- |||||||||| lidocaine topical / Generic mfg.
Retrospective data, Review, Journal: A Literature Review of Factors Associated with Pain from Fine Needle Aspiration Biopsy of Thyroid Nodules. (Pubmed Central) - Jun 9, 2022
Based on >30 controlled clinical trials, we were able to formulate specific and evidence-based recommendations. With increasing use of FNAB as the diagnostic test of choice for assessing thyroid nodules, understanding patient-, procedure-, and analgesic-related factors associated with optimal patient satisfaction is imperative.
- |||||||||| Aphthasol (amlexanox) / Abeona Therap, Esteve, Lamprene (clofazimine) / Novartis
Review, Journal: Recurrent Aphthous Stomatitis: A Comprehensive Review and Recommendations on Therapeutic Options. (Pubmed Central) - Jun 9, 2022
This review will summarize current treatment options for RAS with discussion of prevention, topical measures, natural treatments, systemic therapies, and new potential therapies. Furthermore, this review will provide recommendations on therapeutic options for RAS based on disease severity and patient circumstances.
- |||||||||| lidocaine topical / Generic mfg.
Journal: API-Polymer Interactions in Sepineo P600 based Topical Gel Formulation- Impact on Rheology. (Pubmed Central) - Jun 8, 2022
Lidocaine, a free base drug (pK 7.92) was used as a model drug in all formulations...This study provides valuable insights into rheological behaviors of Sepineo P600 gel and emulgel which can be modified or tuned though the interplay of the API properties and critical formulation parameters such as pH. The tunable rheological properties with simpler manufacturing process make Sepineo P600 gel and emulsion gel very suitable systems for use in semisolid topical formulations.
- |||||||||| Provoked Vestibulodynia: epidemiology, consensus for first-line and second-line treatments (Auditorium) - Jun 3, 2022 - Abstract #ESCRH2022ESCRH_45;
It affects women of all ages with a peak frequency between 20 and 29 years (29%) - the prevalence can be estimated between 10 and 16% of women Consensus for first-line treatment : 1 / Treatment of local hyperalgesia of the vulvar vestibule by bi-daily application in the long term, of local anesthetics (Lidocaine 2 -10%)...Possible combination with the use of a pelvic sensitization treatment: Amitriptyline first-line, then Pregabalin or Gabapentin in case of comorbidities...In the event of failure of the first-line therapeutic protocol, numerous therapeutic options have been described, without being able to confirm their true interest and their precise indication, in the light of the results reported in the literature. Here we report these techniques, which are currently being validated when they are indicated and remain in the domain of centers of expertise: - Vaginal vestibular infiltrations - Other topicals in the treatment of hyperalgesia of the vulvar vestibule - Botulinum toxin injections - TENS devices - CO2 Laser - Therapies and phototherapies by LED lamps - Lipofilling - Infiltration of the impar ganglion - Surgical Vestibulectomy: represents, among the therapeutic options that we have placed in the second line, the technique which benefits from the greatest number of publications in the literature and since the greatest number of years, with a grade B of levels of proof and incontestably a large number of healings As a result, vestibulectomy appears to be widely used by centers of expertise, particularly in North America
- |||||||||| lidocaine topical / Generic mfg.
Enrollment closed: Pain Control for Breast Cancer Patients Receiving Injection of Radioactive Tracer (clinicaltrials.gov) - May 27, 2022
P3, N=167, Active, not recruiting,
Here we report these techniques, which are currently being validated when they are indicated and remain in the domain of centers of expertise: - Vaginal vestibular infiltrations - Other topicals in the treatment of hyperalgesia of the vulvar vestibule - Botulinum toxin injections - TENS devices - CO2 Laser - Therapies and phototherapies by LED lamps - Lipofilling - Infiltration of the impar ganglion - Surgical Vestibulectomy: represents, among the therapeutic options that we have placed in the second line, the technique which benefits from the greatest number of publications in the literature and since the greatest number of years, with a grade B of levels of proof and incontestably a large number of healings As a result, vestibulectomy appears to be widely used by centers of expertise, particularly in North America Recruiting --> Active, not recruiting
- |||||||||| lidocaine topical / Generic mfg., nifedipine immediate release / Generic mfg., nitroglycerin / Generic mfg.
Clinical, Review, Journal: Management and Treatment of External Hemorrhoidal Thrombosis. (Pubmed Central) - May 21, 2022
The management and treatment of EHT is still controversial since no specific guidelines have been published. Both medical and surgical treatment have been proven effective but randomized clinical trials and structured consensus-based guidelines are warranted.
- |||||||||| diltiazem / Generic mfg., metronidazole topical / Generic mfg., lidocaine topical / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Topical Analgesia Post-Haemorrhoidectomy (clinicaltrials.gov) - May 18, 2022
P2/3, N=192, Completed,
We found that nasal packing with lidocaine, epinephrine and TXA was not superior to each other in terms of stopping bleeding time. Recruiting --> Completed | Trial completion date: Sep 2022 --> Feb 2022 | Trial primary completion date: Aug 2022 --> Feb 2022
- |||||||||| lidocaine topical / Generic mfg.
Trial initiation date: Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment (clinicaltrials.gov) - May 17, 2022
P1/2, N=100, Not yet recruiting,
Recruiting --> Completed | Trial completion date: Sep 2022 --> Feb 2022 | Trial primary completion date: Aug 2022 --> Feb 2022 Initiation date: Apr 2022 --> Sep 2022
- |||||||||| YM-254890 / Astellas, Germanin (suramin) / Optimum Therap
Journal: Understanding the Pro-Apoptotic Mechanisms of Bitter Local Anesthetics in Head and Neck Squamous Cell Carcinoma. (Pubmed Central) - May 14, 2022
This was distinct from the structurally-related T2R agonist denatonium, which activates calcium responses inhibited by G inhibitor YM-254890 but not pertussis toxin...Lidocaine or other T2R agonists may aid in eradication of residual cancer cells and extend time between initial surgery and reoccurrence/metastasis as an alternative or complementary therapy. With their promising effects on oral and oropharyngeal SCC cells and accessibility of the oral cavity to topically applied lidocaine gels, further work is warranted to understand the effects of bitter local anesthetics and T2R signaling in HNSCC and normal surrounding epithelia.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Approaches of 112 ambulance service staffers to children with burns: A survey assessment. (Pubmed Central) - May 6, 2022
It is expected that the knowledge of 112 ambulance services who see pediatric burn patients first, perform the first intervention, and provide transfer would be suitable. However, our questionnaire shows that these personnel have insufficient knowledge and need to be trained.
- |||||||||| Fortacin (lidocaine/prilocaine spray) / Regent Pacific Group, Recordati
Clinical, Journal: Real-life use of the eutectic mixture lidocaine/prilocaine spray in men with premature ejaculation. (Pubmed Central) - Apr 27, 2022
Overall, FORTACIN™ emerged to be a safe and effective treatment option in PE patients of various types, with almost one fourth of patients still under treatment after 12 months. Timing and dosing of the drug can deserve to be adjusted according to patient's needs and their sexual ecology.
- |||||||||| lidocaine topical / Generic mfg.
In-Office Pterygium Excision with Cryopreserved Amniotic Membrane (WEWCC) - Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_529;
AM is glued into place, sutured with 8-0 vicryl, and BCL applied. Such technique is feasible for excision of small (<2.0mm), primary pterygium with patients not on blood thinners.
- |||||||||| lidocaine topical / Generic mfg.
Management of Pterygium in-Office with Amniotic Membrane (WEWCC) - Apr 26, 2022 - Abstract #ASCRSASOA2022ASCRS-ASOA_347;
During the excision, topical proparacaine and intralesional 1% lidocaine was injected followed by blunt dissection to sclera...Preliminary outcomes demonstrate excellent aesthetic appearance, improved vision, and no complication. Further long-term follow-up is warranted.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia. (Pubmed Central) - Apr 24, 2022
In the tail flick test, the topical anesthesia efficacy of the Li-HAMNs group was much better than clinical lidocaine cream (EMLA cream, LDC, 1.2 mg) in spite of a relatively lower LDC dose with Li-HAMNs (LDC, 0.5 mg). It is believed that the proposed adhesive microneedle patch could enhance transmucosal delivery of anesthetics and thus open a new chapter in the painless treatment of oral diseases.
- |||||||||| lidocaine topical / Generic mfg.
TIMLEY PLACEMENT OF TOPICAL ANESTHETICS PRIOR TO PORT ACCESS () - Apr 20, 2022 - Abstract #ASPHO2022ASPHO_453;
Topicals can decrease pain and anxiety and improve quality and safety. Family and staff education are needed to optimize timely placement of topical anesthetics.
- |||||||||| lidocaine topical / Generic mfg.
Trial completion date, Trial primary completion date: Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. (clinicaltrials.gov) - Apr 7, 2022
P4, N=304, Not yet recruiting,
The participants underwent SSW using lidocaine and prilocaine topical cream...We introduced the DW Trial completion date: Dec 2022 --> Jun 2023 | Trial primary completion date: Sep 2022 --> Mar 2023
- |||||||||| dutasteride capsule / Generic mfg., lidocaine topical / Generic mfg., minoxidil / Generic mfg.
Clinical, Journal: Frontal edema due to mesotherapy for androgenetic alopecia: a case series. (Pubmed Central) - Apr 5, 2022
To the best of our knowledge, this is the largest case series focused on frontal edema after mesotherapy for AGA and gives clinicians helpful information for when performing this technique. Dermatologists should already consider and be conscious of this possible mesotherapy side effect, as it can be remarkably disruptive to affected patients.
- |||||||||| NN1213 / Novo Nordisk, Rituxan (rituximab) / Roche
Trial completion, Trial completion date, Trial primary completion date: AAV9-GAA_IM: Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease (clinicaltrials.gov) - Apr 5, 2022
P1, N=2, Completed,
Dermatologists should already consider and be conscious of this possible mesotherapy side effect, as it can be remarkably disruptive to affected patients. Active, not recruiting --> Completed | Trial completion date: Dec 2022 --> Aug 2021 | Trial primary completion date: Dec 2021 --> Aug 2021
- |||||||||| gabapentin / Generic mfg., duloxetine / Generic mfg., dextromethorphan / Generic mfg.
Review, Journal: An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy. (Pubmed Central) - Mar 29, 2022
Currently, the FDA approved medications for painful diabetic neuropathies include duloxetine, pregabalin, tapentadol extended release, and capsaicin (for foot PDN only)...The drugs recommended by other regulatory bodies include gabapentin, amitriptyline, dextromethorphan, tramadol, venlafaxine, sodium valproate, and 5 % lidocaine patch...This review gives an insight on the pathways involved in the pathogenesis of PDN and the potential pharmacotherapeutic agents. This will be followed by an overview on the FDA-approved drugs for PDN and commercially available topical analgesic and their effects on painful diabetic neuropathies.
- |||||||||| levofloxacin / Generic mfg., lidocaine topical / Generic mfg.
Journal: Fabricating scalable, personalized wound dressings with customizable drug loadings via 3D printing. (Pubmed Central) - Mar 23, 2022
The influence that each wound dressing design has on the release profile of drugs was also shown by fitting them with drug release kinetic models. This study thus shows the feasibility of utilizing 3D printing to fabricate wound dressings with customizable shapes, drug dosage and drug release rates that can be tuned according to the patient's requirements.
- |||||||||| lidocaine topical / Generic mfg.
Review, Journal: Trigeminal Traumatic Neuroma: a Comprehensive Review of the Literature Based On a Rare Case. (Pubmed Central) - Mar 19, 2022
Topical treatment with lidocaine gel, utilizing a custom-made neurosensory stent, rendered the patient significant and sustained pain relief...Topical medications such as local anesthetics may be a good viable alternative to systemic medications to manage the pain associated with the condition. Early identification of the lesion and the associated pain helps in the succinct management of symptomatic trigeminal traumatic neuromas.
- |||||||||| lidocaine topical / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department (clinicaltrials.gov) - Mar 10, 2022
P4, N=132, Completed,
Lower patient body weights trend toward higher peak lidocaine plasma concentrations and require further investigation. Recruiting --> Completed | Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Sep 2019 --> Dec 2021
- |||||||||| lidocaine topical / Generic mfg.
Retrospective data, Journal: Oral Appliances in the Management of Neuropathic Orofacial Pain: A Retrospective Case Series. (Pubmed Central) - Mar 9, 2022
Oral neurosensory appliances, whether used alone as a physical barrier or as a vehicle to deliver topical anesthetic, represent a safe and effective modality for the management of neuropathic orofacial pain disorders. Additional studies are needed to assess long-term efficacy.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Facial topical cream promotes facemask tolerability and compliance during COVID-19 pandemic. (Pubmed Central) - Mar 8, 2022
Topical creams minimise facemask complications, thereby promoting compliance; topical lidocaine was the most effective in reducing pain and enabling facemask compliance. Topical hydrocortisone, diphenhydramine, and zinc oxide were effective in reducing facial redness, and topical petrolatum produced the best user satisfaction.
- |||||||||| Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Mar 4, 2022
P=N/A, N=48, Active, not recruiting,
Topical hydrocortisone, diphenhydramine, and zinc oxide were effective in reducing facial redness, and topical petrolatum produced the best user satisfaction. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
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