lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / generics
    Retrospective data, Review, Journal:  Effectiveness of periprostatic block to prevent pain in transrectal prostate biopsy: a systematic review and a network meta-analysis. (Pubmed Central) -  Sep 5, 2019   
    Periprostatic block (lidocaine) + intrarectal gel (lidocaine + prilocaine) vs. periprostatic block (lidocaine) showed an RR -0.9 (95%CI - 1.9 to 0.074); intrarectal gel (lidocaine) vs. periprostatic block (lidocaine) had a RR 0.77 (95%CI 0.14 to 1.4); placebo/no intervention vs. periprostatic block (lidocaine) + intrarectal gel (lidocaine+prilocaine) RR 3 (95%CI 1.9 to 4); intrarectal gel (lidocaine) versus periprostatic block (lidocaine) + intrarectal gel (lidocaine + prilocaine) RR 1.7 (95%CI 0.64 to 2.7). The blockage of the periprostatic plexus in the performance of a transrectal ultrasound-guided prostatic biopsy, alone or in combination with intrarectal analgesia or sedation, is an effective method to reduce pain.
  • ||||||||||  lidocaine topical / generics
    Journal:  Day-surgery stapled prolassectomy: a "ten minutes job". (Pubmed Central) -  Aug 23, 2019   
    The absence of surgical wounds in the perineal region allows for a reduced stimulation of pain receptors, leading to a less painful post-operatory course and to a reduced risk of long term complications such as stenotizing scarring and soiling .The use of a mechanic stapler leads to higher costs, but they are in part balanced by the possibility of a faster recovery of patients and of an earlier resumption of work activities. The possibility to perform the operation in day surgery may allow for a global reduction health care expenses leaving more resources available for more complex cases.
  • ||||||||||  meloxicam / Generic mfg., lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Lidocaine-prilocaine Cream Versus Rectal Meloxicam on Relief of Post-episiotomy Pain (clinicaltrials.gov) -  Aug 19, 2019   
    P3,  N=190, Completed, 
    The possibility to perform the operation in day surgery may allow for a global reduction health care expenses leaving more resources available for more complex cases. Trial completion date: Jul 2018 --> Oct 2018 | Trial primary completion date: May 2018 --> Aug 2018
  • ||||||||||  lidocaine topical / generics
    Preclinical, Journal:  Reversing Effect of Insulin on Local Anesthetics-Induced Sciatic Nerve Block in Rats. (Pubmed Central) -  Aug 17, 2019   
    Complete recovery time of nerve conduction status in bupivacaine + normal saline group was 116 ± 16 min and that in bupivacaine + insulin group was 36 ± 4 min and the two groups were significantly different (p < 0.01). Insulin can reverse peripheral nerve block induced by lidocaine or bupivacaine.
  • ||||||||||  Qutenza (capsaicin) / Grunenthal
    Journal:  Postherpetic neuralgia of the left trigeminus nerve V1 : Successful therapy with capsaicin 8% patch (Pubmed Central) -  Aug 9, 2019   
    ...Despite medication with gabapentin 1800 mg/d, oxacarbazepine 600 mg, tapentadol 500 mg/d, amitriptyline 20 mg as well as ambroxol 20% ointment and lidocaine patch topically, the pain reached an intensity of 8-10 on the numeric rating scale (NRS)...Also lidocaine infusions with dexamethasone and supraorbitalis blockades were unsuccessful, and a ganglionic local opioid analgesia (GLOA) was anatomically not feasible...Three months after the second treatment, the patient was almost pain-free during the day. Topical capsaicin 8% patch is, in our opinion, also safe and successful to use on the face with appropriate experience of the user.
  • ||||||||||  lidocaine topical / generics
    Methemoglobinemia: A Life-Threatening Complication of Topical Pharyngeal Anesthetics (Exhibit Halls 3 and 4 (Street Level)) -  Aug 8, 2019 - Abstract #ACG2019ACG_2670;    
    If the use of topical pharyngeal anesthetics is deemed necessary during an EGD, topical viscous lidocaine should be preferred over benzocaine to avoid this potentially life-threatening complication. There is insufficient evidence for methemoglobinemia caused by topical pharyngeal lidocaine alone and reported cases of lidocaine associated methemoglobinemia occurred in patients with either cardiorespiratory diseases or with the use of other anesthetic agents.
  • ||||||||||  Remicade (infliximab) / Mitsubishi Tanabe, J&J, Opdivo (nivolumab) / Ono Pharma, BMS
    When the Cure Is the Cause: Checkpoint Inhibitor-Induced Lymphocytic Esophagitis (Exhibit Halls 3 and 4 (Street Level)) -  Aug 8, 2019 - Abstract #ACG2019ACG_2579;    
    For refractory symptoms of esophagitis, immunosuppressants such as Infliximab could be considered. It is important to recognize the diversity and severity of immune-related adverse events to avoid incomplete treatment or a delay in therapy.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial primary completion date, Endobronchial ultrasound:  Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound (clinicaltrials.gov) -  Jul 30, 2019   
    P3,  N=48, Recruiting, 
    No positive healing benefits were observed with the use of Oral-norm gel. Trial primary completion date: Jul 2019 --> Jul 2020
  • ||||||||||  lidocaine topical / Generic mfg.
    New P4 trial:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  Jul 29, 2019   
    P4,  N=70, Not yet recruiting, 
  • ||||||||||  lidocaine topical / generics
    Clinical, Journal:  Level and predictors of anxiety in patients undergoing diagnostic bronchoscopy. (Pubmed Central) -  Jul 25, 2019   
    Prebronchoscopy anxiety assessment can help bronchoscopists to anticipate the anxiety levels of patients, and then further use it to tailor sedation requirements. Special attention should be given to older patients, patients with high BMI, and the ones undergoing bronchoscopy in outpatient settings.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion:  Lidocaine for Pain After Urodynamic Testing (clinicaltrials.gov) -  Jul 18, 2019   
    P4,  N=134, Completed, 
    Special attention should be given to older patients, patients with high BMI, and the ones undergoing bronchoscopy in outpatient settings. Recruiting --> Completed
  • ||||||||||  lidocaine topical / generics
    Clinical, Journal:  Evaluation of protocols on the use of analgesics for pain management in patients with extracorporeal shock wave lithotripsy (ESWL) (Pubmed Central) -  Jul 5, 2019   
    ...The patients were randomized to three groups: group I, included 100 patients who received intramuscular injection of 2cc of physiological saline solution (placebo), group II included 100 patients who received intramuscular injection of ketoprofen 100mg while group III included 100 patients who received lidocaine and prilocaine topical cream...Pain treatment is necessary during ESWL sessions. Two painkillers molecules were assessed, which showed good pain control as well as an increase in the effectiveness of lithotripsy.
  • ||||||||||  Emla-cream / Akorn, AstraZeneca
    Enrollment change, Trial termination, Biopsy:  Pain Perception During Vulvar Biopsy (clinicaltrials.gov) -  Jun 27, 2019   
    P4,  N=37, Terminated, 
    Two painkillers molecules were assessed, which showed good pain control as well as an increase in the effectiveness of lithotripsy. N=120 --> 37 | Recruiting --> Terminated; interim analysis produced significant results, so we ended enrollment
  • ||||||||||  lidocaine topical / generics
    Journal:  The prescription of lidocaine patches in osteoarthritis-a complete audit cycle. (Pubmed Central) -  Jun 24, 2019   
    A large proportion of inpatients are inappropriately prescribed TLP predominantly for musculoskeletal pain, resulting in substantial avoidable cost to the hospital. Education of prescribers and implementation of policies is required to limit inappropriate prescribing.
  • ||||||||||  fentanyl citrate / generics, lidocaine topical / generics
    Clinical, Journal:  Survey of flexible bronchoscopy practice in adults in Saudi Arabia. (Pubmed Central) -  Jun 23, 2019   
    Midazolam was used by 62%, fentanyl by 50%, and propofol by 12% of respondents...Safety procedures for bronchoscopists, for example, wearing masks and eye protection, and for patients, for example, availability of anesthetic reversal agents, were not universally applied.  Bronchoscopy is not standardized in Saudi Arabia. National guidelines for the indications and practice of bronchoscopy are required.
  • ||||||||||  lidocaine topical / generics
    Clinical, Journal:  Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. (Pubmed Central) -  Jun 15, 2019   
    As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral and central sensitization in 657 healthy subjects undergoing experimental models of nerve block (NB) (compression block and topical lidocaine), primary hyperalgesia (PH) (sunburn and topical capsaicin), or secondary hyperalgesia (intradermal capsaicin and electrical high-frequency stimulation), and in 902 patients suffering from neuropathic pain...Sorting of the 902 patients into these mechanistic phenotypes led to a similar distribution as the original heuristic clustering (65% identity, Cohen's κ=0.44), but the denervation phenotype was more frequent than in heuristic clustering. These data suggest that sorting according to human surrogate models may be useful for mechanism-based stratification of neuropathic pain patients for future clinical trials, as encouraged by the European Medicines Agency.
  • ||||||||||  lidocaine topical / Generic mfg., prochlorperazine maleate / Generic mfg.
    New P3 trial:  SPG Block for Acute Pediatric Migraine (clinicaltrials.gov) -  Jun 12, 2019   
    P3,  N=72, Recruiting, 
  • ||||||||||  lidocaine topical / generics
    Preclinical, Journal:  Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo. (Pubmed Central) -  Jun 11, 2019   
    ...Pharmacological treatments were applied: topical instillation of atropine, pilocarpine or oxybuprocaine, intravitreal injection of lidocaine, norepinephrine or "blocker" of the visual photoreceptor transmission, and intraperitoneal injection of a melanopsin antagonist...The phototoxic message was transmitted to the trigeminal system, inducing both inflammation at the ocular surface and stress in the retina. Further investigations of retina-TG connections are needed.
  • ||||||||||  lidocaine topical / generics
    Journal:  Beyond-use dating of lidocaine alone and in two "magic mouthwash" preparations. (Pubmed Central) -  Jun 7, 2019   
    Further investigations of retina-TG connections are needed. A BUD of 21 days is recommended for lidocaine prepared with diphenhydramine and aluminum hydroxide-magnesium hydroxide-simethicone in ratios of 1:1:1 and 1:2.5:2.5 and stored at room temperature in amber oral plastic syringes.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Trial completion date:  Post-Op Lidocaine Patch (clinicaltrials.gov) -  Jun 4, 2019   
    P4,  N=50, Completed, 
    A BUD of 21 days is recommended for lidocaine prepared with diphenhydramine and aluminum hydroxide-magnesium hydroxide-simethicone in ratios of 1:1:1 and 1:2.5:2.5 and stored at room temperature in amber oral plastic syringes. Recruiting --> Completed | Trial completion date: Jun 2019 --> Mar 2019
  • ||||||||||  lidocaine topical / generics
    Journal:  Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. (Pubmed Central) -  May 29, 2019   
    ...The ORG formulations contained a mixture of oleic acid-lanolin (OA-LAN), poloxamer (PL407), and the commonly used local anesthetic lidocaine (LDC)...In vivo pharmacological evaluation showed that the ORG-based drug delivery system presented low cytotoxicity, increased and prolonged the local anesthetic effects compared to commercial alternatives. The data from this study indicate that ORG represent a promising new approach to effectively enhance the topical administration of local anesthetics.
  • ||||||||||  Review, Journal:  Contact Dermatitis to Medications and Skin Products. (Pubmed Central) -  May 26, 2019   
    Finally, we examine the ingredients in the excipients of these products, such as the formaldehyde releasers (quaternium-15, 2-bromo-2-nitropropane-1,3 diol, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin), the non-formaldehyde releasers (isothiazolinones, parabens, methyldibromo glutaronitrile, iodopropynyl butylcarbamate, and thimerosal), fragrance mixes, and Myroxylon pereirae (Balsam of Peru) for contact allergy incidence and prevalence. Furthermore, strategies, recommendations, and two online tools (SkinSAFE and the Contact Allergen Management Program) on how to avoid these allergens in commercial skin care products will be discussed at the end.
  • ||||||||||  Loperium (loperamide hydrochloride) / Remedica
    Clinical, Review, Journal:  Topical loperamide for the treatment of localized neuropathic pain: a case report and literature review. (Pubmed Central) -  May 25, 2019   
    As a topical formulation, it is preferable over other opioids due to its low systemic bioavailability and low risk of crossing the blood-brain barrier. Peripheral upregulation and sensitization of opioid receptors at peripheral nerve endings and perhaps at other cell populations in the epidermis might be targets of topical loperamide.
  • ||||||||||  lidocaine topical / generics
    Journal:  Study of pain response in neonates during venipuncture with a view to analyse utility of topical anaesthetic agent for alleviating pain. (Pubmed Central) -  May 9, 2019   
    ...This cross sectional study was conducted at a tertiary care centre using Premature Infant Pain Profile (PIPP) score with 4% lidocaine as local anaesthetic agent to produce surface anaesthesia of skin prior to intravenous cannulation...This study found that topical anesthetic agents were effective in reducing pain during venipuncture. Based on the facts of the study, it is recommended that pain scoring should be a part of routine monitoring in neonatal intensive care units and appropriate measures should be used to reduce pain.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Endobronchial ultrasound:  Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound (clinicaltrials.gov) -  May 8, 2019   
    P3,  N=48, Recruiting, 
    Based on the facts of the study, it is recommended that pain scoring should be a part of routine monitoring in neonatal intensive care units and appropriate measures should be used to reduce pain. Not yet recruiting --> Recruiting
  • ||||||||||  Lysteda (tranexamic acid) / Ferring
    Journal:  Topical tranexamic acid for the treatment of acute epistaxis in the emergency department. (Pubmed Central) -  May 7, 2019   
    However, this data does add to existing evidence that TXA may be associated with a reduction in resource utilization, suggesting it may provide more effective bleeding control. Overall, more data is needed to confirm the potential benefits of this practice.
  • ||||||||||  Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
    Trial completion date, Trial primary completion date:  The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) -  Apr 26, 2019   
    P=N/A,  N=48, Active, not recruiting, 
    From the present study, it can be concluded that the topical gel loaded with transfersomal lidocaine shows enhanced skin permeation effect along with increase in local anesthetic action of lidocaine. Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
  • ||||||||||  NN1213 / Novo Nordisk, Rituxan (rituximab) / Roche
    Trial completion date, Trial primary completion date:  AAV9-GAA_IM: Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease (clinicaltrials.gov) -  Apr 23, 2019   
    P1,  N=7, Recruiting, 
    The most prominent in vitro permeation efficiency and in vivo anesthetic effect of TPGS/LID-NLC could be the evidence that TPGS-modified NLC could function as a promising drug delivery system for prolonged and efficient local anesthetic therapy. Trial completion date: Jun 2019 --> Jun 2020 | Trial primary completion date: May 2019 --> Dec 2019
  • ||||||||||  Journal:  Herpes Zoster and Postherpetic Neuralgia: Prevention and Management. (Pubmed Central) -  Apr 21, 2019   
    The varicella zoster virus vaccine decreases the incidence of herpes zoster and is approved for adults 50 years and older. The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices recommends this vaccine for adults 60 years and older, except for certain immunosuppressed patients.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Pharmacokinetics of Lidocaine in Healthy Adults (clinicaltrials.gov) -  Apr 16, 2019   
    P4,  N=24, Recruiting, 
    Active, not recruiting --> Completed Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Oct 2019
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  Apr 8, 2019   
    P3,  N=58, Recruiting, 
    Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Oct 2019 Not yet recruiting --> Recruiting