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- |||| psilocybin (COMP360) / Compass Pathways
Clinical: Synthetic #psilocybin reduced depression severity for patients with major depressive disorder, reported Alan K. Davis, PhD, of the @JHPsychedelics, in @JAMAPsych. By @hlavinka_e, @MedPagePsych. W/comment from @CFReynolds3MD. #medtwitter https://t.co/fa4aaDzVsa (Twitter) - Nov 8, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical, Interview: I was interviewed by Business Insider about our new randomized clinical trial showing large effects for #psilocybin in treating depression. https://t.co/rVFljCWhQv (Twitter) - Nov 8, 2020
- || psilocybin (COMP360) / Compass Pathways
Clinical, Journal: Subjective features of the psilocybin experience that may account for its self-administration by humans: a double-blind comparison of psilocybin and dextromethorphan. (Pubmed Central) - Nov 6, 2020
This analysis provides new information about domains of psilocybin subjective effects proposed to be related to its reinforcing effects (alternatively described as the "motivation" to use). Observed differences on these domains between psilocybin and DXM are consistent with the relative rates of non-medical use of psilocybin and DXM.
- ||| psilocybin (COMP360) / Compass Pathways
Interview: I was interviewed about the Oregon #psilocybin therapy initiative which passed by a large margin. In the same story my colleague @BryonAdinoff provided insights about the expansion of cannabis regulation to new states. Big election for drug policy reform! https://t.co/hkwKMDZ3N6 (Twitter) - Nov 6, 2020
- || psilocybin (COMP360) / Compass Pathways
Clinical, Journal: Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study. (Pubmed Central) - Nov 6, 2020
P1
Groups may be an effective and efficient means of delivering psychotherapy pre- and post-psilocybin to patients with complex medical and psychiatric needs. Carey Turnbull, Heffter Research Institute, NIMH R25 MH060482, NIH UL1 TR001872, River Styx Foundation, Saisei Foundation, Sarlo Foundation, Stupski Foundation, Usona Institute, US Department of Veterans Affairs (Advanced Neurosciences Fellowship and IK2CX001495).
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: Finally encouraged lead author to get on Twitter 🙏 #GDS most recent collab b/w @JEC_Anthony (@Cambridge_Uni) @ProfDavidNutt (@imperialcollege) @GlobalDrugSurvy (@ucl) and me (@UQMedicine @UQ_News @UQ_CHSR ). Timely given psilocybin now legal in Oregon https://t.co/jgwrmm19uF (Twitter) - Nov 5, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Rigorous Study Backs A Psychedelic Treatment For Major Depression (via @NPR) @FredBarrettPhD @n_sepeda @Drug_Researcher @p_fi @CFReynolds3MD @JHPsychedelics @HopkinsMedNews @HopkinsMedicine #psilocybin #psychedelics #depression https://t.co/dWKPgdUuHD (Twitter) - Nov 5, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Our piece on the ethics of psychedelic therapy was published today in Scientific American! With @ExistWell. Perfect timing with publication of our #psilocybin study showing big results in depression & passage of the psilocybin therapy initiative in Oregon https://t.co/RL3PxfHrz3 (Twitter) - Nov 5, 2020
- |||| psilocybin (COMP360) / Compass Pathways
La psilocybine traite la dépression. Après les kétamines, les champi hallucinogènes ! Les psychiatres sont quand même beaucoup plus rigolos que les épidémiologiques, les infectiologues et peut-être même que certains chirurgiens 😂😂 @APHP @laurentKarila https://t.co/llZLtwJA9a (Twitter) - Nov 5, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Michael Polan. How to Change Your Mind explains the unjustified banning by US fed gov of psilocybin. An extremely effective plant based cure for depression. (Twitter) - Nov 5, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical: A rigorous study found that "psilocybin-assisted therapy was efficacious in producing large, rapid, and sustained antidepressant effects in patients with major depressive disorder." #psychedelic #psychedelicmedicine @npr @Drug_Researcher https://t.co/CaIOko5Ctt (Twitter) - Nov 5, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: Hey, OR is allowing therapeutic use of psilocybin. Means we can study it for efficacy now! RCTs here we go! (Twitter) - Nov 4, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical: #amazing outcome; well done. We've recently published an exploratory paper in Drug Science, Policy & Law- Jesse Anthony @ProfDavidNutt @GlobalDrugSurvy @JasonFerris22 on #psilocybin / #psychedelics & colourblindness. Perhaps a question in your future work? https://t.co/28QduLstW7 (Twitter) - Nov 4, 2020
- ||| psilocybin (COMP360) / Compass Pathways
#Psilocybin Effective For Major Depression https://t.co/7V5CMzlPLF (Twitter) - Nov 4, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical: We just published the 1st randomized study of #psilocybin for major depressive disorder. Over two thirds had clinically significant response & over half were in remission at follow up visits. Effect sizes met the definition of "huge" (Cohen's d=2 for stats nerds) or much larger. (Twitter) - Nov 4, 2020
- ||||| psilocybin (COMP360) / Compass Pathways
Clinical: The question: Is psilocybin-assisted therapy efficacious among patients with major depressive disorder? @JHPsychedelics has shone light on the topic with their recent publication in @JAMAPsych. @FredBarrettPhD @Drug_Researcher @p_fi @rrg1 Read more: https://t.co/zo1fJmaFdk (Twitter) - Nov 4, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical: Exciting new publication from @JHPsychedelics @Drug_Researcher in @JAMAPsych. Large, rapid antidepressant effect of 2 x #Psilocybin + Psychotherapy-sessions Randomized waiting-list controlled trial, n=24, blinded clinician-rated depression severity. https://t.co/Hi9KnqCRPY (Twitter) - Nov 4, 2020
- |||| psilocybin (COMP360) / Compass Pathways
Clinical: Proud to co-author the 1st randomized controlled trial showing rapid (1 day) and sustained (1 month) antidepressant FX of psilocybin in patients with major depressive disorder, w/ Davis, May, Sepeda, Cosimano, @Drug_Researcher @p_fi @rrg1 https://t.co/tYMR171bQj (Twitter) - Nov 4, 2020
- || psilocybin (COMP360) / Compass Pathways
I took all sorts of psychedelics for years, but still fail to score more than 1 or 2 out of about 25 on the Ishihara test I’ll be interested to try it on my next psilocybin trip... I’ll keep you posted (Twitter) - Nov 4, 2020
- || psilocybin (COMP360) / Compass Pathways
📊 #PsychedelicResearch 📉 Up to date review of modern #LSD, #psilocybin & #ayahuasca studies. Hat tip to Kristoff Anderson, David Erritzoe, @ProfDavidNutt & @RCarhartHarris Published Oct 30, 2020: https://t.co/7iG3aex7pz (Twitter) - Nov 3, 2020
- || psilocybin (COMP360) / Compass Pathways
Clinical, Journal: Microdosing psychedelics: Motivations, subjective effects and harm reduction. (Pubmed Central) - Nov 2, 2020
Recent findings from clinical trials with standard psychedelic doses for depression and anxiety suggest that a neurobiological effect beyond placebo is not unreasonable. Randomised controlled trials are needed, complemented by mixed methods social science research and the development of novel resources on microdosing harm reduction.
- | psilocybin (COMP360) / Compass Pathways
Journal: Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis. (Pubmed Central) - Nov 1, 2020
The stipes contained approximately half the amount of tryptamine alkaloids (0.52 wt.%) than the caps (1.03 wt.%); however, these results were not statistically significant, as the concentration of tryptamines in individual fruiting bodies is highly variable. The storage conditions showed that the highest degradation of tryptamines was seen in fresh mushrooms stored at -80°C and the lowest decay was seen in dried biomass stored in the dark at room temperature.
- || psilocybin (COMP360) / Compass Pathways
Escitalopram muted my senses and made me soulless Psilocybin opened me up ..made me feel and has changed my life. 🍄 (Twitter) - Oct 28, 2020
- || psilocybin (COMP360) / Compass Pathways
Can you give us a hint? Psilocybin right? 🤫 (Twitter) - Oct 28, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Off to @ProfDavidNutt’s house about 12 years after last there where we met ahead of our v first ethics meeting for a psychedelic research study (psilocybin fmri). Today we meet to discuss our psilocybin vs escitalopram for depression trial results and finalise our report. (Twitter) - Oct 28, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Prof. Matthew Johnson (@Drug_Researcher) is paving the way for psilocybin-assisted therapy to address one of the most damaging social burdens of modern society - drug addiction. Check out more in this podcast from @Drug_Science. #psilocybin #psychotherapy https://t.co/c7dMhfEwsQ (Twitter) - Oct 25, 2020
- || psilocybin (COMP360) / Compass Pathways
MDMA therapy - that's a possibility. But the idea of giving psilocybin or ayahuasca to any politician with access to the nuclear football is frightening. Seen too many sessions. 😳 (Twitter) - Oct 24, 2020
- | psilocybin (COMP360) / Compass Pathways
Journal: Psychedelic Psychiatry's Brave New World. (Pubmed Central) - Oct 21, 2020
After a legally mandated, decades-long global arrest of research on psychedelic drugs, investigation of psychedelics in the context of psychiatric disorders is yielding exciting results. Outcomes of neuroscience and clinical research into 5-Hydroxytryptamine 2A (5-HT2A) receptor agonists, such as psilocybin, show promise for addressing a range of serious disorders, including depression and addiction.
- | psilocybin (COMP360) / Compass Pathways
Journal: Psilocybin-assisted group therapy: A new hope for demoralization. (Pubmed Central) - Oct 19, 2020
Outcomes of neuroscience and clinical research into 5-Hydroxytryptamine 2A (5-HT2A) receptor agonists, such as psilocybin, show promise for addressing a range of serious disorders, including depression and addiction. No abstract available
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: What ever happened to the screenshot of your e-mail to @andyreports @PsilocybinAlpha? It was a great summary of not only the issues in the reporting, but also of the current state of play regarding for-profit #psycheedleicscience #clinicaltrial status. (Twitter) - Oct 16, 2020
- || psilocybin (COMP360) / Compass Pathways
Clinical, Journal: Increased use of illicit drugs in a Dutch cluster headache population. (Pubmed Central) - Oct 16, 2020
Conclusion In the Netherlands, people with cluster headache use illicit drugs more often than the general population. The question remains whether this is due to an actual alleviatory effect, placebo response, conviction, or common pathophysiological background between cluster headache and addictive behaviours such as drug use.
- | psilocybin (COMP360) / Compass Pathways
Journal: What Psilocybin Taught Me About Dying. (Pubmed Central) - Oct 16, 2020
The question remains whether this is due to an actual alleviatory effect, placebo response, conviction, or common pathophysiological background between cluster headache and addictive behaviours such as drug use. No abstract available
- || psilocybin (COMP360) / Compass Pathways
To elaborate, why does such a thing exist in nature? I almost get Ophiocordyceps unilateralis vibes from it. There has been other research suggesting that psilocybin consumed by insects alters *their* minds as well--but as a hunger suppressant... https://t.co/ezbV2rJMSZ (Twitter) - Oct 16, 2020
- || psilocybin (COMP360) / Compass Pathways
Wow. This is a seriously strong scientific advisory board; with world-leading representatives from the fields of ketamine, psilocybin & MDMA therapies. All of them overseen by Prof Nutt. The future for medicine has AWAKN @ProfDavidNutt @Drug_Researcher @MAPS @JHPsychedelics (Twitter) - Oct 15, 2020
- || psilocybin (COMP360) / Compass Pathways
psilocybin is perhaps not the best substance to challenge bedrock beliefs. I've tried it several times but never had "breakthrough" experience. however, after two tabs of LSD, I believe I encountered what people call "god." (Twitter) - Oct 13, 2020
- || psilocybin (COMP360) / Compass Pathways
Could you elaborate more on the “God” survey group? Was this the clergy psilocybin study group? (Twitter) - Oct 12, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: Hmm... here's a question. What if someone is intolerant and full of hate, but slipped a dose of psilocybin against their knowledge or consent to change? Is there potential for that subject to become further cemented into their hateful ideology and now be *certain* it's correct? (Twitter) - Oct 12, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: One is that such effects e.g. increasing belief in God, have been overstated, even by researchers. I’ve seen hundreds of #psilocybin sessions & people come out basically where they started. Our "God" survey was not a population study but a targeted, perhaps very extreme, group. (Twitter) - Oct 12, 2020
- | psilocybin (COMP360) / Compass Pathways
Trial initiation date: The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. (clinicaltrials.gov) - Oct 12, 2020
P2, N=12, Not yet recruiting, Sponsor: Sheppard Pratt Health System
No abstract available Initiation date: Jul 2020 --> Nov 2020
- | psilocybin (COMP360) / Compass Pathways
Trial initiation date: An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) (clinicaltrials.gov) - Oct 12, 2020
P2, N=15, Not yet recruiting, Sponsor: Sheppard Pratt Health System
Initiation date: Jul 2020 --> Nov 2020 Initiation date: Jul 2020 --> Nov 2020
- ||| psilocybin (COMP360) / Compass Pathways
Some budget pressures due to grant disappointment: Any mental health professionals interested in volunteering for our psychedelic research at Imperial? Psilocybin for chronic pain, anorexia, DMT research... @ProfDavidNutt DM me. (Twitter) - Oct 9, 2020
- || psilocybin (COMP360) / Compass Pathways
Good point. But what about structurally? There is evidence that thickness of the rostral anterior cortex predicts emotional response to psilocybin. Might there be structural differences in very experienced psychedelic users? https://t.co/7auaHlQkrE (Twitter) - Oct 6, 2020
- || psilocybin (COMP360) / Compass Pathways
“Psilocybin is able to get to the underlying roots of disorders rather than treating symptoms.” - @Drug_Researcher (Twitter) - Oct 5, 2020
- ||| psilocybin (COMP360) / Compass Pathways
What I find odd is that a scientist is talking about the potential harms of psilocybin without saying anything about how those harms compare to other drugs (@ProfDavidNutt 's chart below). That smacks of unscientific, evidence-free, special-interest-driven, drug policy. (Twitter) - Oct 5, 2020
- || psilocybin (COMP360) / Compass Pathways
I only ask because we're wanting to use this atlas for our psilocybin research (for consistency's sake) and it's got me baffled, I also found that the ROIs from the Bioimagesuite do not line up with the ROIs from that NITRC download page (Twitter) - Oct 5, 2020
- || psilocybin (COMP360) / Compass Pathways
Regardless, there are a number of other inaccuracies in the piece which have been nicely summarised in the email to Andy from @PsilocybinAlpha in this thread. If this were an Australian media outlet we would have escalated this to @TheRealPBarry from @ABCmediawatch by now. (Twitter) - Oct 3, 2020
- || psilocybin (COMP360) / Compass Pathways
Definitely read the entire thread of comments by @ManojDoss under his original tweet. The good doctor provides a hardcore but easily understood breakdown of the major points. The paper has wide ranging implications for psychedelic neuroscience, including #psilocybin mechanism. (Twitter) - Oct 3, 2020
- || psilocybin (COMP360) / Compass Pathways
It would seem that if one has any queries they should email the journalist directly. @D__Nickles has taken him up on the offer. Also @PsilocybinAlpha has stepped in. All very odd 🤔 https://t.co/b0mMRvkuzh (Twitter) - Oct 3, 2020
- || psilocybin (COMP360) / Compass Pathways
Whats the data on Psilocybin when mushrooms where openly sold in hedshops in the uk ? Im pretty sure the uk didn't fall into chaos or anything bad happened to society. (Twitter) - Oct 3, 2020
- ||| psilocybin (COMP360) / Compass Pathways
Clinical: There is so much data on this subject. Psilocybin is very low toxicity compared to most other recreational drugs. (Twitter) - Oct 2, 2020