lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Erratum: Eyestalk Ablation to Increase Ovarian Maturation in Mud Crabs. (Pubmed Central) -  May 26, 2023   
    In crustacean eyestalk ablation, chemical anesthetics (i.e., xylocaine, lidocaine) are used at the base of the eyestalk before eyestalk ablation...In crustacean eyestalk ablation, chemical anesthetics (i.e., xylocaine, lidocaine) are used at the base of the eyestalk before eyestalk ablation...Applied Animal Behaviour Science. 247, 105553 (2022).
  • ||||||||||  lidocaine topical / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Local Anesthetics, Clinical Uses, and Toxicity: Recognition and Management. (Pubmed Central) -  May 26, 2023   
    Intravenous lipid emulsion is an important life-saving treatment in severe, life-threatening cases. This narrative review article is designed to cover the clinical uses of LA in children, recognition, and management of untoward effects of the agents, with special emphasis on the LAST.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples. (Pubmed Central) -  May 18, 2023   
    Results & The developed methods were successfully applied for estimating lidocaine content in two commercial products demonstrating 97.4-104.0% for product A and 105.0-110.7% for product B. The LC-MS/MS method displayed successful analysis of lidocaine from human serum samples. The developed methods are recommended for quantifying systemic exposure and residual drug analysis of topical systems.
  • ||||||||||  valacyclovir / Generic mfg., lidocaine topical / Generic mfg., acyclovir / Generic mfg.
    Journal:  What is known about the diagnosis and treatment of herpes labialis? (Pubmed Central) -  May 13, 2023   
    In frequent recurrences, prophylactic Valaciclovir can also be given for a period of many months. Treatment should be started as soon as possible and will slightly shorten the duration of the disease.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change, Trial completion date:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  May 12, 2023   
    P3,  N=116, Active, not recruiting, 
    Treatment should be started as soon as possible and will slightly shorten the duration of the disease. N=194 --> 116 | Trial completion date: Jun 2023 --> Sep 2023
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal, Reflex, Intubation:  Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. (Pubmed Central) -  May 10, 2023   
    N=194 --> 116 | Trial completion date: Jun 2023 --> Sep 2023 In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial primary completion date:  Action of Intra-auricular Topical Lidocaine on Tinnitus (clinicaltrials.gov) -  May 10, 2023   
    P=N/A,  N=33, Active, not recruiting, 
    In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI. Trial primary completion date: Feb 2023 --> Jun 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Comparative Assessment of Pain during Infiltration by a Two-stage Infiltration Technique: A Double-blind Clinical Trial. (Pubmed Central) -  Apr 23, 2023   
    Topical 10% lidocaine spray applied ten minutes before venous cannulation is as effective as EMLA cream applied an hour before cannulation in children in providing dermal analgesia for intravenous cannulation with an added advantage of rapid onset of action in the former group. Topical anesthesia can be used routinely before infiltration, and LA infiltration injections are less painful if administered in two stages.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Effect of Topical Spray Containing Lidocaine on Piglet Behaviour Post castration. (Pubmed Central) -  Mar 27, 2023   
    Behaviors in the castrated piglets differed from those that were handled only, but the piglets that received the spray did not exhibit significantly different behaviors from castrated pigs that received no spray. Play, exploratory behavior, and continuous behavioral observations proved to be sensitive modalities for detecting alterations in behavior postcastration and revealed that topical lidocaine spray does not provide effective pain mitigation for piglets undergoing castration and would thus not be recommended as a method for providing postcastration pain relief in piglets.
  • ||||||||||  lidocaine topical / Generic mfg.
    Methemoglobinemia After Topical Benzocaine in a Patient With Liver Disease (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_8069;    
    MB acts as an extrinsic electron acceptor through G6PD pathway. It can inversely worsen the clinical condition in patients who have G6PD deficiency because it can act as an oxidative stress resulting in hemolysis, thus it needs to be avoided in such scenarios and ascorbic acid should be used instead.
  • ||||||||||  lidocaine topical / Generic mfg.
    From Transdermal Patches to Hypoxia: A Rare Complication of Lidocaine (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) -  Mar 25, 2023 - Abstract #ATS2023ATS_6625;    
    While methemoglobinemia remains a rare cause of hypoxia in patients, this case highlights a dangerous potential side effect of a commonly used medication. Drawing attention to the rare possibility that transdermal amide anesthetics may induce methemoglobinemia and that prompt recognition could be lifesaving.
  • ||||||||||  lidocaine topical / Generic mfg., sirolimus / Generic mfg.
    OR NOT NEEDED! IN-CLINIC UNSEDATED TRANSNASAL ESOPHAGOSCOPY IN HIGH-RISK PEDIATRIC PATIENTS FOR ESOPHAGEAL VARICEAL EVALUATION USING A SINGLE USE PEDIATRIC TRANSNASAL GASTROSCOPE (South Hall A, Poster Hall - McCormick Place) -  Mar 23, 2023 - Abstract #DDW2023DDW_4983;    
    She had known chronic liver disease and was maintained on sirolimus and mycophenolate...Topical 4% lidocaine and phenylephrine were administered prior to procedure...2 Pediatric patients with complex co- morbidities pose a unique high-risk status for anesthesia and when combined without need for sedation, shorter procedural time, a single-use fully functional gastroscope design, TNE appears to be a feasible choice for first line diagnostic endoscopic investigation for EV screening. This technique allows selection of patients for conventional upper endoscopy if therapeutics are required.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Intubation:  Discomfort in Upper Airways Due to intubation-a Randomized Controlled Trial (clinicaltrials.gov) -  Mar 22, 2023   
    P=N/A,  N=120, Recruiting, 
    This technique allows selection of patients for conventional upper endoscopy if therapeutics are required. Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Micro-Pillar Tunnel Stamp for Enhanced Transdermal Delivery of Topical Drug Formulations. (Pubmed Central) -  Mar 20, 2023   
    In vivo analysis showed that, compared to topical administration, MPTS-delivered lidocaine had 5-fold greater permeation and the MPTS-delivered group showed 1.25-fold higher skin residual amount, confirming enhanced delivery...DMNs were fabricated using polycaprolactone (PCL), a slowly dissolving polymer, to maintain their structure inside the skin and prolong the opening duration of the microchannels. This system achieved significantly improved delivery of topically administered external drugs via integration with slowly dissolving DMNs, while offering the possibility of its development as a universal delivery system for various topical pharmaceuticals.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Topical Anesthetic Use in Cosmetic Dermatology. (Pubmed Central) -  Mar 7, 2023   
    We found that the most popular topical anesthetic was benzocaine 20% / lidocaine 6% / tetracaine 4%...J Drugs Dermatol. 2023;22(3): doi:10.36849/JDD.6978.
  • ||||||||||  Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
    Trial completion date, Trial primary completion date:  The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) -  Feb 21, 2023   
    P=N/A,  N=48, Active, not recruiting, 
    In vivo pain perception studies by verbal rating score (VRS) and visual analogue score (VAS) on healthy subjects show a comparable local anesthetic effect between NIO-HAMIN F1-C emulgel and EMLA cream. Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment closed, Enrollment change:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  Feb 21, 2023   
    P3,  N=194, Active, not recruiting, 
    Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 Recruiting --> Active, not recruiting | N=58 --> 194
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  A quantitative evaluation of aerosol generation during awake tracheal intubation. (Pubmed Central) -  Jan 31, 2023   
    Specific risks are associated with lidocaine spray of the larynx, instrumentation of the vocal cords, procedural coughing and deep breaths. Given the proximity of practitioners to patient-generated aerosol, airborne infection control precautions are appropriate when undertaking awake upper airway endoscopy (including awake tracheal intubation, nasendoscopy and bronchoscopy) if respirable pathogens cannot be confidently excluded.
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Cooling Anesthesia for Intravitreal Injections - A Review. (Pubmed Central) -  Jan 21, 2023   
    This article highlights the role of cooling anesthesia in reducing pain, anxiety and discomfort associated with needle penetration at the time of injection. PubMed and MedLine search were related to anesthesia for intravitreal injections, cooling anesthesia, mechanism of cooling anesthesia, COOL-1 trial, COOL-2 trial, results of COOL-1 trial and ultrarapid cooling anesthesia.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial initiation date, Intubation:  Discomfort in Upper Airways Due to intubation-a Randomized Controlled Trial (clinicaltrials.gov) -  Jan 20, 2023   
    P=N/A,  N=120, Not yet recruiting, 
    PubMed and MedLine search were related to anesthesia for intravitreal injections, cooling anesthesia, mechanism of cooling anesthesia, COOL-1 trial, COOL-2 trial, results of COOL-1 trial and ultrarapid cooling anesthesia. Initiation date: Nov 2022 --> Apr 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  USTMS: Uddevalla Sk (clinicaltrials.gov) -  Jan 13, 2023   
    P=N/A,  N=40, Enrolling by invitation, 
    More studies are needed to better assess recurrence rates. Not yet recruiting --> Enrolling by invitation | Trial completion date: Dec 2024 --> Mar 2025 | Trial primary completion date: Dec 2024 --> Mar 2025
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. (Pubmed Central) -  Jan 8, 2023   
    Bupivacaine may be superior to lidocaine with epinephrine and mepivacaine with regard to time to and amount of analgesic consumption. Benzocaine may be superior to placebo in reducing pain for 20 through 30 minutes after application.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  Jan 4, 2023   
    P4,  N=70, Recruiting, 
    Benzocaine may be superior to placebo in reducing pain for 20 through 30 minutes after application. Trial completion date: Oct 2022 --> Apr 2023 | Trial primary completion date: Oct 2022 --> Apr 2023