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Review, Journal: EPA's pleiotropic mechanisms of action: a narrative review. (Pubmed Central) - Aug 13, 2021 Treatment with icosapent ethyl 4 g/day, a highly purified and stable ethyl ester of eicosapentaenoic acid (EPA), demonstrated a significant reduction in atherosclerotic cardiovascular disease (ASCVD) events and death in REDUCE-IT...Clinically, this may translate into improved vascular health, including regression of atherosclerotic plaque. Overall, EPA has a range of pleiotropic effects that contribute to a reduction in ASCVD.
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Journal: When to lower triglycerides? (Pubmed Central) - Aug 4, 2021 There is evidence for the benefits of IPE in preventing ASCVD events. A novel fibrate is in clinical trials.
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Enrollment closed, Preclinical, Trial completion date, Trial primary completion date: BRAVE-EPA: Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid (clinicaltrials.gov) - Jul 26, 2021 P2/3, N=150, Active, not recruiting, Consequently, purified EPA appears to be the treatment of choice for high-risk patients with hypertriglyceridemia. Recruiting --> Active, not recruiting | Trial completion date: Nov 2021 --> Jan 2023 | Trial primary completion date: Nov 2021 --> Jan 2023
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VASCEPA! (Twitter) - Jul 24, 2021
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