- |||||||||| amitriptyline / Generic mfg.
Journal: G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression. (Pubmed Central) - Sep 8, 2023
In this study, we discovered that amitriptyline, a typical TCA, directly binds to the lysophosphatidic acid receptor 1 (LPAR1), a G protein-coupled receptor, and activates downstream G protein signaling, while exerting a little effect on ?-arrestin recruitment...Pathway analysis indicated that long-term treatment with OMPT activated LPAR1 downstream signaling (Rho and MAPK), whereas LPA suppressed LPAR1 signaling. Our findings provide insights into the mechanisms underlying the non-monoaminergic antidepressant effects of TCAs and identify the G protein-biased agonism of LPAR1 as a promising target for the development of novel antidepressants.
- |||||||||| amitriptyline / Generic mfg.
Trial completion, Trial completion date: Amitriptyline vs GON and SON Blocks in Migraine (clinicaltrials.gov) - Sep 8, 2023
P=N/A, N=57, Completed,
Our findings provide insights into the mechanisms underlying the non-monoaminergic antidepressant effects of TCAs and identify the G protein-biased agonism of LPAR1 as a promising target for the development of novel antidepressants. Recruiting --> Completed | Trial completion date: Feb 2024 --> Jul 2023
- |||||||||| aspirin / Generic mfg., amitriptyline / Generic mfg., clobazam / Generic mfg.
Secondary erythromelagia induced by diabetic neuropathy (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3599;
It may occur as a primary or secondary disorder with a similar clinical presentation. EM is characterized by episodes of erythema, increased temperature, and burning pain, mainly involving the extremities.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Drug-Induced Erythromelalgia: A Case Report (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2416;
EM is characterized by episodes of erythema, increased temperature, and burning pain, mainly involving the extremities. Case report: A 38-year-old patient, with no history of smoking or alcoholism, was followed up for ileo-coecal Crohn
- |||||||||| Cerebrolysin (porcine brain-derived proteolytic peptide fraction) / Novartis, EVER Pharma
Clinical, Review, Journal: Pharmacological treatment in early rehabilitation after ischemic stroke (Pubmed Central) - Aug 29, 2023
This review provided a summary of the evidence on pharmacological supportive care in early rehabilitation of post-acute ischemic stroke patients. This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population.
- |||||||||| Clinical, Review, Journal, Adverse events: Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review. (Pubmed Central) - Aug 25, 2023
As for antipsychotics, drugs like Clozapine, Olanzapine, and Risperidone were linked to weight gain, diabetes, and deterioration of the lipid profile...Future research should focus on conducting field studies to further expand knowledge on the metabolic effects of other commonly prescribed psychotropic drugs. Overall, the study highlights the significance of understanding and managing metabolic alterations induced by psychopharmacological treatment to enhance patient care and well-being.
- |||||||||| Challenges in treatment of erythromelalgia: a case report (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_5391;
Despite previous treatments, the patient still needed to soak his foot on ice to improve the pain, which caused burns and necrosis of the toes, necessitating debridement and straining surgery. Thus, treatment with transcranial magnetic stimulation was indicated, with good response, maintaining VAS 5 and improving her quality of life.
- |||||||||| Review, Journal: Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations. (Pubmed Central) - Aug 16, 2023
The anti-epileptic drugs topiramate and divalproex sodium and antidepressants venlafaxine and amitriptyline are effective for migraine exacerbation prophylaxis but have associated side effects. The decision for pharmacologic management should ultimately be made following consideration of risk vs. benefit and discussion between patient and physician.
- |||||||||| pregabalin / Generic mfg., amitriptyline / Generic mfg., duloxetine / Generic mfg.
Trial completion date, Trial primary completion date: The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia (clinicaltrials.gov) - Aug 15, 2023
P=N/A, N=40, Recruiting,
The decision for pharmacologic management should ultimately be made following consideration of risk vs. benefit and discussion between patient and physician. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Jun 2023 --> Jun 2024
- |||||||||| amitriptyline / Generic mfg.
Journal: Spontaneous Formation of Ultrasmall Unilamellar Vesicles in Mixtures of an Amphiphilic Drug and a Phospholipid. (Pubmed Central) - Aug 2, 2023
We have observed ultrasmall unilamellar vesicles, with diameters of less than 20 nm, in mixtures of the tricyclic antidepressant drug amitriptyline hydrochloride (AMT) and the unsaturated zwitterionic phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in physiological saline solution...Most interestingly, the size of the vesicles was observed to be strongly dependent on the chemical structure of the phospholipid, and in mixtures of AMT and the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), the vesicles were observed to be considerably larger in size. The self-assembly behavior in the phospholipid-drug surfactant system in many ways resembles the formation of equilibrium micelles and vesicles in mixed anionic/cationic surfactant systems.
- |||||||||| amitriptyline / Generic mfg.
Journal: Global Research Trends and Hotspots Analysis of the Scientific Production of Amitriptyline: A Bibliometric Approach. (Pubmed Central) - Jul 29, 2023
In addition, we seek to map in the chosen articles study design and research findings. We found that since 1980, the use of amitriptyline has expanded beyond depression, moving to off-label use to treat a variety of diseases and conditions, including post-herpetic neuralgia, neuropathic pain, primary fibrosis, fibromyalgia, and migraine, can be considered a drug with more clinical applicability than its original clinical indication.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Trial completion: To Compare the Efficacy of Drugs in Combination for Treating Irritable Bowel Syndrome Associated With Diarrhea (clinicaltrials.gov) - Jul 27, 2023
P4, N=162, Completed,
We found that since 1980, the use of amitriptyline has expanded beyond depression, moving to off-label use to treat a variety of diseases and conditions, including post-herpetic neuralgia, neuropathic pain, primary fibrosis, fibromyalgia, and migraine, can be considered a drug with more clinical applicability than its original clinical indication. Active, not recruiting --> Completed
- |||||||||| Miostat (carbachol) / Novartis
Differential Effects of Anticholinergic Medications in a Human Neuronal Model of AD (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_6283;
Preliminary results suggest that different ACh drugs have differential effects on AD-associated cellular outcomes. Future work will test this panel of medications on hiPSC-Ns derived from Adult Changes in Thought (ACT) cohort subjects with high and low AD genetic risk
- |||||||||| amitriptyline / Generic mfg., gabapentin / Generic mfg.
Hansen's Disease: Shrouded in Headache? () - Jul 3, 2023 - Abstract #WCD2023WCD_7493;
In addition, standard regimen of therapy like steroids and other immune-modulators may not always be the answer to treatment of reaction. A newer perspective and a different approach with use of drugs like Amitriptyline and Gabapentine could be undertaken
- |||||||||| Dermatitis Artefacta: A Rare And Challenging Dermatosis () - Jul 3, 2023 - Abstract #WCD2023WCD_6966;
Three weeks prior to our visit, she has been on Acyclovir, Prednisolone, Clindamycin, Amoxicillin and Clavulanic acid and Mupirocin ointment...She was treated with normal saline for dressing, amitriptyline and cognitive behavioral therapy was given...She did not admit responsibility for the creation of the lesions hence making management more difficult. The management of this patient required a detailed Dermatologic and Psychiatric assessment
- |||||||||| amitriptyline / Generic mfg.
Thoracic Trophic Syndrome, A Distinct Overlooked Entity () - Jul 3, 2023 - Abstract #WCD2023WCD_6040;
The patient was also started on amitriptyline 10mg every night, with increasing doses as tolerated...Journal of the American Academy of Dermatology. 2010;63(4):724
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Review, Journal: Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management. (Pubmed Central) - Jun 26, 2023
Among the large clinical trials, candesartan, topiramate, amitriptyline, and onabotulinumtoxinA were the most used preventative therapies, providing further support for these agents. MOH management requires a multifaceted and patient-centered approach that involves patient education, behavioral interventions, withdrawal of the overused medication, and initiation of preventative medication.
- |||||||||| amitriptyline / Generic mfg.
Trial completion date, Trial primary completion date: Amitriptyline for Repetitive Behaviors in Autism Spectrum Disorders (clinicaltrials.gov) - Jun 22, 2023
P3, N=30, Not yet recruiting,
Trial primary completion date: Oct 2024 --> Jan 2024 Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Jun 2024 --> Jun 2025
- |||||||||| Eroxon (MED3000) / Futura Medical
Journal: Mechanisms of interfacial catalysis and mass transfer in a flow-through electro-peroxone process. (Pubmed Central) - Jun 21, 2023
The flow-through cathode design improved the mass transfer of aqueous O and in-situ generated HO, leading to an increased yield of hydroxyl radicals, as well as the contact time and space between hydroxyl radicals and amitriptyline. Ultimately, this resulted in a higher degradation efficiency of the system.
- |||||||||| amitriptyline / Generic mfg., fluoxetine / Generic mfg.
Journal: Experimental Study of Antidepressant Properties of Afobazole. (Pubmed Central) - Jun 20, 2023
Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The ?1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of ?1 receptors in the antidepressant effect of the drug.
- |||||||||| amitriptyline / Generic mfg.
Journal: Managing Vulvodynia with Central Sensitization: Challenges and Strategies. (Pubmed Central) - Jun 10, 2023
Overall, this study highlights the importance of considering central sensitization in the diagnosis and treatment of vulvodynia and the need for individualized treatment based on the patient's symptoms and underlying mechanisms. Vulvodynia patients with central sensitization had more pain during intercourse, urination, or defecation, and responded worse to treatment, requiring more time and medication.
- |||||||||| Journal: Changes in Psychotropic Drug Blood Levels After SARS-CoV-2 Vaccination: A Two-Center Cohort Study. (Pubmed Central) - Jun 10, 2023
This study provides the first evidence of major changes in the plasma levels of escitalopram, fluoxetine, trazodone, and quetiapine after COVID-19 vaccination. When planning COVID-19 vaccination for patients treated with these medications, clinicians should monitor rapid changes in bioavailability and consider short-term dose adjustments to ensure safety.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Journal: Empagliflozin significantly prevents QTc prolongation due to amitriptyline intoxication. (Pubmed Central) - Jun 7, 2023
This effect was probably due to the opposite effects of these two agents in the intracellular calcium balance. With more clinical trials, the routine use of empagliflozin may be suggested to prevent QT and QTc prolongation in diabetic patients receiving amitriptyline.
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