||||||||||Q701 / Qurient Personalized circulating tumor DNA testing for recurrence detection and treatment response monitoring in patients with metastatic invasive lobular carcinoma (Hall 2-3) - Nov 4, 2023 - Abstract #SABCS2023SABCS_1835; At variant level, PIK3CA p.H1047R (22%) and RBM26 p.Q701Tfs*23 (10%) were the top two somatic variants identified...Conclusions ctDNA status and dynamics correlate well with clinical status of patients with mILC, as determined by conventional monitoring tools such as imaging and biopsy. Our results indicate that personalized, tumor-informed, longitudinal ctDNA testing may serve as a useful tool for detection of progression and monitoring treatment response in mILC patients.
||||||||||Q701 / Qurient Biomarker, Journal: Mutational analysis of residues in PriA and PriC affecting their ability to interact with SSB in Escherichia coli K-12. (Pubmed Central) - May 6, 2021 Here, we further studied the SSB-binding pockets of PriA and PriC by placing priA341(R697A), priA344(R697E), priA345(Q701E), and priC351(R155A) on the chromosome and characterizing the mutant strains...These phenotypes were partially suppressed by SSB overproduction. These studies give us further insight into the reactions needed for replication restart.