Aklief (trifarotene) / Galderma 
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  • ||||||||||  Aklief (trifarotene) / Galderma
    Review, Journal:  An Overview on the Management of Atrophic Acne Scars: The Role of Trifarotene as an Adjunct. (Pubmed Central) -  Jul 4, 2024   
    Recently, data on trifarotene supports its application in acne scarring. Herein, we provide a succinct review on various treatments for acne scarring and explore how trifarotene and its mechanism of action present an additional topical approach to target atrophic acne scarring.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Journal:  Editor's Highlights (Pubmed Central) -  May 24, 2024   
    We will also delve into the early and aggressive treatment of HS and highlight a link between HS and increased cardiovascular risk. These insights demand a paradigm shift toward a more proactive and holistic management of HS, integrating skin and systemic health considerations to enhance patient outcomes significantly.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Journal:  Trifarotene-based holistic management of acne. (Pubmed Central) -  May 24, 2024   
    These insights demand a paradigm shift toward a more proactive and holistic management of HS, integrating skin and systemic health considerations to enhance patient outcomes significantly. No abstract available
  • ||||||||||  Aklief (trifarotene) / Galderma
    Review, Journal:  A review of the topical management of acne and its associated sequelae in the Asia-Pacific region with a spotlight on trifarotene. (Pubmed Central) -  May 24, 2024   
    The combination of trifarotene and skincare correlated with high patient satisfaction and adherence to the treatment protocol. Along with highlighting the importance of a comprehensive skincare regimen to increase treatment efficacy and adherence, we discuss topical retinoids and retinoid combination options in the acne armamentarium that may be beneficial for sequelae prevention and management, such as adapalene 0.3%?
  • ||||||||||  Winlevi (clascoterone cream 1%) / Cassiopea
    Journal:  Guidelines of care for the management of acne vulgaris. (Pubmed Central) -  Apr 15, 2024   
    No significant differences in efficacy were observed between clascoterone, trifarotene, and tazarotene after 12 These guidelines provide evidence-based recommendations for the management of acne vulgaris.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Retinoids and Risk: A FAERS Database Study of Tretinoin, Adapalene, Trifarotene, and Tazarotene () -  Feb 20, 2024 - Abstract #AAD2024AAD_3304;    
    We found that there are marked differences in both the gender and median age of individuals experiencing adverse drug associated with retinoids. These findings may guide dermatologists in personalizing retinoid therapy to minimize adverse reactions in specific patient populations.
  • ||||||||||  Aklief (trifarotene) / Galderma
    PHASE IV STUDIES SHOW TRIFAROTENE IS EFFICACIOUS AND SUITABLE FOR BROAD RANGE OF PATIENT TYPES (San Diego Convention Center (Upper Level, Sails Pavilion, Poster Center 1)) -  Feb 20, 2024 - Abstract #AAD2024AAD_2522;    
    These findings may guide dermatologists in personalizing retinoid therapy to minimize adverse reactions in specific patient populations. Across a broad range of subject types, trifarotene had good efficacy for improving acne, atrophic scars, and hyperpigmentation, and safety.
  • ||||||||||  Aklief (trifarotene) / Galderma
    TRIFAROTENE SHOWN TO IMPROVE ACNE AND RELATED SEQUELAE (SCARS, PIGMENTATION) (San Diego Convention Center (Upper Level, Sails Pavilion, Poster Center 1)) -  Feb 20, 2024 - Abstract #AAD2024AAD_2519;    
    Management of atrophic acne scarring and hyperpigmentation is an important consideration in acne therapy. Trifarotene achieved rapid improvements in these acne sequelae along with efficacious acne control.
  • ||||||||||  Winlevi (clascoterone cream 1%) / Cassiopea
    Journal:  Drugs for acne. (Pubmed Central) -  Jan 31, 2024   
    Patients described noticeable and meaningful changes in the appearance of PIH and daily life impacts. No abstract available
  • ||||||||||  Aklief (trifarotene) / Galderma
    Efficacy and safety of trifarotene cream 50 (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_2261;    
    P4
    PAHPI total facial score and IGA success, respectively, demonstrated numerically and significant advantages for trifarotene treatment. Trifarotene was well-tolerated with a lower incidence of TEAEs compared with the vehicle group across all skin types throughout the study.
  • ||||||||||  isotretinoin oral / Generic mfg.
    Unilateral breast enlargement  (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_2164;    
    It seemed to be dose dependent and subsided after lowering the dose of the medication or stopping the treatment. The cause of this phenomenon remains unknown, however dysfunction of retinaldehyde dehydrogenases should be considered as a possible explanation.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Trial completion, Trial primary completion date:  Study Comparing Trifarotene Cream, 0.005% To AKLIEF  (clinicaltrials.gov) -  Aug 24, 2023   
    P3,  N=807, Completed, 
    The cause of this phenomenon remains unknown, however dysfunction of retinaldehyde dehydrogenases should be considered as a possible explanation. Active, not recruiting --> Completed | Trial primary completion date: Jun 2023 --> Jan 2023
  • ||||||||||  Aklief (trifarotene) / Galderma
    Trifarotene in Context: Exploring the Acne Burden in Latin America () -  Jul 3, 2023 - Abstract #WCD2023WCD_4606;    
    Active, not recruiting --> Completed | Trial primary completion date: Jun 2023 --> Jan 2023 Trifarotene is effective and well tolerated in people with acne, including in subjects with darker FSTs and LatAm subjects
  • ||||||||||  Aklief (trifarotene) / Galderma
    Trifarotene Effects on Acne-Related Gene Expression () -  Jul 3, 2023 - Abstract #WCD2023WCD_4605;    
    Trifarotene is effective and well tolerated in people with acne, including in subjects with darker FSTs and LatAm subjects This study revealed that trifarotene affects both epidermal and immune components of acne pathogenesis
  • ||||||||||  Aklief (trifarotene) / Galderma
    Phase 3 pooled analysis of safety and efficacy of trifarotene 0.005% cream within adolescent population () -  Jul 3, 2023 - Abstract #WCD2023WCD_4554;    
    Trifarotene monotherapy was associated with good clinical efficacy, safety, and tolerability in adolescent subjects aged 12-17 years with moderate acne. Once-daily application offers convenience for patients, and the low concentration of trifarotene makes it well-suited to use on large body surface areas such as trunk
  • ||||||||||  Aklief (trifarotene) / Galderma
    Enrollment closed:  Study Comparing Trifarotene Cream, 0.005% To AKLIEF  (clinicaltrials.gov) -  Feb 17, 2023   
    P3,  N=807, Active, not recruiting, 
    In this study, Schr Recruiting --> Active, not recruiting
  • ||||||||||  Aklief (trifarotene) / Galderma
    Trial completion, Trial completion date:  LEAP: AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation (clinicaltrials.gov) -  Dec 21, 2022   
    P4,  N=123, Completed, 
    In two head-to-head studies comparing the irritation potential of third- and fourth-generation retinoids, tazarotene 0.045% lotion was significantly less irritating than trifarotene 0.005% cream and numerically less irritating than adapalene 0.3% gel. Active, not recruiting --> Completed | Trial completion date: Apr 2023 --> Dec 2022
  • ||||||||||  Review, Journal:  Biphenyls in Clusiaceae: Isolation, structure diversity, synthesis and bioactivity. (Pubmed Central) -  Dec 20, 2022   
    In this review, we summarize the progress and development in the chemistry and biological activity of biphenyls in Clusiaceae, providing an in-depth discussion of their structural diversity and medicinal potential. We also present a preliminary discussion of the biological effects with or without prenyl groups on the biphenyls.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Journal:  Novel and emerging treatment options for acne vulgaris (Pubmed Central) -  Nov 3, 2022   
    Recently, in addition to other fixed combinations, a fixed combination of adapalene and benzoyl peroxide that targets acne scars has been made available for the first time. The newly available products and other potentially emerging treatment options will increase the armamentarium of acne therapies and potentially reduce its prevalence worldwide.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Enrollment closed, Trial primary completion date:  START: Study of Trifarotene Cream to Assess Risk of a Trophic Acne Scar Formation (clinicaltrials.gov) -  Oct 17, 2022   
    P4,  N=118, Active, not recruiting, 
    The newly available products and other potentially emerging treatment options will increase the armamentarium of acne therapies and potentially reduce its prevalence worldwide. Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2022 --> Mar 2023
  • ||||||||||  Aklief (trifarotene) / Galderma
    Journal:  Trifarotene 0.005% Cream in the Treatment of Facial and Truncal Acne Vulgaris in Patients with Skin of Color: a Case Series. (Pubmed Central) -  Aug 24, 2022   
    Two subjects received 24 weeks of treatment with trifarotene 0.005% cream for moderate AV on the face and trunk, while three subjects received 12 weeks of treatment with trifarotene 0.005% cream in association with 120 mg oral doxycycline with modified polymer coating for severe facial AV. This case series supports the favorable efficacy and safety of facial and truncal AV treatment with trifarotene 0.005% cream, with or without oral doxycycline, in subjects with SoC (phototypes III-VI).
  • ||||||||||  Aklief (trifarotene) / Galderma
    Enrollment closed:  LEAP: AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation (clinicaltrials.gov) -  Jul 29, 2022   
    P4,  N=120, Active, not recruiting, 
    T+D was demonstrated to be safe and efficacious as a treatment option for patients with severe acne. Recruiting --> Active, not recruiting
  • ||||||||||  Aklief (trifarotene) / Galderma
    Journal:  Update: Mechanisms of Topical Retinoids in Acne. (Pubmed Central) -  Jul 12, 2022   
    This review discusses physiologic pathways in skin that are affected by topical retinoids during acne therapy, with a focus on new data from trifarotene, a retinoid which is highly selective for the RAR-γ receptor...2022;21(7):734-740. doi:10.36849/JDD.6890.
  • ||||||||||  Aklief (trifarotene) / Galderma
    Review, Journal:  Trifarotene: A Novel Therapeutic Option for Acne. (Pubmed Central) -  Jun 8, 2022   
    The exclusive topical retinoid that adheres precisely to RAR-gamma, the epidermis' most frequent isoform, is trifarotene, approved in October 2019. The current review evaluates the role of trifarotene in treating acne.