| Olysio (simeprevir) / J&J, Medivir |
NCT01727323 / 2010-021337-31: A Study to Assess the Safety, Tolerability and Efficacy of TMC435 Along With Pegylated Interferon Alpha-2a (Pegasys) and Ribavirin (Copegus) Triple Therapy in Chronic Hepatitis C Genotype-1 Infected Patients Co-infected With Human Immunodeficiency Virus-Type 1 |
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| Active, not recruiting | 3 | 109 | US, Canada, Europe | TMC435, Pegylated interferon alpha-2a, Ribavirin | Janssen Research & Development, LLC, Janssen R&D Ireland, Tibotec Pharmaceuticals | Hepatitis C Virus Genotype-1 | 08/13 | 08/13 | | |
NCT02256176 / 2014-003446-27: Efficacy and Safety Study of Simeprevir in Combination With Sofosbuvir in Subjects With Chronic Genotype 4 Hepatitis C Virus Infection |
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| Not yet recruiting | 3 | 40 | Europe | Simeprevir, TMC435, Sofosbuvir | Janssen R&D Ireland, Janssen R&D Ireland | Chronic Hepatitis C, Genotype 4 Chronic Hepatitis C | 11/15 | 01/16 | | |
NCT05616598: Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters |
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| Completed | 2/3 | 200 | RoW | Sofosbuvir +daclatasvir+ simeprevir+Ribavirin | Benha University | Male Infertility, HCV | 11/22 | 12/22 | | |
| Recruiting | 2 | 160 | RoW | PR4 + LDV/SOF + ASV 4 wk, Pegasys®, Copegus®, Harvoni®, Sunvepra®, PR4 + LDV/SOF + SMV 4 wk, OLYSIO®, PR4 + LDV/SOF + ASV 6 wk, PR4 + LDV/SOF + SMV 6 wk, PR4 + LDV/SOF + ASV 8 wk, PR4 + LDV/SOF + SMV 8 wk, PR4 + LDV/SOF + ASV 12 wk, PR4 + LDV/SOF + SMV 12 wk | Humanity and Health Research Centre, Beijing 302 Hospital, Nanfang Hospital of Southern Medical University | Chronic Hepatitis C Infection | 10/22 | 12/22 | | |
NCT05728619: HTMC0435 and Temozolomide in Treating Patients With Small Cell Lung Cancer |
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| Recruiting | 1b/2 | 64 | RoW | HTMC0435, Temozolomide | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. | Recurrent Extensive Stage Small Cell Lung Carcinoma | 08/24 | 10/24 | | |
CTR20200573: Phase I/II clinical trial evaluating HTMC0435 tablets in patients with advanced malignant solid tumors |
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| Recruiting | 1/2 | 42 | China | HTMC0435 - Shanghai Huilun | Shanghai Huilun Life Technology Co., Ltd./Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. | Avanced malignant solid tumors | | | | |
