levocetirizine / Generic mfg. 
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 43 Diseases   16 Trials   16 Trials   362 News 


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  • ||||||||||  prednisolone / Generic mfg., levocetirizine / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, HEOR, Cost-analysis:  Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion (clinicaltrials.gov) -  Jun 19, 2020   
    P4,  N=160, Completed, 
    Not yet recruiting --> Completed | Trial completion date: Sep 2019 --> Mar 2020 | Trial primary completion date: Jul 2019 --> Feb 2020
  • ||||||||||  Rupex (rupatadine) / Incepta, levocetirizine / Generic mfg., desloratadine / Kaken, Incepta, Merck (MSD), Generic mfg.
    Journal:  Route to Prolonged Residence Time at the Histamine H Receptor: Growing from Desloratadine to Rupatadine. (Pubmed Central) -  Jun 18, 2020   
    However, cycloaliphatic substituents directly attached to the piperidine amine (i.e., lacking the spacer) have decreased binding affinity and residence time compared to their methylene-linked structural analogues. Guided by docking studies, steric constraints within the binding pocket are hypothesized to explain the observed differences in affinity and binding kinetics between analogues.
  • ||||||||||  levocetirizine / Generic mfg.
    [VIRTUAL] Mast cell activation syndrome: Evolving diagnosis in children () -  May 19, 2020 - Abstract #EAACI2020EAACI_2169;    
    Treatment and follow-up: Initially prescribed adrenaline autoinjector along with oral cetirizine...Sodium cromoglycate is a rarely used drug which acts as a mast cell stabilizer.Mast cell activation syndrome is increasingly well recognised diagnosis in children. Mast cell mediators are increased during these episodes.
  • ||||||||||  levocetirizine / Generic mfg.
    [VIRTUAL] Allergic contact dermatitis after hair dye application in 14-year old male () -  May 19, 2020 - Abstract #EAACI2020EAACI_2125;    
    On the next day swelling was more visible therefore patient received methylprednisolone every 8 hour for a one day...Reported patient had experienced edema after henna tattoo few years ago, without further medical investigation which explains fast reaction after hair coloring. Reports on ACD show high sensitization rate in children to PPD (even 16% of suspected ACD) therefore application of henna tattoos and hair dyes in such population should be avoided.
  • ||||||||||  tacrolimus / Generic mfg., levocetirizine / Generic mfg.
    [VIRTUAL] Atopic keratoconjuctivitis: Is there any role for sublingual immunotherapy? A case report () -  May 19, 2020 - Abstract #EAACI2020EAACI_1860;    
    Symptoms were not controlled, despite the fact that she was on cyclosporin, prednisolone, olapatadine eye drops and artificial tears.The symptoms started at the age of 6 years, progressively deteriorated and wereworse from spring to summer, but between December and January the patient was asymptomatic...She is still using tacrolimus eye drops, the artificial tears and oral cetirizine...The next step is to consider grass immunotherapy, as symptoms are worse mainly during the summer. This case demonstrates that immunotherapy can play a role in difficult cases of atopic keratoconjuctivitis, when despite the fact that all available treatments have been tried, the patient is still suffering from severe symptoms.
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis, levocetirizine / Generic mfg.
    [VIRTUAL] Allergic reaction to L-thyroxine in a patient with poor response to thyroid hormone supplementation () -  May 19, 2020 - Abstract #EAACI2020EAACI_1598;    
    Finally, the only medication, which enables life-saving substitution of L-thyroxine in this patient seems to be very high dose of diphenylhydramine i.v. 30mg/2ml used daily after every i.v. L-thyroxine dose. Because of complicated situation and polymorbidities, we would like to recommend further examination of the patient by a clinical pharmacologist to exclude abnormal resorption or malabsorption of the drugs.
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis, levocetirizine / Generic mfg.
    [VIRTUAL] Successful treatment of hypocomplementemic urticarial vasculitis with omalizumab: A case report () -  May 19, 2020 - Abstract #EAACI2020EAACI_1527;    
    Levocetirizine was used as antihistamine...Therefore, we decided to increase the frequency of omalizumab 450 mg to every 2 weeks, leading to complete remission of skin lesions and angioedema.Nevertheless, complement levels remained low in the last blood sample (C3 62.8 mg/dL [75-140 mg/dL], C4 6.2 mg/dL [10-34 mg/dL]). The patient has remained asymptomatic with the same therapeutic protocol (omalizumab alone) since 2017.
  • ||||||||||  cetirizine oral / Generic mfg., levocetirizine / Generic mfg., Quzyttir (cetirizine injection) / TerSera Therap
    Journal:  Intravenous Cetirizine (Quzyttir) for Acute Urticaria. (Pubmed Central) -  May 19, 2020   
    The multidisciplinary approach to diagnostics and management of this patient, omalizumab administration allowed us to achieve total disease control and, finally, its remission. No abstract available
  • ||||||||||  clarithromycin / Generic mfg., levocetirizine / Generic mfg.
    Review, Journal:  Interventions for pityriasis rosea. (Pubmed Central) -  Feb 25, 2020   
    Small study sizes, heterogeneity, and bias in blinding and selective reporting limited our conclusions. Further research is needed to investigate different dose regimens of acyclovir and the effect of antivirals on pityriasis rosea.
  • ||||||||||  tranexamic acid oral / Generic mfg., levocetirizine / Generic mfg.
    Enrollment open, Combination therapy:  TACUS: Tranexamic Acid and Spontaneous Chronic Urticaria (clinicaltrials.gov) -  Dec 26, 2019   
    P4,  N=80, Recruiting, 
    The statistical result of the pharmacokinetic study in Sprague-Dawley rats showed a significant change in pharmacokinetic parameters for PRN upon co-administration of the three drugs. Not yet recruiting --> Recruiting
  • ||||||||||  clarithromycin / Generic Mfg.
    TREATMENT OF COUGH/COLD SYMPTOMS WITH SECOND GENERATION ANTIHISTAMINE, LEVOCETIRIZINE WITH INCREASED SAFETY AND RAPID RESPONSE () -  Nov 13, 2019 - Abstract #ACAAI2019ACAAI_984;    
    Prescribed Levocetirizine 5mg QHS, continued on Guaifenesin, and switched to Fluticasone Furoate/Vilanterol 200/25 mcg with rapid relief of Cough and URI symptoms. Discussion This case illustrates that Levocetirizine, a second generation, minimally sedating antihistamine with minimal anticholinergic effects, provided rapid relief of cold/cough symptoms in setting of asthma and hypertension where antibiotics,asthma medications, and Guaifenesin did not.
  • ||||||||||  fexofenadine / Generic mfg., levocetirizine / Generic mfg.
    Phase classification:  LAWAF: Safety Study of Levocetirizine and Fexofenadine (clinicaltrials.gov) -  Oct 4, 2019   
    P4,  N=18, Completed, 
    Discussion This case illustrates that Levocetirizine, a second generation, minimally sedating antihistamine with minimal anticholinergic effects, provided rapid relief of cold/cough symptoms in setting of asthma and hypertension where antibiotics,asthma medications, and Guaifenesin did not. Phase classification: P1 --> P4
  • ||||||||||  Veramyst (fluticasone furoate nasal spray) / GSK
    Journal:  OTC drugs for seasonal allergies. (Pubmed Central) -  Aug 6, 2019   
    Not yet recruiting --> Recruiting No abstract available
  • ||||||||||  tranexamic acid oral / Generic mfg., levocetirizine / Generic mfg.
    Trial initiation date, Combination therapy:  TACUS: Tranexamic Acid and Spontaneous Chronic Urticaria (clinicaltrials.gov) -  May 6, 2019   
    P4,  N=80, Not yet recruiting, 
    This study will be the first to explore the mechanism of action of Chinese herbal medicine on the gut microbiota in AR. Initiation date: Feb 2019 --> Jul 2019
  • ||||||||||  cetirizine oral / generics, levocetirizine / generics
    Journal:  Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H₁ Receptors. (Pubmed Central) -  Apr 3, 2019   
    The mutation of Lys191 to alanine reduced the affinities for levocetirizine and (S)-cetirizine, through a reduction in the entropy-dependent hydrophobic binding forces of levocetirizine and the enthalpy-dependent electrostatic binding forces of (S)-cetirizine. These results suggested that Lys191 differentially regulates the binding enthalpy and entropy of these enantiomers, and that Lys191 negatively regulates the enthalpy-dependent electrostatic binding forces of levocetirizine, contrary to the predictions derived from the ligand-receptor docking simulations.
  • ||||||||||  tranexamic acid oral / Generic mfg., levocetirizine / Generic mfg.
    New P4 trial, Combination therapy:  TACUS: Tranexamic Acid and Spontaneous Chronic Urticaria (clinicaltrials.gov) -  Dec 27, 2018   
    P4,  N=80, Not yet recruiting, 
  • ||||||||||  levocetirizine / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  COURAGE: COrticosteroids in acUte uRticAria in emerGency dEpartment (clinicaltrials.gov) -  Nov 5, 2018   
    P3,  N=240, Not yet recruiting, 
    Further research is needed to validate this hypothesis. Trial completion date: Jun 2021 --> Jan 2021 | Initiation date: Jun 2018 --> Dec 2018 | Trial primary completion date: Jun 2018 --> Nov 2020
  • ||||||||||  Avastin (bevacizumab) / Roche
    Trial completion, Trial primary completion date, Combination therapy:  Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer (clinicaltrials.gov) -  Jul 23, 2016   
    P2,  N=47, Completed, 
    Recruiting --> Completed | N=48 --> 72 Active, not recruiting --> Completed | Trial primary completion date: Jul 2015 --> Oct 2015
  • ||||||||||  Avastin (bevacizumab) / Roche
    Enrollment closed, Enrollment change, Combination therapy:  Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer (clinicaltrials.gov) -  Aug 11, 2015   
    P2,  N=47, Active, not recruiting, 
    Active, not recruiting --> Completed | Trial primary completion date: Jul 2015 --> Oct 2015 Recruiting --> Active, not recruiting | N=36 --> 47