lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open:  Topic Cervical Anesthesia Plus Paracervical Blockade for Pain Control During Endouterine Manual Aspiration (clinicaltrials.gov) -  Apr 13, 2021   
    P=N/A,  N=100, Recruiting, 
    The 3P-trial has demonstrated that the preventive application of the self-occlusive lidocaine 7%-tetracaine 7% cream is very effective in reducing the procedure-associated pain during MAL-cPDT for the treatment of AK lesions. Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion:  Pharmacokinetics of Lidocaine in Healthy Adults (clinicaltrials.gov) -  Apr 9, 2021   
    P4,  N=23, Completed, 
    The result suggests better tolerability and improved outcomes using the combined therapy. Active, not recruiting --> Completed
  • ||||||||||  funapide (XEN-402) / Xenon
    Clinical, Review, Journal:  Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain-Narrative Review. (Pubmed Central) -  Apr 7, 2021   
    For topical amitriptyline, menthol, and gabapentin, evidence comes from case reports and case series...The discussed data from clinical studies and observations support the usefulness of topical treatments in neuropathic pain management. This review may help clinicians in making decisions regarding whether and which topical treatment may be a beneficial option, particularly in frail patients not tolerating systemic pharmacotherapy.
  • ||||||||||  pregabalin / Generic mfg.
    Review, Journal:  Treatment of diabetic peripheral neuropathy: a review. (Pubmed Central) -  Mar 30, 2021   
    Evidence supports the use of specific anticonvulsants and antidepressants for pain management in patients with diabetic peripheral neuropathy. All current guidelines advise a personalised approach with a low-dose start that is tailored to the maximum response having the least side effects or adverse events.
  • ||||||||||  ketorolac / Generic mfg.
    [VIRTUAL] A RANDOMIZED CONTROLLED TRIAL OF ROPIVACAINE FOR POST-OPERATIVE PAIN IN POEM (DDW Virtual) -  Mar 15, 2021 - Abstract #DDW2021DDW_2957;    
    We currently use a multimodal approach to pain management with topical lidocaine, ketorolac and liquid acetaminophen...A mean of 87.5 mg of fentanyl in the placebo group (SD 46.0 mg) and a mean of 110.0 mg in the ropivacaine group (SD 62.6 mg) (p = 0.372) was used...2 and 4 hours postprocedural 1 patient in each group used 1mg of morphine...Half of the patients in this study were willing to have the procedure done as an outpatient. Future research should explore in whom a same-day discharge may be a safe and effective strategy.
  • ||||||||||  lidocaine topical / Generic mfg.
    Retrospective data, Journal:  The Treatment of Topical Drugs for Postherpetic Neuralgia: A Network Meta-Analysis. (Pubmed Central) -  Feb 27, 2021   
    The resulting TAT/PB LID NLC exhibited good skin penetration and anesthetic efficiency, which could be applied as a promising anesthesia system. Compared with other topical drugs, lidocaine was the most effective and most tolerable drug to be recommended for PHN.
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Topical Analgesic and Local Anesthetic Agents for Pain Associated with Chronic Leg Ulcers: A Systematic Review. (Pubmed Central) -  Feb 23, 2021   
    For topical analgesic agents, ibuprofen foam reduced chronic leg ulcer pain significantly, whereas morphine gel was ineffective.Lidocaine/prilocaine cream and ibuprofen foam are effective agents for reducing wound-related pain associated with chronic leg ulcers. Effective use of topical agents could reduce the need for systemic pain relief agents, mitigating potential adverse effects, while giving clinicians another treatment option to manage wound-related pain associated with chronic leg ulcers.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a prospective, multicentre, randomized trial. (Pubmed Central) -  Feb 17, 2021   
    Effective use of topical agents could reduce the need for systemic pain relief agents, mitigating potential adverse effects, while giving clinicians another treatment option to manage wound-related pain associated with chronic leg ulcers. Findings provide strong evidence that physical therapy is effective for pain, sexual function and sexual distress, and support its recommendation as the first-line treatment of choice for provoked vestibulodynia.
  • ||||||||||  lignocaine / Generic mfg.
    Clinical, Journal:  DentalVibe reduces pain during the administration of local anesthetic injection in comparison to 2% lignocaine gel: results from a clinical study. (Pubmed Central) -  Feb 16, 2021   
    The primary outcome was pain, which was recorded immediately after the administration of anesthetic injection using the Visual Analogue Scale [VAS 0 - 10]. The VAS pain scores ranged from 4 to 10 for site A and 0 to 6 for site B. Comparison between the two sites showed a statistically significant difference [Mann-Whitney U test value = 51.50, P < 0.001] favoring site B. This study showed that DentalVibe reduces pain during injection of local anesthesia compared to topical anesthetic gel.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Corneal anesthesia associated with topical application of 2% lidocaine nonophthalmic gel to healthy canine eyes. (Pubmed Central) -  Feb 11, 2021   
    The VAS pain scores ranged from 4 to 10 for site A and 0 to 6 for site B. Comparison between the two sites showed a statistically significant difference [Mann-Whitney U test value = 51.50, P < 0.001] favoring site B. This study showed that DentalVibe reduces pain during injection of local anesthesia compared to topical anesthetic gel. In the current study, the 2% lidocaine gel provided a sustained, deep and well-tolerated corneal anesthesia in ophthalmically normal dogs.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Effect of a Vibration System on Pain Reduction during Injection of Dental Anesthesia in Children: A Randomized Clinical Trial. (Pubmed Central) -  Feb 11, 2021   
    P=N/A
    Half of the children were in the control group and received maxillary buccal infiltration, by injecting 1.8 ml of 2% lidocaine with 1 : 100,000 adrenaline using topical anesthesia 20% benzocaine gel for 15 seconds, while the other half were in the test group and received the same anesthesia using a commercially available external cold and a vibrating device...Combined external cold and vibrating devices can be an effective alternative in reducing experienced pain and fear in children undergoing infiltration dental anesthesia. This study was registered with clinical trial registry of the United States National Institutes of Health (NIH) at ClinicalTrials.gov (NCT03953001).
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Surgery:  IOLANT: Lidocaine And Neuromonitoring in Thyroid Surgery (clinicaltrials.gov) -  Feb 10, 2021   
    P4,  N=231, Recruiting, 
    This study was registered with clinical trial registry of the United States National Institutes of Health (NIH) at ClinicalTrials.gov (NCT03953001). Not yet recruiting --> Recruiting
  • ||||||||||  lidocaine topical / Generic mfg.
    Enrollment open, Trial completion date:  Lidocaine Patch for Neck Pain (clinicaltrials.gov) -  Feb 2, 2021   
    P=N/A,  N=84, Recruiting, 
    Addition of infiltration of 1% lidocaine with epinephrine 1:100,000 to topical application of epinephrine 1:1000 for preparation of ESS does not significantly improve surgical field of view compared to topical epinephrine alone. Not yet recruiting --> Recruiting | Trial completion date: Jan 2023 --> May 2023
  • ||||||||||  Priligy (dapoxetine) / AbbVie
    Clinical, Journal:  Oral dapoxetine versus topical lidocaine as on-demand treatment for lifelong premature ejaculation: A randomised controlled trial. (Pubmed Central) -  Feb 2, 2021   
    Global Efficacy Question for the patient's assessment of the effectiveness of drugs showed that lidocaine was described as being effective by 43 cases and ineffective by 12 cases, oral dapoxetine was described as being effective by 16 cases and ineffective by 39 cases. From these accumulated data, it is concluded that topical lidocaine is more effective on-demand therapy for lifelong PE compared with oral dapoxetine.
  • ||||||||||  lidocaine topical / Generic mfg., pregabalin / Generic mfg., epinephrine / Generic mfg.
    [VIRTUAL] Allergic Contact Dermatitis to Sodium Metabisulfite in Lidocaine with Epinephrine () -  Jan 30, 2021 - Abstract #CDAI2020CDA-I_86;    
    His usual medications included esomeprazole, celecoxib, pregabalin, acetaminophen and hydroxyzine.Physical examination revealed numerous erythematous papules and vesicles on poorly-circumscribed, eczematous plaques...Results of his patch test read at 96-hours: sodium metabisulfite (+++), bacitracin (+++), polymyxin-B (+++), tixocortol-21-pivalate (+++), pramoxine (++) and linalool (+).ConclusionsThe acute eruption within one day postoperatively, along with clustering of lesions around lidocaine infiltration sites and positive patch test results, suggest that the patient had developed a systemic contact dermatitis to sodium metabisulfite, present in the lidocaine with epinephrine administered perioperatively...He was started on topical clobetasol ointment and recovered in a few weeks.Learning Objective1.True allergy (Type I hypersensitivity) to local anesthetic is rare.2.Sodium metabisulfite is an antioxidant present in local anesthetic solutions with vasoconstrictors, and can be a cause of allergic contact dermatitis.3.Sodium metabisulfite can also be present in other topical creams, such as hydrocortisone and ketoconazole creams.4.Patients with contact dermatitis to sodium metabisulfite should be patch tested for plain lidocaine and plain epinephrine (without the added sodium metabisulfite) to determine allergy status.Takeaway MessageSodium metabisulfite is present, as an antioxidant, only in local anesthetic solutions with vasoconstrictors. In patients with “local anesthetic allergy”, patch testing should be performed to the individual components of local anesthetic solution to determine allergy status
  • ||||||||||  lidocaine topical / Generic mfg.
    [VIRTUAL] Hereditary Leiomyomatosis and Renal Cell Carcinoma Presenting with Segmental Leiomyomas: A Case Report () -  Jan 30, 2021 - Abstract #CDAI2020CDA-I_57;    
    When painful, therapeutic options include topical lidocaine, botulinum toxin, nifedipine or gapapentin. Conclusions Multiple cutaneous leiomyomas may be associated with HLRCC...Long-term imaging surveillance with annual contrast-inhanced magnetic resonance imaging (MRI) is required starting at the age of 10 years. Learning Objective 1.To recognize the clinical manifestations, associations and genetic mutation of HLRCC2.To understand the histopathologic findings of cutaneous leiomyomas3.To recognize the necessity of a prompt diagnosis and long-term clinical and imaging surveillance Takeaway Message Multiple cutaneous leiomyomas may be associated with HLRCC. Prompt diagnosis and genetic testing are important as patients are at risk of aggressive renal cell carcinomas.
  • ||||||||||  Vistide (cidofovir) / Gilead
    [VIRTUAL] Extensive Eyelid Molluscum Treated With Carbon Dioxide Laser () -  Jan 30, 2021 - Abstract #CDAI2020CDA-I_52;    
    At his three-month follow-up, the patient had complete resolution of his lesions without recurrence or side effects. Conclusions This is the first report of ablative carbon dioxide laser treatment for extensive eyelid MC. The ablative nature and the thermal effects of this laser therapy likely caused destruction of the virus in the epidermis, yielding complete clearance of the patient’s MC. Learning Objective 1.Review molluscum contagiosum.2.Review treatment options for molluscum contagiosum.3.Present a carbon dioxide laser as a treatment option for extensive and/or eyelid molluscum contagiosum. Takeaway Message Use of carbon dioxide laser presents a possible treatment alternative for patients with extensive and/or eyelid molluscum contagiosum.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Review, Journal:  Regulations, Liability, Safety, and Economics Related to Compounding. (Pubmed Central) -  Jan 23, 2021   
    Recent heightened regulations have made compounding more challenging for dermatologists and prompted this review of regulations, liability and safety related to compounding. With this information, providers may minimize liability and maximize safety while caring for their patients.
  • ||||||||||  Clinical, Journal:  Implementing an opioid reduction protocol in renal transplant recipients. (Pubmed Central) -  Jan 5, 2021   
    Patients continued to be prescribed excess opioids at discharge compared to inpatient opioid use the day prior to discharge. Ongoing communication with all providers caring for renal transplant recipients and protocolization of the different stages of a patient's post-operative hospitalization are crucial.
  • ||||||||||  Maalox (aluminum hydroxide/simethicone/magnesium hydroxide) / Sanofi
    [VIRTUAL] Comparing Clinical Outcomes of GI Cocktail versus Antacid alone () -  Dec 26, 2020 - Abstract #ASHP2020ASHP_1229;    
    One previous double-blinded study compared Mylanta alone, Mylanta and Donnatal, or Mylanta, Donnatal and lidocaine to assess which combination provided the most relief of dyspepsia in emergency room patients. Their results concluded that the addition of Donnatal or Donnatal plus lidocaine did not significantly relieve dyspepsia more than antacid alone4.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Efficiency and Cost: E-Recruitment Is a Promising Method in Gynecological Trials. (Pubmed Central) -  Dec 23, 2020   
    P=N/A
    Their results concluded that the addition of Donnatal or Donnatal plus lidocaine did not significantly relieve dyspepsia more than antacid alone4. The study findings revealed that e-recruitment is a valuable recruitment method because of its comparable efficiency and cost-effectiveness to health professional referrals and conventional methods, respectively.