused by cigarette smoke exposure. Our study provides valuable insights into advancing nanomedicine and drug delivery, with the potential for expanding the clinical applications of nanoparticles.
- |||||||||| deferoxamine / Generic mfg.
Journal: Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration. (Pubmed Central) - Feb 13, 2024
The biomimetic periosteum is composed of a bilayer with an asymmetric structure in which an aligned electrospun poly(?-caprolactone)/gelatin/deferoxamine (PCL/GEL/DFO) layer mimics the outer fibrous layer of the periosteum, while a random coaxial electrospun PCL/GEL/aspirin (ASP) shell and PCL/silicon nanoparticles (SiNPs) core layer mimics the inner cambial layer...In particular, different stages of bone repair are modulated in a rat skull defect model to achieve faster and better bone regeneration. The proposed biomimetic periosteum is expected to be a promising candidate for bone defect healing.
- |||||||||| deferoxamine / Generic mfg.
Preclinical, Journal: Oral treatment of human gut microbiota associated IL-10-/- mice suffering from acute campylobacteriosis with carvacrol, deferoxamine, deoxycholic acid, and 2-fucosyl-lactose. (Pubmed Central) - Feb 12, 2024
Remarkably, the carvacrol, deferoxamine, and combination treatment regimens dampened ex-vivo IFN-? secretion in the colon, the kidneys, and even in the serum to basal concentrations on day 6 p.i. In conclusion, carvacrol alone and its combination with deferoxamine, deoxycholate, and 2-fucosyl-lactose constitute promising antibiotics-independent treatment options to fight acute campylobacteriosis.
- |||||||||| deferoxamine / Generic mfg.
Journal: Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification. (Pubmed Central) - Feb 8, 2024
(HIF-1?)...We demonstrate this system can strengthen the ECO healing and convert mixed or mixed or IMO-guided routes to ECO-dominated approach in large-size models with clinical relevance. Collectively, these findings demonstrate a biomaterial-based strategy for driving ECO-dominated healing, paving a promising pave towards its clinical use in addressing large bone defects.
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