- |||||||||| pregabalin / Generic mfg.
Clinical, Journal: Treatment Patterns and Medication Use in Patients with Postherpetic Neuralgia. (Pubmed Central) - Apr 23, 2020
Improving adherence to evidence-based PHN treatment regimens offers the potential to reduce opioid prescribing first line and reduce overall treatment costs. Given the emphasis to reduce opioid prescribing to minimize the risk of dependence, abuse, and diversion, multimodal analgesic treatments that can avoid or reduce opioid use should be considered.
- |||||||||| Trial completion, Trial completion date, Trial primary completion date: A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin (clinicaltrials.gov) - Apr 19, 2020
P=N/A, N=44, Completed,
Given the emphasis to reduce opioid prescribing to minimize the risk of dependence, abuse, and diversion, multimodal analgesic treatments that can avoid or reduce opioid use should be considered. Active, not recruiting --> Completed | Trial completion date: Dec 2020 --> Dec 2019 | Trial primary completion date: Dec 2019 --> Aug 2019
- |||||||||| lidocaine topical / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Sexual Dysfunction in Gynecologic Oncology Patients (clinicaltrials.gov) - Apr 16, 2020
P4, N=120, Recruiting,
Active, not recruiting --> Completed | Trial completion date: Dec 2020 --> Dec 2019 | Trial primary completion date: Dec 2019 --> Aug 2019 Not yet recruiting --> Recruiting | Trial completion date: Jul 2020 --> Jul 2021 | Trial primary completion date: Jul 2020 --> Jul 2021
- |||||||||| Journal: Medications and the larynx. (Pubmed Central) - Apr 12, 2020
Postoperative cognitive dysfunction following elective cataract surgeries under local anesthesia can be attributed to the effect of local anesthesia rather than the effect of surgery. Further study is warranted to explore the effects that these and other classes of agents, such as antibiotics, have on the structure and function of the larynx.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Safety of in-office laryngology procedures. (Pubmed Central) - Apr 12, 2020
Although complication rates of IOLP are low, patient characteristics and potential complications of both the procedure and of topical anaesthetic use must be considered. One must be prepared and equipped to deal with these potential complications.
- |||||||||| lidocaine topical / Generic mfg.
Enrollment closed: Occipital Blocks for Acute Migraine (clinicaltrials.gov) - Apr 8, 2020
P3, N=58, Active, not recruiting,
One must be prepared and equipped to deal with these potential complications. Recruiting --> Active, not recruiting
- |||||||||| lidocaine topical / Generic mfg., acyclovir / Generic mfg.
Journal: Stability-indicating HPLC method for acyclovir and lidocaine in topical formulations. (Pubmed Central) - Apr 1, 2020
The skin extraction efficiency for acyclovir and lidocaine was 92.8±0.7 and 91.3±3.2, respectively with no interference from the skin leachables. Thus, simultaneous quantification of acyclovir and lidocaine in the topical formulations was achieved.
- |||||||||| Emla-cream / Akorn, AstraZeneca, lidocaine topical / Generic mfg.
Journal: EMLA-induced methemoglobinemia after laser-assisted hair removal procedure. (Pubmed Central) - Mar 26, 2020
This is the case of a 23-year-old female with a past medical history of ADHD and Depression who was evaluated in the emergency department for perioral cyanosis and hypoxia after application of the eutectic mixture of lidocaine and prilocaine (EMLA) local anesthetic prior to a laser-assisted hair removal procedure. This report illustrates a case of methemoglobinemia which is a rare but significant complication of topical anesthetic use.
- |||||||||| diltiazem / Generic mfg., metronidazole topical / Generic mfg., lidocaine topical / Generic mfg.
Enrollment change: Topical Analgesia Post-Haemorrhoidectomy (clinicaltrials.gov) - Mar 18, 2020
P2/3, N=212, Not yet recruiting,
The proposed systematic review and network meta-analysis will not only provide a more thorough review of common medications used to decrease emergence coughing, but also inform clinicians which of these pharmacological strategies is the best approach. N=148 --> 212
- |||||||||| lidocaine topical / Generic mfg.
Journal: Effect of adding vasopressin on the distribution of lidocaine in tissues, anesthetic action, and circulatory dynamics. (Pubmed Central) - Mar 15, 2020
Peak-to-peak amplitude 30-60 min was significantly lower with L + 0.03 U/mL vasopressin than with L. Lidocaine did not affect blood pressure and pulse rate with 0.03 U/mL vasopressin-only or combined with 2%-lidocaine. Topical 0.03 U/mL vasopressin injection reduced the tissue blood flow, promoted the localization and retention, and extended the anesthesia duration of lidocaine, leaving circulatory dynamics unaffected.
- |||||||||| doxycycline / Generic mfg.
Journal: Furuncular Myiasis of the Lower Leg. (Pubmed Central) - Mar 13, 2020
Despite topical treatment with corticosteroids and antibiotics as well as systemic therapy with oral doxycycline, the lesions did not show any regression or reduction in their secretion...The literature reports a number of treatment options including a) occlusion of the skin opening by paraffin oil, beeswax, petroleum jelly or agents such as liquid nitrogen or ethyl chloride sprays to suffocate the larva and promote self-extrusion; b) removing the larva by forceps after lidocaine instillation; c) surgical removal or d) the use of topical or oral ivermectin (1,8,9)...In conclusion, we described the clinical and histopathological features of furuncular myiasis by DH in a traveler returning from Peru. Given the ever-increasing numbers of international travelers, western dermatopathologists and dermatologists should be familiar with this disease to avoid prescription of unnecessary topical or systemic medications.
- |||||||||| lidocaine topical / Generic mfg., lidocaine 5% / Generic mfg.
Trial initiation date: EASY: Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain (clinicaltrials.gov) - Mar 10, 2020
P3, N=180, Not yet recruiting,
Adjunctive lidocaine 5% patches did not reduce acute pain in postthoracotomy and post-sternotomy patients in the cardiothoracic intensive care unit. Initiation date: Jan 2021 --> Jun 2020
- |||||||||| lidocaine topical / Generic mfg., Silverzine Tulle (Silver Sulfadiazine) / MinaPharm, minocycline / Generic mfg.
Journal: PWD: Treatment Platform for Both Prolonged Field Care and Definitive Treatment of Burn-Injured Warfighters. (Pubmed Central) - Feb 25, 2020
Burns were created on day 0, immediately enclosed with the PWD and treated topically with minocycline and lidocaine...Control wounds were treated with silver sulfadiazine cream...This study demonstrates that the PWD is an effective platform for delivery of antibiotics and negative pressure wound therapy for the treatment of full-thickness burns. Therefore, the PWD may be utilized for both prolonged field care and definitive treatment of burn- and blast-injured warfighters.
- |||||||||| lidocaine topical / Generic mfg., Botox (onabotulinumtoxin A) / GSK, Allergan
Journal: Long-term effectiveness of topical analgesics (Pubmed Central) - Feb 25, 2020
Therefore, the PWD may be utilized for both prolonged field care and definitive treatment of burn- and blast-injured warfighters. Despite the long duration of the disease, the most used off-label topical drugs L and B demonstrated a high primary response rate (in contrast to C), with most benefiting from long-term treatment.
- |||||||||| Journal: Reflexions on 50 Years of Sexual Medicine in Urology Focusing on Male Sexual Dysfunctions (Pubmed Central) - Feb 21, 2020
Regarding premature ejaculation (PE) meanwhile with oral dapoxetine and topical lidocaine/prilocaine spray two effective treatment options are officially available which may be combined in men with severe PE and with PDE-5 inhibitors in men with PE and ED. Hormonal disorders such as hypogonadism, hyperprolactinemia and thyroid disorders may be linked to male sexual disorders and successfully treated with T-substitution, prolactin inhibitors or thyroid specific medications.Whereas vascular surgery for ED such as deep dorsal vein ligation/resection or arterial revascularization procedures dominated the 80ies and 90ies last century they have been considered outdated and are replaced in severe ED of organic etiology by the modern new three piece inflatable penile implants whose high technical standard meanwhile provide 10 years survival rates of about 70 %.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Pediatric pain treatment and prevention for hospitalized children. (Pubmed Central) - Feb 21, 2020
A deferral process (Plan B) may include nitrous gas analgesia and sedation. Failure to implement evidence-based pain prevention and treatment for children in medical facilities is now considered inadmissible and poor standard of care.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Review, Journal: Efficacy of Topical Anesthetics in Pain Perception During Mini-implant Insertion: Systematic Review of Controlled Clinical Trials. (Pubmed Central) - Feb 20, 2020
There was evidence that the efficacy of the analgesia of infiltrative anesthesia was most effective in promoting a lower perception of pain compared to the other anesthetic agents, although an injection was required. Among topical anesthetics, compound topical anesthetics with 20% lidocaine were more effective than compound topical anesthetics with low lidocaine concentration and conventional topical anesthetic with 20% benzocaine.
- |||||||||| diltiazem / Generic mfg., metronidazole topical / Generic mfg., lidocaine topical / Generic mfg.
New P2/3 trial: Topical Analgesia Post-Haemorrhoidectomy (clinicaltrials.gov) - Feb 19, 2020
P2/3, N=300, Not yet recruiting,
- |||||||||| lidocaine topical / Generic mfg., lidocaine 5% / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: EASY: Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain (clinicaltrials.gov) - Feb 18, 2020
P3, N=180, Not yet recruiting,
Among topical anesthetics, compound topical anesthetics with 20% lidocaine were more effective than compound topical anesthetics with low lidocaine concentration and conventional topical anesthetic with 20% benzocaine. Trial completion date: Jan 2022 --> Jan 2023 | Initiation date: Jan 2020 --> Jan 2021 | Trial primary completion date: Jan 2022 --> Jan 2023
- |||||||||| lidocaine topical / Generic mfg.
Review, Journal: Utility of lidocaine as a topical analgesic and improvements in patch delivery systems. (Pubmed Central) - Feb 15, 2020
Other neuropathic or nociceptive pain syndromes may respond to topical lidocaine in select cases and warrant further study. Clinicians should consider local anesthetics and other topical agents as part of their multimodal treatments of acute and chronic pain.
- |||||||||| pregabalin / Generic mfg.
Review, Journal: The potential of transdermal nitric oxide treatment for diabetic peripheral neuropathy and diabetic foot ulcers. (Pubmed Central) - Feb 14, 2020
Our hypothesis is that a deficiency of nitric oxide synthase in diabetic patients leads to a lack of vascularization of the peripheral nerves, which causes DPN; and this could be treated with vasodilators such as nitric oxide. In this paper, the mechanisms of DPN are reviewed and analyzed to elucidate the potential of a transdermal nitric oxide application for the treatment of DPN and diabetic wound ulcers by increasing vasodilation.
- |||||||||| lidocaine topical / Generic mfg.
Enrollment open: Ultrasound-Guided Erector Spinae Plan Block in Patients Undergoing ESWL (clinicaltrials.gov) - Jan 27, 2020
P=N/A, N=60, Recruiting,
CSDGs are a promising topical formulation for local treatment of vaginal bacterial infection and improvement of vaginal wound healing. Not yet recruiting --> Recruiting
- |||||||||| lidocaine topical / Generic mfg.
Journal: Antimicrobial effects of local anaesthetics. (Pubmed Central) - Jan 21, 2020
This study aimed to compare the antimicrobial effects of the topical antimicrobial agent mupirocine with those of the LA lidocaine and the combination of lidocaine and adrenalin...However, caution should be exercised not to antagonise the effective treatment of surgical infections, remembering that controversy on the antimicrobial effects of LAs remains in the literature. Therefore, further comprehensive studies with larger patient populations are warranted to demonstrate the antimicrobial effects of LAs.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Efficacy of Topical Benzocaine in Maxilla: A Randomized Controlled Trial. (Pubmed Central) - Jan 8, 2020
A 27-gauge needle was used to deposit 2% lidocaine with 1:100,000 epinephrine...Results showed that although 20% benzocaine significantly reduced pain on needle penetration during buccal infiltration in maxillary anterior teeth, the difference was small and the clinical significance is not clear. Topical anesthetic did not affect pain of local anesthetic deposition.
- |||||||||| lidocaine topical / Generic mfg., tropicamide / Generic mfg.
Review, Journal: Tropicamide/Phenylephrine/Lidocaine Intracameral Injection: A Review in Cataract Surgery. (Pubmed Central) - Jan 8, 2020
Overall, the preparation was generally well tolerated, with no serious adverse events leading to hospitalization or permanent vision loss. Thus, tropicamide/phenylephrine/lidocaine injectable solution is an emerging option for mydriasis/anaesthesia in adults undergoing cataract surgery.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Nebulized dexmedetomidine-lidocaine inhalation as a premedication for flexible bronchoscopy: a randomized trial. (Pubmed Central) - Jan 8, 2020
The vasoconstrictor dosages were significantly lower in the nebulized dexmedetomidine group than in the intravenous dexmedetomidine group (P<0.001). Nebulized dexmedetomidine-lidocaine inhalation as a premedication for flexible bronchoscopy was well tolerated during bronchoscopies performed under moderate sedation and was associated with a reduced incidence of moderate to severe coughing, a shorter recovery time and reduced vasoconstrictor consumption.
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