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Journal, IO Biomarker: Borrelia host adaptation Protein (BadP) is required for the colonization of a mammalian host by the agent of Lyme disease. (Pubmed Central) - Apr 11, 2019
...Immunoblot analysis of the badR mutants confirmed reduced levels of these enzymes, and one of these enzymes, encoded by bb0086, shares homology to prokaryotic magnesium chelatase and Lon-type proteases...However, badP mutants survived within dialysis membrane chambers (DMCs) implanted within rat peritoneal cavity but unlike the control strains did not display complete switching of OspA to OspC suggesting incomplete adaptation to mammalian phase of infection. These findings have opened a novel regulatory mechanism, which impacts the virulence potential of Bb.
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