lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Lidocaine-Liposomes-A Promising Frontier for Transdermal Pain Management. (Pubmed Central) -  Jan 11, 2024   
    (4) L-LP is a new substance with a substantial analgesic effect demonstrated by the cold plate in the first 120 min. Further studies with more animals are needed to determine the maximum doses that can be applied for a better analgesia with minimum side effects.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change, Trial withdrawal:  Conservative Management of Cutaneous Abscess (clinicaltrials.gov) -  Jan 4, 2024   
    P4,  N=0, Withdrawn, 
    Further studies with more animals are needed to determine the maximum doses that can be applied for a better analgesia with minimum side effects. N=300 --> 0 | Suspended --> Withdrawn
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial suspension, Trial primary completion date:  Conservative Management of Cutaneous Abscess (clinicaltrials.gov) -  Dec 20, 2023   
    P4,  N=300, Suspended, 
    The findings in this study suggest that the application of lidocaine tape before infiltration anesthesia can reduce patient distress. Trial completion date: Jan 2026 --> Jan 2027 | Recruiting --> Suspended | Trial primary completion date: Jan 2025 --> Jan 2026
  • ||||||||||  lidocaine topical / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Midazolam and butorphanol combination for sedating beluga whales (Delphinapterus leucas). (Pubmed Central) -  Dec 18, 2023   
    In beluga whales, optimal midazolam and butorphanol doses were lowest in old whales. These findings contribute to knowledge regarding appropriate sedation and prevention of overdose accidents during minor procedures in beluga whales.
  • ||||||||||  lidocaine topical / Generic mfg., ropivacaine / Generic mfg.
    Review, Journal, Surgery:  Retinal artery occlusion after ophthalmic surgery under regional anaesthesia: A narrative review. (Pubmed Central) -  Dec 2, 2023   
    As there were no definite risk factors identified, no specific recommendations could be made to avoid this devastating outcome. We have provided rationales for some general considerations, which may reduce this risk, and propose anaesthetic options for ophthalmic surgery on the fellow eye if required, based both on our literature review and our personal experience.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Mpox Pain Management with Topical Agents: A Case Series. (Pubmed Central) -  Nov 29, 2023   
    No first line agent with proven beneficial effect has been recommended in these patients. We present two patients' painful experiences with Monkeypox and suggest lessons learned.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion. (Pubmed Central) -  Nov 25, 2023   
    An investigational TDS containing 108 mg lidocaine (SP-103, 5.4% lidocaine), a commercially available TDS containing 36 mg lidocaine (ZTlido, 1.8% lidocaine), and a topical pain relief gel (Pennsaid, 2% diclofenac) were tested...The data showed a clear contribution of diffusive transport to lidocaine concentration, with SP-103 5.4% resulting in a significantly higher lidocaine concentration in muscle tissue than commercially available ZTlido (p = 0.008). These results indicate that SP-103 5.4% is highly effective in delivering lidocaine into muscle tissue in areas of localized pain for the treatment of musculoskeletal pain disorders (e.g., lower back pain).
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Lidocaine Administration Using STAR Particles (clinicaltrials.gov) -  Nov 18, 2023   
    P=N/A,  N=22, Completed, 
    These results indicate that SP-103 5.4% is highly effective in delivering lidocaine into muscle tissue in areas of localized pain for the treatment of musculoskeletal pain disorders (e.g., lower back pain). Recruiting --> Completed | Trial completion date: Oct 2023 --> Jun 2023 | Trial primary completion date: Oct 2023 --> Jun 2023
  • ||||||||||  Focal Musculoskeletal Pain in a Child with Hypercalcemia: A Case Report () -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_991;    
    Her left shoulder pain remained refractory to gabapentin, amitriptyline, topical diclofenac, and topical lidocaine for 2 weeks. Hypercalcemia should be considered as a possible etiology of focal musculoskeletal pain in cases of prolonged immobility.
  • ||||||||||  Diabetes, Abdominal Pain, and Weight Loss: A Case Report on Thoracic Radiculopathy () -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_911;    
    He tried ibuprofen, acetaminophen, lidocaine patches, and physical therapy without relief...Symptomatic treatment included trials of gabapentin, pregabalin, duloxetine, and topicals...They suggested a trial of IV methylprednisolone with close monitoring of his blood glucose, which the patient declined... It is important to include diabetic thoracic radiculopathy in the differential for flank/abdominal pain to avoid delayed diagnosis and prolonged patient suffering.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Case Study: Onabotulinum Toxin Injections for the Management of Notalgia Paresthetica () -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_903;    
    Although standard management should be attempted, in refractory cases onabotulinum toxin injections could be promising for improving symptoms and quality of life. Additionally, we encourage similar cases to be published for the eventual development of a protocol including optimal dosing and administration of medication.
  • ||||||||||  Maalox (aluminum hydroxide/simethicone/magnesium hydroxide) / Sanofi
    Clinical, Review, Journal:  Supportive care and antiviral treatments in primary herpetic gingivostomatitis: a systematic review. (Pubmed Central) -  Nov 8, 2023   
    Placebo-induced changes appeared more pronounced in the elder females. Out of the five studies included in this systematic review, only one was able to provide some weak evidence that ACV is an effective treatment, improving healing of oral lesions and reducing duration of symptoms.
  • ||||||||||  lidocaine topical / Generic mfg., levetiracetam / Generic mfg.
    Review, Journal:  A Review on the Management of Peripheral Neuropathic Pain Following Breast Cancer. (Pubmed Central) -  Nov 6, 2023   
    In particular, comparative studies and the inclusion of patients across a range of pain intensities will be essential to developing a treatment algorithm for PMPS. In conclusion, current management for these patients should be tailored to their individual requirements.
  • ||||||||||  lidocaine topical / Generic mfg.
    Retrospective data, Journal:  Management of puncture pain in hospitalized children (Pubmed Central) -  Nov 4, 2023   
    The application of different strategies to manage pain caused by punctures is associated with low pain scores and favorable parental acceptance. The use of standardized management protocols could allow better approaches and experiences for patients and their parents/caregivers at low cost and easy applicability.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Trial completion date:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  Oct 31, 2023   
    P3,  N=116, Completed, 
    Except the plasma drug level indicator, these pharmacodynamics data should also be evaluated in the anesthetic transdermal pharmacokinetics study. Active, not recruiting --> Completed | Trial completion date: Sep 2023 --> Mar 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change, Trial suspension, Surgery:  IOLANT: Lidocaine And Neuromonitoring in Thyroid Surgery (clinicaltrials.gov) -  Oct 27, 2023   
    P4,  N=110, Suspended, 
    Active, not recruiting --> Completed | Trial completion date: Sep 2023 --> Mar 2023 N=231 --> 110 | Recruiting --> Suspended
  • ||||||||||  lidocaine topical / Generic mfg., nifedipine immediate release / Generic mfg.
    Journal:  The Italian Unitary Society of Colon-proctology (SIUCP: Societ (Pubmed Central) -  Oct 14, 2023   
    In the chronic phase of disease, the conservative treatment with topical 0.3% nifedipine plus 1.5% lidocaine or nitrates may represent the first-line therapy, eventually associated with ointments with film-forming, anti-inflammatory and healing properties such as Propionibacterium extract gel. In case of first-line treatment failure, the surgical strategy (internal sphincterotomy or fissurectomy with flap), may be guided by the clinical findings, eventually supported by endoanal ultrasound and anal manometry.
  • ||||||||||  lidocaine topical / Generic mfg.
    Observational data, Journal:  Airway topicalization in pediatric anesthesia: An international cross-sectional study. (Pubmed Central) -  Oct 11, 2023   
    The results support the need for further research and consensus in this area, in order to provide safe provision of lidocaine airway topicalization in children. It is hoped the results of this study can support future collaborative work in this area.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  USTMS: Uddevalla Sk (clinicaltrials.gov) -  Oct 10, 2023   
    P=N/A,  N=40, Enrolling by invitation, 
    It is hoped the results of this study can support future collaborative work in this area. Trial completion date: Sep 2025 --> Dec 2025 | Trial primary completion date: Sep 2025 --> Dec 2025
  • ||||||||||  lidocaine topical / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Chronic Pain Syndromes: Chronic Neuropathic Pain. (Pubmed Central) -  Oct 9, 2023   
    For persistent pain, physicians can consider referring patients to a pain specialist for nerve blocks or other procedural interventions. Opioids may be considered for refractory pain, but their additional benefit has been shown to be modest compared with those of other treatments.
  • ||||||||||  Emla-cream / Akorn, AstraZeneca
    Enrollment open:  LAB: Local Anesthesia Before Bulkamid Injection (clinicaltrials.gov) -  Sep 28, 2023   
    P=N/A,  N=52, Recruiting, 
    Further studies are warranted to optimize the procedure and to highlight its significant medical and socioeconomic benefits. Not yet recruiting --> Recruiting