- |||||||||| ubidecarenone IV (BPM 31510 IV) / BPGbio
Journal: Advancing coenzyme Q10 delivery with plant protein-based nanoparticle-mediated nanosuspensions. (Pubmed Central) - Nov 27, 2024
To overcome these challenges, we developed high-payload CoQ10 nanosuspensions (CQ@SPNP, CQ@RPNP, and CQ@WPNP) using plant-based protein nanoparticles (NPs) derived from soybean (SPNP), rice (RPNP), and walnut (WPNP)...The observed increases in stability and bioaccessibility were closely related to the specific NPs utilized. This study highlights the potential of plant protein-based NPs in addressing challenges of CoQ10 delivery, offering a promising approach to improve its efficacy.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / BPGbio
Review, Journal: Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions. (Pubmed Central) - Jan 23, 2024
This suggests that the cardio- and neuroprotective efficacy of intravenously administered CoQ10 forms could present new opportunities in treating acute ischemic conditions. Based on these findings, the review provides reasoning supporting further research and implementation of CoQ10 dosage forms for intravenous administration in emergency situations into clinical practice.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / BPGbio
Preclinical, Journal: Effects of coenzyme Q10 in a propofol infusion syndrome model of rabbits. (Pubmed Central) - Oct 20, 2023
The propofol and sevoflurane organ toxicities were attenuated with CoQ10 in liver, gallbladder, urinary bladder, and spleen. The addition of CoQ10 to propofol and sevoflurane anesthesia prevented the propofol-associated increase in troponin T levels at the 12th hour of infusion and decreased anesthetic-induced total liver and organ injury scores.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Review, Journal: Coenzyme Q10 Metabolism: A Review of Unresolved Issues. (Pubmed Central) - Feb 12, 2023
In this article, we have reviewed what is currently known about these factors and where gaps in knowledge exist that need to be further elucidated. Issues addressed include (i) whether the bioavailability of CoQ10 could be improved; (ii) whether CoQ10 could be administered intravenously; (iii) whether CoQ10 could be administered via alternative routes; (iv) whether CoQ10 can cross the blood-brain barrier; (v) how CoQ10 is transported into and within target cells; (vi) why some clinical trials supplementing CoQ10 may have been unsuccessful; and (vii) which is the most appropriate tissue for the clinical assessment of CoQ10 status.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Preclinical, Journal, IO biomarker: Neuroprotective Effects of Some Nutraceuticals against Manganese-Induced Parkinson's Disease in Rats: Possible Modulatory Effects on TLR4/NLRP3/NF-κB, GSK-3β, Nrf2/HO-1, and Apoptotic Pathways. (Pubmed Central) - Dec 24, 2022
Seven groups of adult male Sprague Dawley rats were categorized as follows: group (I) was the control, while groups 2-7 received MnCl either alone (Group II) or in conjunction with oral doses of sesamol (Group III), thymol (Group IV), CoQ10 (Group V), WG (Group VI), or their combination (Group VII)...Notably, the combination group showed more pronounced improvements, which were confirmed by biochemical, molecular, as well as histopathological findings. Sesamol or thymol showed better protection against neuronal degeneration and some behavioral impairments induced by Mn than WG or CoQ10, partly via interplay between Nrf2/HO-1, TLR4/NLRP3/NF-κB, GSK-3β and Bax/Bcl2 pathways.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, IO biomarker: Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder. (Pubmed Central) - Aug 27, 2022
Mitochondrial-ETC complex enzymes, including complex-I, II, IV, V, and CoQ10, were also restored following long-term SNL treatment...Histological examinations also validated Solanesol's protective effect. As a result, our findings suggest that SNL, as a SIRT-1 signalling activator, may be a promising therapeutic approach for BD-like neurological dysfunctions.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Preclinical, Journal: Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease. (Pubmed Central) - Jun 23, 2022
Since the establishment of the AD model, the rats have received intraperitoneal injections of CoQ10, Exo, or CoQ10-loaded ADSCs-Exo (Exo+ CoQ10)...According to the findings of this study, Exo+ COQ10 enhanced cognition and memory deficiency in Alzheimer's disease by boosting BDNF and SOX2 levels in the hippocampus. Hence, the use of exosomes derived from adipose-derived stem cells as the carrier of CoQ10 may increase the therapeutic effect of CoQ10, which can possibly be due to the regenerative properties of the exosomes.
- |||||||||| metformin / Generic mfg.
Journal: Neurological manifestations in m.3243A>G-related disease triggered by metformin. (Pubmed Central) - Mar 15, 2022
In the era of precision medicine and novel therapies, it is prudent to avoid metformin as it could trigger neurological manifestations in this condition. Coenzyme Q10, DPP-IV inhibitors, SGLT2 inhibitors and GLP-1 receptor agonists may be considered.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Journal, IO biomarker: Pretreatment with Coenzyme Q10 Combined with Aescin Protects against Sepsis-Induced Acute Lung Injury. (Pubmed Central) - Jan 18, 2022
Interestingly, combined pretreatment significantly downregulated high mobility group box-1 (HMGB1) by 72.93%, and toll-like receptor 4 (TLR4) by -0.93-fold versus 61.92%, -0.83-fold in CoQ10 and 38.67%, -0.70-fold in AES pretreatment, respectively. Our results showed for the first time that the enhanced anti-inflammatory effect of combined CoQ10 and AES pretreatment prevented LPS-induced ALI via suppression of NLRP-3 inflammasome through regulation of HMGB1/TLR4 signaling pathway and mitochondrial stabilization.
- |||||||||| pentoxifylline / Generic mfg.
Preclinical, Journal: In vitro effects of pentoxifylline and coenzyme Q10 on the sperm of oligoasthenoteratozoospermia patients. (Pubmed Central) - Dec 24, 2021
There was a significant difference between CoQ10 treated and CoQ10 + PTX treated groups in comparison with the OAT group in the percentage of the DNA fragmentation, sperm apoptosis, AB+, HOS test + and sperm mitochondrial activity. Incubated sperm with CoQ10, PTX, and in combination with each other can improve sperm parameters in OAT patients.
- |||||||||| risperidone / Generic mfg., ketamine / Generic mfg.
Retrospective data, Review, Journal: Comparative Efficacy and Tolerability of Adjunctive Pharmacotherapies for Acute Bipolar Depression: A Systematic Review and Network Meta-analysis: Efficacité Et Tolérabilité Comparatives Des Pharmacothérapies D'appoint Pour La Dépression Bipolaire Aiguë: Une Revue Systématique Et Une Méta-Analyse De Réseau. (Pubmed Central) - Aug 20, 2021
Adjunctive racemic intravenous ketamine, coenzyme Q10, pramipexole, fluoxetine, and lamotrigine were more effective than placebo...For completion of treatment, risperidone appeared less tolerable than placebo (RR = 0.59; 95% CI, 0.38 to 0.94), while fluoxetine seemed more tolerable than placebo (RR = 1.13; 95% CI, 1.02 to 1.24)...Fluoxetine appeared to have the most consistent evidence base for both efficacy and tolerability. There remains a need for additional research exploring novel treatment strategies for bipolar depression, particularly head-to-head studies.
- |||||||||| lorazepam / Generic mfg., amantadine / Generic mfg.
[VIRTUAL] Heroin-Induced Toxic Leukoencephalopathy From “Chasing the Dragon” and the Proposed Synergistic Effect of Amantadine and Antioxidants in Its Treatment () - May 2, 2021 - Abstract #APA2021APA_523;
However, he did not have any other classic features of catatonia and the patient was unresponsive to an Ativan challenge...The patient was started on empiric antioxidant therapy including coenzyme Q10, vitamin E, and vitamin C as it has been noted anecdotally in the literature to help with recovery (Cordova)...At this time, there is no consensus on effective treatment. In this poster, we discuss the evaluation of delirium, the diagnosis of heroin-induced leukoencephalopathy, and the proposed mechanism behind the effectiveness of amantadine in this patient.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Journal: The Influence of Statins on the Aerobic Metabolism of Endothelial Cells. (Pubmed Central) - Nov 21, 2020
No changes in mitochondrial biogenesis, cell viability, or ATP levels were observed, whereas a decrease in Coenzyme Q10 (Q10) content was accompanied by an increase in intracellular reactive oxygen species (ROS) production, although mitochondrial ROS production remained unchanged...These changes may cause the observed decrease in mitochondrial membrane potential and an increase in Q10 reduction level as a consequence, leading to elevated mitochondrial ROS formation. The above observations highlight the role of endothelial mitochondria in response to potential metabolic adaptations related to the chronic exposure of endothelial cells to statins.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
[VIRTUAL] Nutritional management to avoid metabolic decompensation at major surgeries in a patient with propionic acidemia related cardiomyopathy: A case report (E-Poster Hall) - Aug 29, 2020 - Abstract #TTS2020TTS_888;
To prevent metabolic decompensation triggered by surgical catabolic stress, vitamin cocktail (Vitamin B1, B2, B12, C, and Ubidecarenone), biotin, L-carnitine, and parenteral nutrition consisting of glucose and amino acid were given immediately after surgery...Although lactate slightly increased for several days after surgery, the postoperative course was uneventful. In patients with PA related cardiomyopathy, meticulous nutritional management based on pathophysiology of PA is useful to prevent metabolic crisis at major surgery, such as LVAD implantation and HTx.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Preclinical, Journal: Effect of coenzyme Q10 supplementation on diabetes induced memory deficits in rats. (Pubmed Central) - May 13, 2020
Diabetic animals which received CoQ10 (600 mg/kg) show a considerable decrease in escape latency and traveled distance compared to diabetic animals (p < 0.05, two-way ANOVA,). The present study has shown that low dose supplementation with CoQ10 in diabetic rats failed to improve deficits in cognitive function but high dose supplementation with CoQ10 reversed diabetes-related declines in spatial learning.
- |||||||||| triheptanoin (UX007) / Ultragenyx, ubidecarenone IV (BPM 31510 IV) / Berg
Clinical, Review, Journal: A Review of the Clinical Evidence for Complementary and Alternative Medicine in Huntington's Disease. (Pubmed Central) - Mar 29, 2020
Currently, there is no evidence supporting disease modification or symptom improvement with any specific dietary or nutraceutical supplement for HD. Supervised exercise and contemporary dance are safe for people with HD, but more robust studies are warranted to guide specific recommendations for these and other mind-body interventions.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Journal: Surfactant-Stripped Micelles for NIR-II Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts. (Pubmed Central) - Feb 14, 2020
The co-loading of Coenzyme Q10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability, and results in a peak absorption wavelength in the NIR-II window close to the 1064 nm output of Nd-YAG lasers used for PAI...ss-CyFaP is imaged through whole compressed human breasts in three female volunteers at depths of 2.6-5.1 cm. Taken together, these data show that ss-CyFaP is an accessible contrast agent for deep tissue PAI in the NIR-II window.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Formulating Photoacoustic Agents with High Contrast at 1064 nm (104B, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_11610;
The co-loading of Coenzyme Q10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability and results in a peak absorption wavelength in the NIR-II window close to the 1064 nm output of Nd-YAG lasers used for photoacoustic imaging...Taken together, these data show that ss-CyFaP is an accessible contrast agent for deep tissue photoacoustic imaging in the NIR-II window. Other NIR-II contrast agents will be discussed as well, including edible contrast agents capable of rapid human translation.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
ACUTE TOXIC LEUKOENCEPHALOPATHY DUE TO HEROIN INHALATION (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 4) - Sep 25, 2019 - Abstract #CHEST2019CHEST_3551;
These results demonstrate that PLG exerts therapeutic effects in a rotenone-induced PD models by restoring the balance between apoptosis and autophagy. He was started on empiric antioxidant therapy with Coenzyme Q10, vitamin E, and vitamin C. Patient's clinical course subsequently improved and he was ultimately discharged to a rehab facility.One method of heroin use is inhalation of the drug as a thick vapor after heating it in aluminum foil, which is called 'Chasing the Dragon.' This can result in a toxic leukoencephalopathy with 3 levels of severity [1, 2]...It is important for critical care clinicians to distinguish this manifestation of opiate abuse from anoxic brain injury and other causes of acute encephalopathy because treatment and prognosis may differ.
- |||||||||| ubidecarenone IV (BPM 31510 IV) / Berg
Journal: Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys. (Pubmed Central) - Aug 22, 2019
...No variation of plasma coenzyme Q10 (CoQ) were found, suggesting that the LDL-lowering effect of Afriplex GRT could be related to its ability to modulate the mevalonate pathway differently from statins...Finally, the direct correlation between the amount of oxidized LDL and total LDL concentration, and the inverse correlation between ox-LDL and plasma CoQ levels, detected in the diabetic monkeys highlighted the potential cardiovascular protective role of green rooibos extract. Taken together, these findings suggest that Afriplex GRT could counteract hyperglycemia, oxidative stress and dyslipidemia, thereby lowering fundamental cardiovascular risk factors associated with diabetes.
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