lidocaine topical / Generic mfg. 
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  • ||||||||||  tacrolimus topical / Generic mfg., lidocaine topical / Generic mfg., nitroglycerin / Generic mfg.
    Journal:  Causes and Management of Pruritus Ani. (Pubmed Central) -  Dec 16, 2022   
    After the methylene blue injection, the severity of his symptoms improved, but pruritus still persisted. A methylene blue injection of the same concentration was repeated in 3 months with complete resolution of symptoms.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change, Trial withdrawal:  Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. (clinicaltrials.gov) -  Dec 12, 2022   
    P4,  N=0, Withdrawn, 
    A methylene blue injection of the same concentration was repeated in 3 months with complete resolution of symptoms. N=304 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change, Trial termination:  Sexual Dysfunction in Gynecologic Oncology Patients (clinicaltrials.gov) -  Dec 6, 2022   
    P4,  N=4, Terminated, 
    Both methods are safe in neonates. N=120 --> 4 | Unknown status --> Terminated; Slow accrual
  • ||||||||||  lidocaine topical / Generic mfg., acyclovir / Generic mfg.
    Journal:  Enhanced Topical Co-delivery of Acyclovir and Lidocaine Gel Formulation Across Dermatomed Human Skin. (Pubmed Central) -  Nov 20, 2022   
    The results of the present study are significant because the co-delivery formulation showed a very high increase in the skin permeation across intact and microporated skin (versus respective commercial formulations). The results of this study demonstrate enhanced co-delivery of acyclovir and lidocaine in a topical formulation across skin (intact or barrier compromised) for the treatment of herpes virus infections.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Survey of Pediatric Otolaryngology Frenotomy Practice Patterns. (Pubmed Central) -  Nov 16, 2022   
    Practice patterns also varied with respect to procedural pain control and frenotomy aftercare recommendations. More frenotomy research is needed to establish a standard of care for patients with ankyloglossia.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Analgesic effect of ketorolac added to lidocaine in surgery of traumatic arm injuries: A double-blind, randomized clinical trial. (Pubmed Central) -  Nov 15, 2022   
    In terms of the occurrence of complications related to the use of ketorolac, no complications were observed in any of the groups receiving this drug. In general, by conducting this study, it can be said that the administration of Ketorolac reduces the intensity of postoperative pain in the recovery room and transfer to the inpatient ward, and reduces the amount of morphine received by patients, but the time of the first request for pain relief by the patient It does not significantly delay and does not affect the overall satisfaction of patients with the quality of analgesia during and after the operation and their satisfaction with the anesthesia method they received.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Effect of Age and Viscosity on Duration of Corneal Anesthesia with Topical 2% Lidocaine Administration. (Pubmed Central) -  Nov 15, 2022   
    It is postulated that viscosity-related increase in corneal contact time through reduced drainage plays a critical role in increasing bioavailability of topical anesthetics in our experimental findings, although nonlinear in character. Age is found to be an important mediator of lidocaine-induced corneal anesthesia.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment (clinicaltrials.gov) -  Nov 14, 2022   
    P1/2,  N=100, Recruiting, 
    Age is found to be an important mediator of lidocaine-induced corneal anesthesia. Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date:  Conservative Management of Cutaneous Abscess (clinicaltrials.gov) -  Nov 1, 2022   
    P4,  N=300, Recruiting, 
    Therefore, although further clinical studies are required, EMBLOCK and LGEL can be used because both EMBLOCK and LGEL attenuated the cardiovascular response to mechanical stimulation of the nasal cavity in dogs. Not yet recruiting --> Recruiting | Trial completion date: Aug 2024 --> Nov 2024 | Initiation date: Aug 2022 --> Nov 2022 | Trial primary completion date: Aug 2023 --> Nov 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Lidosomes: Innovative Vesicular Systems Prepared from Lidocaine Surfadrug. (Pubmed Central) -  Oct 28, 2022   
    Lidocaine, when in form of vesicular aggregates, acted as percutaneous permeation enhancer showing better permeation profiles with respect to drug solutions. Moreover, lidosomes created a significant drug depot into the skin from which the drug was available for a prolonged time, a suitable feature for a successful local therapy.
  • ||||||||||  lidocaine topical / Generic mfg., nortriptyline / Generic mfg.
    Clinical, Journal:  Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). (Pubmed Central) -  Oct 28, 2022   
    P2
    This work is supported by the R01 HD096331 awarded to Drs. Nackley, Rapkin, Geller and Carey by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs.This two-by-two factorial RCT will test the efficacy of these medications in VBD subtypes characterized by distinct clinical characteristics and biomarker profiles.We hope that results will provide clinicians with scientific evidence of therapeutic efficacy in distinct VBD subtypes in an effort to direct and optimize treatment approaches.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Conservative treatment with mouthwashes followed by tongue photo biomodulation therapy in Covid-19: a case report. (Pubmed Central) -  Oct 14, 2022   
    The implication of our report is that we promote the judicious use of topical antibiotics, antivirals, antifungals, and steroids for when they are indicated. We propose lidocaine-containing mouth rinses and steroid mouthwash as an initial, symptomatic treatment regimen for 'COVID-19 tongue.' If there is failure of resolution, we recommend photobiomodulation therapy.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Inhibition of Nematocyst Discharge from Pelagia noctiluca (Cnidaria: Scyphozoa)-Prevention Measures against Jellyfish Stings. (Pubmed Central) -  Oct 1, 2022   
    These last results were subsequently correlated with a significant decrease in hemolytic area in the venom assays versus seawater, a neutral solution. The presented data represent a first step in research to develop preventive products for jellyfish stings while at the same time attempting to clarify some uncertainties about the role of various topical solutions in P. noctiluca first-aid protocols.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Printed graphene-based electrochemical sensor with integrated paper microfluidics for rapid lidocaine detection in blood. (Pubmed Central) -  Sep 30, 2022   
    The sensitivity tests of the platform revealed a sensitivity of ∼0.2 μA μM towards lidocaine concentrations in the clinically relevant range (1-100 μM) in both complex matrix fluids of serum and blood with high cross specificity in the presence of the interfering analytes. This proof-of-concept platform could be regarded as the first step toward the development of low-cost and translational POC devices that could help in better pain management and reduce potential side effects or misuse of analgesics.
  • ||||||||||  lidocaine topical / Generic mfg.
    New trial:  USTMS: Uddevalla Sk (clinicaltrials.gov) -  Sep 28, 2022   
    P=N/A,  N=40, Not yet recruiting, 
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Systematic literature review of topical local anaesthesia or analgesia to donor site wounds. (Pubmed Central) -  Sep 23, 2022   
    Topical local anaesthetics (lidocaine or bupivacaine) provide good analgesia, both during and after STSG harvest, at well below toxic serum levels, but there are no good data determining the best local anaesthetic agent to use. There is no evidence morphine performs better than placebo.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Enrollment change, Surgery, Reflex:  Lidocaine Gel 2% and Muscle Traction Pain During Squint Surgery in Pediatrics (clinicaltrials.gov) -  Sep 19, 2022   
    P=N/A,  N=40, Completed, 
    There is no evidence morphine performs better than placebo. Recruiting --> Completed | N=30 --> 40
  • ||||||||||  lidocaine topical / Generic mfg.
    Bibliometric Analysis of Camphor and Menthol Containing Topical Anesthetics () -  Sep 19, 2022 - Abstract #PAINWeek2022PAINWeek_161;    
    However, given the limited number of studies, a definitive, evidence-based recommendation cannot be made in regard to the use of these agents. As such, given the promising results of earlier studies, the authors recommend that more research be done into the clinical application of Tiger Balm and Tiger Balm-like substances as it pertains to pain management, amongst other uses.
  • ||||||||||  lidocaine topical / Generic mfg.
    SUCH A TWEEZE: BRONCHOSCOPE-MEDIATED EXTRACTION OF ASPIRATED FOREIGN BODY (Convention Center Exhibit Hall: Rapid Area 4B) -  Sep 11, 2022 - Abstract #CHEST2022CHEST_4114;    
    Flexible bronchoscopes are used in children for foreign-body extraction using topical lidocaine and general anesthesia is used for removal via forceps or basket... This case highlights the value of using careful flexible bronchoscopy as first line treatment for some large foreign body extraction (e.g., a set of tweezers) in adult patients with open stomas with resulting ease of extraction and prompt resolution of symptomatology.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  IOLANT: Lidocaine And Neuromonitoring in Thyroid Surgery (clinicaltrials.gov) -  Aug 31, 2022   
    P4,  N=231, Recruiting, 
    Harvesting STSG under TA with EMLA is an effective and efficient approach for most Asian patients with less early postoperative donor site pain and fewer adverse effects. Trial completion date: Dec 2021 --> Dec 2024 | Trial primary completion date: Nov 2021 --> Nov 2024
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Lidocaine spray 10% prior to intravenous catheterisation in dogs. (Pubmed Central) -  Aug 24, 2022   
    The VAS scores were normalised and the mean difference between treatments were compared using Wilcox signed-rank test. This study could not find a statistical difference between the treatments (P = 0.1763) and could conclude that no significant difference in response to intravenous catheterisation was found between application of NaCl 0.9% or lidocaine 10% prior to the procedure.