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- | Undisclosed NOX2 activator / ProNoxis
Journal: Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-?B-Mediated inflammation via NRF2 signaling during urinary tract infections. (Pubmed Central) - Apr 11, 2025
Consistently, the absence of NOX2 (Cybb-/-) in mice led to uncontrolled bacterial infection associated with increased NF-?B signaling, heightened neutrophilic inflammation, and increased bladder pathology during cystitis. These findings underscore a dual role for neutrophil NOX2 in both eradicating UPEC and mitigating neutrophil-mediated inflammation in the urinary tract, revealing a previously unrecognized effector and regulatory mechanism in the control of UTI.