lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg., tropicamide / Generic mfg.
    Journal, Surgery:  Cataract surgery in children using intracameral mydriatic. (Pubmed Central) -  Jun 21, 2024   
    Fixed-dose premixed intracameral injection is effective in pupil dilatation. It alleviates the need for any topical dilators or additional intraoperative supplementation for pediatric cataract surgery.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Sphenopalatine Ganglion Block and Cold Induced Headaches (clinicaltrials.gov) -  Jun 5, 2024   
    P1,  N=30, Not yet recruiting, 
    In dogs, all three investigated techniques attenuated responses during rostral rhinoscopy in dogs, although INB and IVB were more efficacious when biopsies were taken. Trial completion date: Jul 2024 --> Dec 2024 | Initiation date: Apr 2024 --> Aug 2024 | Trial primary completion date: Jun 2024 --> Nov 2024
  • ||||||||||  lidocaine topical / Generic mfg.
    Level and predictors of anxiety in patients undergoing bronchoscopy (PS-31; Poster board no. 17) -  May 31, 2024 - Abstract #ERS2024ERS_2586;    
    Lidocaine instillation was used for administering topical anesthesia...Prebronchoscopy anxiety assessment can help bronchoscopists to anticipate the anxiety levels of patients. Acconrding to our results,special attention should be given to patients living in urbain areas, smokers patients ans presenting cough.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Topical drug delivery by Sepineo P600 emulgel: Relationship between rheology, physical stability, and formulation performance. (Pubmed Central) -  May 30, 2024   
    However, an interesting finding was that the derived skin/vehicle partition coefficient suggested the ionic interaction between lidocaine and Sepineo polymer reducing the free drug, i.e., thermodynamic activity and hence the flux with increasing Sepineo P600 concentration. Overall, this study has provided us with valuable insights into understanding the relationship between the microstructure (rheology), physical stability and skin drug delivery properties which will help to design and optimize topical emulgel formulations.
  • ||||||||||  Qutenza (capsaicin) / Grunenthal, LTS Lohmann Therapy Systems
    Journal:  Neuropathic pain: Evidence based recommendations. (Pubmed Central) -  May 30, 2024   
    Additionally, tramadol, combination therapies, and psychotherapy as adjuncts are proposed second line; high-concentration capsaicin patches, and botulinum toxin A are proposed specifically for focal peripheral neuropathic pain...To ensure optimal management of neuropathic pain in real-life situations, it is imperative to disseminate these recommendations widely and secure the acceptance of practitioners. By doing so, we can bridge the gap between theory and practice, and enhance the overall care and treatment of individuals suffering from neuropathic pain.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron, Proctofoam (pramoxine) / Viatris
    Review, Journal:  Chronic Pruritus: A Review. (Pubmed Central) -  May 29, 2024   
    Chronic pruritus can adversely affect quality of life and can be categorized into inflammatory, neuropathic, or a combined etiology. First-line therapies are topical steroids for inflammatory causes, such as hydrocortisone (2.5%) or triamcinolone (0.1%); topical neuropathic agents for neuropathic causes, such as menthol or pramoxine; and combinations of these therapies for mixed etiologies of chronic pruritus.
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  A systematic review of procedural modalities in the treatment of notalgia paresthetica. (Pubmed Central) -  May 2, 2024   
    Procedural modalities are critical in the multidisciplinary approach to NP, especially for patients who are refractory to topical and oral treatments. Procedural modalities include a spectrum of options that can be applied based on the disease's symptoms and severity.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment change:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  Apr 29, 2024   
    P3,  N=63, Completed, 
    Procedural modalities include a spectrum of options that can be applied based on the disease's symptoms and severity. N=116 --> 63
  • ||||||||||  Journal:  Diabetic Peripheral Neuropathy: Prevention and Treatment. (Pubmed Central) -  Apr 8, 2024   
    First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, amitriptyline, and pregabalin; however, these medications do not restore sensation to affected extremities...Second-line drug therapy includes nortriptyline, imipramine, venlafaxine, carbamazepine, oxcarbazepine, topical lidocaine, and topical capsaicin...Peripheral transcutaneous electrical nerve stimulation is well tolerated and inexpensive, but benefits are modest. Other treatments, such as acupuncture, alpha-lipoic acid, acetyl-L-carnitine, cannabidiol, and onabotulinumtoxinA need further study in patients with diabetic peripheral neuropathy.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date, Intubation:  Discomfort in Upper Airways Due to intubation-a Randomized Controlled Trial (clinicaltrials.gov) -  Apr 4, 2024   
    P=N/A,  N=120, Recruiting, 
    Chictr.org.cn ID: ChiCTR2100042442. Trial completion date: Jan 2024 --> Jan 2025 | Trial primary completion date: Nov 2023 --> Oct 2024
  • ||||||||||  Qutenza (capsaicin) / Grunenthal, LTS Lohmann Therapy Systems
    Preclinical, Review, Journal:  Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence. (Pubmed Central) -  Apr 4, 2024   
    Some pharmacological treatments can be used for both conditions, and non-pharmacological interventions have emerged as promising complementary approaches. Future research should explore novel molecular pathways to enhance treatment options for these interrelated conditions.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Sustainable Alternatives to Petroleum-Derived Excipients in Pharmaceutical Oil-in-Water Creams. (Pubmed Central) -  Apr 1, 2024   
    Natural or synthetic excipients, derived from vegetable sources, were explored as alternatives to petroleum-based excipients in prototype topical creams, with 1% (w/w) lidocaine...The composition of the oil-in-water creams had influence on physicochemical properties and drug release; however, skin permeation was not impacted. Sustainable natural or synthetic excipients in topical cream formulations were found to be suitable alternatives to petroleum-based excipients with comparable key quality attributes and performance attributes and should be considered during formulation development.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  IOLANT: Lidocaine And Neuromonitoring in Thyroid Surgery (clinicaltrials.gov) -  Mar 21, 2024   
    P4,  N=110, Completed, 
    LTG is a potentially effective product for commercial use for piglet castration and tail docking. Suspended --> Completed | Trial completion date: Dec 2024 --> Dec 2023 | Trial primary completion date: Nov 2024 --> Oct 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    USE OF A STERILE SINGLE-USE ULTRA-SLIM GASTROSCOPE FOR PEDIATRIC UNSEDATED TRANSNASAL ENDOSCOPY (UTNE) (Hall A, Poster Hall - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_5780;    
    Patients tolerated the procedure well similar to other reports. Advantages include, the device is FDA cleared for pediatric gastrointestinal use, the risk of prior contamination and repair is eliminated, and it also provides the opportunity to evaluate other conditions as it allows for gastric (TN-EG) and duodenal biopsies (TN-EGD) given its length.
  • ||||||||||  Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
    Trial completion date, Trial primary completion date:  The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) -  Mar 14, 2024   
    P=N/A,  N=48, Active, not recruiting, 
    Eight procedures reached the second or third portion of the duodenum (Figure 1) and 4 reached the stomach. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  A Model for Medicare Part D Savings for Generic Dermatology Drugs (San Diego Convention Center (Upper Level, Sails Pavilion, Poster Center 1)) -  Feb 20, 2024 - Abstract #AAD2024AAD_2166;    
    Lidocaine, clobetasol propionate, and ketoconazole were the costliest generics for Medicare and were also the drugs with the highest potential savings. Medicare Part D originally included a
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Multicenter, Randomized, Placebo-Controlled Crossover Trial Evaluating Topical Lidocaine for Mechanical Cervical Pain. (Pubmed Central) -  Feb 14, 2024   
    WGO was significantly more effective in the treatment of animal-induced ulcer compared to NS oil or CPC and lidocaine oral gel. The differences favoring lidocaine were small and nonsignificant, but the trend toward superiority of lidocaine suggests more aggressive phenotyping and applying formulations with greater penetrance may provide clinically meaningful benefit.
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Local anaesthesia for pain control in first trimester surgical abortion. (Pubmed Central) -  Feb 13, 2024   
    Due to this inconsistency in evidence regarding the effectiveness of topical anaesthesia, its routine use is presently not supported. This review did not include studies of pain management with conscious sedation but, based on the results of our prior Cochrane review and the 2022 WHO guidelines, we recommend that the option of combination of pain management using conscious sedation plus PCB and non-steroidal anti-inflammatory drugs should be offered where conscious sedation is available as it further decreases pain.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal, Surgery:  Regenerative Peripheral Nerve Interface (RPNI) Surgery for Mitigation of Neuroma and Postamputation Pain. (Pubmed Central) -  Feb 13, 2024   
    Nonsurgical treatments of neuromas include desensitization, chemical or anesthetic injections, biofeedback, transcutaneous electrical nerve stimulation, topical lidocaine, and/or other medications (e.g., antidepressants, anticonvulsants, and opioids)...Another suture should be utilized to start the wrapping of the muscle graft around the nerve using a bite through the muscle, a bite through the epineurium of the proximal end of the nerve, and another bite through the other muscle edge in order to form a cylindrical wrap around the nerve.Wrap the entire muscle graft by taking only bites of muscle graft around the nerve to secure the muscle graft in a cylindrical structure using 2 to 4 more sutures.Avoid locating the RPNI near weight-bearing surfaces of the residual limb when closing. The RPNI should be in the muscular tissue, deep to the subcutaneous tissue and dermis.Do perform intraneural dissection for large-caliber nerves to create several (normally 2 to 4) distinct RPNIs, to avoid too many regenerating axons in a single free muscle graft.