- |||||||||| lidocaine topical / Generic mfg.
A Novel Biomarker of Painful Peripheral Neuropathy (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_4251;
Preliminary data suggest lidocaine modulation of DLss-induced thresholds and flare correlates with VAS modulation. Further recruiting and participant tests will provide a rigorous evaluation of DLss-based response combined biomarker.
- |||||||||| lidocaine topical / Generic mfg.
Cutaneous inputs in modulate spinal circuitry during transcutaneous spinal cord stimulation (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_2867;
These outcomes were studied under two types of topical creams applied to the back of the neck, each for 30 minutes: 1) Versapro sham cream (control), and 2) Benzocaine 20%, Lidocaine 10%, and Tetracaine 4% (BLT) cream to block cutaneous receptors...Moreover, when we maintained SEP peak-to-peak amplitudes at a constant level, there was a significant increase in the current intensity needed to achieve the same amplitude of neurological response, demonstrating that cutaneous inputs contribute to spinal excitability as a response to tSCS. As a result, cutaneous inputs have a role in activating neural pathways to the spinal cord while using tSCS as a neuromodulator.
- |||||||||| lidocaine topical / Generic mfg.
Journal: The RELIEF feasibility trial: topical lidocaine patches in older adults with rib fractures. (Pubmed Central) - Aug 21, 2024
Recruitment of older patients with rib fracture(s) in an emergency setting for the evaluation of lidocaine patches is feasible. Refinement of data collection, with a focus on the collection of pain, frailty-specific outcomes and intervention delivery are needed before progression to a definitive trial.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Successful Medical Management Strategy for Injection Site Intolerance in Dupilumab Therapy (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2802;
Despite previous treatment attempts with pantoprazole and oral glucocorticoid therapy, symptoms persisted, with repeat EGD revealing persistent esophageal eosinophilia ( >15/hpf)...In an attempt to improve medication tolerance, a topical cream containing lidocaine-prilocaine was applied to the injection site 15 minutes before administration...Doing so in this case achieved successful resolution of EoE. Figure: Presence of a tender, circumscribed, erythematous injection site reaction over patient's right upper arm after utilizing the pre-filled pen of the Dupilumab 300mg/2ml medication despite multiple alleviating measures.
- |||||||||| lidocaine topical / Generic mfg.
Urgent Intubation in a Patient with a History of Difficult Airway Management and Osteogenesis Imperfecta (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4964;
Airway management for this case included careful positioning, cautious topical lidocaine dosing, BiPAP pre-oxygenation/continuous nasal oxygen supplementation, maintenance of spontaneous ventilation, and flexible bronchoscopy following Ovassapian airway placement. Challenging visualization was complicated by rapid oxygen desaturation events, but a team approach facilitated safe airway securement.
- |||||||||| lidocaine topical / Generic mfg.
Subcutaneous Air in Peritonsillar Abscess: Transtracheal Injection vs. Necrotizing Fasciitis? (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4578;
Airway topicalization with aerosolized lidocaine, bilateral SLN blocks, and transtracheal lidocaine injection was successful...Concern for necrotizing fasciitis was confounded by the injection of local anesthesia leading to increased radiation exposure to monitor the resolution of air. There was a mild decrease in air within 24 hours and complete resolution within 2 weeks suggesting it to be procedurally caused.
- |||||||||| lidocaine topical / Generic mfg.
Safety of Neuraxial Anesthesia with Bupivacaine in a Pregnant Patient with Pre-existing Methemoglobinemia (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4304;
Upon weighing risks of general and spinal anesthesia in this unique scenario, we proceeded with subarachnoid block with low-dose bupivacaine to good effect and no significant impact on her MetHb levels. This case discusses safety considerations for the use of local anesthetics in pregnant patients in the setting of pre-existing methemoglobinemia.
- |||||||||| lidocaine topical / Generic mfg.
Acute Airway Management Following Penetrating Subglottic Tracheal Trauma (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_3953;
The oropharynx was topicalized with 4% lidocaine nebulizer and the fiberoptic scope was advanced into the hypopharynx...The scope was advanced through the glottis and the ETT was advanced into position under direct visualization. No sedation was required until after the airway was secured as the patient remained calm throughout awake intubation.
- |||||||||| remifentanil / Generic mfg., lidocaine topical / Generic mfg., dexmedetomidine / Generic mfg.
Difficult Intubation in a Medically Complex Patient with Chin-on-Chest Deformity (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_3930;
Awake fiberoptic intubation was performed utilizing a 7.5mm Parker endotracheal tube, Berkman intubating oral airway, and flexible fiberoptic bronchoscope. Tolerance of the procedure was achieved using dexmedetomidine and remifentanil infusions as well as topical and aerosolized lidocaine to the oropharynx and trachea.
- |||||||||| lidocaine topical / Generic mfg.
Challenging Airway Due to Extensive Facial Injuries Secondary to Self-Inflicted GSW (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_3881;
The patient tolerated the procedure well with topical lidocaine. The challenges were poor visualization and potential worsening of threatened airway from bleeding, edema, positioning, and injuries to soft tissues adjacent to airway opening.
- |||||||||| lidocaine topical / Generic mfg.
Awake Nasal Fiberoptic Intubation for Compressive Substernal Thyroid Goiter (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_3564;
For her awake nasal fiberoptic intubation, topicalization was achieved with nebulized and atomized lidocaine...After induction/intubation, nerve monitoring sensor depth was confirmed with glidescope. A right bronchial blocker was advanced, and the case proceeded with single lung ventilation.
- |||||||||| clobetasol propionate topical / Generic mfg., lidocaine topical / Generic mfg.
Laser-Assisted Drug Delivery for Red Ink Hypersensitivity Reaction Treatment (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_5130;
By leveraging fractional ablative laser technology to enhance cutaneous drug uptake, this technique offers a potential avenue for improving the potency of topical treatment regimens. Additionally, LADD is less painful than triamcinolone injections and enables the treatment of the entire area of the tattoo in a single session, optimizing convenience and maximizing patient comfort.
- |||||||||| lidocaine topical / Generic mfg.
Eccrine Hidrocystoma: A Hidden Gem on the Ear Helix (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4434;
While eccrine hidrocystomas can develop on various areas of the body, they are more commonly found on the face, particularly around the eyelids. However, cases of eccrine hidrocystomas on the ear helix have been reported in medical literature, albeit less frequently.
- |||||||||| The puzzle of red: Unravelling Pityriasis Rubra Pilaris (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4427;
The histological findings of PRP may overlap with other inflammatory dermatoses, further complicating the diagnostic process. Due to these factors, it is very important to recognise the characteristic features of the condition, to adapt the therapeutic strategies in time and to be aware of the capacity of this condition to mimic other dermatoses, leading to delay in diagnosis.
- |||||||||| Coexistence of follicular lichen planus with nail involvement and erosive oral lichen planus (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4198;
Our patient debuted with an initial form of follicular lichen planus with nail involvement, later adding oral mucosa lesions which pathological anatomy was consistent with erosive oral lichen planus. We highlight the importance of clinical suspicion and the value of pathological anatomy to confirm the entity, in order to install treatment as early as possible.
- |||||||||| lidocaine topical / Generic mfg., epinephrine / Generic mfg.
Electrosurgery for the Treatment of Moderate or Severe Rhinophyma: A case series (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3192;
The need of training, experience, high costs, potential difficulties in access may limit the use of relatively newly developed techniques in the treatment of rhinophyma. On the other hand, electrosurgery is an effective treatment method in rhinophyma which is both easy for dermatologists to perform and comfortable for the patients.
- |||||||||| lidocaine topical / Generic mfg., ibuprofen / Generic mfg., hydroquinone / Generic mfg.
Reduction of Abdominal Skin Laxity with Microneedle Radiofrequency: A Case Series (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2852;
However thicker lesions recurred hence subsequent CO2 laser sessions are needed. Two weeks prior to the treatment, topical regimens consist of moisturizer, tretinoin (range of concentration 0.025%
- |||||||||| lidocaine topical / Generic mfg.
TRACHEAL STENT PLACEMENT USING FLEXIBLE BRONCHOSCOPY WITH TOPICAL ANESTHESIA ALONE: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2954;
This procedure was aborted when the patient went into cardiac arrest soon after a small dose of dexmedetomidine and midazolam were given...A gargling technique with lidocaine 2% was first used to anesthetize the upper airway... For patients with malignant disease and co-morbidities making general anesthesia less safe, airway stenting using LA alone with flexible bronchoscopy is an effective palliative procedure, providing symptomatic relief and improving quality of life.
- |||||||||| Alfenta (alfentanil) / Abbott
THE HEMORRHAGIC BRONCHIAL MUCOSAL SYNDROME: A RARE COMPLICATION OF BRONCHOSCOPY (Convention Center Exhibit Hall: Rapid Fire Area 2D) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1564;
Periprocedural coughing precedes all cases. Prevention or mitigation of cough, especially in patients with history of lung transplant, lung cancer, structural lung disease, and comorbidities that increase risk of bleeding, appears crucial in preventing this condition.
- |||||||||| lidocaine topical / Generic mfg.
Review of OTC Topical Analgesics for the Treatment of Minor Acute Pain Conditions (Exhibit Hall) - Jul 31, 2024 - Abstract #PAINWeek2024PAINWeek_218;
The most common counterirritant products in US formulations include methyl salicylate and turpentine oil (producing skin redness), menthol and camphor (cooling sensation), and capsaicin (mild irritation without redness). Counterirritants are indicated for the temporary relief of minor aches and pains of muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains.
- |||||||||| lidocaine topical / Generic mfg.
Review, Journal, Surgery: A Systematic Review of Loco-Sedative Anesthesia for Urologic Surgery. (Pubmed Central) - Jul 22, 2024
These results support the utility of dOFM as a cutaneous PK-based BE approach for topical lipophilic drugs, including lidocaine and prilocaine. Given the high efficacy rates, loco-sedative anesthesia is a promising technique for urologic interventions and should be further investigated to determine whether it may become be the standard of care.
- |||||||||| prednisone / Generic mfg., lidocaine topical / Generic mfg., mycophenolate mofetil / Generic mfg.
Journal: A Case of an Autoimmune Blistering Disease: Pemphigus Vulgaris. (Pubmed Central) - Jul 5, 2024
Our patient achieved clearance after four weeks of oral prednisone and maintained clearance after a slow prednisone taper and the addition of mycophenolate mofetil 1g twice daily. We aim to bring awareness of the clinical presentation and treatment regimen of pemphigus vulgaris to prevent misdiagnosis and delayed care.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Perioperative Management of Massive Anterior Encephalocele in a Newborn: A Case Report. (Pubmed Central) - Jul 1, 2024
This case report describes a 34 weeks +0 days gestation, 2.6 kg, newborn with a massive nasoethmoidal anterior encephalocele creating significant external airway obstruction, necessitating emergent and thoughtful airway management and anesthetic care. Our most important perioperative considerations for this newborn included spontaneous ventilation using awake fiberoptic bronchoscopic intubation with lidocaine airway topicalization, secure endotracheal tube attachment, and avoiding noninvasive positive airway pressure postoperatively to avoid pneumocephalus.
- |||||||||| ZTlido (lidocaine patch 1.8%) / Sorrento
Decreased Opioid Utilization with Lidocaine Topical System 1.8% Compared to Lidocaine 5% Patch: A Retrospective Claims Analysis (Exhibit Hall) - Jun 29, 2024 - Abstract #PAINWeek2024PAINWeek_114;
51.9% of LTS patients experienced either a decrease or discontinuation of opioid use in the post-prescription period compared to 45.5% of LP patients (Chi-square test, p=0.021). LTS patients had a non-significant change in pre- versus post-prescription median Morphine Milligram Equivalents (MME) (3.1% increase, Wilcoxon signed rank test, p=0.146); while LP patients experienced a significant increase in pre-versus post-prescription median MME (42.9% increase, Wilcoxon signed rank test, p< 0.001).
- |||||||||| ZTlido (lidocaine patch 1.8%) / Sorrento
Decreased Cost Utilization with Lidocaine Topical System 1.8% Compared to Lidocaine 5% Patch: A Retrospective Claims Analysis (Exhibit Hall) - Jun 29, 2024 - Abstract #PAINWeek2024PAINWeek_113;
The median cost of office visits per LTS patient was $2518 pre-index and $2439 post-index (-3%, p=0.003), the median cost of ER/urgent care visits per LTS patient was $1574 pre-index and $1017 post-index (-35%, p=0.663), the median cost of outpatient visits per LTS patient was $2977 pre-index and $2984 post-index (+0.2%, p=0.906 ) and the median cost of pain procedures per LTS patient was $1150 pre-index and $1155 post-index (+0.4%, p=0.107).In contrast, the median cost of office visits per LP patient was $1862 pre-index and $1898 post-index (+2%, p=0.04), the median cost of ER/urgent care visits per LP patient was $2558 pre-index and $2501 post-index (-2%, p=0.624), the median cost of outpatient visits per LP patient was $3636 pre-index and $3926 post-index (+8%, p< 0.001), and the median cost of pain procedures per LP patient was $956 pre-index and $1024 post-index (+7%, p< 0.001). Conclusions/Implications for future research and/or clinical care: The overall cost reduction observed in the LTS cohort, and the cost increase observed in the LP cohort suggests that LTS may be associated with lower costs of care compared to LP due to better pain relief as a result of the superior adhesion qualities of LTS.
- |||||||||| lidocaine topical / Generic mfg.
Journal: The Distinctive Role of Gluconic Acid in Retarding Percutaneous Drug Permeation: Formulation of Lidocaine-Loaded Chitosan Nanoparticles. (Pubmed Central) - Jun 27, 2024
Conclusions/Implications for future research and/or clinical care: The overall cost reduction observed in the LTS cohort, and the cost increase observed in the LP cohort suggests that LTS may be associated with lower costs of care compared to LP due to better pain relief as a result of the superior adhesion qualities of LTS. It was also noted that the in vitro percutaneous permeation flux of lidocaine significantly decreased when gluconate-containing chitosan nanoparticles were applied, i.e., 6.1
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