lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Pharmacokinetics of Lidocaine in Healthy Adults (clinicaltrials.gov) -  Dec 20, 2019   
    P4,  N=23, Active, not recruiting, 
    Use of lidocaine jelly or Tetravisc may increase the risk of endophthalmitis after injection. Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Oct 2019 --> Oct 2020
  • ||||||||||  lidocaine topical / Generic mfg., epinephrine / Generic mfg.
    New P4 trial:  Comparison of Two Application Techniques for LET Gel (clinicaltrials.gov) -  Dec 17, 2019   
    P4,  N=48, Completed, 
  • ||||||||||  Acular (ketorolac ophthalmic) / Allergan, Grunenthal, Omidria (phenylephrine and ketorolac injection) / Omeros
    Journal:  Effect Of Intracameral Phenylephrine And Ketorolac 1.0%/0.3% On Intraoperative Pain And Opioid Use During Cataract Surgery. (Pubmed Central) -  Dec 8, 2019   
    Sixty patients at a single center underwent femtosecond laser (FLACS) or conventional phacoemulsification under topical lidocaine gel anesthesia and intracameral preservative-free lidocaine 1%...For the composite endpoint, patients receiving phenylephrine and ketorolac 1.0%/0.3% were 94% less likely to require fentanyl or to have moderate-to-severe pain (pain VAS ≥ 4; OR, 0.06; 95% CI 0.02-0.24) than patients receiving epinephrine. Our results suggest that the routine use of intracameral phenylephrine and ketorolac 1.0%/0.3% during cataract surgery can significantly reduce patient pain as well as the need for opioids.
  • ||||||||||  lidocaine topical / generics
    Clinical, Journal:  Erythermalgia Involving the Face Alone: Two Case Reports. (Pubmed Central) -  Nov 29, 2019   
    Erythermalgia may involve the face alone, and combinative approaches may be of choice for its treatment. Topical lidocaine compounds are considered to be a good option for palliative treatment.
  • ||||||||||  lidocaine topical / generics
    Clinical, Journal:  The Power of Topical Anesthetics and Distraction for Peripheral Intravenous Catheter Placement in the Pediatric Perianesthesia Area. (Pubmed Central) -  Nov 23, 2019   
    Topical analgesics and distraction are powerful tools that can make inserting a peripheral intravenous catheter easier for the patient, and also easier for a nurse with limited pediatric experience. The purpose of this article is to educate nursing staff of the importance of using topical analgesics such as LMX4 and EMLA, needle free lidocaine injections, as well as different methods of distraction to successfully place a peripheral intravenous catheter in a pediatric patient on first attempt.
  • ||||||||||  lidocaine topical / generics
    Journal:  Practices in the Usage and Reconstitution of Poly-L-Lactic Acid (Pubmed Central) -  Nov 23, 2019   
    Most respondents reconstituted PLLA in sterile water (59.8%) more than 21 hours before use (51.0%) and added lidocaine to the solution (94.7%)...J Drugs Dermatol. 2019;18(9):880-886.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie
    Journal:  Battling Neuropathic Scar Pain With Botulinum Toxin (Pubmed Central) -  Nov 23, 2019   
    Botulinum toxin type A (BTA) is a neurotoxic protein that prevents the release of neurotransmitters from presynaptic nerves and has shown promise in treating neuropathic pain...She had previously tried topical lidocaine, topical and intralesional steroids, and oral gabapentin without improvement...J Drugs Dermatol. 2019;18(9):937-938.
  • ||||||||||  Journal:  Management of peripheral neuropathy induced by chemotherapy. (Pubmed Central) -  Nov 14, 2019   
    Yet, we could not recommend an ideal therapeutic agent for the prevention or treatment of CIPN. Therefore, CIPN continues to be a challenge to clinicians and our patients.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion, Trial completion date:  Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia (clinicaltrials.gov) -  Nov 11, 2019   
    P1/2,  N=56, Completed, 
    Therefore, CIPN continues to be a challenge to clinicians and our patients. Recruiting --> Completed | Trial completion date: Jan 2020 --> Oct 2019
  • ||||||||||  lidocaine topical / generics
    DERMABOND CONTACT DERMATITIS (Monitor 6) -  Nov 9, 2019 - Abstract #ACAAI2019ACAAI_673;    
    He recently underwent excision of an epigastric skin mass under local lidocaine anesthetic...The case highlights the importance of investigating Dermabond adhesive to explain contact reactions following surgical procedures. Dermabond contact dermatitis skin patch test
  • ||||||||||  lidocaine topical / generics
    Review, Journal:  Emerging Roles of Long Non-coding RNAs in Chronic Neuropathic Pain. (Pubmed Central) -  Nov 5, 2019   
    Presently, the available drug treatments (e.g., anticonvulsants acting at calcium channels, serotonin-noradrenaline reuptake inhibitors, tricyclic antidepressants, opioids, topical lidocaine, etc.) for chronic neuropathic pain patients are still rare and have disappointing efficacy, which makes it difficult to relieve the patients' painful symptoms, and, at best, they only try to reduce the patients' ability to tolerate pain...In this article, we primarily review the status of chronic neuropathic pain and provide a general overview of lncRNAs, the detailed roles of lncRNAs in the nervous system and its related diseases, and the abnormal expression of lncRNAs and their potential clinical applications in chronic neuropathic pain. We hope that through the above description, readers can gain a better understanding of the emerging roles of lncRNAs in chronic neuropathic pain.
  • ||||||||||  pregabalin / generics, amitriptyline / generics
    Clinical, Journal:  Diagnostic and therapeutic approach to scalp dysesthesia: A case series and published work review. (Pubmed Central) -  Oct 29, 2019   
    Oral antihistamines and topical corticosteroids did not work sufficiently on their own but added value when used in conjunction with analgesic agents. Our experience and published work also suggest the association of cervical spinal changes, psychiatric disorders, and other environmental and habitual factors.
  • ||||||||||  lidocaine topical / generics
    Journal:  Relation of viscous lidocaine combined with propofol deep sedation during elective upper gastrointestinal endoscopy to discharge. (Pubmed Central) -  Oct 29, 2019   
    There were no statistically significant differences between the lidocaine (n = 46) and placebo (n = 47) groups with respect to recovery time (42 ± 17.8 vs 39 ± 15.9 minutes; P = 0.23), procedure time (6.5 ± 2.7 vs 7 ± 3.6 minutes; P = 0.77), endoscopist satisfaction (83.2 ± 24.4 vs 77 ± 27.7, P = 0.23), patient discomfort (16.6 ± 19.8 vs 24.0 ± 29.7, P = 0.37), or total propofol administered (2.3 ± 1.3 vs 2.3 ± 1.0 mg/kg, P = 0.55). Compared to placebo, topical viscous lidocaine does not appear to delay recovery time or adversely affect sedation-related outcomes.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment closed:  Pharmacokinetics of Lidocaine in Healthy Adults (clinicaltrials.gov) -  Oct 22, 2019   
    P4,  N=23, Active, not recruiting, 
    Our study reveals a clinically relevant compound providing prolonged duration topical corneal anesthesia. Recruiting --> Active, not recruiting
  • ||||||||||  lidocaine topical / Generic mfg., nitroglycerin / Generic mfg.
    Trial completion, Enrollment change:  TNT-RASP: Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention (clinicaltrials.gov) -  Oct 18, 2019   
    P4,  N=100, Completed, 
    This clinical trial was registered at ClinicalTrials.gov (ClinicalTrials.gov ID: NCT03070379). Recruiting --> Completed | N=300 --> 100
  • ||||||||||  lidocaine topical / generics
    Preclinical, Journal:  Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect. (Pubmed Central) -  Oct 17, 2019   
    All mice received a punch biopsy surgery (Day 0) with topical lidocaine gel and their analgesic treatment prior to recovery, and on Days 1 and 2...However, male mice who received analgesia slept more than their female counterparts; this may be related to sex differences in pain perception. Overall, it does not appear that the predictability of disturbance effects sleep fragmentation or stress responses, indicating that husbandry activities do not need to occur at set predictable times to improve welfare.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch (clinicaltrials.gov) -  Oct 16, 2019   
    P=N/A,  N=26, Recruiting, 
    Overall, it does not appear that the predictability of disturbance effects sleep fragmentation or stress responses, indicating that husbandry activities do not need to occur at set predictable times to improve welfare. Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  Sep 30, 2019   
    P4,  N=70, Recruiting, 
    in vivo, resulting in false-negative results in diagnostic tests. Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / generics
    Journal:  Comparative Study of UMA Jeunesse Classic and UMA Jeunesse Ultra. (Pubmed Central) -  Sep 30, 2019   
    Clinical data from this study suggest that performance and outcomes of treatment of medium-to-deep nasolabial folds with UJ and UJU are quite similar. However, treatment with UJU offers enhanced patient comfort and is preferred by patients and injectors.
  • ||||||||||  lidocaine topical / generics
    Clinical, Review, Journal:  Hemorrhoid management in women: the role of tribenoside + lidocaine. (Pubmed Central) -  Sep 27, 2019   
    Fast onset of symptom relief was reported from 10 minutes after administration, lasting up to 10-12 hours. On these bases, tribenoside + lidocaine can represent a fast, effective, and safe option to treat hemorrhoids when conservative therapy is indicated, and it deserves consideration as a first-line treatment of this disease in clinical practice.
  • ||||||||||  Ozurdex (dexamethasone intravitreal implant) / Allergan
    Pain perception in patients treated with intravitreal Ozurdex with different types of anesthesia in diabetic macular edema () -  Sep 26, 2019 - Abstract #EURETINA2019EURETINA_738;    
    Topical anesthesia was not inferior for pain management during intravitreal injection of the dexamethasone prolonged release device. At 24 hours after the application, it showed a lower pain index, statistically significant when it was compared with subconjunctival anesthesia, so topical anesthesia can be a safe alternative, lower cost, and with a lower rate of bleeding than application of subconjunctival anesthesia.
  • ||||||||||  lidocaine topical / generics
    Journal:  Acute pain responses in dairy calves undergoing cornual nerve blocks with or without topical anesthetic. (Pubmed Central) -  Sep 6, 2019   
    There were no treatment differences for any heart rate measures over the 5-min period after the first injection (mean heart rate, root mean square of successive differences, high-frequency power, and the ratio of low-frequency power to high-frequency power). These results suggest that cornual nerve blocks with buffered lidocaine are painful and that a lidocaine-prilocaine cream was not only ineffective in reducing this pain but that it may also worsen it.
  • ||||||||||  lidocaine topical / generics
    Journal:  Use of topical local anesthetics to control pain during treatment of hoof lesions in dairy cows. (Pubmed Central) -  Sep 6, 2019   
    Algometry values showed increased pressure threshold after application of topical anesthetics. This study suggests that the use of topical local anesthesia with lidocaine and bupivacaine helps reduce pain associated with corrective trimming of severe hoof lesions, enhancing animal welfare and potentially ensuring safety of trimmers.