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Journal: Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis. (Pubmed Central) - Jul 11, 2019 Rapid changes in BDNF levels and synaptic/mitochondria plasticity of hippocampus following vortioxetine compared to fluoxetine may be ascribed to vortioxetine's modulation of serotonin receptors. SSRI intake may promote atherosclerosis and therefore potentially increase the risk for acute cardiovascular events by a mechanism that is independent of 5-HT depletion.
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Review, Journal: Serotonin and orthodontic tooth movement. (Pubmed Central) - Jul 11, 2019 In this review, we focus on peripheral serotonin mechanism of regulation of bone remodeling during orthodontic movement. We discuss the differential effect of serotonin on alveolar bone inflammation that may open new strategies in orthodontics.
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Journal: Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance. (Pubmed Central) - Jul 7, 2019 It is commonly assumed that a decreased concentration of FL leads to decreased biological impact. Our study proves that despite the overall decrease in FL concentration, accumulation of toxic (R)-FL and formation of toxic (S)-NFL leads to much higher than presumed toxicological effects.
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Clinical, Journal: Antidepressant treatment outcomes in family medicine. (Pubmed Central) - Jul 3, 2019 Conclusion Success of the treatment with the absence of symptoms of depression was achieved in 10% and the maintenance of depressive episodes occurred in 90% of cases. Adverse reactions with the most commonly prescribed SSRI in our country should be important in creating procedures and strategies for the future treatment of depression in family medicine.
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Clinical, Journal: Case report: Cytochrome P450 implications for comorbid ADHD and OCD pharmacotherapy. (Pubmed Central) - Jul 1, 2019 Genetic testing as a prescriptive tool is not indicated for all medications; however, potential drug-drug interactions, narrow therapeutic drug index, and side effect toxicity contribute to the need for testing. An understanding of CYP450 metabolism and drug interaction as well as metabolism phenotypes should inform prescribing and dosing psychotropic medications.
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Journal: Analysis of four antidepressants in plasma and urine by gas chromatography-mass spectrometry combined with sensitive and selective derivatization. (Pubmed Central) - Jun 30, 2019 Low, medium, and high concentrations of antidepressants were added in plasma and urine samples, spiked recovery ranged from 85.88%-110.34% for plasma and 80.64%-113.07% for urine, respectively. The derivatization reaction was very quickly, only 5 min was needed for the reaction process, in addition, the proposed method exhibited superior sensitivity and selectivity, it showed sufficient advantages for determination of Flu, Nor, Map, and Paro in plasma and urine of patients.
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Journal: The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway. (Pubmed Central) - Jun 26, 2019 ...We hypothesized that FAEW exerts clinical effects through the activity against oxidative stress with fluoxetine as antidepressant control drug...The chemical constituents of FAEW (i.e. paeoniflorin, baicalin) bound to KEAP1 in silico, which hence might be the effective substances of FAEW. In conclusion, FAEW counteracted H2O2-induced oxidative stress through KEAP1-NRF2/HO-1 pathway.
- |||||||||| fluoxetine / Generic mfg.
Enrollment closed: STEP: The Staged Treatment in Early Psychosis Study (clinicaltrials.gov) - Jun 26, 2019 P3, N=340, Active, not recruiting, In conclusion, FAEW counteracted H2O2-induced oxidative stress through KEAP1-NRF2/HO-1 pathway. Recruiting --> Active, not recruiting
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Journal: The easy misuse of antidepressants during pregnancy is depressing. (Pubmed Central) - Jun 24, 2019 Additional studies on the pharmacokinetics and side effects of fluoxetine treatment for anxiety behaviors are warranted in wallabies. No abstract available
- |||||||||| Clinical, Journal: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Association with Commonly Prescribed Drugs in Outpatient Care Other than Anti-Epileptic Drugs and Antibiotics: A Population-Based Case-Control Study. (Pubmed Central) - Jun 22, 2019
However, compared with a placebo, both drugs improved post-stroke motor function. In this observational study, we observed likely causal associations between Stevens-Johnson syndrome/toxic epidermal necrolysis and use of allopurinol, cyclooxygenase-2 inhibitors, and 5-aminosalicylates, and potential associations for proton pump inhibitors, fluoxetine, and mirtazapine.
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Clinical, Journal, HEOR: Quality of Life Assessment in Antidepressant Treatment of Patients with Depression and/or Anxiety Disorder. (Pubmed Central) - Jun 21, 2019 The results of the Q-LES-Q-SF questionnaire showed a significant improvement in quality of life as well as overall pleasure and satisfaction with life due to the use of antidepressants. Therapy with fluoxetine, paroxetine and escitalopram leads to a significant improvement of all recorded parameters, along with the overall quality of life, which makes them very effective in the treatment of depression and/or anxiety disorders.
- |||||||||| fluoxetine / generics
Journal: A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents. (Pubmed Central) - Jun 15, 2019 These results demonstrate, for the first time in depressed adolescents, that fluoxetine has immediate neural effects on core components of the cortico-limbic circuitry prior to clinical changes in mood. The effect on anger is consistent with our previous work and could represent a key mechanism through which fluoxetine may act to alleviate irritability symptoms in adolescent depression.
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Preclinical, Journal: Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats. (Pubmed Central) - Jun 15, 2019 ...The propensity to gain weight might have influenced the rate of catch-up growth and bone allometry, as heavier animals treated with fluoxetine also had enhanced bone features when compared to non-stressed animals...To our knowledge this is the first study reporting that short-term antidepressant treatment has long-lasting effects in restoring the effects of chronic stress in body weight and bone formation. Our findings may be relevant to the understanding and treatment of osteoporosis, a condition of increasing prevalence due to the aging population.
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Journal: Adolescent fluoxetine history impairs spatial memory in adult male, but not female, C57BL/6 mice. (Pubmed Central) - Jun 15, 2019 The implication of these effects for planarian populations in the natural habitat is discussed as well as the need for more research on the effects of neuroactive pharmaceuticals under relevant exposure scenarios. Together, these results demonstrate enduring spatial memory-related deficiencies after pre-exposure to FLX during adolescence in male, but not female, C57BL/6 mice.
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Review, Journal: Antidepressants in epilepsy. (Pubmed Central) - Jun 7, 2019 Implementation of anticonvulsive drugs in depressed patients should include valproate, carbamazepine, lamotrigine, gabapentin, pregabalin. The paper reviews the evidence for the clinical use of antidepressants in PWE.
- |||||||||| Journal: Corbicula fluminea rapidly accumulate pharmaceuticals from an effluent dependent urban stream. (Pubmed Central) - May 31, 2019
Notably, elevated bioaccumulation factors (L/kg) for sertraline were observed between 3361 and 6845, which highlights the importance of developing predictive bioaccumulation models for ionizable contaminants with bivalves. Future research is also necessary to understand different routes of exposure and elimination kinetics for pharmaceutical accumulation in bivalves.
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Review, Journal: Depression in Pregnancy. (Pubmed Central) - May 30, 2019 The use of selective serotonin reuptake inhibitor antidepressants, particularly fluoxetine, which has not been associated with teratogenicity, is recommended, in addition to the implementation of non-pharmacological treatment such as psychotherapy, mindfulness and aerobic exercise. Educating healthcare professionals will facilitate the correct diagnosis and treatment of this condition.
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