- |||||||||| [VIRTUAL] Impact of CYP2C19 and CYP2D6 polymorphism on antidepressants and antipsychotics exposure; a meta-analysis (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_773;
The impact of the CYP2C19/CYP2D6 genotype on the plasma levels of fourteen antidepressants and antipsychotics supports an important role of preemptive CYP2C19/CYP2D6 genotyping in dose personalisation. The results obtained may be used as a scientific foundation for a prospective rediscussing of the dose recommendations for aripiprazole, haloperidol, risperidone, escitalopram, mirtazapine, and sertraline..
- |||||||||| fluoxetine / Generic mfg.
[VIRTUAL] Effects of antidepressants on BDNF levels in patients with major depression: a systematic review (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_677;
One study (243 patients) found no correlation between genotype and response to mirtazapine...Conclusions The results of the revised literature seem to be heterogeneous, with some evidence in support of a significant association between BDNF levels and clinical response to antidepressant treatments and other studies reporting no association. Further studies are needed about the role of BNDF in MDD and in antidepressant therapy and about the determinants of the heterogeneity of results[2][3][4].
- |||||||||| Valdoxan (agomelatine) / Servier, Novartis, Trintellix (vortioxetine) / Lundbeck, Takeda, fluoxetine / Generic mfg.
[VIRTUAL] Effects of vortioxetine and agomelatine in the Differential Reinforcement of Low Rate (DRL) test in the rat (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_403;
Conclusion These data confirm the presence of antidepressant-like effects of vortioxetine, agomelatine and ketamine using the DRL30 test in the rat. The DRL test provides a robust assay to evaluate the anti-impulsive effects of antidepressants acting on numerous targets relevant to depressive disorders.
- |||||||||| fluoxetine / Generic mfg.
Clinical, Journal, Adverse drug reaction: Assessment of incidence, causality, severity, and preventability of suspected adverse drug reactions to antidepressant medications in a psychiatry outpatient setting of a secondary care hospital. (Pubmed Central) - Aug 4, 2020
Most of the suspected ADRs related to antidepressants were "mild," "predictable," and "not preventable" in nature. Continuous monitoring may help in identifying, reducing, and preventing the risk of ADRs.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression. (Pubmed Central) - Aug 2, 2020
Further in vitro study showed that p53 presence is required for fluoxetine activated autophagy flux and fluoxetine promotes astrocytic autophagy in a p53-dependent mechanism. Collectively, this work gives us insights into a novel approach to treat depression depending on astrocytes, and provides a promising molecular target for the development of antidepressant drugs besides regulating neurotransmitters.
- |||||||||| Journal: Effects of selective serotonin reuptake inhibitors on motility of isolated Fallopian tube. (Pubmed Central) - Jul 31, 2020
Escitalopram and paroxetine have clear stimulating effect which may interfere with functioning of the Fallopian tubes, and potentially impair fertility if taken by women in reproductive period of life. The other SSRIs tested in the study did not produce significant effect throughout the concentration range used in the experiments.
- |||||||||| lithium / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Lithium Potentiated, Pyridoxine Abolished and Fluoxetine Attenuated the Anxiolytic Effect of Diazepam in Mice. (Pubmed Central) - Jul 29, 2020
Pretreatments of pyridoxine (90 mg/kg, i.p.) abolished; lithium (50 mg/kg, i.p.) potentiated while fluoxetine (10 mg/kg, i.p.) attenuated the anxiolytic and neurochemical effects of diazepam (1 and 2 mg/kg, i.p.) treatment in mice. Therefore, the combined treatment of lithium and diazepam might be a promising treatment for anxiety.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Demonstration of an action pathway in mouse platelets leading to prolongation of bleeding time by fluoxetine. (Pubmed Central) - Jul 28, 2020
All changes returned to same levels as Control group after fluoxetine withdrawal. These data suggest an action pathway of fluoxetine starting at binding to serotonin transporter, followed by decreased intraplatelet serotonin, increased GPIbα shedding, suppressed GPIIb/IIIa activation, and inhibited α-granule release, and concluding with prolonged bleeding time in mice.
- |||||||||| fluoxetine / Generic mfg.
Review, Journal: Practitioner Review: Therapeutics of unipolar major depressions in adolescents. (Pubmed Central) - Jul 25, 2020
There is now a range of clinically effective treatments for depressed adolescents. Future research needs to reveal moderators of and mechanisms for individual differences to treatment response, determine psychotherapies of value for milder depressions, enhance our understanding of safety and side-effects for all treatments, and consider how to reduce and treat treatment-resistant cases.
- |||||||||| fluoxetine / Generic mfg.
Clinical, Journal: PSA-NCAM colocalized with cholecystokinin-expressing cells in the hippocampus is involved in mediating antidepressant efficacy. (Pubmed Central) - Jul 25, 2020
Pharmacological digestion of PSA-NCAM impaired the efficacy of antidepressant fluoxetine (FLX), a selective serotonin reuptake inhibitor, but not the efficacy of benzodiazepine anxiolytic diazepam...The antidepressant-induced increase in p11 expression was inhibited following PSA-NCAM digestion. We hence hypothesize that PSA-NCAM colocalized with VGluT3/CCK cells may play a unique role in regulating antidepressant efficacy.
- |||||||||| flumazenil / Generic mfg., bupropion / Generic mfg., fluoxetine / Generic mfg.
Preclinical, Journal: Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice. (Pubmed Central) - Jul 25, 2020
EHFAC presented anxiolytic-like effect on the elevated plus-maze, which was partially reversed by flumazenil...In the forced swimming test, EHFAC and CA reduced the immobility time of mice; such effect was potentiated when EHFAC or CA were associated with imipramine, bupropion and fluoxetine...In addition, a pre-treatment with EHFAC and CA did not decrease the latency to 1st seizure of animals that received a sub-convulsive dose of PTZ, nor reduced the intensity of oxotremorine-induced tremors. Taken together, the results indicate that EHFAC and CA have anxiolytic and antidepressant-like effects, which involve important neurotransmitter systems, such as GABAergic and monoaminergic ones, being devoid of side effects, commonly associated with classical psychotropic drugs.
- |||||||||| Review, Journal: Update on Pharmacotherapy in Psychodermatological Disorders. (Pubmed Central) - Jul 24, 2020
Miscellaneous drugs include anticonvulsants such as gabapentin and pregabalin, naltrexone, and N-acetyl cysteine...Usually, drugs are started at a low dose and gradually increased. A literature search was done in Pubmed, Google Scholar, and Medline databases, and articles on treatment were analyzed.
- |||||||||| fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Journal: Trace organic contaminants in field-scale cultivated alfalfa, soil, and pore water after 10 years of irrigation with reclaimed wastewater. (Pubmed Central) - Jul 22, 2020
Pore water collected during non-irrigating periods contained all analyzed TrOCs, from 3 ± 0.1 ng/L (diphenhydramine) to 343 ± 360 ng/L (primidone)...Soils from 0 to 60 cm contained nine TrOCs from below the reporting limit (fluoxetine) to 329 ng/g (carbamazepine)...We estimated that a maximum of 14% of DEET from the reclaimed wastewater was accumulated in alfalfa. Overall, despite some accumulation of TrOCs in the soil, alfalfa uptake was limited, which results in low exposure to foraging animals.
- |||||||||| fluoxetine / Generic mfg.
Journal: Trauma-Associated Sleep Disorder: A Posttraumatic Stress/REM Sleep Behavior Disorder Mash-Up? (Pubmed Central) - Jul 21, 2020
Our case demonstrated overlapping clinical features of PTSD and RBD with polysomnography features of RSWA supportive of idiopathic RBD but no "soft signs" suggesting underlying synucleinopathy. Longitudinal follow-up of larger case series must clarify whether TASD consistently manifests REM sleep atonia loss and determine the phenoconversion risk for synucleinopathy neurodegeneration.
- |||||||||| fluoxetine / Generic mfg.
Trial completion date, Trial primary completion date: FLUORESCE: Fluoxetine for Visual Recovery After Ischemic Stroke (clinicaltrials.gov) - Jul 21, 2020
P2, N=40, Recruiting,
Treatment with the antidepressant fluoxetine seems to counteract these changes by acting mainly on presynaptic α-adrenoceptors expressed in terminal areas. Trial completion date: Jun 2020 --> Jun 2024 | Trial primary completion date: Jun 2020 --> Jun 2024
- |||||||||| Clinical, Review, Journal: Menopause symptom management in women with dyslipidemias: An EMAS clinical guide. (Pubmed Central) - Jul 19, 2020
Non-estrogen-based therapies, such as fluoxetine and citalopram, exert a more favorable effect on the lipid profile than do sertraline, paroxetine and venlafaxine. Non-oral testosterone, used for the treatment of hypoactive sexual desire disorder/dysfunction, has little or no effect on the lipid profile.
- |||||||||| Journal: Bacterial Diversity Controls Transformation of Wastewater-Derived Organic Contaminants in River-Simulating Flumes. (Pubmed Central) - Jul 18, 2020
Notable were the formation of valsartan acid from irbesartan and valsartan, the persistence of N-desmethylvenlafaxine across all treatments and the identification of biuret as novel transformation product of metformin. Twelve additional target transformation products were identified, which were persistent in either pore or surface water of at least one treatment indicating their environmental relevance.
- |||||||||| sertraline / Generic mfg., desvenlafaxine extended release / Generic mfg., fluoxetine / Generic mfg.
Retrospective data, Review, Journal: Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis. (Pubmed Central) - Jul 17, 2020
Despite the scarcity of high-quality evidence, fluoxetine (alone or in combination with CBT) seems to be the best choice for the acute treatment of moderate-to-severe depressive disorder in children and adolescents. However, the effects of these interventions might vary between individuals, so patients, carers, and clinicians should carefully balance the risk-benefit profile of efficacy, acceptability, and suicide risk of all active interventions in young patients with depression on a case-by-case basis.
- |||||||||| doxycycline / Generic mfg., Pierre Fabre, fluoxetine / Generic mfg.
Journal: Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4. (Pubmed Central) - Jul 17, 2020
After 90 days, the average recovery rates were between 90% and 110% for tramadol (5 mg/mL to 30 mg/mL) and doxycycline (2 mg/mL to 10 mg/mL) without organoleptic modification. For fluoxetine, only the formulation at 2 mg/mL was stable; at higher concentrations, the uniformity of the suspension was compromised.
- |||||||||| fluoxetine / Generic mfg.
Journal: Severe symptomatic hyponatremia secondary to fluoxetine. (Pubmed Central) - Jul 17, 2020
For fluoxetine, only the formulation at 2 mg/mL was stable; at higher concentrations, the uniformity of the suspension was compromised. No abstract available
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept. (Pubmed Central) - Jul 11, 2020
We modeled oral SSRI treatment via fluoxetine in the water, in a regimen recapitulating clinical pharmacokinetics and pharmacodynamics...The present preclinical data, appreciated in the context of published 5-HTP clinical data, suggest that 5-HTP SR could represent a new therapeutic approach to the plethora of CNS disorders potentially treatable with a pro-serotonergic drug. 5-HTP SR might in particular be therapeutically relevant when brain 5-HT deficiency is pathogenic and as an adjunctive augmentation therapy to SSRI therapy.
- |||||||||| fluoxetine / Generic mfg.
Clinical, Journal: Chronic exposure to a pervasive pharmaceutical pollutant erodes among-individual phenotypic variation in a fish. (Pubmed Central) - Jul 11, 2020
In addition, mean baseline metabolic rate was disrupted in low-fluoxetine exposed fish, although mean metabolic and behavioural responses to predation threat were not affected. Overall, our study demonstrates that long-term exposure to a pervasive pharmaceutical pollutant alters ecologically relevant traits in fish and erodes among-individual variability, which may be detrimental to the stability of contaminated populations globally.
- |||||||||| citalopram / Generic mfg., fluoxetine / Generic mfg., ibuprofen / Generic mfg.
Journal: Enantiospecific behaviour of chiral drugs in soil. (Pubmed Central) - Jul 11, 2020
Therefore, introduction of the less active enantiomer to soil through irrigation with reclaimed wastewater or biosolids as fertiliser can result in the formation of its active enantiomer, or vice versa. This phenomenon needs considered in risk assessment frameworks to avoid underestimating the risk posed by chiral drugs in amended soils.
- |||||||||| fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Journal: Pharmaceutical uptake kinetics in rainbow trout: In situ bioaccumulation in an effluent-dominated river influenced by snowmelt. (Pubmed Central) - Jul 11, 2020
Spatial and temporal differences for pharmaceutical levels in rainbow trout directly corresponded with surface water exposure concentrations, and uptake kinetics for individual pharmaceuticals did not vary among sites or seasons. Such observations are consistent with recent laboratory bioconcentration studies, which collectively indicate inhalational exposure from water governs rapid accumulation of ionizable base pharmaceuticals by fish in inland surface waters.
- |||||||||| fluoxetine / Generic mfg.
Journal: First record of emerging contaminants in sponges of an inhabited island in the Maldives. (Pubmed Central) - Jul 11, 2020
Norfluoxetine was below the limit of quantification of 10 ng/g d.w. Nitro xylene, N,N-Diethyl-meta-toluamide and galaxolide were found in both areas, with concentrations of 3.51/6.11/8.54 and <LOQ/1.14/0.62 ng/g d.w., respectively. Due to the vital role of the coral reef for the livelihood and economy of the Maldivian people, attention should be paid to this class of contaminant.
- |||||||||| fluoxetine / Generic mfg.
Clinical, Journal: Changes in the levels of comet parameters before and after fluoxetine therapy in major depression patients. (Pubmed Central) - Jul 11, 2020
On categorizing into three age groups, the numbers of major depression patients belonging to 18-30 year age group were higher than 31-40 and 41-50 year age groups. All the parameters of deoxyribonucleic acid damage were reduced after eight week of fluoxetine therapy indicating that fluoxetine has anti-oxidant action along with its antidepressant properties, which cause reversal of oxidative stress induced damage occurring during major depression.
|
