- |||||||||| Journal, CAR T-Cell Therapy, IO biomarker: Effect of signal peptide optimized by site-directed mutagenesis on the function of chimeric antigen receptor T cells (Pubmed Central) - Feb 23, 2024
This study aimed to optimize the SP sequence by site-directed mutagenesis and investigate its impact on the killing function of CD19-CAR-T...In summary, this study revealed that increasing the N-terminal positive charge of the signal peptide can improve the expression efficiency of CAR and promote the killing of CD19+ target cells. These findings provide a scientific basis the optimization and clinical application of CAR structure.
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