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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
IONIS-AGT-LRx / Ionis
ASTRAAS, NCT04714320: A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure	Completed	2	160	Canada, US	IONIS-AGT-LRx, ISIS 757456, Placebo	Ionis Pharmaceuticals, Inc.	Hypertension	09/22	09/22
ASTRAAS-HF, NCT04836182 / 2020-005878-10: A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Participants With Chronic Heart Failure With Reduced Ejection Fraction	Completed	2	72	Europe, US	IONIS-AGT-LRx, ISIS 757456, Placebo	Ionis Pharmaceuticals, Inc.	Chronic Heart Failure With Reduced Ejection Fraction	10/22	01/23