- |||||||||| ketamine / Generic mfg.
Fiberoptic Inspection Of Acute Upper Airway Obstruction In The Icu (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4265;
Removal of a 6 x 9 cm inspissated supraglottic cast resolved the extrathoracic obstruction and respiratory distress. In the setting of respiratory and hemodynamic compensation during acute airway obstruction, awake fiberoscopy can save lives.
- |||||||||| lidocaine topical / Generic mfg.
Successful Nasotracheal Intubation of a Patient with Apert Syndrome (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3958;
Given her history of difficult intubation, airway management was performed after otolaryngology removed nasal debris. A nasotracheal intubation was performed with moderate difficulty due to abnormal anatomy after topicalization with nebulized lidocaine.
- |||||||||| lidocaine topical / Generic mfg.
Difficult Airway Management In Transsphenoidal Surgery For Acromegaly (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3645;
Topicalized airway with nebulized 4% lidocaine and added lidocaine cream-soaked cotton tipped applicators to tonsillar pillars in preop...Intubated after 3 attempts with flexible fiberoptic endoscope. Surgery went well; extubated successfully in PACU after trial with tube-exchanger in-situ.
- |||||||||| sevoflurane / Generic mfg., lidocaine topical / Generic mfg.
You Think You Had A Difficult Intubation? (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3549;
The pt was then induced with sevoflurane. Subsequently, pt developed high peak pressure and therefore it was considered best to withdraw the ETT under direct visualization by fiberoptic scope.
- |||||||||| lidocaine topical / Generic mfg.
Journal: The effect of topical lidocaine on intradermal testing in atopic dogs. (Pubmed Central) - Sep 19, 2021
Topical lidocaine may be used as adjunctive analgesia during IDT with caution in interpretation of subjective house dust scoring. Lidocaine cream appeared to reduce pain score and may allow reduction in concurrent sedation.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., duloxetine / Generic mfg.
Review, Journal: French guidelines for neuropathic pain: An update and commentary. (Pubmed Central) - Sep 16, 2021
Third-line treatments include high-frequency repetitive transcranial magnetic stimulation of the motor cortex, spinal cord stimulation and strong opioids (in the lack of alternative). Disseminating these recommendations and ensuring that they are well accepted by French practitioners will be necessary to optimize neuropathic pain management in real life.
- |||||||||| lidocaine topical / Generic mfg.
Ultrasound-Guided Dorsal Penile Blocks as an Effective Form of Analgesia for Circumcision () - Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_98;
This study does have limitations, including small sample size, as well as lack of standardization of the type of anesthetic used for ring block as well as dosage of lidocaine used for dorsal penile block. Future efforts will focus on standardizing these measures with a larger sample size to create a proposed standardized protocol for pain control in neonatal circumcisions.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., duloxetine / Generic mfg.
L-Methylfolate as an Adjunctive Therapy in Diabetic Peripheral Neuropathy () - Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_40;
One preclinical animal study and 7 human clinical trials have shown that LMF has a multi-factorial effect on DPN that extends beyond symptomatic relief to modulate the underlying pathophysiology that leads to the progression and symptoms of DPN. The effectiveness of LMF is driven by neurogenesis, antioxidation, and increased blood flow and is sustained in patients over 12 months of treatment.Genetic polymorphisms on the MTFHR gene are emerging as important factors in determining the impact of LMF treatment in patients with DPN, requiring further study to achieve better treatment outcomes.
- |||||||||| lidocaine topical / Generic mfg.
Preclinical, Journal: Effect of perivascular low dose ethanol on rat femoral vessels: Preliminary study. (Pubmed Central) - Sep 15, 2021
The rats were randomly divided into three groups: saline (group S, n = 8), lidocaine (group L, n = 9) and 96% ethanol (group E, n = 9)...Vasodilatation obtained by ethanol is a rapid onset and long-lasting effect. It is also inexpensive and effective for peripheral vasodilatation.
- |||||||||| lidocaine topical / Generic mfg.
A Cautionary Tale of Viscous Lidocaine (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2940;
The diagnosis of lidocaine toxicity is made clinically taking into account timing, dose and route of delivery. Most EGD protocols involve using 600mg lidocaine (15ml of 4% Viscous Lidocaine) that is gargled for 2-minutes then swallowed.The oral bioavailability is nearly 30% with a biphasic half-life of 90-120 minutes.In this case, although serum levels of lidocaine were therapeutic, they were obtained over 2-hours after the event when the patient was stabilized.Majority of the medication is absorbed through the GI tract and metabolized by the liver with nearly negligible amount entering the vascular system.However, medical conditions that compromise hepatic perfusion like congestive heart failure or hepatic dysfunction accompanying the use of lidocaine and its derivatives, can predispose patients to toxic levels that can lead to acute cardiac or cerebral compromise.The early signs of unintentional and toxic absorption of the local anesthetic into the vasculature space includes bradycardia, hypotension, heart block and arrhythmias.Larger overdoses can cause CNS depression including seizures, unconsciousness and coma.Topical lidocaine is widely regarded as a safe analgesic that provides patients ease and comfort during invasive and painful procedures.This is a cautionary tale of potential lidocaine toxicity in the setting of delayed clearance.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. (Pubmed Central) - Sep 3, 2021
Most EGD protocols involve using 600mg lidocaine (15ml of 4% Viscous Lidocaine) that is gargled for 2-minutes then swallowed.The oral bioavailability is nearly 30% with a biphasic half-life of 90-120 minutes.In this case, although serum levels of lidocaine were therapeutic, they were obtained over 2-hours after the event when the patient was stabilized.Majority of the medication is absorbed through the GI tract and metabolized by the liver with nearly negligible amount entering the vascular system.However, medical conditions that compromise hepatic perfusion like congestive heart failure or hepatic dysfunction accompanying the use of lidocaine and its derivatives, can predispose patients to toxic levels that can lead to acute cardiac or cerebral compromise.The early signs of unintentional and toxic absorption of the local anesthetic into the vasculature space includes bradycardia, hypotension, heart block and arrhythmias.Larger overdoses can cause CNS depression including seizures, unconsciousness and coma.Topical lidocaine is widely regarded as a safe analgesic that provides patients ease and comfort during invasive and painful procedures.This is a cautionary tale of potential lidocaine toxicity in the setting of delayed clearance. Adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia might attenuate CSF IL-6 concentration increase in patients with brain aneurysm.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery. (Pubmed Central) - Aug 28, 2021
The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater...This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.
- |||||||||| Seizalam (midazolam intramuscular) / Pfizer
Clinical, Journal: Awake fiberoptic intubation and use of bronchial blockers in ankylosing spondylitis patients. (Pubmed Central) - Aug 28, 2021
Proper doses of penehyclidine hydrochloride, dexmedetomidine, fentanyl, and midazolam, combined with 2% lidocaine, administered prior to intubation, can provide satisfactory conditions for tracheal intubation while maintaining the comfort and safety of patients. BBs are safe and effective for one-lung ventilation in such patients during thoracotomy.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: A Novel Use of Topical Ketamine for the Treatment of Oral Pemphigus: A Case Report. (Pubmed Central) - Aug 28, 2021
He was placed on steroids and received both lidocaine mouthwash and opioids, but his pain persisted...Painful stomatitis from PNP may be refractory to standard treatment. We found that the application of topical ketamine was very effective in this patient with hemorrhagic stomatitis from PNP.
- |||||||||| lidocaine topical / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, Surgery, Reflex: Lidocaine Gel 2% and Muscle Traction Pain During Squint Surgery in Pediatrics (clinicaltrials.gov) - Aug 23, 2021
P=N/A, N=30, Recruiting,
Phase classification: P=N/A --> P4 Trial completion date: Jul 2021 --> Oct 2021 | Initiation date: Jan 2021 --> Aug 2021 | Trial primary completion date: Jul 2021 --> Oct 2021
- |||||||||| lidocaine topical / Generic mfg.
Journal: Use of topical anaesthesia and peribulbar anaesthesia in Descemets membrane endothelial keratoplasty. (Pubmed Central) - Aug 21, 2021
For TA, patients were given 0.4% Oxybuprocaine eye drops followed by a 2% Lidocain Hydrochloride-Gel and an intraoperative injection of a 2% Lidocaine Hydrochloride solution into the anterior chamber...Anaesthesia-related side effects were more frequent in the PAB group than in the TA group. Although levels of subjective pain are lower under PBA than under TA, in selected patients without ocular comorbidities TA can achieve levels of pain acceptable for DMEK surgery.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Analgesic Effect of Topical Lidocaine is Enhanced by Cold Atmospheric Plasma Pretreatment in Facial CO Laser Treatments. (Pubmed Central) - Aug 21, 2021
Although levels of subjective pain are lower under PBA than under TA, in selected patients without ocular comorbidities TA can achieve levels of pain acceptable for DMEK surgery. Plasma pretreatment of 5 minutes before topical anesthetic cream application gives significant pain reduction during the laser procedures, showing the potential effects of CAP on promoting transdermal drug delivery, with no obvious adverse effects reported.
- |||||||||| cyclosporine / Generic mfg.
Review, Journal: Treatment of the feline atopic syndrome - a systematic review. (Pubmed Central) - Aug 20, 2021
Evidence supported low-to-moderate efficacy of mesenchymal stem cells, inhaled lidocaine and oclacitinib as treatments for feline asthma. For almost all therapeutic options (with the exception of glucocorticoids and ciclosporin), more randomised controlled trials are needed.
- |||||||||| lidocaine topical / Generic mfg.
Journal: Decision aid and preference assessment of topical anesthesia for otolaryngology procedures. (Pubmed Central) - Aug 18, 2021
New patients presenting to subspecialty clinics over a 2-month pre-COVID-19 period completed a pre-procedure survey about their priorities, then were asked to choose between topical oxymetazoline/lidocaine spray or none...Given the aerosolizing potential of both spray and no spray conditions, this insight may be consequential when devising office protocols for post-COVID-19 practice. II.
- |||||||||| ketamine / Generic mfg., lidocaine topical / Generic mfg.
Journal: Neuropathic pain in spinal cord injury: topical analgesics as a possible treatment. (Pubmed Central) - Aug 11, 2021
Case reports, case series and interviews suggest that the use of topical analgesics can be beneficial in treating SCI-related NP. Placebo-controlled studies are required to investigate the effect of topical analgesics on SCI-related NP.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Review, Journal: PEER systematic review of randomized controlled trials: Management of chronic neuropathic pain in primary care. (Pubmed Central) - Aug 5, 2021
There is moderate certainty of evidence that anticonvulsant medications and SNRIs provide a clinically meaningful reduction in pain in those with neuropathic pain, with lower certainty of evidence for rubefacients and opioids, and very low certainty of evidence for TCAs. Owing to low-quality evidence for many interventions, future high-quality trials that report responder analyses will be important to strengthen understanding of the relative benefits and harms of treatments in patients with neuropathic pain.
- |||||||||| Emla-cream / Akorn, AstraZeneca
Journal: Small and large cutaneous fibers display different excitability properties to slowly increasing ramp pulses. (Pubmed Central) - Aug 4, 2021
The results from the computational model suggested that differences in accommodation between the two fiber types may originate from selective expression of voltage-gated ion channels, particularly the transient Na and/or K. e PTT technique could assess the excitability changes during accommodation in different nerve fibers. Therefore, the PTT technique may be a useful tool for studying excitability in nerve fibers both in healthy as well as in pathological conditions.
- |||||||||| lidocaine topical / Generic mfg.
Clinical, Journal: Topical anaesthesia as an adjuvant to local anaesthetic injection in open trigger digit release: a randomized controlled trial. (Pubmed Central) - Jul 30, 2021
We conducted a randomized controlled trial to compare pain scores and patient satisfaction between topical anaesthetic cream (5% lidocaine-prilocaine cream) versus placebo cream, applied approximately 90 minutes before local anaesthetic injection for open trigger digit release...No complications were found during the study period. The topical anaesthetic drug was ineffective to use on the palmar skin during open trigger digit release surgery.Level of evidence: II.
- |||||||||| ketamine / Generic mfg., lidocaine topical / Generic mfg.
Retrospective data, Review, Journal: Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation: A Systematic Review and Network Meta-analysis. (Pubmed Central) - Jul 29, 2021
Our analysis shows that, among the 6 topical medications studied, lidocaine is not optimal for topical use to prevent POST. Glycyrrhizin, corticosteroids, NSAIDs, and NMDA receptor antagonists (ketamine and magnesium) are associated with a reduced postoperative pharyngeal pain across the 4 postsurgical time intervals studied, all of which can be chosen according to the clinical experience of the anesthesiologists and the patient preferences and are recommended for the reduction of postoperative throat pain.
- |||||||||| lidocaine topical / Generic mfg.
The Additive Effect of Topical Mydriatics to Intracamerally Administered Mydriatic Solution () - Jul 19, 2021 - Abstract #ASCRSASOA2021ASCRS_ASOA_182;
The pupil size was registered preoperatively, 45 seconds after ICM injection, after OVD injection prior to capsulorhexis, after cortex cleaning, after OVD injection preceding the IOL-implantation and at day one after surgery.ResultsThere was a significantly larger pupil at 45 seconds after ICM injection as well as after OVD injection in the group given TM compared to the group given placebo drops. ConclusionThis study strengthens that there is an additive effect on pupil size when TM is given as a supplement to ICM in phacoemulsification cataract surgery.
- |||||||||| lidocaine topical / Generic mfg., tropicamide / Generic mfg.
Instant Mydriasis and Sustained Anaesthesia with Intracameral Injection of Fixed Combination Tropicamide, Phenylephrine and Lidocaine () - Jul 19, 2021 - Abstract #ASCRSASOA2021ASCRS_ASOA_152;
Neither drug related toxic reactions in immediate post-op nor cystoid macular oedema in late post-op periods were noticed in Gr- 2 ConclusionThis RCT demonstrated instant mydriasis & sustained anesthesia with single intracameral injection of fixed combination Tropicamide, Phenylephrine & Lidocaine within seconds, reducing patient preparation time prior to surgery and no adverse effects post-surgery. Its use may be a challenge in tropicamide hypersensitivity & pre-existing pupillopathy
- |||||||||| lidocaine topical / Generic mfg.
Trial initiation date: Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens (clinicaltrials.gov) - Jul 8, 2021
P=N/A, N=22, Not yet recruiting,
Overall, LPC appears to be an appropriate alternative to IL in reducing pain during thoracentesis and abdominocentesis, but it seemed to increase unsuccessful medical procedure attempts. Initiation date: May 2021 --> Sep 2021
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