lidocaine topical / Generic mfg. 
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  • ||||||||||  diltiazem / Generic mfg., metronidazole topical / Generic mfg., lidocaine topical / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Topical Analgesia Post-Haemorrhoidectomy (clinicaltrials.gov) -  Aug 31, 2020   
    P2/3,  N=192, Recruiting, 
    N=48 --> 29 | Recruiting --> Terminated; COVID lack of cases/recruitment Not yet recruiting --> Recruiting | Trial completion date: Jun 2022 --> Sep 2022 | Trial primary completion date: Nov 2021 --> Aug 2022
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Procedural pain reduction strategies in paediatric nuclear medicine. (Pubmed Central) -  Aug 2, 2020   
    A comprehensive pain management program should consider all available interventions - pharmacological, adjuvant, physical and psychological. Further randomized clinical trials are needed to evaluate if a combination of two or more methods of pharmacological and adjuvant interventions are more effective to reduce procedural pain compared with only one method.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Hybrid nanofilms as topical anesthetics for pain-free procedures in dentistry. (Pubmed Central) -  Jul 11, 2020   
    Therefore, we have prepared different hybrid nanofilms composed of biopolymer matrices (chitosan, pectin, and chitosan-pectin) blended with nanostructured lipid carriers (NLC) loading the eutectic mixture of 5% lidocaine-prilocaine (LDC-PLC), in order to fulfill this gap in the market...Then, the in vivo efficacy of PCT/NLC formulation was compared to biopolymer film and commercial drug, exhibiting the longest-lasting anesthetic effect (> 7 h), assessed by tail flick test in mice. These pectin-based hybrid nanofilms open perspectives for clinical trials and applications beyond Dentistry.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  Occipital Blocks for Acute Migraine (clinicaltrials.gov) -  Jul 9, 2020   
    P3,  N=58, Recruiting, 
    We advocate a BIS range of 80-86 for feasibly performing the AFNI procedure. Active, not recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Personalized anesthetic patches for dental applications. (Pubmed Central) -  Jul 1, 2020   
    To address this issue, we proposed the use of three-dimensional printing (3DP) to fabricate a customizable dental anesthetic patch loaded with lidocaine that can be fitted perfectly onto the affected tooth...In addition, the results illustrated the possibility of controlling the drug release profile by altering the shape of the patch, as well the use of a 3DP tooth model as the drug testing platform. Taken together, these data further reinforce the vast potential of the application of 3DP technology in personalized medicine.
  • ||||||||||  lidocaine topical / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion, Trial completion date, Trial initiation date, Trial primary completion date, Reflex:  Effect of Palatable Lidocaine Gel on Gag Reflex for Patients Undergoing Upper Gastrointestinal Endoscopy (clinicaltrials.gov) -  Jun 22, 2020   
    P=N/A,  N=120, Completed, 
    In this paper, we emphasize the potentiality of flavonoids for the management of NP. Recruiting --> Completed | Trial completion date: Feb 2020 --> Jun 2020 | Initiation date: Apr 2019 --> Jan 2020 | Trial primary completion date: Jan 2020 --> Apr 2020
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Topical anesthetics for pediatric laser treatment. (Pubmed Central) -  Jun 19, 2020   
    The advancement of new knowledge in laser technology have contributed to the development of new lasers that are commonly used in a pediatric population, such as Pulsed Dye, Carbon-dioxide and Nd:YAG laser. The most commonly used topical anesthetics in young patients for minimally or moderately painful laser cutaneous procedures are Lidocaine, Prilocaine, Tetracaine gel and combinations thereof.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Efficacy of midazolam addition to local anesthetic in peribulbar block : Randomized controlled trial. (Pubmed Central) -  Jun 15, 2020   
    In view of the positive side effect profile, topical ambroxol for patients with such a highly impaired quality of life should be investigated further as a matter of urgency. Addition of midazolam to local anesthetic significantly improved the quality of peribulbar block, hastened the onset of sensory anesthesia, lid and globe akinesia and increased the duration of analgesia without notable side effects.
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  Jun 9, 2020   
    P4,  N=70, Recruiting, 
    These data suggest that a mucoadhesive electrospun patch may be used as a vehicle for rapid uptake and sustained anaesthetic drug delivery and may reduce the need for injection. Suspended --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Ultrasound-Guided Erector Spinae Plan Block in Patients Undergoing ESWL (clinicaltrials.gov) -  Jun 4, 2020   
    P=N/A,  N=60, Not yet recruiting, 
    Suspended --> Recruiting Trial completion date: Jul 2020 --> Oct 2020 | Initiation date: Jan 2020 --> Jun 2020 | Trial primary completion date: May 2020 --> Sep 2020
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  The Use of Periareolar Topical Lidocaine Jelly After Needle Localization May Reduce Pain of Subsequent Lymphoscintigraphy. (Pubmed Central) -  Jun 3, 2020   
    For patients who received the lidocaine jelly only five minutes prior to injection, the average pain score was 6. Conclusion The application of lidocaine jelly after the conclusion of needle localization, with a 15-40-minute delay prior to periareolar injections with 99mTc-SC for sentinel node lymphoscintigraphy, appears to substantially reduce the pain associated with the injection of 99mTc-SC.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Evaluation of Hydrocodone/Acetaminophen for Pediatric Laceration Repair: A Randomized Trial. (Pubmed Central) -  May 28, 2020   
    The formulations of LID developed exhibit significantly less toxicity than LID alone. Adjuvant oral hydrocodone/acetaminophen is more effective than placebo in reducing pain in children younger than 8 years undergoing topical lidocaine-treated laceration repair, but it does not decrease pain or anxiety in older children.
  • ||||||||||  colchicine / Generic mfg.
    [VIRTUAL] EFFECTIVENESS OF COMBINED LOCAL COLCHICINE AND STEROIDS IN ORAL ULCERS OF BEHÇET’S DISEASE (Poster View) -  May 22, 2020 - Abstract #EULAR2020EULAR_1611;    
    Patients were randomly divided into two equal groups; group I received combined local therapy (lidocaine HCL 2.0% gel mixed with grinded tablet of 5 mg prednisone and grinded tablet of 0.6 mg colchicine). Combined local therapy (colchicine, steroid, antibiotic and anesthetic) is an effective method in management of oral ulcers in BD.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Optimizing Analgesic Use During Infant Lumbar Puncture in the Emergency Department. (Pubmed Central) -  May 20, 2020   
    Topical lidocaine use increased from 56% preintervention to 73%...We created a streamlined process to ensure all infants undergoing lumbar puncture received at least 1 analgesic and increased the proportion of infants treated with 2 or more analgesics. This work could be expanded to improve analgesia during other invasive procedures in the emergency department.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial suspension, Trial primary completion date:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  May 13, 2020   
    P4,  N=70, Suspended, 
    The tested substance proved analgesic properties longer and higher than EMLA but did not influenced the inflammatory reaction. Trial completion date: Jul 2020 --> Oct 2021 | Recruiting --> Suspended | Trial primary completion date: Jul 2020 --> Oct 2021
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Review, Journal:  Topical Treatment of Localized Neuropathic Pain in the Elderly. (Pubmed Central) -  May 13, 2020   
    However, more information is needed on the efficacy and safety of lidocaine 5% and capsaicin 8% in older old persons and on the long-term effects of these pharmaceuticals. These studies should also pave the way for research and development in the field of topical analgesics with a satisfactory level of evidence-based medicine.
  • ||||||||||  ibuprofen / Generic mfg.
    Journal:  Permeation kinetics of active drugs through lanolin-based artificial membranes. (Pubmed Central) -  May 12, 2020   
    It may be deduced from these tests that these systems provide more reliable results for compounds with low to medium lipophilicity. The results demonstrated that new lanolin-based artificial membranes have the potential to be exploited as screening models for determining the permeability of a compound destined to be topically delivered.
  • ||||||||||  lidocaine topical / Generic mfg., tropicamide / Generic mfg.
    Clinical, Journal:  Pain Following the Use of Anesthesia Formulation Among Individuals Undergoing Cataract Surgery: A Randomized Controlled Trial. (Pubmed Central) -  May 8, 2020   
    There were no statistically significant differences between the two anesthetic methods with respect to pain intensity during the surgery (p = 0.94) and the influence of pain during the last 24 h on activity (p = 0.79), mood (p = 0.31), social contacts (p = 0.29), sleep (p = 0.5) and the joy of life (p = 0.39). Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (p = 0.98) and post-operative complications (p = 0.4) on the experienced pain measured during the surgery and in the last 24 h. New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia.
  • ||||||||||  Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Galderma
    Trial completion date, Trial primary completion date:  The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) -  May 8, 2020   
    P=N/A,  N=48, Active, not recruiting, 
    Additionally, there was no statistically significant influence of age, sex, lateralization, co-existing ophthalmological diseases (p = 0.98) and post-operative complications (p = 0.4) on the experienced pain measured during the surgery and in the last 24 h. New commercially available intraocular anesthetic solution (Mydrane™) seems to be as effective as off-label traditional anesthetic formulation, in reducing the pain experienced during cataract surgery under topical anesthesia. Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2021
  • ||||||||||  lidocaine topical / Generic mfg.
    New trial:  Lidocaine Patch for Neck Pain (clinicaltrials.gov) -  May 6, 2020   
    P=N/A,  N=84, Not yet recruiting, 
  • ||||||||||  pregabalin / Generic mfg.
    Journal:  Pharmacological management of neuropathic pain (Pubmed Central) -  Apr 30, 2020   
    This work also highlighted molecules with inconclusive recommendations or non-recommended pharmacological treatments based on a low quality of evidence, a lack of efficacy or a bad safety profile. The objective of this paper is to present the different treatments and to detail their mechanisms of action.