quemliclustat (AB680) / Arcus Biosci, Gilead 
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11 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
quemliclustat (AB680) / Arcus Biosci, Gilead
2021-006291-16: A safety and efficacy study of treatment combinations with and without chemotherapy in adult patients with advanced upper gastrointestinal tract malignancies

Not yet recruiting
2
360
Europe
Domvanalimab, Zimberelimab, Quemliclustat, AB154, AB122, AB680, Solution for infusion, Lyophilisate for solution for infusion
Arcus Biosciences, Inc., Arcus Biosciences, Inc.
Advanced Upper Gastrointestinal Tract Malignancies, Upper Gastrointestinal Tract Cancer, Diseases [C] - Cancer [C04]
 
 
SBRT-AMICO, NCT05915442: Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer

Recruiting
2
23
US
Quemliclustat, AB680, Etrumadenant, AB928, Zimberelimab, AB122, Stereotactic Body Radiation Therapy, SBRT
Catherine Spina, Arcus Biosciences, Inc.
Oligometastatic Prostate Cancer
12/25
12/28
QUIC, NCT06048133: Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers

Recruiting
2
39
US
Gemcitabine, Cisplatin, Zimberelimab, AB122, Quemliclustat, AB680
Nataliya Uboha, Arcus Biosciences, Inc., Gilead Sciences, University of Wisconsin, Madison
Biliary Tract Carcinoma, Cholangiocarcinoma, Bile Duct Cancer
01/25
07/25
EDGE-Gastric, NCT05329766: A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Calendar Jan 2023 - Dec 2024: Data from ARC-21 trial for esophageal adenocarcinoma, gastroesophageal junction and gastric adenocarcinoma
Recruiting
2
360
Europe, Canada, US, RoW
Domvanalimab, Quemliclustat, Zimberelimab, Fluorouracil, Leucovorin, Oxaliplatin
Arcus Biosciences, Inc., Gilead Sciences
Gastrointestinal Tract Malignancies
09/26
06/27
EDGE-Lung, NCT05676931: Study With Immunotherapy Combinations in Participants With Metastatic Non-Small Cell Lung Cancer

Recruiting
2
320
Europe, US, RoW
Domvanalimab, Quemliclustat, Zimberelimab, Docetaxel, Platinum-Based Doublet
Gilead Sciences, Arcus Biosciences, Inc.
Advanced Non-Small Cell Lung Cancer
09/26
09/26
AIRPanc, NCT06048484: Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

Recruiting
2
60
US
Stereotactic body radiotherapy (SBRT), Zimberelimab, AB122, Quemliclustat, AB680, Etrumadenant, AB928, Modified FOLFIRINOX, mFOLFIRINOX
Gulam Manji, Arcus Biosciences, Inc.
Pancreatic Ductal Adenocarcinoma
04/27
04/27
2020-005386-13: A Study Evaluating the Efficacy and Safety of AB928-Based Treatment Combinations in Patients with Metastatic Colorectal Cancer Estudio para evaluar la seguridad y la eficacia de combinaciones terapéuticas de AB928 en pacientes con cáncer colorrectal metastásico

Not yet recruiting
1/2
247
Europe
Etrumadenant, Zimberelimab, AB928, AB122, AB680, Capsule, hard, Concentrate for solution for infusion, Powder for injection
Arcus Biosciences, Inc., Arcus Biosciences Inc, Arcus Biosciences, Inc., ARCUS BIOSCIENCES INC
Metastatic colorectal cancer Cáncer colorrectal metastásico, Metastatic colorectal cancer Cáncer colorrectal metastásico, Diseases [C] - Cancer [C04]
 
 
ARC-9, NCT04660812: An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.

Jul 2023 - Dec 2023: Interim data from ARC-9 trial for metastatic colorectal cancer
Active, not recruiting
1/2
227
Europe, US, RoW
AB680, Etrumadenant, AB928, Zimberelimab, AB122, Bevacizumab, m-FOLFOX-6 regimen, Regorafenib
Arcus Biosciences, Inc., Gilead Sciences
Metastatic Colorectal Cancer
10/24
10/24
ARC-6, NCT04381832: Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer

Hourglass Jul 2022 - Dec 2022 : Interim analysis data from ARC-6 trial in combination with Zimberelimab for castrate-resistant prostate cancer
Active, not recruiting
1/2
173
Canada, US
Etrumadenant, AB928, Zimberelimab, AB122, Quemliclustat, AB680, Enzalutamide, Xtandi, Docetaxel, Taxotere, SG, Trodelvy
Arcus Biosciences, Inc., Gilead Sciences
Prostatic Neoplasms, Castration-Resistant, Androgen-Resistant Prostatic Neoplasms, Castration Resistant Prostatic Neoplasms, Prostatic Cancer, Castration-Resistant
08/24
08/24
NCT05688215: Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

Suspended
1/2
56
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Core Biopsy, BIOPSY, CORE, CNB, Core Needle, Core Needle Biopsy, Needle Biopsy, Fluorouracil, 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-Fu, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Irinotecan, Leucovorin, Folinic acid, Leucovorin Calcium, Adinepar, Calcifolin, Calcium (6S)-Folinate, Calcium Folinate, Calcium Leucovorin, Calfolex, Calinat, Cehafolin, Citofolin, Citrec, Citrovorum Factor, Cromatonbic Folinico, Dalisol, Disintox, Divical, Ecofol, Emovis, Factor, Citrovorum, Flynoken A, Folaren, Folaxin, FOLI-cell, Foliben, Folidan, Folidar, Folinac, Folinate Calcium, folinic acid, Folinic Acid Calcium Salt Pentahydrate, Folinoral, Folinvit, Foliplus, Folix, Imo, Lederfolat, Lederfolin, Leucosar, leucovorin, Rescufolin, Rescuvolin, Tonofolin, Wellcovorin, Oxaliplatin, 1-OHP, Ai Heng, Aiheng, Dacotin, Dacplat, Diaminocyclohexane Oxalatoplatinum, Eloxatin, Eloxatine, JM-83, Oxalatoplatin, Oxalatoplatinum, RP 54780, RP-54780, SR-96669, Quemliclustat, AB 680, AB-680, AB680, CD73 Inhibitor AB680, Zimberelimab, AB 122, AB-122, AB122, Anti-PD-1 Monoclonal Antibody GLS-010, GLS 010, GLS-010, GLS010, WBP-3055
Jonsson Comprehensive Cancer Center, Arcus Biosciences, Inc.
Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma
05/25
05/26
ARC-8, NCT04104672: A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies

Recruiting
1
195
US
AB680, Zimberelimab, AB122, Nab-paclitaxel, Abraxane, Gemcitabine, Gemzar
Arcus Biosciences, Inc.
Advanced Pancreatic Cancer
05/27
05/27

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