- |||||||||| tetracycline / Generic mfg.
Journal: First Trimester Tetracycline Exposure and Risk of Major Congenital Malformations. (Pubmed Central) - Nov 16, 2024
In this cohort study, first trimester tetracycline exposure was not associated with increased risks of any MCMs. Additional studies are needed to rule out potential risks owing to power limitations for several MCM subgroups and individual malformations.
- |||||||||| Tetralysal (lymecycline) / Galderma
The effect of lymecycline on paediatric cystic fibrosis related diabetes in the modulator era (Exhibition and Poster Area) - Mar 22, 2024 - Abstract #ECFS2024ECFS_515;
This case shows that lymecycline treatment used for acne, can trigger glucose intolerance, but after discontinuation this restores to baseline levels. If lymcycline is commenced, we propose closer monitoring of blood glucose, and alternative treatment if problems of CFRD arise.
- |||||||||| Tetralysal (lymecycline) / Galderma
Journal: Identification of unknown impurities J, RRT 2.2, 2.4, 2.6 and 3.4 in tetralysal (Pubmed Central) - Oct 22, 2023
Based on both monographs Galderma has focused on characterizing most of specified and unspecified impurities to better understand the stability and degradation processes of the formulation. In this manuscript, through both formal synthesis, preparative LCMS and formal degradation studies, we are the first group to confirm the structural identities of 5 unidentified impurities (Impurity J (RRT 1.6), RRT 2.2, 2.4, 2.6 and 3.4), conditions which exacerbate the formation of all 5 impurities and response factors for RRT 2.2, 2.6 and 3.4.
- |||||||||| isotretinoin oral / Generic mfg.
Unilateral breast enlargement (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2164;
It seemed to be dose dependent and subsided after lowering the dose of the medication or stopping the treatment. The cause of this phenomenon remains unknown, however dysfunction of retinaldehyde dehydrogenases should be considered as a possible explanation.
- |||||||||| Tetralysal (lymecycline) / Galderma
Dermatitis and the Dangers of Fashion () - Jul 3, 2023 - Abstract #WCD2023WCD_5123;
She was treated for erythrasma, folliculitis and fungal infections: clobetasone butyrate, fusidic acid & betamethasone valerate, topical erythromycin, emollients, topical terbinafine, oral lymecycline and oral erythromycin...Topical lignocaine was used to alleviate ongoing dysesthesia...The presentation is highly variable, and one must exercise a high index of suspicion. In the context of today
- |||||||||| spironolactone / Generic mfg.
Spironolactone in Adolescent acne vulgaris: a case report () - Jul 3, 2023 - Abstract #WCD2023WCD_4578;
The patient had refused isotretinoin as a treatment option...It is not prescribed to adolescents due to potential side effects; however, current data indicate that most side effects are mild, and that potential associations with hyperkalemia and increased risk of cancer are not sufficiently supported. Hence, spironolactone may be a safe and effective therapy for adolescent acne
- |||||||||| Desonate (desonide gel) / LEO Pharma, Tetralysal (lymecycline) / Galderma
Severe papulopustular rosacea with demodicosis in a 47-year-old Filipino female: A case report () - Jul 3, 2023 - Abstract #WCD2023WCD_4575;
Due to the persistence of centrofacial erythema, papules and pustules, the patient was given prednisone 10mg once a day for 1 month and low dose isotretinoin 10mg once a day for 8 months which resulted in significant decrease in erythema and number of existing lesions...Gentle skin care measures, sunscreen, metronidazole 0.75% cream once a day, and desonide 0.05% cream twice a day for 1 week in cases of acute flares were maintained during the treatment course. KEY MESSAGE: An armamentarium of topical and oral antibiotics, corticosteroids, isotretinoin and non-ablative long-pulsed Nd:YAG 1064 nm laser showed significant improvement in the inflammatory papules, pustules, and centrofacial erythema of rosacea and proves to be beneficial in the maintenance of its long-term remission
- |||||||||| Tetralysal (lymecycline) / Galderma
Journal: Long-Term Use of Silybum marianum fruit extract Contributes to Homeostasis in Acne-Prone Skin-A 12-Month Follow-Up International "Real Life" Cohort Study. (Pubmed Central) - Jan 22, 2023
KEY MESSAGE: An armamentarium of topical and oral antibiotics, corticosteroids, isotretinoin and non-ablative long-pulsed Nd:YAG 1064 nm laser showed significant improvement in the inflammatory papules, pustules, and centrofacial erythema of rosacea and proves to be beneficial in the maintenance of its long-term remission This open, real-life, year-long multicentre study confirms a previous 48-week proof of concept study and qualifies the use of S. marianum fruit extract as a "field-dermo cosmetic" contributing to homeostasis of acne-prone skin in association with acne drugs.
- |||||||||| Rocephine, riffadine, plaquenil, azythromicine, cortancyl, tetralysal, texodil, bactrim, triflucan, feldene, aerius, dhea50, zelitrex, doxy, neurontin... Tout en même temps sur plusieurs mois consécutifs. Bon ça tue lyme, mais pas que (Twitter) - Jan 18, 2023
- |||||||||| Tetralysal (lymecycline) / Galderma
Journal: Completion of the impurity profile of lymecycline: Formal identification of impurities E and F. (Pubmed Central) - Sep 21, 2022
In the current monograph, the structural identity of all impurities except E and F have been formally identified. In this manuscript, through both formal synthesis and preparative chromatography, we are the first group to confirm the structural identity, response factor of Impurity F and conditions which exacerbate the formation of both impurities.
- |||||||||| Tetralysal (lymecycline) / Galderma
Maculopapular cutaneous mastocytosis mimicking seborrhoeic folliculitis () - Jul 15, 2022 - Abstract #BAD2022BAD_756;
This had been widely investigated and managed as follicular eruption with long-term antibiotics in the past (lymecycline and doxycycline)...Urgent skin biopsies were carried out using lidocaine without adrenaline...He was started on fexofenadine 180 mg twice daily with topical mometasone furoate 0·1% cream, which resulted in a slight improvement...Gastrointestinal symptoms are second only to pruritus and seen in 60–80% of patients with systemic disease. This case report highlights the importance of re-evaluation, a high degree of clinical suspicion and clinicopathological correlation in arriving at a diagnosis of a rare skin disease with variable presentations as they are often misdiagnosed and underdiagnosed.
- |||||||||| Hydromol (sodium pyrrolidone carboxylate) / Alliance, Tetralysal (lymecycline) / Galderma
Erosive pustular dermatosis of the scalp in a patient commenced on a bispecific antibody targeting epidermal growth factor receptor and mesenchymal–epithelial transition factor () - Jun 23, 2022 - Abstract #BAD2022BAD_545;
The reaction was mild and responded to mildly potent topical steroids and oral lymecycline...Subsequently, treatment was interrupted and dermatological treatments instigated, including Hydromol ointment and daily dressings to soften and lift the crust, and super-potent topical steroids, which were switched to tacrolimus ointment following an improvement...This case highlights the profound follicular reactions that may occur following targeted treatments in oncology, particularly those agents targeting the EGFR pathway. Collaborative multidisciplinary management is required to unravel the critical roles these mechanisms play in follicular and epithelial homeostasis, while allowing the development of effective skin-management strategies for these growing array of novel therapies.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie, Tetralysal (lymecycline) / Galderma
Enteral nutrition in the management of refractory orofacial Crohn disease (M1) - Jun 23, 2022 - Abstract #BAD2022BAD_544;
The patient started a cinnamon and benzoate-free diet and azathioprine 50 mg twice daily...This spread to involve the contralateral side, despite treatment including topical betamethasone, tacrolimus and mometasone, and systemic medications, including short-courses of prednisolone, fexofenadine, azithromycin, lymecycline and doxycycline...Adalimumab was started in 2020 owing to the refractory orofacial disease and ongoing abdominal pain...This case demonstrates the need for ongoing gastroenterology review in children who present with OFG due to the potential risk of developing intestinal CD. It also highlights the possible role for EEN in the management of orofacial CD.
- |||||||||| Tetralysal (lymecycline) / Galderma
Journal: Pseudotumor cerebri syndrome secondary to lymecycline therapy. (Pubmed Central) - May 19, 2022
Lymecycline significantly reduces bacillary index, recurrence of skin lesions and nerve function impairment through its possible immunomodulatory, antiapoptotic, and neuroprotective effects. No abstract available
- |||||||||| tetracycline / Generic mfg.
Review, Journal: Tetracyclines and photosensitive skin reactions: a narrative review. (Pubmed Central) - Aug 25, 2021
Available data on incidence, severity and clinical relevance of Tetracyclines-related photo-sensitive reactions are scarce, heterogeneous and weak. What we can extrapolate is that some Tetracyclines are more often related to phototoxic skin reactions than others and some of those seem to have a very low risk of phototoxicity.
- |||||||||| Tetralysal (lymecycline) / Galderma
Journal: Lymecycline reverses acquired EGFR-TKI resistance in non-small-cell lung cancer by targeting GRB2. (Pubmed Central) - Jul 8, 2021
Lymecycline inhibited the resistance of the cell cycle to EGFR-TKI and induced apoptosis in NSCLC by inhibiting EGFR phosphorylation and GRB2-mediated AKT/ERK/STAT3 signaling pathways. This provided strong support that Lymecycline when combined with EGFR targeting drugs, enhanced the efficacy of treatments for drug-resistant NSCLC.
- |||||||||| Tetralysal (lymecycline) / Galderma
[VIRTUAL] Lunar landscape of the leg () - Jul 5, 2021 - Abstract #BAD2021BAD_302;
Blastomycosis-like pyoderma with good response to acitretin. Ann Dermatol 2011; 23: 365–8).
- |||||||||| Tetralysal (lymecycline) / Galderma
Clinical, Journal: An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. (Pubmed Central) - Jul 1, 2021
The improvements in AQoL scores in patients treated with zinc sulphate were significantly higher than those in the lymecycline group. Our study suggests that zinc sulphate is a valid alternative therapeutic approach in the treatment of mild to moderate papulopustular acne relative to lymecycline in terms of clinical efficacy, tolerability, and the occurrence of side effects.
- |||||||||| Mizollen (mizolastine) / Sanofi, Mitsubishi Tanabe, Tetralysal (lymecycline) / Galderma
Clinical, Journal: An in-silico evaluation of COVID-19 main protease with clinically approved drugs. (Pubmed Central) - Nov 18, 2020
Moreover, the ADMET analysis also indicated drug-likeness properties. Thus it is suggested that the identified compounds can inhibit Chymotrypsin-like protease (3CL) of SARS-CoV-2.
- |||||||||| Tetralysal (lymecycline) / Galderma Laboratories
Journal: Isotretinoin and lymecycline treatments modify the skin microbiota in acne. (Pubmed Central) - Apr 10, 2019
There were no differences in alpha diversity between control and acne patients in any of the sampled skin areas, but the diversity of the microbiota on the cheek and the back was significantly increased after acne treatments. This study provides insight into the skin microbiota in acne and how it is modulated by systemic acne treatment.
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