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26 Diseases |  |
7 Trials |
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7 Trials |  |
4331 News |  |
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- | colchicine / Generic mfg., icosapent ethyl / Generic mfg.
Journal: Optimal medical therapy after coronary artery bypass grafting: a primer for surgeons. (Pubmed Central) - Sep 23, 2021
We review the foundations of optimal medical therapy after CABG, and summarize recent advances with a focus on practical application for the busy cardiac surgeon.
- || icosapent ethyl / Generic mfg.
Clinical, Journal: The EVAPORATE trial provides important mechanistic data on plaque characteristics that have relevance to the REDUCE-IT results and clinical use of icosapent ethyl. (Pubmed Central) - Sep 22, 2021
We review the foundations of optimal medical therapy after CABG, and summarize recent advances with a focus on practical application for the busy cardiac surgeon. No abstract available
- | icosapent ethyl / Generic mfg.
Journal: Underlying mechanisms involved in the icosapent ethyl reduction of cardiovascular events still cannot be attributed to an anti-atherosclerotic effect. (Pubmed Central) - Sep 22, 2021
No abstract available No abstract available
- ||||||| icosapent ethyl / Generic mfg.
Trial completion: PREPARE-IT. Prevention and Treatment of COVID19 With EPA in Subjects at Risk - Intervention Trial (clinicaltrials.gov) - Sep 17, 2021
P3, N=4093, Completed, Sponsor: Estudios Clínicos Latino América
No abstract available Active, not recruiting --> Completed
- || icosapent ethyl / Generic mfg.
@amarincorp should be broadcasting this and NOT tweets about education. It's about #vacespa #vazkepa Do you know about this presentation? Here is some ulterior motive that they should explain some day. They can't be that fools (Twitter) - Sep 17, 2021
- ||| icosapent ethyl / Generic mfg.
The KEY of Prior MI @Amarincorp @DLBHATTMD @drpablocorral @VietHeartPA @ACCinTouch @society_eas #vacespa #vazkepa #ACC21 @ACCinTouch (Twitter) - Sep 17, 2021
- ||| icosapent ethyl / Generic mfg.
@Amarincorp @DLBHATTMD @drpablocorral the 10y INSPIRE Study by @VietHeartPA clearly shows that MACE Events are significantly reduced when the EPA/DHA r is>1 @ACCinTouch @society_eas #vacespa #vazkepa #ACC21 @ACCinTouch (Twitter) - Sep 17, 2021
- | icosapent ethyl / Generic mfg.
@Amarincorp #VAZKEPA should be there & invite Dr. Mason, Dr. Bhatt o Dr. Corral. Stay tunned 😆 (Twitter) - Sep 16, 2021
- || icosapent ethyl / Generic mfg.
Maybe a combo statins + EPA would maximize the benefits. @Amarincorp #vacespa #IPE #EPA #vazkepa (Twitter) - Sep 16, 2021
- | icosapent ethyl / Generic mfg.
Preclinical, Journal: Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120-mediated connexin43 phosphorylation. (Pubmed Central) - Sep 15, 2021
SIN-1 abolished the Cx43 phosphorylation of icosapent ethyl without affecting GPR120 levels. Taken together, chronic use of icosapent ethyl after infarction is associated with up-regulation of connexin43 phosphorylation through a GPR120-dependent antioxidant pathway and thus plays a beneficial effect on arrhythmogenic response to programmed electrical stimulation.
- | icosapent ethyl / Generic mfg.
Trial primary completion date: A PET Study With [11C]PBR-28 and an Experimental Medication, Ethyl Eicosapentaenoic Acid (clinicaltrials.gov) - Sep 13, 2021
P4, N=3, Recruiting, Sponsor: New York State Psychiatric Institute
Taken together, chronic use of icosapent ethyl after infarction is associated with up-regulation of connexin43 phosphorylation through a GPR120-dependent antioxidant pathway and thus plays a beneficial effect on arrhythmogenic response to programmed electrical stimulation. Trial primary completion date: Aug 2021 --> Jan 2022
- ||||| icosapent ethyl / Generic mfg.
Clinical: Beyond icosapent ethyl, @DLBHATTMD is the clinical trialist’s clinical trialist ☺️ - I am excited to see clinical cases presented on emerging novel therapies in #HFrEF #HF #HFSA2021 @VindicoMedEd @HFSA (Twitter) - Sep 12, 2021
- || icosapent ethyl / Generic mfg.
Will the transcript or abstract be published? Thank you for your work spreading EPA Maybe @Amarincorp should publicize much more these training webinars about the IPE / EPA and its product #vacespa and now in the EU #vazkepa (Twitter) - Sep 12, 2021
- ||||| icosapent ethyl / Generic mfg.
Starting shortly - Icosapent Ethyl and Omega-3 Fatty Acids in Cardiovascular Protection Webinar at 11:00AM - 3:15PM (ENG) Register at https://t.co/nKxlgMOwJn an Accredited Group Learning #medtwitter #CardioTwitter #EndotwitterSession @DLBHATTMD (Twitter) - Sep 11, 2021
- || icosapent ethyl / Generic mfg.
Clinical, Review, Journal: Mechanistic Insights from REDUCE-IT STRENGTHen the Case Against Triglyceride Lowering as a Strategy for Cardiovascular Disease Risk Reduction. (Pubmed Central) - Sep 11, 2021
However, new mechanistic insights are provided by the REDUCE-IT trial that used icosapent ethyl (IPE), a purified formulation of the n3-FA eicosapentaenoic acid...Benefits with IPE appear linked to broad pleiotropic actions associated with on-treatment EPA levels. These studies indicate that while TGs are a potential biomarker of cardiovascular risk, there is no evidence that TG-lowering itself is an effective strategy for reducing such risk.
- || Parmodia (pemafibrate) / Kowa
Review, Journal: Lipid Lowering Drugs: Present Status and Future Developments. (Pubmed Central) - Sep 10, 2021
For hypertriglyceridemia, cardiovascular benefit has been achieved by the use of icosapent ethyl, whereas results with pemafibrate, a selective agonist of PPAR-α, are eagerly awaited...Despite the demonstrated benefits of statins, a large number of patients still remain at significant risk because of inadequate LDL-C reduction or elevated blood triglyceride-rich lipoproteins or lipoprotein(a). The area of lipid modulating agents is still ripe with ideas and major novelties are to be awaited in the next few years.
- |||| icosapent ethyl / Generic mfg.
Review: Great review article by @MananPareekMD - Icosapent ethyl: safely reducing cardiovascular risk in adults with elevated triglycerides https://t.co/Ovox4nvcsD #cardiotwitter #cardiology #prevention (Twitter) - Sep 8, 2021
- icosapent ethyl / Generic mfg., fenofibrate / Generic mfg.
Successful and Rapid Correction of Severe Hypertriglyceridemia With Insulin in a Case of Hypertriglyceridemic Pancreatitis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1212;
Our case demonstrates the effectiveness of insulin in rapidly correcting TG levels within 48 hours and decreasing length of hospitalization. Therefore, our case supports the evolving role of insulin as a safe, readily available, and effective alternative for treatment of HTGP.
- | icosapent ethyl / Generic mfg.
Trial primary completion date: MITIGATE: A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults (clinicaltrials.gov) - Sep 8, 2021
P4, N=16500, Recruiting, Sponsor: Kaiser Permanente
Therefore, our case supports the evolving role of insulin as a safe, readily available, and effective alternative for treatment of HTGP. Trial primary completion date: Aug 2021 --> Feb 2022
- ||| icosapent ethyl / Generic mfg., fenofibrate / Generic mfg.
Recommending a substitution of #VASCEPA (a CVD & TG reducing drug) for #Fenofibrate (*only* a TG reducing drug)?! Shame on @RxSaving 💰 @TerraPharma1 @DLBHATTMD @mmillermd1 @VietHeartPA @drpablocorral @FDACommissioner @DrWoodcockFDA @ACCinTouch @American_Heart @AmDiabetesAssn (Twitter) - Sep 6, 2021
- || icosapent ethyl / Generic mfg., Epanova (eicosapentaenoic acid/docosahexaenoic acid) / AstraZeneca
Would this explain that with epanova, even if EPA blood levels were as high as with icosapent ethyl, the DHA in epanova would have had the differential effect on membranes, and thus potentially negating any benefit? (Twitter) - Sep 6, 2021
- || colchicine / Generic mfg., icosapent ethyl / Generic mfg.
Two Swings, Two Misses With Colchicine, Vascepa in COVID-19 https://t.co/XS9EDnoKrP #ESC21 (Twitter) - Sep 5, 2021
- | icosapent ethyl / Generic mfg.
Journal: Vazkepa - kardiovaskuläre Prävention : Einziges hoch dosiertes reines Eicosapentaensäure-Präparat. (Pubmed Central) - Sep 4, 2021
Trial primary completion date: Aug 2021 --> Feb 2022 No abstract available
- || icosapent ethyl / Generic mfg.
You are wrong, Pure EPA (VASCEPA) is a CVD drug and not just a TG lowering drug. I am guessing you are a doctor, hence I am suggesting (may be recommending) that you must read the REDUCE-IT trial details before sending loose comments which may degrade you.. Good luck.. (Twitter) - Sep 3, 2021
- ||||| icosapent ethyl / Generic mfg.
Clinical: No mention of the fact that the 15,000 pts in the control arm SHOULD ALREADY be on #Vascepa because it would reduce their risk of MACE by 25%. At study competition all 16,500 pts should be given IPE for their cardiovascular disease regardless of respiratory infections (Twitter) - Sep 2, 2021
- ||| icosapent ethyl / Generic mfg.
Hey @Amarincorp @amazon @amazonnews, The below 📸 isn't accurate. Vascepa has 2 indications: •to treat high TG (only 7% of Vascepa Rx) •to treat CVD (93% of Vascepa Rx) 🚨 AMAZON DOES NOT MENTION THE CVD INDICATION @DLBHATTMD @VietHeartPA @drpablocorral @mmillermd1 $AMRN (Twitter) - Sep 2, 2021
- ||| icosapent ethyl / Generic mfg.
Congrats & good work. Also congrats to @amarincorp @kpthrive for continuing to investigate the effects of IPE on Cov19, Ath, CVD & Upper Respiratory Tract Infections. #vacespa #vazkepa can be a game changer @ATHjournal @atherosociety @ESC_Journals (Twitter) - Sep 2, 2021
- || icosapent ethyl / Generic mfg.
Clinical, Journal: A Randomized Trial of Icosapent Ethyl in Ambulatory Patients with COVID-19. (Pubmed Central) - Sep 1, 2021
P2
Overall, this report provides evidence of an early anti-inflammatory effect of icosapent ethyl in a modest sample, including an initial well-tolerated loading dose, in symptomatic COVID-19 outpatients. ClinicalTrials.gov Identifier: NCT04412018.
- ||| colchicine / Generic mfg., icosapent ethyl / Generic mfg.
Two swings, two misses with colchicine, Vascepa in COVID-19. https://t.co/A87CfpQYd2 #ESCongress #ESC21 (Twitter) - Sep 1, 2021
- ||| icosapent ethyl / Generic mfg.
Journal, Adverse events: Icosapent Ethyl for Primary Versus Secondary Prevention of Major Adverse Cardiovascular Events in Hypertriglyceridemia-Value for Money Analysis. (Pubmed Central) - Sep 1, 2021
ClinicalTrials.gov Identifier: NCT04412018. Prioritizing IPE therapy for patients with an established CVD may provide significantly more value for money than primary prevention.
- | icosapent ethyl / Generic mfg.
Journal: Vascepa protects against high-fat diet-induced glucose intolerance, insulin resistance, and impaired β-cell function. (Pubmed Central) - Aug 31, 2021
Vascepa improved beta cell function, reduced liver triglycerides with enhanced expression of hepatic fatty acid oxidation genes, and altered microbiota composition. Vascepa has protective effects on diet-induced insulin resistance and glucose intolerance in mice.
- || icosapent ethyl / Generic mfg.
@Amarincorp how does the UK's announcement about the new heart drug Incliseren by @Novartis impact Vascepa? (Twitter) - Aug 31, 2021
- || icosapent ethyl / Generic mfg.
@DLBHATTMD Not sure if you can or want to answer... but if you were a king with an unlimited budget, which 1 study would you run with Icosapent Ethyl? (Twitter) - Aug 30, 2021
- ||| icosapent ethyl / Generic mfg.
"The results were consistent with the overall trial in terms of being positive with significant large reductions in the primary endpoint" @DLBHATTMD on data from REDUCE-IT PRIOR MI presented at #ESCCongress. https://t.co/9sZzAKkEon @Amarincorp #IcosapentEthyl (Twitter) - Aug 30, 2021
- || icosapent ethyl / Generic mfg.
Statin + #Vacespa #vazkepa combo. it should be very big (Twitter) - Aug 30, 2021
- ||| icosapent ethyl / Generic mfg.
CVD drug pure EPA as IPE #Vascepa has already shown stat sig reductions in Pt Covid symptoms, CRP and d-dimer levels in the CardioLink-9 trial by @DLBHATTMD presented at the NLA in Dec 2020 published by ACC. New 2000 pt trial results due in September https://t.co/277u0naURG (Twitter) - Aug 30, 2021
- |||| icosapent ethyl / Generic mfg.
#icosapentethyl is great for CV prevention, but does not prevent #SARSCoV2 infection. However, nice to learn that even 8g/day of IPE was well tolerated. #PREPAREIT at #ESCCongress2021 https://t.co/f9pBYL1r97 @DLBHATTMD @BudoffMd (Twitter) - Aug 29, 2021
- |||| icosapent ethyl / Generic mfg.
PREPARE-IT 1 : Icosapent ethyl did not prevent COVID19 #ESCCongress @escardio @ESC_Journals @DLBHATTMD @DrJennHaythe @PeterHotez @EricTopol @ErinMichos @MihaiTrofenciuc @CMichaelGibson @mmamas1973 @SilCastelletti @biljana_parapid @MeralKayikcoglu @lipiddoc @ProfKausikRay (Twitter) - Aug 29, 2021
- ||||| icosapent ethyl / Generic mfg.
Clinical: #ESCCongress #cardiotwitter Is Vascepa able to prevent #Covid_19 infection? The Prepare-it trial didn't show any difference from placebo in 1ary outcome, but raises the possibility that an 8-g dose can be safely used in the acute setting of an atherosclerotic CV event @DLBHATTMD (Twitter) - Aug 29, 2021
- ||| icosapent ethyl / Generic mfg.
$AMRN #VASCEPA @DLBHATTMD https://t.co/6QZXpeh8By (Twitter) - Aug 28, 2021
- |||| icosapent ethyl / Generic mfg.
Clinical: Results of Reduce-It study on patients with a history of PRIOR MI presented today by @DLBHATTMD at #ESCCongress were astonishing “Icosapent ethyl was associated with a 40% reduction in risk of sudden cardiac death and a 56% reduction in risk of cardiac arrest compared to placebo (Twitter) - Aug 28, 2021
- ||| icosapent ethyl / Generic mfg.
🚨🚨🚨 EPA > DHA > AA @TerraPharma1 @drpablocorral @DLBHATTMD @mmillermd1 @VietHeartPA $AMRN #VASCEPA #ESCCongress (Twitter) - Aug 28, 2021
- |||| icosapent ethyl / Generic mfg.
Clinical: Have a look at this #ESCAbstract on the #ESCCongress Research Gateway https://t.co/hqn95zQHAS # via @escardio @SCC_CCS Benefits outweigh risks in pts with Afib for treatment with #Vascepa @DLBHATTMD @RonBlankstein @DrMarthaGulati (Twitter) - Aug 28, 2021
- ||||| icosapent ethyl / Generic mfg.
Clinical: Collegial debate on Icosapent Ethyl at #ESC2021 w @CBallantyneMD & Michael Lincoff. Interesting take by discussant Chris Packard. Seemed skeptical mineral oil placebo accounted for REDUCE-IT. Pointed to studies by Mason and Tabas for EPA’s possible mechanism of benefit. (Twitter) - Aug 28, 2021
- || ezetimibe / Generic mfg., icosapent ethyl / Generic mfg.
Review, Journal: Preventing Diabetes and Atherosclerosis in the Cardiometabolic Syndrome. (Pubmed Central) - Aug 28, 2021
The residual risk of MACE in such a high-risk population can be further mitigated by treatment with an omega-3 fatty acid such as icosapent ethyl. Lifestyle modifications and the use of proven pharmacological therapies are essential for the prevention and progression of diabetes and ASCVD in those with the cardiometabolic syndrome.
- ||| icosapent ethyl / Generic mfg.
Clinical: ICYMI: "Patients with prior MI, and other patients who would have been eligible for REDUCE-IT based on triglyceride elevation, should be screened to see if they are appropriate candidates for icosapent ethyl” @DLBHATTMD @EndocrineToday #CardioTwitter https://t.co/83P81DLSqn (Twitter) - Aug 28, 2021
- || icosapent ethyl / Generic mfg.
The CHERRY trial (IVUS) and the EVAPORATE trial (CT angio) both found early, significant reductions in the rate of plaque progression with icosapent ethyl versus control (on a background of statins). (Twitter) - Aug 27, 2021
- ||||| icosapent ethyl / Generic mfg.
Clinical: Icosapent ethyl provides substantial CV risk reduction in the high-risk REDUCE-IT population #ESCCongress2021 @escardio @LaleTokgozoglu @doctormutlu @vaytekin @TKDsosyal @DLBHATTMD @ESCardioNews @ozlemyt @MeralKayikcoglu (Twitter) - Aug 27, 2021
- ||| icosapent ethyl / Generic mfg.
Not really. Discounts #REDUCEIT and #EVAPORATE supporting type of fish oil (EPA/Icosapent ethyl) @DLBHATTMD @BudoffMd #ESCCongress #CVprev (Twitter) - Aug 27, 2021
- |||| icosapent ethyl / Generic mfg.
Late-breaking abstract: Very interesting. The very successful #Vascepa Covid trial CARDIOLINK-9 was presented by @DLBHATTMD last December at the NLA as a “Late Breaking Trial” is now published online 3 days before @drpablocorral @ferbotto presentation of PREPARE-IT “Late Breaking Trial” at @escardio (Twitter) - Aug 27, 2021