etevritamab (AMG 596) / Amgen 
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  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial termination, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Oct 29, 2024   
    P1,  N=30, Terminated, 
    Completed --> Terminated; Amgen business decision
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial completion, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Oct 5, 2021   
    P1,  N=30, Completed, 
    Together, these data show a compelling preclinical efficacy and safety profile of AMG 596, supporting its development as a novel immune therapy for treatment of GBM. Active, not recruiting --> Completed
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Aug 18, 2021   
    P1,  N=30, Active, not recruiting, 
    Active, not recruiting --> Completed Trial primary completion date: Dec 2021 --> Jul 2021
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Dec 11, 2020   
    P1,  N=30, Active, not recruiting, 
    Trial primary completion date: Dec 2021 --> Jul 2021 Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: Mar 2021 --> Dec 2021
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Jul 8, 2020   
    P1,  N=30, Active, not recruiting, 
    Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: Mar 2021 --> Dec 2021 Recruiting --> Active, not recruiting | N=200 --> 30 | Trial completion date: Sep 2024 --> Jun 2021 | Trial primary completion date: Feb 2024 --> Mar 2021
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Enrollment change, Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Feb 23, 2020   
    P1,  N=200, Recruiting, 
    Recruiting --> Active, not recruiting | N=200 --> 30 | Trial completion date: Sep 2024 --> Jun 2021 | Trial primary completion date: Feb 2024 --> Mar 2021 N=82 --> 200 | Trial primary completion date: Aug 2024 --> Feb 2024
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Dec 3, 2019   
    P1,  N=82, Recruiting, 
    N=82 --> 200 | Trial primary completion date: Aug 2024 --> Feb 2024 Trial completion date: Jun 2022 --> Aug 2024 | Trial primary completion date: Jun 2022 --> Aug 2024
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Aug 14, 2019   
    P1,  N=82, Recruiting, 
    NCT03296696. Trial completion date: Apr 2021 --> Jun 2022 | Trial primary completion date: Apr 2021 --> Jun 2022
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Trial initiation date, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Mar 3, 2018   
    P1,  N=82, Recruiting, 
    Trial completion date: Apr 2021 --> Jun 2022 | Trial primary completion date: Apr 2021 --> Jun 2022 Initiation date: Feb 2018 --> Mar 2018
  • ||||||||||  zeluvalimab (AMG 404) / Amgen, etevritamab (AMG 596) / Amgen
    Enrollment open, Combination therapy, Monotherapy:  Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma (clinicaltrials.gov) -  Oct 23, 2017   
    P1,  N=82, Recruiting, 
    Initiation date: Feb 2018 --> Mar 2018 Not yet recruiting --> Recruiting