- |||||||||| AV-353 / LG Chem, alisertib (MLN8237) / Puma
Pharmacological blockade of AURKA and NOTCH3 oncogenic pathways to inhibit cancer cell plasticity in triple negative breast cancer (Section 34; Poster Board No: 5) - Mar 25, 2025 - Abstract #AACR2025AACR_7767;
This study demonstrates that selective AURKA and NOTCH3 pharmacological blockade results in the inhibition of cancer cell plasticity that is linked to reduction of undruggable nuclear PD-L1 in TNBC cells. Our findings provide the strong preclinical rationale to develop novel clinical trials for patients with advanced TNBC that are refractory to chemotherapy and show limited response to FDA-approved ICIs.
|
