lidocaine topical / Generic mfg. 
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  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  A survey of anaesthetic preferences in cataract surgery. (Pubmed Central) -  Feb 22, 2022   
    Compared with previous literature our survey shows that topical anaesthesia is being increasingly used in cataract surgery, especially in conjunction with intracameral injection. The predominant reasons for this seem to be patient comfort and ease of technique.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery, Reflex:  Lidocaine Gel 2% and Muscle Traction Pain During Squint Surgery in Pediatrics (clinicaltrials.gov) -  Feb 14, 2022   
    P=N/A,  N=30, Recruiting, 
    Moreover, due to the reaction of the essential oil components with SC lipids, the EOEa could be an effective permeation enhancer of topically applied hydrophilic and lipophilic drugs. Trial completion date: Oct 2021 --> Apr 2022 | Trial primary completion date: Oct 2021 --> Mar 2022
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Lidocaine Patch for Neck Pain (clinicaltrials.gov) -  Feb 9, 2022   
    P=N/A,  N=84, Recruiting, 
    It provides for less pain during the administering of the anesthetic but significantly less analgesic effect than LI. Trial completion date: May 2023 --> Dec 2023 | Trial primary completion date: Feb 2023 --> Aug 2023
  • ||||||||||  lidocaine topical / Generic mfg.
    Review, Journal:  Topical Lidocaine for Chronic Pain Treatment. (Pubmed Central) -  Feb 2, 2022   
    Topical lidocaine has been approved by health authorities for the treatment of post-herpetic neuralgia in a number of countries, and studies present some degree of evidence of its efficacy and safety in postsurgical pain, diabetic peripheral neuropathy, carpal tunnel syndrome, chronic lower back pain and osteoarthritis. Topical lidocaine may be a great alternative alone or in addition to systemic drugs and non-pharmacological approaches for an optimized pain management and in multimodal analgesia.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Histopathology after lidocaine/prilocaine cream administration for vulvar biopsy. (Pubmed Central) -  Feb 1, 2022   
    This histopathologic analysis of a randomized trial between lidocaine/prilocaine cream and injected lidocaine as anesthesia for vulvar biopsy shows the absence of significant disruptive histopathologic features secondary to the type of anesthetic. Additional studies in different clinical contexts are warranted.
  • ||||||||||  lidocaine topical / Generic mfg.
    Multicomponent synthesis of lidocaine in an organic laboratory course (In-Person Room (Virtual Room)) -  Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_3306;    
    Students also evaluated three lidocaine synthesis procedures using green chemistry principles and explored the reaction mechanisms of both traditional (N-acylation then N-alkylation) and multicomponent lidocaine syntheses. A comprehensive experimental analysis worksheet was created for remote instruction.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Effect of topical analgesia on desensitization following 8% topical capsaicin application. (Pubmed Central) -  Jan 27, 2022   
    To prevent pain associated with 8% capsaicin application, pretreatment with local anesthetics, such as EMLA (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%), is considered an option...After pretreatment, 8% capsaicin patches were applied for 3 hours in 1 placebo and 1 EMLA pretreated area, obtaining the following four areas: Capsaicin + EMLA, Capsaicin + Placebo, EMLA alone, and Placebo...Perspective: Pretreatment with local anesthetic EMLA cream might be considered a good therapeutic option to reduce the pain associated with 8% capsaicin application currently used for treatment of neuropathic pain syndromes. This study also suggests the existence of a synergistic effect of capsaicin and EMLA on the process of neurogenic inflammation.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Prospective cohort study of topical versus general anaesthesia for flexible bronchoscopy. (Pubmed Central) -  Jan 26, 2022   
    Fractional CO2 laser therapy has achieved statistically significant improvement of the texture and reduction of hypertrophic scars and overall improvement of functional and esthetic result in our study. Compared with TA, GA significantly reduced the total complication scores of perioperative discomforts and improved the satisfaction score of patients for FB.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Journal:  Less Exposure for Health Care Workers, More Comfort for Patients During COVID-19 Swab Testing. (Pubmed Central) -  Jan 19, 2022   
    Thus, this study demonstrates the potential of using Pluronic® F68-reduced graphene oxide nanocarriers to realize prolonged effects of local anesthesia for effective pain management. Our results suggest that applying LS to the OP and NP area prior to swab testing reduces DFR frequencies without affecting (RT-PCR) test results for SARS-CoV-2 and may increase patient and practitioner comfort.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Intranasal Lidocaine for Prevention of Postoperative Nausea and Vomiting. (clinicaltrials.gov) -  Jan 19, 2022   
    P4,  N=304, Not yet recruiting, 
    Our results suggest that applying LS to the OP and NP area prior to swab testing reduces DFR frequencies without affecting (RT-PCR) test results for SARS-CoV-2 and may increase patient and practitioner comfort. Trial completion date: May 2022 --> Dec 2022 | Trial primary completion date: May 2022 --> Sep 2022
  • ||||||||||  ketorolac / Generic mfg.
    Journal:  Sphenopalatine ganglion block for ipsilateral shoulder pain following open pancreaticoduodenectomy. (Pubmed Central) -  Jan 14, 2022   
    After just one topical sphenopalatine ganglion block, using a cotton-tipped applicator, the patient's shoulder pain entirely resolved and did not return. This is the first report of a successful treatment of intractable ipsilateral shoulder pain following an open pancreaticoduodenectomy with transnasal sphenopalatine ganglion block.
  • ||||||||||  lidocaine topical / Generic mfg.
    Preclinical, Journal:  Focused ultrasound enhances the anesthetic effects of topical lidocaine in rats. (Pubmed Central) -  Jan 13, 2022   
    This is the first report of a successful treatment of intractable ipsilateral shoulder pain following an open pancreaticoduodenectomy with transnasal sphenopalatine ganglion block. Unbinding lidocaine from the plasma proteins by exposure to non-thermal low-intensity ultrasound is attributed as the main mechanism behind the observation.
  • ||||||||||  lidocaine topical / Generic mfg.
    Clinical, Observational data, Journal:  5% Lidocaine Hydrochloride Cream for Wound Pain Relief: A Multicentre Observational Study. (Pubmed Central) -  Jan 1, 2022   
    Thus, mesh nebulizers may be a faster way of nebulization before flexible bronchoscopy as an alternative to jet nebulizers. The treatment of painful wounds with 5% Lidocaine Cream for 14 days resulted in reduced pain intensity, and showed high safety and tolerability.
  • ||||||||||  lidocaine topical / Generic mfg.
    Retrospective data, Review, Journal:  Efficacy of topical tranexamic acid in epistaxis: A systematic review and meta-analysis. (Pubmed Central) -  Dec 31, 2021   
    The treatment of painful wounds with 5% Lidocaine Cream for 14 days resulted in reduced pain intensity, and showed high safety and tolerability. Topical TXA is associated with better bleeding cessation rates after treatment compared to the standard practices.
  • ||||||||||  PERIANAL PSEUDOVERRUCOUS PAPULES AND NODULES PRESENTING AS SUSPECTED CHILD ABUSE. (Promenade Lobby (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_583;    
    The subject was then prescribed topical mupirocin, bacitracin, lidocaine, and oral Keflex at multiple outside ED visits...Patient was discharged on hydrocortisone, ketoconazole, and zinc oxide for four months with significant improvement of lesions...The mainstay of treatment targets the inciting factors, including diaper use, encopresis, and colostomy bag. Therapy should be aimed to restore the skin barrier, eliminate any source of irritations, and treat superimposed infections.
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Episcleral venous pressure response to brain stem stimulation: Effect of topical lidocaine. (Pubmed Central) -  Dec 17, 2021   
    The present data suggest that distinct neuronal mechanisms controlling the episcleral circulation of rats exist. This is in keeping with previous reports of two distinct arterio-venous anastomoses, one in the limbal circulation and one in the conjunctival/episcleral circulation.
  • ||||||||||  Qutenza (capsaicin) / Grunenthal, LTS Lohmann Therapy Systems
    Journal:  Localized neuropathic pain. (Pubmed Central) -  Dec 16, 2021   
    Topical treatments are included as part of second-line strategies in the Canadian Pain Society guidelines. Despite the lack of guidelines, 5 % lidocaine patches and 8 % capsaicin patches have been proven effective in LNP models.
  • ||||||||||  lidocaine topical / Generic mfg.
    Preclinical, Journal:  Assessment of Drug Delivery Kinetics to Epidermal Targets In Vivo. (Pubmed Central) -  Dec 1, 2021   
    A significantly higher delivery of lidocaine from the cream than from the patch was found. The different input rates between drugs and formulations in vivo were confirmed qualitatively and quantitatively in vitro in conventional diffusion cells using dermatomed abdominal pig skin.
  • ||||||||||  lidocaine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  LULU: Lessons on Urethral Lidocaine in Urodynamics (clinicaltrials.gov) -  Nov 30, 2021   
    P4,  N=70, Recruiting, 
    The different input rates between drugs and formulations in vivo were confirmed qualitatively and quantitatively in vitro in conventional diffusion cells using dermatomed abdominal pig skin. Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Oct 2021 --> Oct 2022
  • ||||||||||  lidocaine topical / Generic mfg.
    Journal:  Evaluation of eutectic lidocaine/prilocaine cream for jugular blood sampling in cats. (Pubmed Central) -  Nov 29, 2021   
    The present study provides evidence for the efficacy of the EMLA cream after a 30-min application time for jugular venepuncture in cats, together with significantly reduced stress for patients. Therefore, this study supports the routine use of EMLA cream as good practice to enhance the welfare of cats and to simplify venepuncture procedures.
  • ||||||||||  ketamine / Generic mfg., lidocaine topical / Generic mfg.
    Journal:  Evaluation of the time to desensitization of the larynx of cats following topical lidocaine application. (Pubmed Central) -  Nov 29, 2021   
    Therefore, this study supports the routine use of EMLA cream as good practice to enhance the welfare of cats and to simplify venepuncture procedures. As the lowest overall reactivity score occurred at T45, it is recommended to wait at least 45 s after application of topical lidocaine before attempting tracheal intubation.