- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date: RESOLUTE ONYX China Single Arm Study (clinicaltrials.gov) - Oct 14, 2021 P=N/A, N=591, Active, not recruiting, Recruiting --> Completed | N=126 --> 81 Trial completion date: Dec 2024 --> Oct 2025
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date: RESOLUTE ONYX China RCT Study (clinicaltrials.gov) - Oct 14, 2021 P=N/A, N=550, Active, not recruiting, Trial completion date: Dec 2024 --> Oct 2025 Trial completion date: Dec 2024 --> Sep 2025
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date: ONYX PAS: RESOLUTE ONYX Post-Approval Study (clinicaltrials.gov) - Oct 11, 2021 P=N/A, N=416, Active, not recruiting, Trial completion date: Dec 2024 --> Sep 2025 Trial completion date: Aug 2023 --> Sep 2022
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic, NN1213 / Novo Nordisk
Trial primary completion date, Surgery: FAME 3: A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease (clinicaltrials.gov) - Sep 21, 2021 P4, N=1500, Active, not recruiting, The absence of a difference in 2-year mortality between BP-EES, DP-EES, and DP-ZES suggests that stent choice decisions could be made based on other factors, including durability, availability, and cost. Trial primary completion date: Dec 2020 --> Dec 2021
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Preclinical, Journal: Radiopacity of Coronary Stents, an In Vitro Comparative Study. (Pubmed Central) - Aug 26, 2021 This study highlighted significant differences in the radiopacity of coronary stents deployed in a bench test model. The strut thickness and the presence of platinum increased the radiopacity.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Clinical, Review, Journal: Abbreviated Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in High Bleeding Risk Patients: LEADERS-FREE and ONYX ONE. (Pubmed Central) - Aug 20, 2021 The risk of late stent thrombosis appears less with newer-generation stents, and polymer-free drug-coated stents (DCS) may improve clinical efficacy relative to a bare metal stent without the potential long-term hazards associated with a durable polymer. Based on the outcomes of recent clinical trials, risk stratification to identify high bleeding risk patients and appropriate selection of a polymer-free drug-coated or durable-polymer zotarolimus-eluting stent may optimize clinical outcomes in patients who require an abbreviated DAPT regimen.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic, Xience (everolimus-eluting stent) / Abbott
Journal: Comparison of Acute Thrombogenicity and Albumin Adsorption in Three Different Durable Polymer Coronary Drug-Eluting Stents. (Pubmed Central) - Jun 30, 2021 The present OCT study demonstrated that uncovered struts and malapposed struts were less common with bioabsorbable-polymer stents than with durable-polymer stents. These results suggest that thromboresistance and albumin retention vary by polymer type and that these differences might result in different suitability for short-term dual antiplatelet therapy.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Clinical, Journal: Patient-specific modelling of stent overlap: Lumen gain, tissue damage and in-stent restenosis. (Pubmed Central) - May 15, 2021 Abaqus CAE was used to create the models for Resolute Integrity™ drug-eluting stents and tri-folded expansion balloons...Also, non-overlapping stents induced more tissue damage and higher rate of in-stent restenosis than overlapping stents. With respect to long-term clinical outcomes, the study recommended the use of a single stent where possible or multiple stents with minimal overlaps to treat long or angulated lesions.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Journal: Times up to demonstrate a difference is current DES platforms. (Pubmed Central) - May 1, 2021 The Orsiro DES has both a bioresorbable polymer and ultra thin struts and has the potential to improve the safety of DES. In this all comers trial, 3 year outcomes with Orsiro DES were similar to the durable polymer zotarolimus eluting stent.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date, Trial primary completion date: Infinity-Swedeheart Registry Based Randomized Clinical Trial (R-RCT) (clinicaltrials.gov) - Apr 28, 2021 P=N/A, N=2400, Recruiting, In this all comers trial, 3 year outcomes with Orsiro DES were similar to the durable polymer zotarolimus eluting stent. Trial completion date: Sep 2026 --> Dec 2026 | Trial primary completion date: Sep 2022 --> Dec 2022
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date: RESOLUTE ONYX Post-Approval Study (Bifurcation Cohort) (clinicaltrials.gov) - Apr 22, 2021 P=N/A, N=205, Active, not recruiting, Trial completion date: Sep 2026 --> Dec 2026 | Trial primary completion date: Sep 2022 --> Dec 2022 Trial completion date: Jan 2023 --> Apr 2023
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date: ONYX PAS: RESOLUTE ONYX Post-Approval Study (clinicaltrials.gov) - Apr 22, 2021 P=N/A, N=416, Active, not recruiting, Trial completion date: Jan 2023 --> Apr 2023 Trial completion date: Feb 2021 --> Aug 2023
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Clinical, Clinical data, Journal: Comparison of the Major Clinical Outcomes for the Use of Endeavor® and Resolute Integrity® Zotarolimus-Eluting Stents During a Three-Year Follow-up. (Pubmed Central) - Apr 14, 2021 Although I-ZES utilizes a more advanced stent platform, stent design, and polymer system than E-ZES, both the ZESs showed comparable efficacy and safety during the 3-year follow-up period in this single-center, all-comers registry. However, further large-scaled, randomized, well-controlled trials with long-term follow-up are needed to verify these results.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Journal: Staged Repair of Van Praagh Truncus Type A3. (Pubmed Central) - Mar 31, 2021 The pulmonary arteries grew and at four months of age had an acceptable McGoon ratio and Nakata index. The patient then underwent repair which included unifocalization of the branch pulmonary arteries, closure of the ventricular septal defect, and placement of a right ventricle-to-pulmonary artery homograft conduit.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Clinical, Clinical data, Journal: Five-year clinical outcomes for the Resolute zotarolimus-eluting stent in total coronary occlusions. (Pubmed Central) - Mar 25, 2021 The patient then underwent repair which included unifocalization of the branch pulmonary arteries, closure of the ventricular septal defect, and placement of a right ventricle-to-pulmonary artery homograft conduit. In this large population of patients who had R-ZES implanted, five-year clinical outcomes were similar whether or not the stents were implanted in total occlusions.
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
Trial completion date, Trial primary completion date: Comparison of the Biolimus A9-eluting Stent With the Zotarolimus -Eluting Stent in Multi-vessel PCI (clinicaltrials.gov) - Feb 21, 2021 P=N/A, N=932, Active, not recruiting, In conclusion, 1M DAPT followed by prasugrel monotherapy after second-generation drug-eluting stent implantation was not inferior to standard-duration DAPT in terms of intrastent thrombus formation and composite adverse events. Trial completion date: Dec 2020 --> Jun 2021 | Trial primary completion date: Dec 2020 --> Jun 2021
- |||||||||| Resolute ZES (zotarolimus-eluting stent) / Medtronic
[VIRTUAL] COVID-19 TRIGGERED ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_166; Our case aims to express the possible cardiovascular complications of COVID-19 in a patient without any risk factors or history predisposing to cardiac disease, making the presentation even more striking. Current treatment regimens for COVID-19 now includes anticoagulation in order to prevent hypercoagulable sequalae and decrease patient morbidity and mortality.
|