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26 Diseases |  |
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7 Trials |  |
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- || icosapent ethyl / Generic mfg., Epanova (eicosapentaenoic acid/docosahexaenoic acid) / AstraZeneca, omega-3 ethylester concentrate / Generic mfg.
Epanova is carboxylic acid which may have been an issue. I think your 2:2 mineral oil vs corn oil and 4g of Vascepa vs 4g of Lovaza (EPA/DHA Ethyl Esters) would answer the question. (Twitter) - Jun 29, 2022
- ||| icosapent ethyl / Generic mfg., Epanova (eicosapentaenoic acid/docosahexaenoic acid) / AstraZeneca
Clinical: What are your thoughts on the comparator placebo in the strength trial? https://t.co/DWDC8I4c4V Should we do a 2:2 trial of Corn oil Vs Mineral oil and Vascepa Vs Epanova @DLBHATTMD Vs @ProfSNicholls 🧐😉😜. Please post thoughts to @hmkyale @ethanjweiss great thread 👍 (Twitter) - Jun 29, 2022
- ||| icosapent ethyl / Generic mfg.
Seems a lot. Among those allocated to mineral oil, median % increases after 12 mos ranged between 10-30% for LDL cholesterol, oxidized LDL, interleukin‐6, lipoprotein-associated phospholipase A2, high-sensitivity CRP, and interleukin‐1beta. Not seen in icosapent ethyl group. (Twitter) - Jun 29, 2022
- ||| icosapent ethyl / Generic mfg.
Biomarker, Clinical: They also write: 'Resolution of this controversy can only be addressed formally by undertaking biomarker trial randomly allocating patients to pharmaceutical grade mineral oil and a fully neutral placebo or by a second icosapent ethyl trial using a non–mineral oil comparator.' (Twitter) - Jun 29, 2022
- || aspirin / Generic mfg., icosapent ethyl / Generic mfg., ibuprofen / Generic mfg.
I do like Vascepa. I wonder why this safe drug isn’t available without a prescription? Not a dietary supplement but over the counter? It’s a lot safer than aspirin and ibuprofen yet this is more beneficial and safer? (Twitter) - Jun 28, 2022
- |||| icosapent ethyl / Generic mfg.
FDA event: I would say to try VASCEPA® (icosapent ethyl). It has been well-studied and approved by the FDA as an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, and coronary revascularization. https://t.co/VfaBxQ1tMg (Twitter) - Jun 27, 2022
- || atorvastatin / Generic mfg., ezetimibe / Generic mfg., icosapent ethyl / Generic mfg.
Let’s make this simple: What is the ultimate goals for Lipid Lowering therapies? To prevent or reduce the risk of a MACE. LDL-C lowering is the primary defense. The Lower the better. Same with TG’s. Lipitor +ezetimibe + VASCEPA = 65-70% RRR for MACE (Twitter) - Jun 26, 2022
- ||| icosapent ethyl / Generic mfg.
Clinical: Yes you must add Vascepa, the real Vascepa to the patients medication. (Twitter) - Jun 26, 2022
- || ezetimibe / Generic mfg., icosapent ethyl / Generic mfg.
ezetimibe + VASCEPA (Twitter) - Jun 26, 2022
- ||||| icosapent ethyl / Generic mfg.
Clinical: 💥 VASCEPA 4000 mg 💥 Statin 20 mg 💥 Zinc 30 mg 💥 Vit C 1000 mg 💥 Vit D 5000 iu 💥 no added sugars 💥 no processed food 💥🏋♂️🏃♂️ #healthy #healthylifestyle #HealthyLiving #CardioTwitter #Cardiology @DLBHATTMD @VietHeartPA @SABOURETCardio @American_Heart @NBSaphierMD (Twitter) - Jun 26, 2022
- | icosapent ethyl / Generic mfg.
Journal: N-3 polyunsaturated fatty acids for cardiovascular risk. (Pubmed Central) - Jun 25, 2022
Additionally, both trials showed an increase in the incidence of atrial fibrillation. With the unclear benefit of OM3FA supplementation and possibility of harm, the current data suggest that the risk of routine use of OM3FA outweighs the possibility of reduction in risk of cardiovascular events.
- || icosapent ethyl / Generic mfg.
@DLBHATTMD any update on Dr. Preston’s testing of fake Vascepa vs the real Vascepa? Would love to know if it really is inferior to the proven and tested V. @ra_fun @Amarincorp (Twitter) - Jun 25, 2022
- || Parmodia (pemafibrate) / Kowa
Review, Journal: New therapeutic approaches for the treatment of hypertriglyceridemia. (Pubmed Central) - Jun 22, 2022
Apolipoprotein C-III and ANGPTL3 protein seem to be quite promising targets based on solid genetic data. Larger studies of long duration, many of them currently ongoing, are needed to establish the role these medications will play in the treatment of hypertriglyceridemia in clinical practice.
- | icosapent ethyl / Generic mfg.
Journal: Vascepa patents under legal scrutiny. (Pubmed Central) - Jun 22, 2022
Larger studies of long duration, many of them currently ongoing, are needed to establish the role these medications will play in the treatment of hypertriglyceridemia in clinical practice. No abstract available
- ||| icosapent ethyl / Generic mfg.
Review: 2/2 For now, an amateur review is what is available. Amarin management says Vascepa's molecule is fragile, & they have proprietary manufacturing technology. Oxidation is highly undesirable. https://t.co/9YoSND77aO Fishy smell is consistent with oxidation https://t.co/V70xa8sKjj (Twitter) - Jun 22, 2022
- ||| icosapent ethyl / Generic mfg.
Video: 1/2 I hesitate to mention this unverified non-scientific video report that a generic had earlier expiration date than genuine Vascepa (Sept 2022 vs Feb 2024) & a fishy smell Vascepa didn’t have, consistent with undesirable partial oxidation (spoilage). https://t.co/v7xjda7166 (Twitter) - Jun 22, 2022
- || icosapent ethyl / Generic mfg.
Any issues with icosapent ethyl generic? @DLBHATTMD @BudoffMd @SABOURETCardio (Twitter) - Jun 20, 2022
- ||| icosapent ethyl / Generic mfg.
Clinical: Good to see. Supported by JELIS, a randomized trial that also showed benefit of icosapent ethyl, esp. in secondary prevention pts, two important angiographic trials, and mechanistic studies as noted in Arterioscler Thromb Vasc Biol. 2020;40:1135–1147. Latter paper worth reading. (Twitter) - Jun 18, 2022
- ||| icosapent ethyl / Generic mfg.
NICE endorses icosapent ethyl to prevent #heartattack and #stroke based on data from REDUCE-IT. #cardiotwitter #cardiology #prevention @gabrielsteg @mmillermd1 @CBallantyneMD @CMichaelGibson @rgiugliano @BudoffMd @payalkohlimd @webmd11 https://t.co/SwHE5h4XzD (Twitter) - Jun 18, 2022
- || icosapent ethyl / Generic mfg.
Congrats @DLBHATTMD, well deserved! Cue them in on how valuable of an asset Vascepa may be to their arsenal 😉 https://t.co/gEUr6geXiR (Twitter) - Jun 15, 2022
- icosapent ethyl / Generic mfg.
Icosapent Ethyl diminishes CVD risk in smokers: REDUCE-IT smoking (Science Box 3) - Jun 15, 2022 - Abstract #ESC2022ESC_3255;
In the REDUCE-IT study, IPE treatment significantly reduced the risk of CV events in current and former smokers to levels observed in never smokers. While smoking cessation should always be recommended, these data raise the possibility that IPE treatment may markedly attenuate the CV hazards attributable to smoking.
- icosapent ethyl / Generic mfg.
Cost-effectiveness of icosapent ethyl for primary and secondary cardiovascular prevention in the UK (Research Gateway 10) - Jun 15, 2022 - Abstract #ESC2022ESC_1701;
While smoking cessation should always be recommended, these data raise the possibility that IPE treatment may markedly attenuate the CV hazards attributable to smoking. Icosapent ethyl is cost-effective for primary and secondary cardiovascular prevention at an annual price of £2,064 in the UK.
- rivaroxaban / Generic mfg., icosapent ethyl / Generic mfg.
Sustained usage of an app-based clinical-decision making aid for the management of atherosclerotic cardiovascular disease (Research Gateway 10) - Jun 15, 2022 - Abstract #ESC2022ESC_300;
This tool demonstrates sustained usage among clinicians, as well as subjective utility in aiding therapeutic decision making. Future clinical research will focus on the ability of this tool to impact physician prescribing patterns and clinical outcomes.
- | icosapent ethyl / Generic mfg.
Journal: Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management. (Pubmed Central) - Jun 15, 2022
Triglyceride lowering via IPE may reduce the risk of developing T2D in populations of European ancestry. However, experimental validation using animal models is needed to substantiate our results and to motivate randomized control trials (RCTs) for IPE as putative treatment for T2D prevention.
- ||| icosapent ethyl / Generic mfg.
Clinical, Adverse events: Do you get paid out of my taxes to do your job? If so I want my money back. Vascepa is taken alongside statins and has side effects as per the attached images. Health Secretary, Death Secretary, or Drug Mule? (Twitter) - Jun 14, 2022
- |||| icosapent ethyl / Generic mfg.
#Vascepa #Vazkepa @Amarincorp @DLBHATTMD @VietHeartPA @American_Heart @ACCinTouch @mmillermd1 @KPHeartDoc #cardiovascular #CardioTwitter @SABOURETCardio $AMRN #AlexDenner @TerraPharma1 @BudoffMd #CVD (Twitter) - Jun 11, 2022
- || icosapent ethyl / Generic mfg.
In the REDUCE IT they use icosapent ethyl (IPE) 4 g per day, but in Italy we don't have formulation with IPE (i.e. Vascepa in the U.S.A.), we only have pills containing EPA 85% (Twitter) - Jun 11, 2022
- | icosapent ethyl / Generic mfg.
Actually Vascepa is safe. (Twitter) - Jun 11, 2022
- || icosapent ethyl / Generic mfg.
Review: Pankaj, please review the Re ude - It study showing the efficiency of Vazkepa. Cholesterol is only one element of the puzzle. (Twitter) - Jun 11, 2022
- |||| icosapent ethyl / Generic mfg.
NICE: More coverage of @NICEComms positive decision regarding icosapent ethyl Very much going to be an option to reduce cardiovascular events @DLBHATTMD @GoggleDocs @BritishCardioSo @SWBH_RandD @DrRaniKhatib https://t.co/6DYz8dWPtO (Twitter) - Jun 11, 2022
- | icosapent ethyl / Generic mfg.
$AMRN 'We have tremendous confidence in our multi-billion dollar revenue opportunity for VASCEPA/VAZKEPA globally...' - CEO https://t.co/OIaOk3rLYO (Twitter) - Jun 6, 2022
- ||| icosapent ethyl / Generic mfg.
Below are declining sales of Vascepa. @Amarincorp lost MARINE (TG reduction) patents and are still patent-protected for REDUCE-IT indication but as you can 👀 Generics are infringing. PS we don't even know if Generic Vascepa has the same biological properties as brand Vascepa (Twitter) - Jun 4, 2022
- ||| icosapent ethyl / Generic mfg.
How do you optimally identify candidates for aggressive lipid lowering beyond statins such as #IcosapentEthyl? @MaBMortensen shows CAC-> identify groups least likely (#PowerOfZero) and more importantly to derive highest benefit among those meeting REDUCE-IT criteria @DLBHATTMD (Twitter) - Jun 3, 2022
- icosapent ethyl / Generic mfg.
When, Why And How To Lower High Triglyceride Levels: Value Of Vascepa To Decrease Cardiac Risk In Vascular Patients: Based On The REDUCE-IT RCT (Grand Ballroom West, 3rd Floor) - Jun 2, 2022 - Abstract #VEITH2022VEITH_371;
- |||| icosapent ethyl / Generic mfg.
Trial completion date, Trial primary completion date: Efficacy of Ethyl Icosapentate in Patients With Severe Hypertriglyceridemia (clinicaltrials.gov) - Jun 1, 2022
P3, N=300, Recruiting, Sponsor: Mochida Pharmaceutical Company, Ltd.
However, experimental validation using animal models is needed to substantiate our results and to motivate randomized control trials (RCTs) for IPE as putative treatment for T2D prevention. Trial completion date: May 2022 --> Dec 2023 | Trial primary completion date: Mar 2022 --> Dec 2023
- | icosapent ethyl / Generic mfg.
Trial completion date: IPE-PREVENTION: The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk (clinicaltrials.gov) - Jun 1, 2022
P4, N=70, Recruiting, Sponsor: Canadian Medical and Surgical Knowledge Translation Research Group
Trial completion date: May 2022 --> Dec 2023 | Trial primary completion date: Mar 2022 --> Dec 2023 Trial completion date: Jul 2022 --> Nov 2022
- || icosapent ethyl / Generic mfg.
So Vascepa is now needed more than ever? (Twitter) - May 31, 2022
- || rivaroxaban / Generic mfg., icosapent ethyl / Generic mfg.
Review, Journal: Macrovascular Complications. (Pubmed Central) - May 29, 2022
For primary prevention, most individuals should be on statin therapy, whereas those at high atherosclerotic cardiovascular disease risk should also be on glucagon-like peptide 1 receptor agonists (GLP1RA) or sodium/glucose cotransporter-2 inhibitors (SGLT2i) at any hemoglobin A1c. For secondary prevention, addition of GLP1RA or SGLT2i, PCKS9i, rivaroxaban, and/or icosapent ethyl should be considered in addition to a statin and low-dose aspirin.
- icosapent ethyl / Generic mfg.
Analysis #4 – Icosapent Ethyl () - May 27, 2022 - Abstract #NLA2022NLA_6;
- ||| icosapent ethyl / Generic mfg.
Clinical: Yes, but how about if patients were given Vascepa from @Amarincorp (Twitter) - May 25, 2022
- ||| icosapent ethyl / Generic mfg.
An absolute privilege and honor to meet @DLBHATTMD at @SCAI 2022 Sessions as a med student! Congrats on MSCAI! Wonderful insight into mechanisms of Icosapent Ethyl. Make sure to read the latest on REDUCE-IT! #SCAI2022 #SCAI22 #CardioTwitter (Twitter) - May 22, 2022
- ||| icosapent ethyl / Generic mfg.
Thank you we need more and more cardiologist to spread the news on Vascepa. So many lives can be saved @CardioNerds, @CardiovascMed (Twitter) - May 19, 2022
- | icosapent ethyl / Generic mfg.
Journal: The potential population health impact of treating REDUCE-IT eligible US adults with Icosapent Ethyl. (Pubmed Central) - May 17, 2022
Treating all REDUCE-IT eligible US adults has substantial medication costs but could prevent a substantial number of ASCVD events and associated direct costs. Indirect cost savings by preventing events could outweigh much of the incurred direct costs.
- ||| icosapent ethyl / Generic mfg.
Clinical: We say that being Guyanese is a risk factor! There is deffinately a genetic prediliction along with the fact we* have smaller caliber coronary arteries. Think vascepa and statins are a treatment plan? (Twitter) - May 16, 2022
- ||| icosapent ethyl / Generic mfg., omega-3 ethylester concentrate / Generic mfg.
Clinical: Completely understand the scope of the presentation and I appreciate your work in this field - you are directly & positively impacting patients’ lives - frustrated by the lack of distinction between typical OTC blended fish oil pills, EPA/DHA blended Lovaza, and pure EPA Vascepa (Twitter) - May 16, 2022
- ||| icosapent ethyl / Generic mfg.
Clinical: Maintaining a healthy weight is incredibly important, maintaining a healthy diet is incredibly important, but the table ought to have an additional row showing the proven, significant impact of 100% EPA (highly purified, non-oxidized, and 0% DHA) #vascepa #vazkepa (Twitter) - May 16, 2022
- ||| icosapent ethyl / Generic mfg.
Two prominent politicians just suffered from stroke: US Senator Chris Van Hollen from MD & Lt Governor John Fetterman from PA. A wonder drug VASCEPA (brand, not generic) reduces the incident of stroke by ~30%. More folks need to take VASCEPA. @DLBHATTMD @VietHeartPA (Twitter) - May 16, 2022
- ||| icosapent ethyl / Generic mfg.
If there was a drug that reduced incident of stroke by ~30%. ***** VASCEPA ***** @DLBHATTMD @VietHeartPA @mmillermd1 @BudoffMd @Amarincorp (Twitter) - May 15, 2022
- || icosapent ethyl / Generic mfg.
Needed and needs Vascepa 👇 @DLBHATTMD @VietHeartPA @mmillermd1 @BudoffMd (Twitter) - May 15, 2022
- || Nexletol (bempedoic acid) / Esperion Therap, Otsuka
Review, Journal: Etiology and Management of Dyslipidemia in Patients With Cancer. (Pubmed Central) - May 14, 2022
The role of non-statin therapies, including ezetimibe, PCSK9 inhibitors, bempedoic acid and icosapent ethyl in the management of lipid disorders in patients with cancer remains largely unknown. A contemporary cancer patient needs a personalized comprehensive cardiovascular assessment, management of lipid abnormalities, and prevention of late CVD to achieve optimal overall outcomes.