| Legalon (silibinin) / Viatris |
ChiCTR-TRC-14004857: Silibinin Capsules (Shui Linjia) for the prevention of tuberculosis drugs induced liver injury, randomized, multi center, opening clinical study |
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| Completed | 4 | 550 | | Silibinin capsule + anti tuberculosis drugs ;anti tuberculosis drugs only | Tongji University Affiliated Hospital of Shanghai City; Changchun City hospital for infectious diseases, TASLY | Tuberculosis | | | | |
2006-002099-16: The effect of milk thistle extract (Legalon) versus tea on serum iron increase after a meal containing non-haem iron in hereditary haemochromatosis |
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| Ongoing | 4 | 10 | Europe | Legalon 140 mg (Legalon forte), Madaus GmbH, Germany, Legalon 140 mg (Legalon Forte), Legalon 140 mg (Legalon Forte) | King\'s College London | Type 1 hereditary haemochromatosis is associated with homozygous inheritance of the C282Y mutation in the HFE gene. The phenotype is characterised by increased serum iron levels, tissue iron accumulation and may result in liver fibrosis, cirrhosis, and liver carcinomas. Treatment initially involves removal of one unit of blood per week to remove body iron burden, then removal of one unit of blood 2-6 times per year to prevent the re-accumualtion of iron stores. | | | | |
2012-001457-50: Intravenous Silimaryn in hepatitis C Liver Trasplantation Silimarina intravenosa en trasplante hepático |
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| Ongoing | 2 | 6 | Europe | LEGALON SIL, Solution for infusion, Legalon SIL | fUNDACIÓN iNVESTIGACIÓN HOSPITAL RAMÓN Y CAJAL, ISCIII | Patients transplanted for chronic liver disease or hepatocarcinoma relating to C virus being replicated at the time of the OLT (orthotopic liver transplantation). pacientes sometidos a trasplante hepático secundario a hepatocarcinoma por VHC, Patients transplanted for chronic liver disease and hepatitis C infection pacientes sometidos a trasplante hepatico con infección por el virus de la hepatitis C, Diseases [C] - Digestive System Diseases [C06] | | | | |
2005-002966-12: PHYSIOPATHOLOGY OF NONALCOHOLIC HEPATIC STEATOSIS AND EFFICACY OF SILYMARIN IN THE THERAPY OF NONALCOHOLIC HEPATIC STEATOSIS |
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| Ongoing | 2 | 100 | Europe | LEGALON-140*30 CPR RIV.140MG, LEGALON-140*30 CPR RIV.140MG | TRASTEC | Nonalcoholic hepatic steatosis | | | | |
2020-001794-77: Randomised clinical trial to test if silibinin administration can prevent the respiratory failure secondary to the COVID19 lung infection in oncologic patients. Ensayo clÃnico randomizado para evaluar si la silibinina puede prevenir el fallo respiratorio secvundario a la infección pulmonar por COVID19 en pacientes oncológicos |
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| Ongoing | 2 | 92 | Europe | Capsule, LEGALON | INSTITUT CATALÀ D'ONCOLOGIA GIRONA - HOSPITAL JOSEP TRUETA, Girona Biomedical Research Institute | COVID19 respiratory failure Fallo respiratorio por COVID19, COVID19 infection Infección por COVID19, Diseases [C] - Virus Diseases [C02] | | | | |
2020-005580-32: Pilot study on silibinin as a possible therapeutic agent for mildly ill COVID-19 patients |
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| Ongoing | 2 | 30 | Europe | Legalon SIL, Lyophilisate for solution for infusion, Legalon SIL | Medical University of Vienna, Medizinische Universität Wien | antiviral effect of silibinin against SARS-CoV2, antiviral effect of silibinin against SARS-CoV2, Diseases [C] - Virus Diseases [C02] | | | | |
NCT05051527: Study to Evaluate the Effectiveness of Legalon® |
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| Recruiting | N/A | 362 | RoW | Legalon® 140 mg | Mylan Inc., Meda Pharma S.p.A. | Non-alcoholic Fatty Liver Disease (NAFLD) | 07/23 | 07/23 | | |
NCT05069298: Effect of Silibinin(A) as a Potential Anti-obesity Agent |
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| Active, not recruiting | N/A | 60 | Europe | Silibinin A, Milk thistle derivative | Universidad Católica San Antonio de Murcia | Overweight and Obesity, Hypercholesterolemia, Hypertriglyceridemia | 12/23 | 12/23 | | |
NCT05497765: An Intervention Study of Compound Silymarin in Patients With Non-alcoholic Fatty Liver Disease |
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| Completed | N/A | 94 | RoW | Silibinin extract, mixed power of pueraria, schisandra and salvia miltiorrhiza, Silibinin extract, Placebo | Guangzhou Medical University, Affiliated Hospital of Guangdong Medical University | Nonalcoholic Fatty Liver Disease | 01/24 | 02/24 | | |
| Recruiting | N/A | 70 | Europe | Silibinin, Sillbrain, Placebo | Azienda Ospedaliera Città della Salute e della Scienza di Torino | Brain Metastases, Adult, Non Small Cell Lung Cancer, Breast Cancer | 09/25 | 09/27 | | |
NCT05793489: Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin |
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| Recruiting | N/A | 44 | Europe | Silibinin | Istituto Clinico Humanitas | Brain Metastases, Adult | 03/25 | 03/26 | | |
ACTRN12619001296123: Effect of Milk Thistle extract (Silibinin) On circulating unconJugated bilirubin levels and markers for Oxidative stress and inflammation: MOJO study
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| Recruiting | N/A | 65 | | | Endeavour College of Natural Health, Endeavour College of Natural Health | Oxidative stress and Inflammation, Cardiovascular Disease | | | | |
