- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine partially alleviates inflammation in the kidney of socially stressed male C57 BL/6 mice. (Pubmed Central) - Sep 7, 2023
Moreover, fluoxetine also modulated gene expression of stress-related hormone receptors, including prolactin and melanin-concentrating hormone. These results suggest that CSDS can induce gene expression changes associated with inflammation in the kidney of C57 BL/6 male mice, and this inflammation can be treated effectively by fluoxetine.
- |||||||||| risperidone / Generic mfg.
A case of trichotillomania as the preceding symptom of Huntington () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_994;
TTM is an obsessive-compulsive disorder characterized by uncontrollable, self-inflicted hair pulling resulting in noticeable hair loss. Since it is a very rare psychiatric manifestation of HD, we presented this case to keep TTM in mind as a possible preceding symptom of HD, and to emphasize the potential positive effect of risperidone in the treatment of TTM and choreic movements in HD.
- |||||||||| When pandemic leaves you alone with a mirror (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_4341;
Treatment with fluoxetine, lorazepam and gabapentin was initiated. Management of DA should adopt a multidisciplinary team approach composed of dermatologists and mental health professionals.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
A rare case of NXP-2 and TIF1-? positive dermatomyositis (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_3607;
For treatment resistant disease, rituximab can be used. While most patients respond to corticosteroids and immunosuppressants, approximately one third of patients do not respond or poorly respond to available therapies and remain debilitated such as this patient.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Lamotrigine-induced atypical DRESS syndrome with erythema multiforme-like eruption (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2396;
As in our patient, Dress syndrome can manifest as target or targetoid lesions and pustules can also be seen. This case highlights these atypical manifestations of a severe systemic drug reaction to insure early diagnosis and the dermatologist
- |||||||||| Cerebrolysin (porcine brain-derived proteolytic peptide fraction) / Novartis, EVER Pharma
Clinical, Review, Journal: Pharmacological treatment in early rehabilitation after ischemic stroke (Pubmed Central) - Aug 29, 2023
This review provided a summary of the evidence on pharmacological supportive care in early rehabilitation of post-acute ischemic stroke patients. This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Fluoxetine Ameliorates the Aggravation of UC Symptoms in C57BL/6 Mice Induced by CUMS. (Pubmed Central) - Aug 29, 2023
This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population. CUMS aggravated the UC symptoms induced by DSS, and fluoxetine could improve the UC symptoms due to its improvement in the inflammatory level and behavioral abnormalities.
- |||||||||| Priligy (dapoxetine) / AbbVie
Preclinical, Journal: Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous system effects. (Pubmed Central) - Aug 28, 2023
Although duloxetine (DLX), dapoxetine (DPX), atomoxetine (ATX) and propranolol (PRL) also possess the AOPA pharmacophore and are used to treat some psychiatric disorders, the capabilities of these drugs to increase the brain AP and the possible involvement of AP in their CNS effects remain to be fully elucidated...In addition, the brain and serum AP levels had a remarkably high positive correlation after the administration of DLX, DPX and PRL. Thus, this study proposed the AP-related novel mechanism of actions of DLX, DPX and PRL in the CNS.
- |||||||||| fluoxetine / Generic mfg.
Retrospective data, Journal: Acupuncture-adjuvant therapies for treating perimenopausal depression: A network meta-analysis. (Pubmed Central) - Aug 25, 2023
Randomized clinical trials (RCTs) are needed to confirm these results, starting with the molecules with the greatest effect size in the study, e.g., fluoxetine, escitalopram, and amlodipine. The findings of this network meta-analysis may help patients and therapists choose the best acupuncture therapy for treating perimenopausal depression patients and furnish reliable evidence for guidelines.
- |||||||||| Clinical, Review, Journal, Adverse events: Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review. (Pubmed Central) - Aug 25, 2023
As for antipsychotics, drugs like Clozapine, Olanzapine, and Risperidone were linked to weight gain, diabetes, and deterioration of the lipid profile...Future research should focus on conducting field studies to further expand knowledge on the metabolic effects of other commonly prescribed psychotropic drugs. Overall, the study highlights the significance of understanding and managing metabolic alterations induced by psychopharmacological treatment to enhance patient care and well-being.
- |||||||||| fluoxetine / Generic mfg.
Journal: Perineuronal Nets Alterations Contribute to Stress-Induced Anxiety-Like Behavior. (Pubmed Central) - Aug 24, 2023
FXT treatment in CRS mice not only ameliorated their deficits in behavior and synaptic transmissions, but also prevented CRS-induced reduction of PNNs and ACAN expressions. This study demonstrates that proper PNNs level is critical to brain functions, and their decline may serve as a pathological mechanism of anxiety disorders.
- |||||||||| Aimovig (erenumab-aooe) / Amgen, Novartis
Case of the Shakes (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_4988;
Carbamazine was started and her DBS current increased slightly with full resolution of her symptoms. The etiology remains unclear.
- |||||||||| fluoxetine / Generic mfg.
Journal: The influence of fluoxetine on neuroimmune interaction in multiple sclerosis (Pubmed Central) - Aug 14, 2023
These findings highlight the importance of considering reproductive status in Fluoxetine may have an anti-inflammatory effect in MS that could be mediated by suppression of Th17- and Th1-cells or macrophage-induced Th17- and Th1-immune response.
- |||||||||| temozolomide / Generic mfg., fluoxetine / Generic mfg.
Enrollment open: Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT) (clinicaltrials.gov) - Aug 14, 2023
P1, N=30, Recruiting,
Fluoxetine may have an anti-inflammatory effect in MS that could be mediated by suppression of Th17- and Th1-cells or macrophage-induced Th17- and Th1-immune response. Not yet recruiting --> Recruiting
- |||||||||| imipramine / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Antidepressant and Anxiolytic Effects of L-Methionine in the WAG/Rij Rat Model of Depression Comorbid with Absence Epilepsy. (Pubmed Central) - Aug 12, 2023
Taken together, our findings suggest that L-MET could serve as a promising new antidepressant drug with anxiolytic properties for the treatment of depression comorbid with absence epilepsy. Increases in the level of monoamines and their metabolites-DA, DOPAC, HVA, NA, and MHPG-in several brain structures, is suggested to be a neurochemical mechanism of the beneficial phenotypic effect of L-MET.
- |||||||||| fluoxetine / Generic mfg., lurasidone / Generic mfg.
Journal: Lurasidone as add-on to fluoxetine in obsessive-compulsive disorder with comorbid restrictive anorexia: a case report. (Pubmed Central) - Aug 9, 2023
Full remission was reported after 3 months (Y-BOCS scoring ?14) (P?<?0.01). Further longitudinal and real-world effectiveness studies should be implemented to confirm these novel results, to investigate the potential of lurasidone as add-on strategy to SSRI in poor responder OCD patients, including treatment-resistant-OCD (tr-OCD), as well as in improving eating disorder symptomatology, whereas there is comorbidity with AN-r.
- |||||||||| fluoxetine / Generic mfg.
Journal: MPFC PV interneurons are involved in the antidepressant effects of running exercise but not fluoxetine therapy. (Pubmed Central) - Aug 7, 2023
However, running exercise but not fluoxetine therapy improved the dendritic complexity level of PV interneurons in the MPFC of mice exposed to CUS. In summary, the number and dendritic complexity level of PV interneurons may be important therapeutic targets for the mechanism by which running exercise reverses depression-like behavior faster and more effectively than fluoxetine therapy.
- |||||||||| Viibryd (vilazodone) / AbbVie
Journal: Drugs for anxiety disorders. (Pubmed Central) - Aug 3, 2023
FLX and CUMS distinctly regulated the gut microbiota in depressed rats. No abstract available
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Repeated seizures lead to progressive ventilatory dysfunction in SS rats. (Pubmed Central) - Aug 3, 2023
Fluoxetine treatment in SS rats prevented the repeated seizure-induced progressive respiratory suppression but failed to prevent seizure-related mortality. We conclude that repeated seizures cause a progressive compromise of ventilatory control in the immediate postictal period largely mediated by serotonin system suppression in brainstem regions of respiratory control, but that other unknown factors contribute to overall survival following repeated seizures in this model.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Serotonin Transporter Activity in Mouse Oocytes Is a Positive Indicator of Follicular Growth and Oocyte Maturity. (Pubmed Central) - Aug 2, 2023
An in vivo experiment on administration of the selective serotonin reuptake inhibitor fluoxetine (20 mg/kg) for 7 days showed a significant decrease in the content of serotonin in both growing GV-oocytes and ovulated mature MII-oocytes. The data obtained clearly indicate that the mechanism of specific membrane transport of serotonin normally ensures the accumulation of serotonin in maturing oocytes, and can be considered as a promising positive marker of their mature status.
- |||||||||| fluoxetine / Generic mfg.
Journal: A Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications. (Pubmed Central) - Aug 1, 2023
All in all, probe 1 with its high specificity, good biological compatibility and liver tissue penetration ability is expected to assist with the early diagnosis of DILI and the clinical screening of various new drugs. We expect that probe 1 could be efficiently used as a powerful molecular tool to predict clinical DILI and explore molecular mechanisms between molecules and disease.
- |||||||||| fluoxetine / Generic mfg.
Serotonin Syndrome in a Patient with Crohn (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1272;
He was receiving ustekinumab with no response in addition to opioids and fluoxetine 40 mg daily...Treatment was initiated with infliximab at 10 mg/kg every 4 weeks, but the CD continued to progress, resulting in the formation of additional fistulae and multiple abscesses...Int J Mol Sci . 2019; 20:2288
- |||||||||| Review, Journal: Review on Surface-Modified Electrodes for the Enhanced Electrochemical Detection of Selective Serotonin Reuptake Inhibitors (SSRIs). (Pubmed Central) - Jul 29, 2023
This review article aims to present functional materials such as polymers, carbon nanomaterials, metal nanomaterials as well as composites for surface modification of electrodes for sensitive detection and quantification of SSRIs, including fluoxetine, citalopram, paroxetine, fluvoxamine and sertraline. Sensor fabrication, sensor/analyte interactions, design rationale and properties of functional material and the electrocatalytic effect of the modified electrode on SSRI detection are discussed.
- |||||||||| fluoxetine / Generic mfg.
Journal: Reactivity Umpolung of Tertiary Amide Enabled by Catalytic Reductive Stannylation. (Pubmed Central) - Jul 22, 2023
By leveraging this umpolung reactivity, drug Fluoxetine was derivatized to 12 different analogues via reacting with various electrophiles and four biologically active molecules were prepared concisely. This unlocked umpolung reactivity of tertiary amide is expected to find applications to synthesize complex amines from amides.
- |||||||||| Journal: Treatment-Resistant Depression (TRD): Is the Opioid System Involved? (Pubmed Central) - Jul 18, 2023
Reboxetine induced a weak antinociceptive effect with no significant opioid involvement, while moclobemide, fluoxetine, and fluvoxamine had no opioid-involved antinociceptive effects. Controlled clinical studies are needed to establish the efficacy of the augmentation of opiate antidepressants in persons with treatment-resistant depression and the optimal dosage of drugs prescribed.
- |||||||||| Retrospective data, Journal: Significant Increase in Deliberate Self-Poisonings Among Adolescents During the Second Year of the COVID-19 Pandemic. (Pubmed Central) - Jul 18, 2023
Overall, metabolic fingerprints combined with the ROC curve and SVM-LK may represent a new approach to identifying marker candidates or predictive metabolites for ongoing disease or disease risk and treatment outcome. The strong increase in the number of DSPs during the second year of the COVID-19 pandemic suggests that long-term containment measures such as quarantines, lockdowns, and school closures may enhance self-harm behavior among adolescents, especially among younger females (13-15
- |||||||||| duloxetine / Generic mfg.
Journal: Status Cataplecticus Induced by an Abrupt Duloxetine Withdrawal-A Case Report. (Pubmed Central) - Jul 17, 2023
We review the pathophysiology of antidepressant withdrawal-induced status cataplecticus. In persons with narcolepsy type 1, physicians discontinuing any antidepressant should counsel on adverse effects of antidepressant withdrawal and reduce the dose in tapering manner.
- |||||||||| fluoxetine / Generic mfg.
Journal: EPD1504: a novel ?-opioid receptor partial agonist attenuates obsessive-compulsive disorder (OCD)-like behaviors. (Pubmed Central) - Jul 17, 2023
In this study, we show that doses of EPD1504 and buprenorphine that occupy small fractions of MORs in the CNS (approximately 20%) are as effective as fluoxetine at ameliorating OCD-like behaviors in two different rat models (an operant probabilistic reversal task and marble burying)...Additionally, EPD1504 had effects comparable to buprenorphine in the conditioned place preference assay. These results indicate that EPD1504 may provide a safer alternative to buprenorphine for the treatment of OCD patients.
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