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Preclinical, Journal: Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion. (Pubmed Central) - Jun 12, 2023
Ectopically expressed viral non-structural proteins NS1 and NS2 are sufficient to cause host-cell replication stress, as is the presence of UV-inactivated non-replicative MVM genomes...Overexpressing RPA in host cells prior to UV-MVM infection rescues DNA fiber lengths and increases MVM replication, confirming that MVM genomes deplete RPA stores to cause replication stress. Together, these results indicate that parvovirus genomes induce replication stress through RPA exhaustion, rendering the host genome vulnerable to additional DNA breaks.
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Trial completion, Enrollment change, Trial completion date, Trial primary completion date: RESET Trial - Part 1 - A Phase 3 Trial in Subjects With Sj (clinicaltrials.gov) - Nov 9, 2020
P3, N=11, Completed,
Together, these results indicate that parvovirus genomes induce replication stress through RPA exhaustion, rendering the host genome vulnerable to additional DNA breaks. Suspended --> Completed | N=39 --> 11 | Trial completion date: Dec 2020 --> Jan 2020 | Trial primary completion date: Dec 2020 --> Jan 2020
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Trial suspension: RESET Trial - Part 1 - A Phase 3 Trial in Subjects With Sj (clinicaltrials.gov) - Mar 19, 2020
P3, N=39, Suspended,
Suspended --> Completed | N=39 --> 11 | Trial completion date: Dec 2020 --> Jan 2020 | Trial primary completion date: Dec 2020 --> Jan 2020 Recruiting --> Suspended
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Trial initiation date: RESET Trial - Part 1 - A Phase 3 Trial in Subjects With Sj (clinicaltrials.gov) - Jun 26, 2018
P3, N=39, Recruiting,
Collectively, this study suggests that RSV NS1 interacts with TRIM25 and interferes with RIG-I ubiquitination to suppress type-I interferon signaling. Initiation date: Apr 2018 --> Jul 2018
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Enrollment closed: A Study of Topical NS2 Cream to Treat Ichthyosis in Sj (clinicaltrials.gov) - May 19, 2016
P2, N=12, Active, not recruiting,
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
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Trial primary completion date: A Study of Topical NS2 Cream to Treat Ichthyosis in Sj (clinicaltrials.gov) - Oct 2, 2015
P2, N=12, Recruiting,
Recruiting --> Active, not recruiting Trial primary completion date: Aug 2015 --> Mar 2016
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