Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi 
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132 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
ACTRN12611001224910: REmoval Of Tacrolimus For Sirolimus Following Thymoglobulin Induction On The Development of REgulatory T Cells in Kidney Transplant Patients

Not yet recruiting
4
30
 
Department of Health, Genzyme Australia, Pfizer Australia
Development of circulating regulatory T cells, Kidney transplant function, complications and biopsy, Cardiovascular health, Metabolic outcomes (glucose abnormality), Clinical significant infections and cancers
 
 
ACTRN12610000697088: Ciclosporine Azathioprine versus Tacrolimus mycophenolate mofetil in renal transplantation

Active, not recruiting
4
300
 
Assistance publique des Hopitaux de Marseille, Assistance publique des Hopitaux de Marseille
renal transplantation, Immunosuppressive treatment in renal transplantation, Acute rejection and transplant survival in renal transplantation
 
 
2006-004830-34: TACROLIMUS AND PRETRANSPLANT HIGH-DOSE R-ATG INDUCTION VS TACROLIMUS MONOTHERAPY AS TOLEROGENIC IMMUNOSUPPRESSION IN ADULT LIVER TRANSPLANTATION.AN OPEN LABEL, RANDOMISED, PROSPECTIVE AND CONTROLLED TRIAL.

Ongoing
4
100
Europe
R-ATG, TACATG, Intravenous infusion, R- ATG
UNIVERSITY HOSPITALS ST LUC
Studying the possibility of tolerance induction in adult liver transplantation adding one single dose of polyclonal antilymphocytic antibodies to an calcineurin -inhibitor based immunosuppression using tacrolimus.
 
 
2005-000855-14: Multicenter, not controlled, prospectic clinical phase IV study: safety and efficacy of an immunosuppressive regimen with Thymoglobuline and Rapamune in patients receiving a renal transplantation from a marginal donor.

Ongoing
4
65
Europe
NA, NA, RAPAMUNE*1MG 100 CPR, RAPAMUNE*2MG 30 CPR, RAPAMUNE*OS 60 ML 1 MG, THYMOGLOBULINE*IV 1F 25MG +F, RAPAMUNE*1MG 100 CPR, RAPAMUNE*2MG 30 CPR, RAPAMUNE*OS 60 ML 1 MG, THYMOGLOBULINE*IV 1F 25MG +F
AZIENDA OSPEDALIERA DI PADOVA
Acute rejection prophylaxis after single-double kidney transplantation from marginal donors making use of a not nephrotoxic immunosuppressive regimen.
 
 
ChiCTR1800017266: A single center prospective study comparing the effects of induction therapy in Chinese donation after cardiac death (DCD) patients between rabbit anti-human thymocyte immunoglobulin (Thymoglobulin) and basiliximab ( Simulect)

Recruiting
4
80
 
rATG standard dose (5.0-6.0 mg/kg) ;rATG standard dose (4.0-5.0 mg/kg) ;Basiliximab standard dose
General Hospital of Chinese People's Armed Police Forces; General Hospital of Chinese People's Armed Police Forces, Hospital
Kidney Transplantation
 
 
ChiCTR-OIN-17011174: A Study of Thymoglobuline? Induction Therapy in Adult Recipients of Donated After Cardiac Death Kidney Transplant

Recruiting
4
 
The First Affiliated Hospital of Xi'an JiaoTong University; Sanofi (Beijing) Pharmaceutical Co., Ltd., Sanofi (Beijing) Pharmaceutical Co., Ltd.
Diseases of the kidney and urinary system
 
 
NCT02745717: The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Completed
4
60
RoW
Thymoglobulin, Thymoglobuline, Cord blood, Cyclosporine Oral Product, cyclosporine A
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine, Zhejiang Provincial Hospital of TCM
Severe Aplastic Anemia
12/21
12/21
NCT02938741: ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors

Recruiting
4
130
RoW
Anti-human Thymoglobulin, (r-ATG ）, Placebo
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lymphoblastic Lymphoma
12/21
12/22
NCT04009525: Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study

Recruiting
4
800
RoW
Busulfan, Bu, Cyclophosphamide, Cy, Fludarabine, Flu, Thymoglobulin, ATG, cyclosporine A, CsA, Mycophenolate mofetil, MMF, Tacrolimus, FK506, Methotrexate, MTX, Basiliximab, Simulect, Ruxolitinib
First Affiliated Hospital of Guangxi Medical University, Peking University People's Hospital, Ruijin Hospital, The 923th Hospital of People's Liberation Army, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou General Hospital, Hainan General Hospital, The Affiliated Hospital Of Guizhou Medical University, The First People's Hospital of Yunnan
Thalassemia Major
05/22
05/23
SIMPLE, NCT04773392: Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR

Recruiting
4
80
US
Twice-daily Tacrolimus, Once-daily envarsus XR, Induction Immunosuppression with Basiliximab or Rabbit Anti Thymoglobulin (rATG), Methylprednisolone, prednisone, Steroids, Mycophenolate mofetil (MMF) or Mycophenolic acid (MPA), Twice a day anti-metabolite, Azathioprine, Once a day anti-metabolite
University of Southern California, Veloxis Pharmaceuticals
Kidney Transplantation, Kidney Transplant Rejection
02/25
02/25
BETTER, NCT04849533: Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation ( Trial)

Recruiting
4
120
US
Belatacept, Nulojix, Everolimus, Zortress, mycophenolate mofetil, Cellcept, corticosteroids, Prednisone, rabbit antithymocyte globulin, rATG, thymoglobulin
University of Cincinnati
Kidney Transplant Rejection
07/23
07/24
NCT05634915: Clinical Study of rATG Individualized Administration in Haploidentical Hematopoietic Stem Cell Transplantation

Recruiting
4
90
RoW
Individual ATG, ATG
The First Affiliated Hospital of Soochow University
Hematopoietic Stem Cell Transplantation, Acute Leukemia
12/24
05/25
PHASAL-GA, NCT05743400: Thymoglobulin® Pharmacokinetics in Patients Undergoing Hematopoietic Stem Cell Transplantation

Recruiting
4
35
Europe
Thymoglobulin 25 milligrams (mg) Injection, blood test
Hospices Civils de Lyon
Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy
04/25
04/25
2011-002052-14: EURO-HIT-HLH European cooperative pilot study for testing Hybrid ImmunoTherapy for Hemophagocytic LymphoHistiocytosis Studio cooperativo pilota per la valutazione della terapia immunologica combinata della Linfoistiocitosi Emofagocitica Familiare

Ongoing
3/4
24
Europe
THYMOGLOBULINE*1F 25MG 10ML, DESAMETASONE FOSF*IM EV 3F 4MG, ETOPOSIDE TEVA*FL 10ML 20MG/ML, METHOTREXATE*INIET 1FL 500MG20, THYMOGLOBULINE*1F 25MG 10ML, DESAMETASONE FOSF*IM EV 3F 4MG, ETOPOSIDE TEVA*FL 10ML 20MG/ML, METHOTREXATE*INIET 1FL 500MG20
AZIENDA OSPEDALIERA MEYER, AOU Meyer, AOUMeyer, Florence, HistiozytoseHilfe e.V., Universitätsklinikum Hamburg Eppendorf, St. Anna Kinderkrebsforschung e.V.
Familial hemophagoytic lymphohistiocytosis Linfoistiocitosi emofagocitica familiare.
 
 
2021-003282-36: Studying Conditioning Regimen In Pediatric Transplantation – AML

Ongoing
3
230
Europe
Cyclophosphamide, Melphalan, Fludarabine, Clofarabine, Concentrate for dispersion for infusion, Powder for solution for infusion, Powder for dispersion for infusion, Busilvex, Grafalon, Thymoglobuline
Västra Götalands Regionen, Funding application submitted.
Acute myeloid leukemia (AML) in children, AML is a type of blood cancer, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
2006-004067-53: A multicenter randomized study on the use of rabbit anti-T-Lymphocite globulin ATG different doses to prevent GVHD in children receiving allogenic stem cell transplantation

Ongoing
3
200
Europe
THYMOGLOBULINE*1F 25MG+1F 5ML, THYMOGLOBULINE*1F 25MG+1F 5ML
OSPEDALE POLICLINICO S. MATTEO
ematological malignant neoplasm
 
 
2006-004598-83: High dose immunoablation and autologous hematopoietic stem cell transplantation versus monthly intravenous pulse therapy cyclophosphamide in severe systemic sclerosis ( ‘ASTIS’-TRIAL: Autologous Stem Cell Transplantation International Scleroderma Trial)

Ongoing
3
15
Europe
Cyclophosphamide, Filgrastim, Thymoglobuline, Methylprednisolone, Mesna, rbATG, Cyclophosphamide, Neupogen, Thymoglobuline, Solu-Medrone, Mesna, Cyclophosphamide, Neupogen, Thymoglobuline, Solu-Medrone, Mesna
EBMT (European group for Blood and Marrow Transplantation)
Severe systemic sclerosis
 
 
2015-004406-42: Prophylactic treatment with Valganciclovir in kidney transplant CMV-seropositve patients. Profilaxis del tratamiento con Valganciclovir en transplantados renales CMV seropositivo

Ongoing
3
150
Europe
Tablet, VALCYTE 450 mg comprimidos recubiertos con película
FIBICO, FIBICO
Kidney transplant cytomegalovirus-seropositive Trasplante renal citomegalovirus seropositivo, Kidney transplant cytomegalovirus-seropositive Trasplante renal citomegalovirus seropositivo, Diseases [C] - Virus Diseases [C02]
 
 
2017-002545-30: Controlled trial to assess low intensity autologous stem cell transplant in refractory Crohn's Disease

Ongoing
3
99
Europe
Cyclophosphamide, Filgrastim, Fludarabine, Thymoglobuline, Powder for solution for injection, Solution for injection, Concentrate for solution for injection/infusion, Powder for solution for infusion, Cyclophosphamide, Filgrastim, Fludarabine, Thymoglobuline
Barts Health NHS Trust
Refractory Crohn's Disease, Crohn's Disease that has not responded to previous treatment, Diseases [C] - Digestive System Diseases [C06]
 
 
2019-003723-37: rATG versus rATG combined with IVIG induction immunosuppression in HLA incompatible transplantation Randomizovaná, otevřená studie fáze III.b prokazující non-inferioritu indukční imunosuprese pomocí rATG ve srovnání s kombinací rATG a IVIG u HLA inkompatibilních pacientů po transplantaci ledvin

Not yet recruiting
3
138
RoW
Thymoglobuline 5 mg/ml, prášek pro infuzní roztok, Privigen 100 mg/ml infuzní roztok, Powder for concentrate for solution for infusion, Solution for infusion, Thymoglobuline 5 mg/ml prášek pro infuzní roztok, Privigen 100 mg/ml infuzní roztok
Institut klinické a experimentální medicíny (IKEM), Institut klinické a experimentální medicíny (IKEM)
Trial participants will be end-stage renal disease (ESRD) patients listed for deceased donor / living donor kidney transplantation with anti HLA antibody screening performed within 12 months before transplantation and with last DSA 1 000 - 5 000, negative CDC prior to transplantation. Pacienti v terminálním stadiu selhání ledvin (ESRD), kteří podstoupili transplantaci ledviny od zemřelého či žijícího dárce, a kteří mají preformované anti-HLA protilátky zjištěné screeningovým vyšetřením v průběhu 12 měsíců před transplantací, poslední zjištěné hladiny DSA v rozmezí 1 000–5 000 MFI a negativní CDC crossmatch., Kidney transplantation Transplantace ledvin, Not possible to specify
 
 
INHIBIT, NCT04302805: rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation

Completed
3
17
RoW
Privigen, IVIG, Kiovig, Thymoglobulin, rATG, Plasma Exchange, PE
Institute for Clinical and Experimental Medicine
Kidney Transplantation
04/24
06/24
NCT04945096: Outcomes of Patients After Allo-HSCT With Decitabine and NAC

Not yet recruiting
3
100
NA
decitabine, 5-aza-2'-deoxycytidine, Acetylcysteine, Acetadote, Semustine, Methyl-CCNU, Cytarabine, Cytosine arabinoside, Busulfan, Myleran, Cyclophosphamide, Cytoxan, Cyclosporin A, Cyclosporine, Anti-thymocyte globulin, Thymoglobulin, Mycophenolate, CellCept
The First Affiliated Hospital of Soochow University
Engraft Failure, Relapse, GVHD
07/25
12/25
NCT04547049: A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies

Recruiting
3
160
RoW
Cytarabine, Busulfan, Cyclophosphamide, Me-CCNU, Rabbit antithymocyte globulin, Allogeneic HSCT, Cyclosporin A, Mycophenolate Mofetil, MTX
First Affiliated Hospital of Zhejiang University
Leukemia
09/25
12/25
OPTISAGE, NCT06083129: Phase III Study Comparing GVHD Prophylaxis With ATG-thymoglobulin to ATLG-grafalon in Elderly Patients With Acute Myeloid Leukemia or Myelodysplasic Syndrome and Receiving an Allogeneic Hematopoietic Stem Cell Transplantation With a 10/10 HLA Matched Unrelated Donor

Not yet recruiting
3
324
NA
Grafalon, Thymoglobulin
Assistance Publique - Hôpitaux de Paris
GVHD
02/27
11/28
INSTEAD, NCT05385432: Induction in Sensitized Kidney Transplant Recipients Without Pre-existing Donor-specific antiboDies

Not yet recruiting
3
244
NA
Rabbit Anti thymocyte globulin (rATG), Maintenance immunosuppressive regimen is the same in experimental and control groups combining tacrolimus, mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS) and steroids, Basiliximab
University Hospital, Tours
Renal Transplant Rejection, Induction Therapy
03/27
03/30
NCT05457556: Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Recruiting
3
435
Canada, US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Busilvex, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B-518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, WR-138719, Echocardiography, EC, Fludarabine, Fluradosa, Haploidentical Hematopoietic Cell Transplantation, Haploidentical Stem Cell Transplantation, HLA-Haploidentical Hematopoietic Cell Transplantation, Stem Cell Transplantation, Haploidentical, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Antithymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, Thymoglobulin, Lumbar Puncture, LP, Spinal Tap, Matched Unrelated Donor Hematopoietic Cell Transplantation, MUD-HCT, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Mycophenolate Mofetil, CellCept, MMF, Myeloablative Conditioning, Myeloablation, Myeloablative, Myeloablative Cytoreduction, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Rituximab, ABP 798, BI 695500, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF-05280586, Riabni, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-pvvr, RTXM83, Ruxience, Truxima, T-Cell Depletion Therapy, T-Cell Depletion, T-Lymphocyte Depletion Therapy, Tacrolimus, FK 506, FK-506, Fujimycin, Hecoria, Prograf, Protopic, Tacforius, Thiotepa, 1,1',1''-Phosphinothioylidynetrisaziridine, Girostan, N,N', N''-Triethylenethiophosphoramide, Oncotiotepa, STEPA, Tepadina, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312, Total-Body Irradiation, SCT_TBI, TBI, Total Body Irradiation, Whole Body, Whole Body Irradiation, Whole-Body Irradiation
Children's Oncology Group
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myelodysplastic Syndrome
12/27
12/27
TransIT, NCT05600426: A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (, BMT CTN 2202)

Recruiting
3
234
US
cyclosporine, Matched Unrelated Donor Hematopoetic Stem Cell Transplant, horse anti-thymocyte globulin (ATG), ATGAM, rabbit anti-thymocyte globulin (ATG), thymoglobulin, Methotrexate, Fludarabine, Cyclophosphamide, low-dose total body irradiation (TBI), Immunosuppressive Therapy (IST)
Boston Children's Hospital, Center for International Blood and Marrow Transplant Research, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), North American Pediatric Aplastic Anemia Consortium, Pediatric Transplantation and Cellular Therapy Consortium, Blood and Marrow Transplant Clinical Trials Network
Severe Aplastic Anemia
12/29
12/29
FORUM, NCT01949129 / 2012-003032-22: Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Recruiting
2/3
1800
Europe, Canada, RoW
VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin
St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group
Acute Lymphoblastic Leukaemia
06/25
04/30
NCT03818334: Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

Recruiting
2/3
50
RoW
Cyclophosphamide, Cytoxan, ATG, Thymoglobulin
Hospital Israelita Albert Einstein
Bone Marrow Transplant Complications, Graft Versus Host Disease, Infection Viral, Engraft Failure, Immunologic Suppression
11/21
11/26
NCT04046549: A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant

Completed
2a
25
US
Belatacept, VIB4920, Thymoglobulin, Methylprednisolone
Viela Bio (acquired by Horizon Therapeutics)
Allografts, Rejection; Transplant, Kidney, Transplant Rejection, Kidney Transplantation
07/22
03/23
ACTRN12619000348156: Autologous Haematopoietic Stem Cell Transplantation for highly active treatment resistant multiple sclerosis.

Recruiting
2
50
 
Alfred Health, Alfred Health
Relapsing Remitting Multiple Sclerosis
 
 
ACTRN12609000173291: A Phase II Study of the Impact of Two Different Schedules of Thymoglobulin on the Incidence of Extensive Chronic Graft Verus Host Disease (GVHD) in Patients Undergoing Unrelated Donor or Mismatched Related Donor Stem Cell Transplantation

Recruiting
2
120
 
The Royal Melbourne Hospital, Genzyme
Chronic Graft versus Host Disease in Haematology Malignancy Patients receiving donor stem cell transplantation
 
 
ACTRN12619000268145: A multi-centre trial of a new immunosuppression regime for pancreatic islet transplant recipients

Recruiting
2
15
 
The University of Sydney, JDRF Australia
Hypoglycaemia Unawareness, Type 1 Diabetes, Islet graft survival
 
 
ACTRN12623000292673: A multi-centre Phase 2 study exploring optimal dosing and scheduling of cyclophosphamide in systemic sclerosis patients undergoing haematopoietic stem cell transplantation.

Recruiting
2
40
 
St Vincent's Hospital, Sydney , St Vincent's Hospital, Sydney
systemic sclerosis
 
 
2008-004884-20: Protocole Clinique de Phase II multicentrique non randomisé évaluant l’efficacité, la tolérance et la toxicité d’un conditionnement à intensité réduite combinant Clofarabine (Evoltra) + Busulfan IV (Busilvex) + ATG (Thymoglobuline) (CBT) chez des patients nécessitant une allogreffe pour une MDS, LAM ou une LAL à haut risque

Ongoing
2
30
Europe
Concentrate for solution for infusion, Evoltra, BUSILVEX, Thymoglobuline
CHU de Nantes
LAL Leucémie Aiguë lymphoblastiqueLAM Leucémie Aiguë Myéloblastique MDS Syndrome MyéloDysplasique
 
 
2010-023560-40: Blood stem cell transplantation for patients with relapsiong-remitting multiple sclerosis, in whom standard treatment has failed. Blodstamcellstransplantation för patienter med skovvis förlöpande MS (multipel sklerosis), där standardbehandling givit otillräcklig effekt.

Ongoing
2
120
Europe
, Powder for solution for injection, Powder for infusion*, Solution for injection, Powder and solvent for dispersion for injection, Tysabri, Sendoxan, Thymoglobuline, Neupogen, Solu-Medrol
Uppsala l�ns landsting
Relapsing-remitting multiple sclerosis
 
 
NCT01534767: Sirolimus, Tacrolimus, Anti-Thymocyte Globulin, and Rituximab in Preventing Graft-versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Recruiting
2
19
US
sirolimus, AY 22989, Rapamune, rapamycin, SLM, tacrolimus, FK 506, Prograf, rituximab, IDEC-C2B8, IDEC-C2B8 monoclonal antibody, Mabthera, MOAB IDEC-C2B8, Rituxan, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, laboratory biomarker analysis, flow cytometry
Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Blastic Phase Chronic Myelogenous Leukemia, Chronic Eosinophilic Leukemia, Chronic Myelomonocytic Leukemia, Chronic Neutrophilic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Contiguous Stage II Adult Burkitt Lymphoma, Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Contiguous Stage II Adult Lymphoblastic Lymphoma, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Grade 3 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma, Contiguous Stage II Marginal Zone Lymphoma, Contiguous Stage II Small Lymphocytic Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Essential Thrombocythemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Hepatosplenic T-cell Lymphoma, Intraocular Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Nodal Marginal Zone B-cell Lymphoma, Noncontiguous Stage II Adult Burkitt Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma, Noncontiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous Stage II Grade 1 Follicular Lymphoma, Noncontiguous Stage II Grade 2 Follicular Lymphoma, Noncontiguous Stage II Grade 3 Follicular Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma, Noncontiguous Stage II Marginal Zone Lymphoma, Noncontiguous Stage II Small Lymphocytic Lymphoma, Noncutaneous Extranodal Lymphoma, Peripheral T-cell Lymphoma, Polycythemia Vera, Previously Treated Myelodysplastic Syndromes, Primary Myelofibrosis, Progressive Hairy Cell Leukemia, Initial Treatment, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Hodgkin Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Hairy Cell Leukemia, Refractory Multiple Myeloma, Relapsing Chronic Myelogenous Leukemia, Secondary Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes, Secondary Myelofibrosis, Small Intestine Lymphoma, Splenic Marginal Zone Lymphoma, Stage I Adult Burkitt Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Mixed Cell Lymphoma, Stage I Adult Diffuse Small Cleaved Cell Lymphoma, Stage I Adult Hodgkin Lymphoma, Stage I Adult Immunoblastic Large Cell Lymphoma, Stage I Adult Lymphoblastic Lymphoma, Stage I Adult T-cell Leukemia/Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage I Cutaneous T-cell Non-Hodgkin Lymphoma, Stage I Grade 1 Follicular Lymphoma, Stage I Grade 2 Follicular Lymphoma, Stage I Grade 3 Follicular Lymphoma, Stage I Mantle Cell Lymphoma, Stage I Marginal Zone Lymphoma, Stage I Multiple Myeloma, Stage I Mycosis Fungoides/Sezary Syndrome, Stage I Small Lymphocytic Lymphoma, Stage II Adult Hodgkin Lymphoma, Stage II Adult T-cell Leukemia/Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Cutaneous T-cell Non-Hodgkin Lymphoma, Stage II Multiple Myeloma, Stage II Mycosis Fungoides/Sezary Syndrome, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Multiple Myeloma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Hodgkin Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, T-cell Large Granular Lymphocyte Leukemia, Testicular Lymphoma, Untreated Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Myeloid Leukemia, Untreated Hairy Cell Leukemia, Waldenstrom Macroglobulinemia
06/13
10/13
NCT01414127: Tacrolimus and ATG as GVHD Prophylaxis in Patients Undergoing Related Donor HSCT

Active, not recruiting
2
22
US
tacrolimus, FK 506, Prograf, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, laboratory biomarker analysis, flow cytometry, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell
Barbara Ann Karmanos Cancer Institute
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12), Adult Acute Myeloid Leukemia With t(16;16)(p13;q22), Adult Acute Myeloid Leukemia With t(8;21)(q22;q22), Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Chronic Myelomonocytic Leukemia, Chronic Phase Chronic Myelogenous Leukemia, Contiguous Stage II Adult Burkitt Lymphoma, Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Stage II Adult Diffuse Small Cleaved Cell Lymphoma, Stage II Adult Immunoblastic Large Cell Lymphoma, Contiguous Stage II Adult Lymphoblastic Lymphoma, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Grade 3 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, de Novo Myelodysplastic Syndromes, Hepatosplenic T-cell Lymphoma, Intraocular Lymphoma, Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Nodal Marginal Zone B-cell Lymphoma, Noncontiguous Stage II Adult Burkitt Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma, Noncontiguous Stage II Adult Lymphoblastic Lymphoma, Noncontiguous Stage II Grade 1 Follicular Lymphoma, Noncontiguous Stage II Grade 2 Follicular Lymphoma, Noncontiguous Stage II Grade 3 Follicular Lymphoma, Noncontiguous Stage II Mantle Cell Lymphoma, Peripheral T-cell Lymphoma, Post-transplant Lymphoproliferative Disorder, Previously Treated Myelodysplastic Syndromes, Primary Myelofibrosis, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Diffuse Mixed Cell Lymphoma, Recurrent Adult Diffuse Small Cleaved Cell Lymphoma, Recurrent Adult Grade III Lymphomatoid Granulomatosis, Recurrent Adult Hodgkin Lymphoma, Recurrent Adult Immunoblastic Large Cell Lymphoma, Recurrent Adult Lymphoblastic Lymphoma, Recurrent Adult T-cell Leukemia/Lymphoma, Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Grade 3 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Marginal Zone Lymphoma, Recurrent Mycosis Fungoides/Sezary Syndrome, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Refractory Hairy Cell Leukemia, Small Intestine Lymphoma, Splenic Marginal Zone Lymphoma, Stage I Adult Burkitt Lymphoma, Stage I Adult Diffuse Large Cell Lymphoma, Stage I Adult Diffuse Mixed Cell Lymphoma, Stage I Adult Diffuse Small Cleaved Cell Lymphoma, Stage I Adult Hodgkin Lymphoma, Stage I Adult Immunoblastic Large Cell Lymphoma, Stage I Adult Lymphoblastic Lymphoma, Stage I Adult T-cell Leukemia/Lymphoma, Stage I Chronic Lymphocytic Leukemia, Stage I Cutaneous T-cell Non-Hodgkin Lymphoma, Stage I Grade 1 Follicular Lymphoma, Stage I Grade 2 Follicular Lymphoma, Stage I Grade 3 Follicular Lymphoma, Stage I Mantle Cell Lymphoma, Stage I Marginal Zone Lymphoma, Stage I Multiple Myeloma, Stage I Mycosis Fungoides/Sezary Syndrome, Stage I Small Lymphocytic Lymphoma, Stage II Adult Hodgkin Lymphoma, Stage II Adult T-cell Leukemia/Lymphoma, Stage II Chronic Lymphocytic Leukemia, Stage II Cutaneous T-cell Non-Hodgkin Lymphoma, Stage II Multiple Myeloma, Stage II Mycosis Fungoides/Sezary Syndrome, Stage III Adult Burkitt Lymphoma, Stage III Adult Diffuse Large Cell Lymphoma, Stage III Adult Diffuse Mixed Cell Lymphoma, Stage III Adult Diffuse Small Cleaved Cell Lymphoma, Stage III Adult Hodgkin Lymphoma, Stage III Adult Immunoblastic Large Cell Lymphoma, Stage III Adult Lymphoblastic Lymphoma, Stage III Adult T-cell Leukemia/Lymphoma, Stage III Chronic Lymphocytic Leukemia, Stage III Cutaneous T-cell Non-Hodgkin Lymphoma, Stage III Grade 1 Follicular Lymphoma, Stage III Grade 2 Follicular Lymphoma, Stage III Grade 3 Follicular Lymphoma, Stage III Mantle Cell Lymphoma, Stage III Marginal Zone Lymphoma, Stage III Multiple Myeloma, Stage III Mycosis Fungoides/Sezary Syndrome, Stage III Small Lymphocytic Lymphoma, Stage IV Adult Burkitt Lymphoma, Stage IV Adult Diffuse Large Cell Lymphoma, Stage IV Adult Diffuse Mixed Cell Lymphoma, Stage IV Adult Diffuse Small Cleaved Cell Lymphoma, Stage IV Adult Hodgkin Lymphoma, Stage IV Adult Immunoblastic Large Cell Lymphoma, Stage IV Adult Lymphoblastic Lymphoma, Stage IV Adult T-cell Leukemia/Lymphoma, Stage IV Chronic Lymphocytic Leukemia, Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma, Stage IV Grade 1 Follicular Lymphoma, Stage IV Grade 2 Follicular Lymphoma, Stage IV Grade 3 Follicular Lymphoma, Stage IV Mantle Cell Lymphoma, Stage IV Marginal Zone Lymphoma, Stage IV Mycosis Fungoides/Sezary Syndrome, Stage IV Small Lymphocytic Lymphoma, T-cell Large Granular Lymphocyte Leukemia, Testicular Lymphoma, Waldenstrom Macroglobulinemia
10/13
10/13
2007-001413-42: Study of Fludarabine based conditioning for Allogeneic Stem cell Transplantation for Myelofibrosis

Ongoing
2
20
Europe
FLUDARA, ALKERAN*1FL 50MG/10ML+FL 10ML, THYMOGLOBULINE*1F 25MG+1F 5ML, FLUDARA, ALKERAN*1FL 50MG/10ML+FL 10ML, THYMOGLOBULINE*1F 25MG+1F 5ML
AZIENDA OSPEDALIERA \"OSPEDALI RIUNITI DI BERGAMO\" (A.O. DI RILIEVO NAZIONALE)
MYELOFIBROSIS
 
 
2009-012673-35: Etude pharmacocinétique et pharmacodynamique comparant deux posologies différentes de la Thymoglobuline® en transplantation rénale.

Ongoing
2
20
Europe
THYMOGLOBULINE® 5 mg/ml, THYMOGLOBULINE® 5 mg/ml
CHRU de TOURS
Renal transplantation
 
 
2012-005538-12: A Randomised Trial of the FLAMSA-BU Conditioning Regimen in Patients with Acute Myeloid Leukaemia and Myelodysplasia Undergoing Allogeneic Stem Cell Transplantation

Ongoing
2
170
Europe
Alemtuzumab, Fludarabine, Melphalan, Busilvex, Cytarabine, Amsacrine, Thymoglobulin, Alemtuzumab, Fludarabine, Melphalan, Busulphan, Cytarabine, Amsacrine, Anti-thymocyte Globulin (Rabbit), Campath, Busilvex, Thymoglobulin, Campath, Busilvex, Thymoglobulin
University of Birmingham, Leukaemia and Lymphoma Research, Pierre Fabre
Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS)
 
 
2014-004849-26: Parachute trial: research on individualized dosing regimen of Thymoglobuline Parachute onderzoek: wetenschappelijk onderzoek naar een geïndividualiseerde dosering van het medicijn Thymoglobuline

Ongoing
2
53
Europe
Thymoglobuline, Thymoglobuline, Thymoglobuline
UMC Utrecht, Sanofi-Aventis
Leukemia and immunedeficiency syndromes Leukemie en immuundeficientie syndromen
 
 
2020-000419-56: A 12-Month Clinical Research Study to evaluate a new investigational medication (siplizumab) compared to another medication (anti-thymocyte globulin) for the prevention of rejection in patients who have received a kidney transplant.

Not yet recruiting
2
40
Europe
siplizumab, TCD601, Concentrate for solution for infusion, Powder for solution for infusion, Thymoglobuline
ITB-MED AB, ITB-MED AB
renal transplantation, kidney transplantation, Body processes [G] - Immune system processes [G12]
 
 
NCT06365437: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Recruiting
2
40
Europe
TCD601, Siplizumab, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
08/25
08/25
NCT03412409: RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT

Recruiting
2
50
RoW
Cytarabine, Busulfan, Cyclophosphamide, Fludarabine, Semustine, Antithymocyte globulin
Peking University People's Hospital
Acute Leukemia, Myelodysplastic Syndromes
09/25
09/25
NCT02464878: Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant

Completed
2
2
US
Alpha 1-Antitrypsin, Glassia, Islet Transplantation, Thymoglobulin, Antithymocyte Globulin, Basiliximab, Etanercept, Enbrel
Massachusetts General Hospital, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Iowa
Kidney Transplant, Type 1 Diabetes
11/22
12/22
TRANSFORM, NCT02757885: Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

Completed
2
10
US
Bone Marrow Transplant (BMT), Hydroxyurea, Thiotepa, Fludarabine monophosphate, Cyclophosphamide, Rabbit Anti-thymocyte Globulin, Total Body Irradiation
Emory University
Sickle Cell Disease
12/21
12/21
NCT04328727: Combination of Eltrombopag With Immunosuppressive Therapy in East-Asian Patients With Severe Aplastic Anemia

Active, not recruiting
2
36
Japan, RoW
eltrombopag, ETB115, rabbit anti-thymocyte globulin (r-ATG), r-ATG, cyclosporine A (CsA), CsA
Novartis Pharmaceuticals
Severe Aplastic Anemia (SAA)
06/22
12/24
NCT05214066: Efficacy and Safety Study of 4-Day ATG Regimen for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT

Recruiting
2
60
RoW
Rabbit ATG, Thymoglobuline
Chinese PLA General Hospital
aGVHD, cGVHD
08/22
08/22
NCT02441803: Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT) Initial Salvage Therapy for Induction Failure Acute Myeloid Leukemia (AML)

Completed
2
11
US
Busulfan, Busulfex, Myleran, Fludarabine, Fludarabine Phosphate, Fludara, Clofarabine, Clofarex, Clolar, Total Body Irradiation (TBI), TBI, XRT, Thymoglobulin, ATG (Rabbit), Rabbit Antithymocyte Globulin, Rabbit Antilymphocyte Globulin, Rabbit ATG, rATG, Stem Cell Infusion, Cyclophosphamide, Cytoxan, Neosar, Tacrolimus, Prograf, Mycophenolate mofetil, MMF, CellCept, Decitabine, Dacogen, Cytarabine, Ara-C, Cytosar, DepoCyt, Cytosine Arabinosine Hydrochloride, Idarubicin, Idamycin
M.D. Anderson Cancer Center
Leukemia
09/20
09/21
NCT04903054: Selective CD28 Blockade in Renal Transplant Recipients

Withdrawn
2
54
US
Lulizumab, BMS-931699, anti-CD28 domain antibody (anti-CD28 dAb), Tacrolimus, Prograf®, Thymoglobulin®, antithymocyte globulin, Methylprednisolone, corticosteroid, Mycophenolate Mofetil, MMF, CellCept®, Prednisone
National Institute of Allergy and Infectious Diseases (NIAID), Bristol-Myers Squibb, PPD
Kidney Transplantation, Renal Transplant Recipients
09/22
09/22
NCT04395222: Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation

Active, not recruiting
2
21
US
Tocilizumab, Actemra, Fludarabine, Fludara, Melphalan, Alkeran, Anti-thymocyte globulin (rabbit), Thymoglobulin, Total Body Irradiation
Weill Medical College of Cornell University
Hematologic Malignancy, Bone Marrow Transplant
09/22
05/27
NCT02582775: MT2015-20: Biochemical Correction of Severe EB by Allo HSCT and Serial Donor MSCs

Completed
2
17
US
Thymoglobulin, ATG, anti-thymocyte globulin, Cyclophosphamide, Cytoxan, Fludarabine, fludarabine phosphate, Fludara, Total Body Irradiation, TBI, Bone marrow infusion, HCT, Tacrolimus, Prograf, Mycophenolate Mofetil, MMF, Donor mesenchymal stem cell infusions, Busulfan
Masonic Cancer Center, University of Minnesota
Epidermolysis Bullosa
11/22
07/23
NCT03412266: RIC Regimen for Low- and Intermediate-risk MDS Receiving Haplo-HSCT

Recruiting
2
50
RoW
Cytarabine, busulfan, Cyclophosphamide, Fludarabine, Semustine, antithymocyte globulin
Peking University People's Hospital
Myelodysplastic Syndromes
03/23
03/23
NCT01811368: Zevalin Before Stem Cell Transplant in Treating Patients With Non-Hodgkin Lymphoma

Active, not recruiting
2
20
US
rituximab, IDEC-C2B8, Mabthera, Rituxan, ibritumomab tiuxetan, Zevalin, anti-thymocyte globulin, ATG, ATGAM, lymphocyte immune globulin, Thymoglobulin, total nodal irradiation, TLI, total lymphoid irradiation, peripheral blood stem cell transplantation, PBPC transplantation, PBSC transplantation, peripheral blood progenitor cell transplantation, transplantation, peripheral blood stem cell, allogeneic hematopoietic stem cell transplantation, cyclosporine, cyclosporin, cyclosporin A, CYSP, Sandimmune, mycophenolate mofetil, Cellcept, MMF
Joseph Tuscano, Spectrum Pharmaceuticals, Inc
Refractory Non Hodgkin Lymphoma, Relapsed Non Hodgkin Lymphoma
04/23
12/23
STRIDE2, NCT02766465: Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)

Completed
2
138
US
Busulfan, Busulfex, Fludarabine, Fludara, r-ATG, Rabbit antithymocyte globulin, Hematopoietic Cell Transplant, Bone Marrow Transplant; BMT; HCT, Tacrolimus, Prograf®, Methotrexate, MTX, Standard of Care, Alemtuzumab, Lemtrada, Total Body Irradiation (TBI), Sirolimus, Rapamune, Melphalan, Alkeran, G-CSF, Granulocyte colony-stimulating factor
Medical College of Wisconsin, National Heart, Lung, and Blood Institute (NHLBI), Blood and Marrow Transplant Clinical Trials Network, Dana-Farber Cancer Institute, National Marrow Donor Program, Emory University
Sickle Cell Disease
05/23
05/23
NCT01810588: Targeting the IPA and Matching for the Non-Inherited Maternal Antigen for Haplo-Cord Transplantation

Active, not recruiting
2
273
US
CliniMACS® CD34 Reagent System, Fludarabine, Fludara, Fludarabine phosphate, Melphalan, anti-thymocyte globulin (rabbit), rATG, Rabbit ATG, Rituximab, Rituxan, Total Body Irradiation, TBI, Mycophenolate Mofetil, Cellcept, MMF, Tacrolimus, Prograf
Weill Medical College of Cornell University
Hematologic Malignancies
08/23
04/28
NCI-2022-02150, NCT05293509: Pharmacologic Pretransplant Immunosuppression (PTIS) + Reduced Toxicity Conditioning (RTC) Allogeneic Stem Cell Transplantation in Inherited Hematologic Disorders

Withdrawn
2
24
US
Fludarabine, Fludara™, Dexamethasone, Cyclophosphamide, Cytoxan™, Bortezomib, Velcade®, Rituximab, Rituxan®, Busulfan, Busulfex™, Cyclophosphamide (Cy), Tacrolimus (or cyclosporine), Mycophenolate mofetil (MMF), Rabbit ATG
M.D. Anderson Cancer Center
Stem Cell Transplantation
09/23
09/23
NCT06199427: PTCy and and Ruxolitinib for GVHD Prophylaxis After HSCT With Thymoglobulin in Conditioning Regimen in Patients With Inborn Errors of Immunity

Recruiting
2
100
RoW
Cyclophosphamide, Ruxolitinib
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Inborn Errors of Immunity
11/26
12/27
NCT04872595: A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

Active, not recruiting
2
59
US
Personalized rATG (P-rATG), Hyper fractionated total body irradiation, Thiotepa, Cyclophosphamide, GCSF, Busulfan, Melphalan, Fludarabine
Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia (AML), Acute Lymphoid Leukemia (ALL), Myelodysplastic Syndromes (MDS)
04/25
04/25
NCT03121014: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

Recruiting
2
38
US
Fludarabine, Fludara®, Busulfan, Busulfex®, ATG, Thymoglobulin®, Total Marrow Irradiation, Stem Cell Product Infusion, Tacrolimus, FK-506, Prograf®, Methotrexate, Trexall®
University of Illinois at Chicago
Acute Myeloid Leukemia, Myelodysplastic Syndromes
04/24
04/24
CY-MET-RIC, NCT06252870: Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation

Not yet recruiting
2
82
NA
Methotrexate, MTX, Post-Transplant Cyclophosphamide, CY, Fludarabine, Fludarabine Baltimore, Cycophosphamide, Anti-Thymoglobulin, ATG, total body irradiation, TBI, hematopoietic stem cells, HSC, Graft nuclear cells, Donor Lymphocytes Injection, DLI, Clofarabine, Thiotepa, Busulfan, Fludarabine TBF
Nantes University Hospital
Graft Versus Host Disease, Hematologic Malignancy
09/27
05/28
NCT06412497: MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.

Recruiting
2
60
US
Rituximab, Rabbit ATG, Thymoglobulin, Cyclophosphamide, Fludarabine, Total Body Irradiation, TBI, Cell Infusion, Post-Transplant G-CSF, Filgrastim, Tacrolimus, Mycophenolate Mofetil, MMF
Masonic Cancer Center, University of Minnesota
Severe Aplastic Anemia, Acquired Amegakaryocytic Thrombocytopenia, Acquired Pure Red Cell Aplasia, Paroxysmal Nocturnal Hemoglobinuria
05/35
05/36
RAFA, NCT02143830: HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

Recruiting
2
70
US
Busulfan, Myleran, Busulfex IV, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, rabbit ATG, thymoglobulin, G-CSF, Granulocyte colony-stimulating factor, filgrastim, neupogen, Peripheral blood stem cell
Children's Hospital Medical Center, Cincinnati, Memorial Sloan Kettering Cancer Center, Fred Hutchinson Cancer Center
Fanconi Anemia, Severe Marrow Failure, Myelodysplastic Syndrome (MDS), Acute Myelogenous Leukemia (AML)
07/24
07/26
NCT02790515: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

Recruiting
2
52
US
Anti-thymocyte globulin (rabbit), Thymoglobulin®, rabbit ATG, Blinatumomab, Blincyto, Cyclophosphamide, Cytoxan, Fludarabine, Fludara, G-CSF, Filgrastim, Neupogen®, Melphalan, L-phenylalanine mustard, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran, Mesna, Mesnex, Rituximab, Rituxan™, Tacrolimus, FK506, Prograf®, Protopic®, Thiotepa, Thioplex® by Immunex, TESPA, TSPA, HPC,A Infusion, Transplant, CliniMACS, Cell Selection System, Sirolimus, Rapamycin, Rapamune®
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myeloid Sarcoma, Chronic Myeloid Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML), Myelodysplastic Syndrome (MDS), Non-Hodgkin Lymphoma (NHL)
07/24
07/25
NCT03615105: Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors

Terminated
2
9
US
Hyperfractionated total body irradiation, Thiotepa, Cyclophosphamide, Busulfan, Fludarabine, Melphalan, Clofarabine, HPC(A) stem cell allograft, Rituximab, Rabbit antithymocyte globulin
Memorial Sloan Kettering Cancer Center
Acute Lymphoid Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
03/24
03/24
HAP2HCT, NCT03849651: TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Active, not recruiting
2
140
US
Cyclophosphamide, Cytoxan, Fludarabine, Fludara, Thiotepa, Thioplex, Melphalan, Alkeran, G-csf, Neupogen, Filgrastim, Mesna, Mesnex, CliniMACS, CliniMACS Prodigy, ATG (rabbit), Thymoglobulin, Blinatumomab, Blincyto, TCRα/β+, CD19+, CD45RA-depleted DLI
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), NK-Cell Leukemia, Hodgkin Lymphoma, Non Hodgkin Lymphoma (NHL), Juvenile Myelomonocytic Leukemia (JMML), Chronic Myeloid Leukemia (CML)
07/24
07/25
Meld-ATG, NCT04509791 / 2019-003265-17: MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D)

Active, not recruiting
2
114
Europe
Anti-Human Thymocyte Immunoglobulin, Rabbit, ATG
Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus, Type 1
12/24
12/24
STAT, NCT01413100: Scleroderma Treatment With Autologous Transplant () Study

Active, not recruiting
2
21
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Autologous Hematopoietic Stem Cell Transplantation, Autologous Stem Cell Transplantation, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Filgrastim, Filgrastim XM02, G-CSF, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, rG-CSF, Tbo-filgrastim, Tevagrastim, Laboratory Biomarker Analysis, Mycophenolate Mofetil, Cellcept, MMF, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplantation, Plerixafor, AMD 3100, JM-3100, Mozobil, SDZ SID 791, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
Fred Hutchinson Cancer Center, National Cancer Institute (NCI)
Systemic Scleroderma
08/24
08/24
NCT03630211: Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

Recruiting
2
8
US
Cyclophosphamide, Mesna, Rituximab, Rituxan, Alemtuzumab, Campath-1H, Thiotepa, GM-CSF, Neupogen, Filgrastim, Intravenous immunoglobulin, Total Body Irradiation, Anti Thymocyte Globulin, Thymoglobulin
Paul Szabolcs
Systemic Sclerosis, Diffuse Sclerosis Systemic, Interstitial Lung Disease, Pulmonary Hypertension
08/24
08/25
BMT CTN 1507, NCT03263559: Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)

Active, not recruiting
2
80
US
Haploidentical Bone Marrow Transplantation, Hydroxyurea, Hydrea, Droxia, Rabbit-ATG, Thymoglobulin, Thiotepa, Chemo, Fludarabine, Fludara, Cyclophosphamide, Cytoxan®, Total Body Irradiation, TBI, Mesna, Mesnex
Medical College of Wisconsin, National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI), Blood and Marrow Transplant Clinical Trials Network, National Marrow Donor Program
Sickle Cell Disease
09/24
12/24
NCT04202835: ATG Plus PTCy vs ATG for CGVHD Prophylaxis

Recruiting
2
80
Canada, RoW
Cyclophosphamide, Anti-Thymocyte globulin (rabbit), Thymoglobulin
McMaster University, Cell Therapy Transplant Canada, Sanofi, Ozmosis Research Inc.
Acute Leukemia, Myelodysplasia, Chronic Graft-versus-host-disease
10/24
12/24
NCT03292861: The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients

Enrolling by invitation
2
60
US
Thymoglobulin, Mycophenolate Mofetil, Tacrolimus, Sirolimus, Corticosteroids
Cedars-Sinai Medical Center, Genzyme, a Sanofi Company
Heart Transplantation
10/24
10/25
NCT04688021: A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT.

Recruiting
2
46
RoW
Cytarabine, Busulfan, Cyclophosphamide, Me-CCNU, Rabbit antithymocyte globulin, Tocilizumab, Allogeneic HSCT, Cyclosporin A, Mycophenolate Mofetil, MTX
Yi Luo
Leukemia, Graft-versus-host-disease
12/24
12/24
NCT06455319: Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

Not yet recruiting
2
60
US
Anti-thymocyte globulin (ATG), Thymoglobulin, verapamil extended release capsule, Calan, Isoptin, Placebo
University of Florida, University of Colorado, Denver, University of Miami
Type 1 Diabetes
04/28
04/30
NCT04530487: Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults

Recruiting
2
40
US
Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Stem Cell Transplantation, Allogeneic, Cyclosporine, 27-400, Ciclosporin, CsA, Cyclosporin, Cyclosporin A, Cyclosporine Modified, Gengraf, Neoral, OL 27-400, Sandimmune, SangCya, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP-16, VP-16-213, VP16, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, rATG, Thymoglobulin, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Mycophenolate Mofetil, CellCept, MMF, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic, Thiotepa, 1,1'',1''''-Phosphinothioylidynetrisaziridine, Girostan, N,N'', N''''-Triethylenethiophosphoramide, Oncotiotepa, STEPA, Tepadina, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312
M.D. Anderson Cancer Center
Desmoplastic Small Round Cell Tumor, Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Desmoplastic Small Round Cell Tumor, Recurrent Malignant Peripheral Nerve Sheath Tumor, Recurrent Malignant Solid Neoplasm, Recurrent Neuroblastoma, Recurrent Rhabdomyosarcoma, Refractory Desmoplastic Small Round Cell Tumor, Refractory Malignant Peripheral Nerve Sheath Tumor, Refractory Malignant Solid Neoplasm, Refractory Neuroblastoma, Refractory Rhabdomyosarcoma
05/25
05/25
NCT01624805: Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome

Recruiting
2
140
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Cyclosporine, 27-400, Ciclosporin, CsA, Cyclosporin, Cyclosporin A, Gengraf, Neoral, OL 27-400, Sandimmun, Sandimmune, SangCya, Filgrastim, FILGRASTIM, LICENSE HOLDER UNSPECIFIED, G-CSF, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, rG-CSF, Tevagrastim, Methylprednisolone, Adlone, Caberdelta M, DepMedalone, Depo Moderin, Depo-Nisolone, Duralone, Emmetipi, Esametone, Firmacort, Medlone 21, Medrate, Medrol, Medrol Veriderm, Medrone, Mega-Star, Meprolone, Methylprednisolonum, Metilbetasone Solubile, Metrocort, Metypresol, Metysolon, Predni-M-Tablinen, Prednilen, Radilem, Sieropresol, Solpredone, Summicort, Urbason, Veriderm Medrol, Wyacort, Pegfilgrastim, Filgrastim SD-01, filgrastim-SD/01, Fulphila, HSP-130, Jinyouli, Neulasta, Neulastim, Pegfilgrastim Biosimilar HSP-130, SD-01, SD-01 sustained duration G-CSF
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Aplastic Anemia, de Novo Myelodysplastic Syndrome, Myelodysplastic Syndrome, Previously Treated Myelodysplastic Syndrome
06/26
06/26
NCT04558736: Haploidentical HCT for Severe Aplastic Anemia

Active, not recruiting
2
21
US
Anti-Thymocyte Globulin (Rabbit), thymoglobulin, rabbit ATG, Fludarabine, Fludara Flu Dara, Cyclophosphamide, CYTOXAN, Mesna, MESNEX, G-CSF, Neupogen, Filgrastim, Total Lymphoid Irradiation (TLI), TLI, CliniMACS, Cell Selection System, HPC, A Infusion, CD45RA-depleted DLI
St. Jude Children's Research Hospital
Aplastic Anemia, Bone Marrow Failure Syndrome
07/25
07/26
NCT02828592: Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Recruiting
2
20
US
Fludarabine, Cyclophosphamide, Total Body Irradiation, TBI, Rabbit ATG
Northside Hospital, Inc.
Severe Aplastic Anemia
08/25
08/26
NCT03456817: HIgh Dose Thymoglobulin Instead of Cyclosporine With a Low Dose of Thymoglobulin for GVHD Prophylaxis

Recruiting
2
200
Canada
Treatment Arm - high dose ATG, Control Arm - standard of care
AHS Cancer Control Alberta
Graft-versus-host-disease, Relapse
09/25
09/25
NCT04965597: Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)

Recruiting
2
40
US
Treosulfan, Dihydroxybusulfan, Ovastat, Treosulphan, Tresulfon, Trecondi, Fludarabine Phosphate, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl), Beneflur, Fludara, Fludarabine-5'-Monophosphate, SH T 586, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, Emthexat, Emtexate, Farmitrexat, Methotrexate LPF, Methylaminopterin, Methotrexatum, Metotrexato, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, rATG, Thymoglobulin, Antithymocyte globulin rabbit ATG, Imtix, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, PBSCT, Peripheral Blood Progenitor Cell Transplantation, PERIPHERAL BLOOD STEM CELL TRANSPLANT, peripheral stem cell support, Peripheral Stem Cell Transplant, peripheral stem cell transplantation, Allogeneic Bone Marrow Transplantation, Allo BMT, Allogeneic Blood and Marrow Transplantation, Allogeneic BMT, Quality-of-Life Assessment, Quality of Life Assessment, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, Multi-Gated Acquisition Scan, MUGA Scan, Radionuclide Ventriculogram Scan, Radionuclide ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Bone Marrow Biopsy, Bone Marrow Aspiration, Biospecimen Collection, Biological Sample Collection, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Computed Tomography, Computed Axial Tomography, CAT Scan, CT Scan
Fred Hutchinson Cancer Center, Blood and Marrow Transplant Clinical Trials Network, National Cancer Institute (NCI), National Marrow Donor Program, National Heart, Lung, and Blood Institute (NHLBI)
Bone Marrow Failure Syndrome, Congenital Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Hereditary Sideroblastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Shwachman-Diamond Syndrome, Hematologic Neoplasm With Germline GATA2 Mutation, Hematologic Neoplasm With Germline SAMD9 Mutation, Hematologic Neoplasm With Germline SAMD9L Mutation
12/25
12/26
MoTD, NCT04888741 / 2019-002419-24: Methods of T Cell Depletion Trial

Recruiting
2
400
Europe
Thymoglobulin, ATG, Cyclophosphamide, Cyclosporine, Sirolimus, Mycophenolate Mofetil, MMF
University of Birmingham, IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Non Hodgkin Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Chronic Myelogenous Leukemia, Myelofibrosis
01/26
01/26
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation

Completed
2
13
US
TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
10/23
10/23
NCT05736419: A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

Recruiting
2
24
US
Fludarabine, Cyclophosphamide, Tacrolimus, Mycophenolate Mofetil, Rabbit ATG, Dexamethasone, Bortezomib, Rituximab
Memorial Sloan Kettering Cancer Center
Sickle Cell Disease, Thalassemia, Beta, Thalassemia
02/26
02/26
CASPER, NCT06066255: PROPHYLAXIS OF GVH IN ELDERLY PATIENTS RECEIVING HAPLOIDENTICAL ALLOGENIC HEMATOPOIETIC STEM CELL TRASNPLANTATION USE OF A LOW DOSE ANTI-LYMPHOCYTIC SERUM

Not yet recruiting
2
27
NA
Thymoglobulin Injectable Product
Institut Paoli-Calmettes, Sanofi
Hematological Malignancy
03/26
03/26
NCT05579769: A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological Malignancies

Recruiting
2
32
US
Ruxolitinib, (Jakafi®), Mesna, (Mesnex), Anti-thymocyte globulin (ATG), (Thymoglobulin®, rabbit ATG), Cyclosporine, (Gengraf), Cyclophosphamide, (Cytoxan), Fludarabine, (Fludara), Methotrexate, Total Body Irradiation (radiation treatment), TBI, Bone marrow infusion, Busulfan, Busulfex), Thiotepa, Triplex by Immunex, TESPA, TSPA
St. Jude Children's Research Hospital
Hematologic Malignancy, Myeloid Malignancy
04/26
04/27
NCT03219359: Autologous Stem Cell Transplant for Crohn's Disease

Recruiting
2
50
US
Autologous stem cell transplant, Bone Marrow Transplant, Cyclophosphamide, Thymoglobulin, ATG, Methylprednisolone, Vedolizumab
Aaron Etra
Crohn Disease
10/26
10/30
NCT06098326: CyFluATG in Lower Risk MDS

Active, not recruiting
2
30
RoW
cyclophosphamide, fludarabine, and antithymocyte globulin
Asan Medical Center
Myelodysplastic Syndromes
12/26
12/26
NCT03980769: Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders

Recruiting
2
40
US
Thiotepa, 1,1',1"-phosphinothioylidynetrisaziridine, N,N', N''-Triethylenethiophosphoramid, Oncotiotepa, STEPA, Tepadina, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Triethylene thiophosphoramide, Triethylenethiophosphoramide, TSPA, Treosulfan, (S-(R*,R*))-1,2,3,4-butanetetrol, 1,4-dimethanesulfonate, [R-(R*,S*)]-, 299-75-2, 39069, Dihydroxybusulfan, Ovastat, Treosulphan, Tresulfon, Fludarabine Phosphate, 2-F-ara-AMP, 312887, 328002, 75607-67-9, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, Fludarabine-5'-Monophosphate, Rabbit Anti-Thymocyte Globulin, Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT
Fred Hutchinson Cancer Center
Non-Neoplastic Hematologic and Lymphocytic Disorder
07/27
07/27
NCT00716066: Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases

Active, not recruiting
2
53
US
Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Autologous Hematopoietic Stem Cell Transplantation, Autologous Stem Cell Transplantation, Carmustine, BCNU, Becenum, Becenun, BiCNU, Bis(chloroethyl) Nitrosourea, Bis-Chloronitrosourea, Carmubris, Carmustin, Carmustinum, FDA 0345, Gliadel, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Nitrourean, Nitrumon, SK 27702, SRI 1720, WR-139021, 154-93-8, Cytarabine, .beta.-Cytosine arabinoside, 1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-.beta.-D-Arabinofuranosylcytosine, 1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone, 1-Beta-D-arabinofuranosylcytosine, 1.beta.-D-Arabinofuranosylcytosine, 2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-, 2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-, Alexan, Ara-C, ARA-cell, Arabine, Arabinofuranosylcytosine, Arabinosylcytosine, Aracytidine, Aracytin, Aracytine, Beta-Cytosine Arabinoside, CHX-3311, Cytarabinum, Cytarbel, Cytosar, Cytosar-U, Cytosine Arabinoside, Cytosine-.beta.-arabinoside, Cytosine-beta-arabinoside, Erpalfa, Starasid, Tarabine PFS, U 19920, U-19920, Udicil, WR-28453, 147-94-4, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16-213, VP-16, VP-16-213, 33419-42-0, Laboratory Biomarker Analysis, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, 148-82-3, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplantation, Prednisone, .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl, Dacortin, DeCortin, Decortisyl, Decorton, Delta 1-Cortisone, Delta-Dome, Deltacortene, Deltacortisone, Deltadehydrocortisone, Deltasone, Deltison, Deltra, Econosone, Lisacort, Meprosona-F, Metacortandracin, Meticorten, Ofisolona, Orasone, Panafcort, Panasol-S, Paracort, PRED, Predicor, Predicorten, Prednicen-M, Prednicort, Prednidib, Prednilonga, Predniment, Prednisonum, Prednitone, Promifen, Servisone, SK-Prednisone, 53-03-2, Syngeneic Bone Marrow Transplantation
Fred Hutchinson Cancer Center
Autoimmune Disease, Neurologic Autoimmune Disease, Autologous Transplant Autoimmune, Multiple Sclerosis Transplant, MS Stem Cell Transplant, Multiple Sclerosis Stem Cell Transplant, Stiff Person Syndrome, HCT for Neurologic Autoimmune Disorders, CIDP Transplant, Myasthenia Gravis Transplant, Autoimmune Nervous System Disorder, Central Nervous System Vasculitis, Cerebellar Degeneration, Chronic Inflammatory Demyelinating Polyneuropathy, Lambert Eaton Myasthenic Syndrome, Myasthenia Gravis, Neuromyelitis Optica, Opsoclonus Myoclonus Syndrome, Rasmussen Subacute Encephalitis
01/25
01/30
NCT00882895: Tandem Stem Cell Transplantation for Non-Hodgkin's Lymphoma

Active, not recruiting
2
18
US
Stem cell infusion, TLI, Anti-thymocyte globulin, ATG, Atgam, Thymoglobulin, Solumedrol, Medrol, Solu-Medrol, Tacrolimus, FK-506, Prograf, Advagraf, Protopic, Mycophenolate mofetil, MMF, CellCept, Myfortic
Washington University School of Medicine
Lymphoma, Non-Hodgkin
06/28
06/28
TN28, NCT04291703: STOP-T1D Low-Dose (ATG)

Recruiting
2
101
US, RoW
Antithymocyte Globulin, Thymoglobulin, Placebo (for ATG)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1
12/28
12/29
NCT03852407: Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning

Recruiting
2
114
Europe
Thymoglobulin, ATG, Melphalan, alkeran, Fludarabine, Cyclophosphamid, PTCy
University of Liege, Belgian Hematological Society
Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma
11/33
11/38
NCI-2012-02072, NCT01664910: CMC-544 and Allogeneic Transplantation for CD22 Positive-Lymphoid Malignancies

Completed
1/2
27
US
Allogeneic Bone Marrow Transplantation, Allo BMT, Allogeneic BMT, Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Bendamustine Hydrochloride, Bendamustin Hydrochloride, Cytostasan Hydrochloride, Levact, Ribomustin, SyB L-0501, Treanda, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Inotuzumab Ozogamicin, Besponsa, CMC-544, Way 207294, WAY-207294, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, PBSCT, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplant, Peripheral Stem Cell Transplantation, Rituximab, ABP 798, BI 695500, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, MabThera, Monoclonal Antibody IDEC-C2B8, PF-05280586, Rituxan, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, RTXM83, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Hematopoietic and Lymphoid Cell Neoplasm
06/23
06/23
NCT04066114: Treg Modulation With CD28 and IL-6 Receptor Antagonists

Completed
1/2
10
US
lulizumab pegol, BMS-931699, antithymocyte globulin (rabbit), ATG (rabbit), Thymoglobulin®, methylprednisolone, Solu-Medrol ®, tocilizumab, Actemra®, Prednisone, prednisone tablets, Rayos®, everolimus, Zortress®, belatacept, Nulojix®, mycophenolate mofetil, MMF, CellCept®, mycophenolic acid, Myfortic®
National Institute of Allergy and Infectious Diseases (NIAID), Bristol-Myers Squibb, Clinical Trials in Organ Transplantation
Living-Donor Kidney Transplant, Kidney Transplant Recipients
09/23
09/23
NCT04224558: Stem Cell Transplantation in Crohn's Disease

Recruiting
1/2
15
US
Mesna, Mesnex, Cyclophosphamide, Cytoxan, Neosar, Filgrastim, Neupogen, Granix, Apheresis catheter placement, Leukapheresis, Fludarabine, Fludara, Methylprednisolone, solu-medrol, Diphenhydramine, Benadryl, Acetaminophen, Tylenol, anti-thymocyte globulin (rabbit), thymoglobulin, lymphocyte immune globulin, ATGAM, Peripheral Blood Stem Cell Infusion
Cedars-Sinai Medical Center
Crohn Disease
01/25
01/25
ABCD-NK, NCT06158828: Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Recruiting
1/2
48
US
Rabbit Anti thymocyte globulin, rATG, Busulfan, Fludarabine, Thiotepa, Melphalan, Evolema, Alkeran, TCR alpha beta / CD19+ depleted haploidentical hematopoietic progenitor cell graft, TCRab/CD19+ depleted haploidentical HPC graft, memory-like natural killer cells, ML NK cells, IL-2, Plerixafor, Granulocyte Colony-Stimulating Factor, G-CSF, CliniMACS
Washington University School of Medicine, The Leukemia and Lymphoma Society, Rising Tide Foundation, St. Louis Children's Hospital Foundation
AML, Childhood, Aml, Acute Myeloid Leukemia, Pediatric, Acute Myeloid Leukemia
09/28
05/30
NCT01701986: Gemcitabine Hydrochloride, Clofarabine, and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

Completed
1/2
64
US
Allogeneic Bone Marrow Transplantation, Allo BMT, Allogeneic BMT, Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Anti-Thymocyte Globulin, Antithymocyte Globulin, Antithymocyte Serum, ATG, ATGAM, ATS, Thymoglobulin, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Clofarabine, Clofarex, Clolar, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemzar, LY-188011, LY188011, Mycophenolate Mofetil, Cellcept, MMF, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, PBSCT, Peripheral Blood Progenitor Cell Transplantation, Peripheral Stem Cell Support, Peripheral Stem Cell Transplant, Peripheral Stem Cell Transplantation, Pharmacological Study, Rituximab, ABP 798, BI 695500, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, MabThera, Monoclonal Antibody IDEC-C2B8, PF-05280586, Rituxan, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, RTXM83, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Hematopoietic Cell Transplantation Recipient, Refractory B-Cell Non-Hodgkin Lymphoma, Refractory Hodgkin Lymphoma, Refractory T-Cell Non-Hodgkin Lymphoma
06/24
06/24
OneLegacy, NCT03707262: Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor

Recruiting
1/2
15
US
Donor CD34+ and CD3+ cells
Jeffrey Veale, MD, OneLegacy Foundation
Renal Transplant Rejection, Tolerance, Kidney Transplant
02/25
02/25
NCT04784052: Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab

Recruiting
1/2
12
US
JSP191, CliniMACS Prodigy System, Depleted Stem Cell Transplant, Rabbit Anti-Thymoglobulin (rATG), Cyclophosphamide, Cytoxan, Fludarabine, Rituximab
Porteus, Matthew, MD
Fanconi Anemia
04/25
04/28
 

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