trotabresib (BMS-986378) / BMS 
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6 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
trotabresib (BMS-986378) / BMS
NCT04047303: CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Terminated
1
20
Europe, US
CC-90010
Celgene
Astrocytoma, Glioblastoma
06/24
06/24
NCT04324840: A Study of CC-90010 in Combination With Temozolomide With or Without Radiation Therapy in Participants With Newly Diagnosed Glioblastoma

Terminated
1
184
Europe, US
CC-90010, Temozolomide, Radiotherapy
Celgene
Glioblastoma
07/24
07/24
NCT03220347: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CC-90010 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin's Lymphomas

Active, not recruiting
1
139
Europe, Japan
CC-90010
Celgene
Lymphoma, Non-Hodgkin, Neoplasms
09/24
09/24
NCT06137651: Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Withdrawn
1
34
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Resection, Surgical Resection, Trotabresib, 4-(2-(Cyclopropylmethoxy)-5-methylsulfonylphenyl)-2-methylisoquinolin-1-one, BET Inhibitor CC-90010, CC 90010, CC-90010, CC90010, Vinorelbine, Dihydroxydeoxynorvinkaleukoblastine
Northwestern University, National Cancer Institute (NCI)
Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Neoplasm in the Leptomeninges
03/24
03/24
NCT05678283: A Study of Absorption, Metabolism, and Elimination CC-90010 in Participants With Advanced Solid Tumors

Withdrawn
1
8
Europe
[14C]CC-90010, CC-90010, BMS-986378
Bristol-Myers Squibb
Advanced Solid Tumors
04/24
04/24
NCT03936465: Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitors BMS-986158 and BMS-986378 in Pediatric Cancer

Active, not recruiting
1
41
Canada, US
BMS-986158, BMS-986378, CC-90010
Dana-Farber Cancer Institute, Stand Up To Cancer
Solid Tumor, Childhood, Lymphoma, Brain Tumor, Pediatric
03/24
09/24

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