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- | LidoPain (lidocaine) / Immune Pharma
Clinical, Journal: A Randomized Double Blind Trial of Needle-free Injected Lidocaine Versus Topical Anesthesia for Infant Lumbar Puncture. (Pubmed Central) - Apr 7, 2019
In a randomized controlled trial of two modalities for local anesthesia in infant lumbar punctures, J-Tip is not superior to topical anesthetic cream as measured by pain control or physiologic changes. Infant LPs performed with J-Tip were twice as likely to be successful.
- | lidocaine topical / Generic mfg.
New P1/2 trial: Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia (clinicaltrials.gov) - Apr 3, 2019
P1/2, N=60, Recruiting, Sponsor: University of Sao Paulo
- | LidoPain (lidocaine) / Immune Pharma
Clinical, Journal: Is burning mouth syndrome a neuropathic pain condition? (Pubmed Central) - Apr 3, 2019
The central type does not respond to local treatments and associates often with psychiatric comorbidity (depression or anxiety), whereas the peripheral type responds to peripheral lidocaine blocks and topical clonazepam. Burning mouth syndrome is most prevalent in postmenopausal women, having led to a hypothesis that BMS is triggered as a consequence of nervous system damage caused by neurotoxic factors affecting especially vulnerable small fibers and basal ganglia in a setting of decrease in neuroprotective gonadal hormones and increase in stress hormone levels, typical for menopause.
- | Priligy (dapoxetine) / Allergan, LidoPain (lidocaine) / Immune Pharma
Review, Journal: Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review. (Pubmed Central) - Apr 3, 2019
Porst H, Burri A. Novel treatment for premature ejaculation in the light of currently used therapies: A review. Sex Med Rev 2018; XX:XXX-XXX.
- | LidoPain (lidocaine) / Immune Pharma
Clinical, Journal, Adverse events: Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children. (Pubmed Central) - Apr 3, 2019
Topical lidocaine premedication significantly reduced the incidence of RAEs in children during UGEs under ketamine sedation. Our findings should be confirmed by a double-blind randomized controlled trial.
- | Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis
Journal: Lid splinting eyelid retraction technique: a minimised sterile approach for intravitreal injections. (Pubmed Central) - Mar 29, 2019
This is beneficial for both the physician and the patient as it minimises patient discomfort as well as the duration of the procedure. To our knowledge, this is one of the largest studies performed to date evaluating intravitreal injection-related endophthalmitis.
- | LidoPain (lidocaine) / Immune Pharma
Preclinical, Journal: Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. (Pubmed Central) - Mar 23, 2019
...Inhibition of fatty acid amide hydrolase, selective antagonism of TRPV1 or the application of lidocaine or its quaternary derivative QX-314, reduced AP frequency, whereas antagonism of TRPA1 had no effect...Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice. These findings suggest that menthol might provide pain relief in patients experiencing PpIX-phototoxicity pain caused by photodynamic therapy or erythropoietic protoporphyria.
- | lidocaine topical / Generic mfg.
New trial: Effects of Topical Lidocaine During Urodynamic Testing In Women (clinicaltrials.gov) - Mar 18, 2019
P=N/A, N=110, Completed, Sponsor: Kristine Zinkgraf
- | lidocaine topical / Generic mfg.
Trial completion date, Trial primary completion date: Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics (clinicaltrials.gov) - Mar 13, 2019
P4, N=100, Recruiting, Sponsor: Ostfold Hospital Trust
These findings suggest that menthol might provide pain relief in patients experiencing PpIX-phototoxicity pain caused by photodynamic therapy or erythropoietic protoporphyria. Trial completion date: Jun 2019 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2020
- | lidocaine topical / Generic mfg.
Journal: Local Anesthetic Systemic Toxicity Induced Cardiac Arrest After Topicalization for Transesophageal Echocardiography and Subsequent Treatment With Extracorporeal Cardiopulmonary Resuscitation. (Pubmed Central) - Feb 27, 2019
Trial completion date: Jun 2019 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2020 No abstract available
- | lidocaine topical / Generic mfg.
Trial initiation date: Occipital Blocks for Acute Migraine (clinicaltrials.gov) - Feb 6, 2019
P3, N=58, Not yet recruiting, Sponsor: Children's Hospital of Philadelphia
No abstract available Initiation date: Jan 2019 --> Apr 2019
- | lidocaine topical / Generic mfg.
New P3 trial, Endobronchial ultrasound: Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound (clinicaltrials.gov) - Feb 4, 2019
P3, N=48, Not yet recruiting, Sponsor: Milton S. Hershey Medical Center
- | lidocaine topical / Generic mfg.
Trial completion date, Trial primary completion date: Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department (clinicaltrials.gov) - Jan 30, 2019
P4, N=126, Recruiting, Sponsor: Centre Hospitalier le Mans
Initiation date: Jan 2019 --> Apr 2019 Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Sep 2018 --> Sep 2019
- | NN1213 / Novo Nordisk
Enrollment change, Trial completion date, Trial initiation date, Trial termination, Trial primary completion date, Surgery: Optimal Method for Mydriasis in Cataract Surgery (clinicaltrials.gov) - Jan 11, 2019
P=N/A, N=3, Terminated, Sponsor: Johns Hopkins University
Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Sep 2018 --> Sep 2019 N=210 --> 3 | Trial completion date: Aug 2019 --> Aug 2018 | Initiation date: Dec 2016 --> Sep 2016 | Recruiting --> Terminated | Trial primary completion date: May 2019 --> Aug 2018; insufficient patient recruitment
- | lidocaine topical / Generic mfg.
New P4 trial: Sexual Dysfunction in Gynecologic Oncology Patients (clinicaltrials.gov) - Jan 11, 2019
P4, N=120, Not yet recruiting, Sponsor: David Bender
- | lidocaine topical / Generic mfg., nitroglycerin / Generic mfg.
Trial completion date, Trial primary completion date: TNT-RASP: Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention (clinicaltrials.gov) - Jan 8, 2019
P4, N=300, Recruiting, Sponsor: Aultman Health Foundation
N=210 --> 3 | Trial completion date: Aug 2019 --> Aug 2018 | Initiation date: Dec 2016 --> Sep 2016 | Recruiting --> Terminated | Trial primary completion date: May 2019 --> Aug 2018; insufficient patient recruitment Trial completion date: Dec 2018 --> Jun 2019 | Trial primary completion date: Jun 2018 --> Jun 2019
- | lidocaine topical / Generic mfg.
New P2/3 trial: Using Intranasal Midazolam (INM) and Lidocaine for Uncooperative Children (clinicaltrials.gov) - Oct 31, 2018
P2/3, N=63, Completed, Sponsor: Tishreen University
- | lidocaine topical / Generic mfg.
Trial completion: Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers. (clinicaltrials.gov) - Oct 24, 2018
P=N/A, N=49, Completed, Sponsor: David Grant U.S. Air Force Medical Center
Trial completion date: Dec 2018 --> Jun 2019 | Trial primary completion date: Jun 2018 --> Jun 2019 Enrolling by invitation --> Completed
- | Emla-cream / Akorn, AstraZeneca
Enrollment open, Biopsy: Pain Perception During Vulvar Biopsy (clinicaltrials.gov) - Oct 22, 2018
P4, N=120, Recruiting, Sponsor: Duke University
Enrolling by invitation --> Completed Not yet recruiting --> Recruiting
- | Enrollment open: A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin (clinicaltrials.gov) - Sep 28, 2018
P=N/A, N=44, Recruiting, Sponsor: Aalborg University
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- | lidocaine topical / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: A Study of the Use of Microneedle Patches to Deliver Topical Lidocaine in the Oral Cavity (clinicaltrials.gov) - Sep 20, 2018
P1, N=16, Completed, Sponsor: Innoture Ltd
Not yet recruiting --> Recruiting Recruiting --> Completed | Trial completion date: Dec 2018 --> Aug 2018 | Trial primary completion date: Dec 2018 --> Aug 2018
- | lidocaine topical / Generic mfg.
New P3 trial: To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo. (clinicaltrials.gov) - Sep 17, 2018
P3, N=46, Not yet recruiting, Sponsor: Hospital Universitari de Bellvitge
- | lidocaine topical / Generic mfg.
Phase classification, Enrollment change, Trial primary completion date: Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia (clinicaltrials.gov) - Sep 13, 2018
P=N/A, N=108, Active, not recruiting, Sponsor: Universit
Recruiting --> Completed | Trial completion date: Dec 2018 --> Aug 2018 | Trial primary completion date: Dec 2018 --> Aug 2018 Phase classification: P4 --> P=N/A | N=224 --> 108 | Trial primary completion date: Jul 2018 --> Mar 2018
- | Emla-cream / Akorn, AstraZeneca
New P4 trial, Biopsy: Pain Perception During Vulvar Biopsy (clinicaltrials.gov) - Aug 31, 2018
P4, N=120, Not yet recruiting, Sponsor: Duke University
- | tetracycline / Generic mfg.
New trial: Effect of Tetracycline Pleurodesis on Prevention of Primary Spontaneous Pneumothorax Recurrence (clinicaltrials.gov) - Aug 15, 2018
P=N/A, N=50, Completed, Sponsor: Isfahan University of Medical Sciences
- | lidocaine topical / Generic mfg.
New P1 trial: A Study of the Use of Microneedle Patches to Deliver Topical Lidocaine in the Oral Cavity (clinicaltrials.gov) - Aug 13, 2018
P1, N=16, Recruiting, Sponsor: Innoture Ltd
- | meloxicam / Generic mfg., lidocaine topical / Generic mfg.
Trial completion, Trial completion date: Lidocaine-prilocaine Cream Versus Rectal Meloxicam on Relief of Post-episiotomy Pain (clinicaltrials.gov) - Aug 3, 2018
P3, N=190, Completed, Sponsor: Assiut University
Phase classification: P4 --> P=N/A | N=224 --> 108 | Trial primary completion date: Jul 2018 --> Mar 2018 Recruiting --> Completed | Trial completion date: Oct 2018 --> Jul 2018
- | New trial: A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin (clinicaltrials.gov) - Jul 15, 2018
P=N/A, N=44, Not yet recruiting, Sponsor: Aalborg University
- | meloxicam / Generic mfg., lidocaine topical / Generic mfg.
Trial completion date, Trial primary completion date: Lidocaine-prilocaine Cream Versus Rectal Meloxicam on Relief of Post-episiotomy Pain (clinicaltrials.gov) - Jun 27, 2018
P3, N=190, Recruiting, Sponsor: Assiut University
Recruiting --> Completed | Trial completion date: Oct 2018 --> Jul 2018 Trial completion date: Feb 2018 --> Oct 2018 | Trial primary completion date: Dec 2017 --> Aug 2018
- | lidocaine topical / Generic mfg.
New P3 trial: Occipital Blocks for Acute Migraine (clinicaltrials.gov) - May 18, 2018
P3, N=58, Not yet recruiting, Sponsor: Children's Hospital of Philadelphia
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Apr 26, 2018
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Trial completion date: Feb 2018 --> Oct 2018 | Trial primary completion date: Dec 2017 --> Aug 2018 Trial completion date: Mar 2018 --> Dec 2018 | Trial primary completion date: Mar 2018 --> Dec 2018
- | lidocaine topical / Generic mfg.
New P4 trial: Post-Op Lidocaine Patch (clinicaltrials.gov) - Apr 18, 2018
P4, N=50, Recruiting, Sponsor: Oregon Health and Science University
- | lidocaine topical / Generic mfg.
Enrollment closed: Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia (clinicaltrials.gov) - Mar 27, 2018
P4, N=224, Active, not recruiting, Sponsor: Universit
Trial completion date: Mar 2018 --> Dec 2018 | Trial primary completion date: Mar 2018 --> Dec 2018 Recruiting --> Active, not recruiting
- | lidocaine topical / Generic mfg.
Enrollment change, Trial termination: To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo (clinicaltrials.gov) - Mar 27, 2018
P4, N=7, Terminated, Sponsor: Hospital Universitari de Bellvitge
Recruiting --> Active, not recruiting N=26 --> 7 | Suspended --> Terminated; Difficulties with the recruitment
- ||| lidocaine topical / Generic mfg.
Enrollment open, Trial initiation date: Fractional CO2 Laser Therapy Versus 4% Topical Lidocaine Gel for Dyspareunia in Breast Cancer Survivors (clinicaltrials.gov) - Mar 27, 2018
P=N/A, N=70, Recruiting, Sponsor: University of Cincinnati
N=26 --> 7 | Suspended --> Terminated; Difficulties with the recruitment Not yet recruiting --> Recruiting | Initiation date: Oct 2017 --> Mar 2018
- | lidocaine topical / Generic mfg.
Enrollment open, Trial initiation date: Pharmacokinetics of Lidocaine in Healthy Adults (clinicaltrials.gov) - Mar 21, 2018
P4, N=24, Recruiting, Sponsor: University of Iowa
Not yet recruiting --> Recruiting | Initiation date: Oct 2017 --> Mar 2018 Not yet recruiting --> Recruiting | Initiation date: Nov 2017 --> Mar 2018
- | lidocaine topical / Generic mfg.
Enrollment open: Lidocaine for Pain After Urodynamic Testing (clinicaltrials.gov) - Mar 14, 2018
P4, N=128, Recruiting, Sponsor: Atlantic Health System
Not yet recruiting --> Recruiting | Initiation date: Nov 2017 --> Mar 2018 Not yet recruiting --> Recruiting
- | lidocaine topical / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant on Sore Throat and Hemodynamics (clinicaltrials.gov) - Mar 9, 2018
P4, N=100, Recruiting, Sponsor: Ostfold Hospital Trust
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Trial completion date: Dec 2017 --> Jun 2019 | Trial primary completion date: Dec 2017 --> Dec 2018
- | Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
Trial completion date, Trial primary completion date: The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - Mar 3, 2018
P=N/A, N=48, Active, not recruiting, Sponsor: Northwestern University
Not yet recruiting --> Recruiting | Trial completion date: Dec 2017 --> Jun 2019 | Trial primary completion date: Dec 2017 --> Dec 2018 Trial completion date: Jan 2018 --> Mar 2018 | Trial primary completion date: Jan 2018 --> Mar 2018
- | lidocaine topical / Generic mfg.
Trial completion, Trial completion date: Comparison Between 2% Lidocaine Gel and 5% Tetracaine Eye Drop as Topical Anesthesia in Phacoemulsification (clinicaltrials.gov) - Feb 28, 2018
P=N/A, N=72, Completed, Sponsor: Indonesia University
Trial completion date: Jan 2018 --> Mar 2018 | Trial primary completion date: Jan 2018 --> Mar 2018 Recruiting --> Completed | Trial completion date: Jan 2018 --> Jan 2018
- | lidocaine topical / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: Pain Relief for Birth Control Implants Insertion (clinicaltrials.gov) - Feb 27, 2018
P3, N=144, Active, not recruiting, Sponsor: Assiut University
Recruiting --> Completed | Trial completion date: Jan 2018 --> Jan 2018 Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2017 --> Sep 2018 | Trial completion date: Sep 2017 --> Sep 2018
- | lidocaine topical / Generic mfg.
New P1 trial: Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine (clinicaltrials.gov) - Feb 22, 2018
P1, N=48, Completed, Sponsor: Galeno Desenvolvimento de Pesquisas Cl
- | lidocaine topical / Generic mfg., nitroglycerin / Generic mfg.
Trial primary completion date: TNT-RASP: Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention (clinicaltrials.gov) - Jan 9, 2018
P4, N=300, Recruiting, Sponsor: Aultman Health Foundation
Recruiting --> Active, not recruiting | Trial primary completion date: Sep 2017 --> Sep 2018 | Trial completion date: Sep 2017 --> Sep 2018 Trial primary completion date: Jun 2017 --> Jun 2018
- | lidocaine topical / Generic mfg.
New P4 trial: Lidocaine for Pain After Urodynamic Testing (clinicaltrials.gov) - Jan 8, 2018
P4, N=128, Not yet recruiting, Sponsor: Atlantic Health System
- | lidocaine topical / Generic mfg.
Enrollment open, Trial primary completion date: Prospective Evaluation of Topical Analgesia for Laceration Repair in the Emergency Department (clinicaltrials.gov) - Jan 3, 2018
P4, N=126, Recruiting, Sponsor: Centre Hospitalier le Mans
Trial primary completion date: Jun 2017 --> Jun 2018 Not yet recruiting --> Recruiting | Trial primary completion date: Mar 2018 --> Sep 2018
- | lidocaine topical / Generic mfg., cyclopentolate hydrochloride / Generic mfg., epinephrine / Generic mfg.
Trial primary completion date, Surgery: Optimal Method for Mydriasis in Cataract Surgery (clinicaltrials.gov) - Dec 26, 2017
P=N/A, N=210, Recruiting, Sponsor: Johns Hopkins University
Not yet recruiting --> Recruiting | Trial primary completion date: Mar 2018 --> Sep 2018 Trial primary completion date: May 2017 --> May 2019
- | lidocaine topical / Generic mfg.
Trial completion, Phase classification, Trial primary completion date: Pain Relief During Repair of Postpartum Perineal Tears (clinicaltrials.gov) - Dec 13, 2017
P4, N=144, Completed, Sponsor: Assiut University
Trial primary completion date: May 2017 --> May 2019 Recruiting --> Completed | Phase classification: P2/3 --> P4 | Trial primary completion date: Dec 2017 --> May 2017
- |||||||||| lidocaine topical / Generic mfg.
New P3 trial: Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser (clinicaltrials.gov) - Dec 8, 2017
P3, N=120, Completed, Sponsor: Galeno Desenvolvimento de Pesquisas Cl
- | lidocaine topical / Generic mfg.
New P4 trial: Lidocaine for Pain Control During Intrauterine Device Insertion (clinicaltrials.gov) - Dec 5, 2017
P4, N=123, Not yet recruiting, Sponsor: Ain Shams University
- | lidocaine topical / Generic mfg.
Trial primary completion date: Pain Relief During Repair of Postpartum Perineal Tears (clinicaltrials.gov) - Nov 14, 2017
P2/3, N=144, Recruiting, Sponsor: Assiut University
Recruiting --> Completed | Phase classification: P2/3 --> P4 | Trial primary completion date: Dec 2017 --> May 2017 Trial primary completion date: Sep 2017 --> Dec 2017