fluoxetine / Generic mfg. 
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  • ||||||||||  Trial completion, Trial completion date:  Electronic Training of Elderly Depression With Cognitive Impairment (clinicaltrials.gov) -  Jul 16, 2024   
    P=N/A,  N=128, Completed, 
    The differences in specific AEs warrant future studies to determine true differences that would affect patient counseling. Recruiting --> Completed | Trial completion date: Jan 2024 --> Aug 2023
  • ||||||||||  imipramine / Generic mfg., fluoxetine / Generic mfg., haloperidol / Generic mfg.
    Preclinical, Journal:  The sinking platform test: a novel paradigm to measure persistence in animal models. (Pubmed Central) -  Jul 15, 2024   
    Finally, comparing transcriptomic profiles of the prefrontal cortex of mice with high and low SPT performance revealed significant enrichment of immediate-early genes known to shape susceptibility for chronic stress. These findings highlight the potential of SPT as a promising method to uncover the biological mechanisms of persistence and evaluate novel interventions to enhance this response.
  • ||||||||||  lithium carbonate ER / Generic mfg., iloperidone / Generic mfg.
    Journal:  Iloperidone (Fanapt) - a new indication for bipolar disorder. (Pubmed Central) -  Jul 15, 2024   
    These findings highlight the potential of SPT as a promising method to uncover the biological mechanisms of persistence and evaluate novel interventions to enhance this response. No abstract available
  • ||||||||||  Review, Journal:  The Black Book of Psychotropic Dosing and Monitoring. (Pubmed Central) -  Jul 12, 2024   
    While acetylcholinesterase inhibitors and memantine have been available for decades, these drugs modestly improve cognition in Alzheimer's disease patients and do not alter the progressive course of the illness...While it remains to be seen how useful these new agents will be in clinical practice, they do represent an approach to treating neuropsychiatric disorders that are a notable departure from the pharmacotherapy of the past half century. It seems likely that some patients who have not been able to respond to or tolerate traditional pharmacotherapy will find hope in these new medications.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (Pubmed Central) -  Jul 10, 2024   
    Although the definitive causal link cannot be established, this case report suggests an increased seizure risk with combination of LSD and lithium, even at subtherapeutic serum lithium levels. This case emphasizes the need for further research, careful clinical practice, and patient education regarding the potential dangers of using psychedelic substances with psychopharmacological treatment.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Clinical effect of acupuncture at ghost points combined with fluoxetine hydrochloride on mild-to-moderate depression. (Pubmed Central) -  Jul 10, 2024   
    This case emphasizes the need for further research, careful clinical practice, and patient education regarding the potential dangers of using psychedelic substances with psychopharmacological treatment. Acupuncture at ghost points combined with paroxetine tablets can safely improve depressive symptoms and sleep disorders, regulate neurotransmitter levels, and reduce stress responses in patients with mild-to-moderate depression.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Effect of depression and the antidepressant fluoxetine on osseointegration-A pre-clinical in (Pubmed Central) -  Jul 4, 2024   
    Depression and fluoxetine negatively affect bone density and implant osseointegration independently, and this damaging effect is exacerbated when both factors are present. The mechanism may be related to the dysregulation of the hypothalamic-pituitary-adrenal axis and inflammation in the body.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal, IO biomarker:  Jingqianshu granules mitigates premenstrual depression by regulating orexin signaling. (Pubmed Central) -  Jul 1, 2024   
    In Part 1, the rats were divided into the control group, the model group, the model + Jingqianshu group, and the model + fluoxetine group...However, the current study is still preliminary and the pathogenesis of PMDD is complex. Therefore, more in-depth exploration is needed.
  • ||||||||||  fluoxetine / Generic mfg.
    Review, Journal:  Emerging Therapeutic Potential of Fluoxetine on Cognitive Decline in Alzheimer's Disease: Systematic Review. (Pubmed Central) -  Jun 27, 2024   
    While more high-quality clinical research is needed to fully understand the mechanisms underlying these effects, fluoxetine is a promising potential treatment for AD patients. If future clinical trials confirm its anti-degenerative and neuroprotective effects, fluoxetine could offer a new therapeutic approach for slowing down the progression of AD.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Clarifying the functional role of serotonin in Meloidogyne graminicola host plant parasitism by immunolocalization and RNA interference. (Pubmed Central) -  Jun 26, 2024   
    In this study, we tested the effects of exogenous serotonin and the pharmacological compounds fluoxetine and methiothepin on the feeding behaviors of Meloidogyne graminicola...Furthermore, we investigated the impact of phytoserotonin on nematode invasion and development in rice by overexpressing OsTDC-3 or supplementing rice plants with tryptamine and found that an increase in phytoserotonin increases nematode pathogenicity. Overall, our study provides insights into the essential role of serotonin in M. graminicola host plant parasitism and proposes that the serotonergic signaling pathway could be a potential target for controlling PPNs.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer (clinicaltrials.gov) -  Jun 24, 2024   
    P1,  N=10, Not yet recruiting, 
    Overall, our study provides insights into the essential role of serotonin in M. graminicola host plant parasitism and proposes that the serotonergic signaling pathway could be a potential target for controlling PPNs. Trial completion date: Jun 2026 --> Dec 2026 | Initiation date: Jun 2024 --> Dec 2024 | Trial primary completion date: Jun 2025 --> Dec 2025
  • ||||||||||  Review, Journal:  Selective Serotonin Reuptake Inhibitors and Symptoms of Depression in Patients on Chronic Hemodialysis: A Systematic Review. (Pubmed Central) -  Jun 19, 2024   
    In one study, citalopram and psychological interventions were both effective in reducing the symptoms of depression and anxiety and, in another study, sertraline was modestly more effective than CBT at 12 weeks in reducing the symptoms of depression...SSRI administration, at the dosage used in the studies included in the present systematic review, seems safe in most hemodialysis patients. However, the paucity of studies and the limited number of patients included in the trials may suggest that further randomized, controlled studies are needed to determine if SSRIs may be used routinely in daily clinical practice in such a population.
  • ||||||||||  sertraline / Generic mfg., fluoxetine / Generic mfg., carbamazepine / Generic mfg.
    Journal:  The Tissue-Specific Eco-Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions. (Pubmed Central) -  Jun 18, 2024   
    Caffeine and sucralose, two common effluent tracers, were quantitated at low micrograms per liter levels in surface water, while an anticonvulsant, carbamazepine, was observed at levels up to 37?ng/L. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and primary metabolites were detected in at least one tissue of all three species at low micrograms per kilogram concentrations..
  • ||||||||||  fluoxetine / Generic mfg.
    Biomarker, Journal, Metabolomic study:  NMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression. (Pubmed Central) -  Jun 17, 2024   
    we established a chronic restraint stress (CRS) induced depression model in mice and employed fluoxetine as a reference drug...In summary, SEO effectively mitigates depressive-like behaviors in CRS mice, predominantly via modulation of glycolysis, amino acid metabolism, and energy metabolism, and potentially exerts antidepressant effects through neural regulation. Our study offers insights into small molecule metabolite alterations in CRS mice through a metabolomics lens, providing evidence for the antidepressant potential of plant essential oils and contributing to our understanding of the mechanisms of traditional Chinese medicine in treating depression.
  • ||||||||||  fluoxetine / Generic mfg.
    Review, Journal:  The Roles of Endogenous Opioids in Placebo and Nocebo Effects: From Pain to Performance to Prozac. (Pubmed Central) -  Jun 14, 2024   
    A common pathway for such outcomes is the endogenous opioid system. This chapter describes the history of placebo/nocebo in medicine; delineates the current state of the literature related to placebo/nocebo in relation to pain modulation; summarizes research findings related to human performance in sports and exercise; discusses the implications of placebo/nocebo effects among diverse patient populations; and describes placebo/nocebo influences in research related to psychopharmacology, including the relevance of endogenous opioids to new lines of research on antidepressant pharmacotherapies.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Fluoxetine for the Treatment of Abdominal Migraine. (Pubmed Central) -  Jun 11, 2024   
    The idea that variation in circadian factors influences response to antidepressants was supported and encourages exploration of circadian mechanisms of depressive disorders and antidepressant treatments. No abstract available
  • ||||||||||  Fintepla (low-dose fenfluramine) / UCB, Nippon Shinyaku
    Preclinical, Journal:  Enhancing the action of serotonin by three different mechanisms prevents spontaneous seizure-induced mortality in Dravet mice. (Pubmed Central) -  Jun 11, 2024   
    Our data demonstrate that elevating serotonergic function by fluoxetine, fenfluramine, or SR 57227 significantly reduces or eliminates SSIM in Dravet mice in a sex-independent manner. These findings suggest that deficits in serotonergic neurotransmission likely play an important role in the pathogenesis of SSIM, and fluoxetine and fenfluramine, which are US Food and Drug Administration-approved medications, may potentially prevent SUDEP in at-risk patients.
  • ||||||||||  amitriptyline / Generic mfg., fluoxetine / Generic mfg.
    Clinical, Review, Journal:  Management of Depression in Adults: A Review. (Pubmed Central) -  Jun 10, 2024   
    Effective first-line depression treatments include specific forms of psychotherapy and more than 20 antidepressant medications. Close monitoring significantly improves the likelihood of treatment success.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Fluoxetine Can Cause Epileptogenesis and Aberrant Neurogenesis in Male Wild Type Mice. (Pubmed Central) -  Jun 4, 2024   
    In conclusion, fluoxetine could induce considerable adverse effects in wild type mice, including seizure-like activity. Fluoxetine-induced neurogenesis increases could be related to this activity, therefore proneurogenic effects of fluoxetine and other antidepressants, especially in the absence of any behavioral therapeutic effects, should be interpreted with caution.
  • ||||||||||  donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  The involvement of neuroinflammation in an animal model of dementia and depression. (Pubmed Central) -  Jun 3, 2024   
    In addition, fluoxetine + donepezil reversed the reduction of IL-10 levels in the hippocampus. The results indicate a pathophysiological interaction between AD and depression, and the association of medications in the future may be a possible therapeutic strategy to reduce inflammation, especially the fluoxetine-associated treatments.